Abdominal Ultrasound Does Not Reveal Significant Alterations in Patients With Nonceliac Wheat Sensitivity
Goals: The goal of this study was (A) to evaluate abdominal ultrasound signs in nonceliac wheat sensitivity (NCWS) patients for features useful in diagnosis and (B) to compare these aspects with those of celiac patients to assess whether ultrasound can be useful in the differential diagnosis between NCWS and celiac disease (CD). Background: NCWS diagnosis is difficult as no biomarkers of this condition have as yet been identified. In CD ultrasound aspects have been identified that have a good diagnostic accuracy. Study: We prospectively recruited 45 NCWS patients (11 males, 34 females; mean age 35.7 y). Thre...
Source: Journal of Clinical Gastroenterology - December 18, 2018 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Diagnostic Yield of 2 Strategies for Adult Celiac Disease Identification in Primary Care
Conclusions: Testing symptomatic subjects at CF only by POCT seems the most cost-effective strategy to bridge the diagnostic gap of adult CD in primary care. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - December 18, 2018 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Artificial intelligence and capsule endoscopy: Is the truly “smart” capsule nearly here?
One wonders whether Gavriel Iddan truly realized what an impact his invention of wireless capsule endoscopy (CE) would have in the world of GI endoscopy.1 Since its official release in 2001, it has revolutionized the management of small-bowel diseases, including GI bleeding, Crohn ’s disease, abnormal radiologic imaging, polyposis syndromes, and celiac disease. Furthermore, the advent of balloon enteroscopy to “chase” the findings of small-bowel CE has brought a very powerful solution to occult GI bleeding. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - December 17, 2018 Category: Gastroenterology Authors: Michael F. Byrne, Fergal Donnellan Tags: New methods Source Type: research

Reply
We appreciate the opportunity to respond to the comments of Meyer et  al concerning our recent publication on the relationship of patent ductus arteriosus (PDA) size and echocardiographic markers of PDA-related shunt volume. Contrary to our data, these investigators have shown an important correlation between acute kidney injury (AKI) and indexed PDA diameter.1 In t heir retrospective study of 422 very low birth weight infants (mean birth weight of 1059.0 ± 308.2 g) they demonstrated that AKI was associated with both clinical (birth weight, gestational age, Apgar score at 10 minutes, PDA su...
Source: The Journal of Pediatrics - December 17, 2018 Category: Pediatrics Authors: Fernando de Freitas Martins, Patrick J. McNamara Tags: Letters to the Editor Source Type: research

Autoimmune diseases in autoimmune atrophic gastritis.
Abstract Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with ...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Rodriguez-Castro KI, Franceschi M, Miraglia C, Russo M, Nouvenne A, Leandro G, Meschi T, De' Angelis GL, Di Mario F Tags: Acta Biomed Source Type: research

Digestive disorders and Intestinal microbiota.
Abstract In the last decade, a barge body of scientific literature has suggested that specific alterations of the gut microbiota may be associated with ther development and clinical course of several gastrointestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, gastrointestinal cancer and Clostridium difficile infection. These alterations are often referred to as "dysbiosis", a generic term designing reduction of gut microbiota biodiversity and alterations in its composition. Here, we provide a synthetic overview of the key concepts on the relationship between...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Nouvenne A, Ticinesi A, Tana C, Prati B, Catania P, Miraglia C, De' Angelis GL, Di Mario F, Meschi T Tags: Acta Biomed Source Type: research

Peripheral neuropathy and gastroenterologic disorders: an overview on an underrecognized association.
CONCLUSIONS: The association between gastrointestinal and peripheral nervous system symptoms is probably still underrecognized but has to be actively sought, in order to provide prompt diagnosis resulting in optimal care and long-term management with the aim to improve quality of life and, at least in some conditions, try to impact on prognosis. PMID: 30561392 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Spagnoli C, Pisani F, Di Mario F, Leandro G, Gaiani F, De' Angelis GL, Fusco C Tags: Acta Biomed Source Type: research

Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?
Abstract Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. Many genes involved in the pathogenesis have been identified and a crucial role is known to be played by the Human Leukocyte Antigen (HLA) system. The main determinants for genetic susceptibility are HLA-DQA1 and HLA-DQB1 genes encoding for HLA-DQ2 and HLA-DQ8 molecules, carried by almost all patients affected. However, since HLA-DQ2 and HLA-DQ8 heterodimers explain almost 40% of the disease heritability, HLA typing should not be applied in diagnosis, but exclusively to c...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Sciurti M, Fornaroli F, Gaiani F, Bonaguri C, Leandro G, Di Mario F, De' Angelis GL Tags: Acta Biomed Source Type: research

Thyroid and celiac disease in pediatric age: a literature review.
Abstract Chronic autoimmune thyroid disease or Hashimoto thyroiditis (HT) and Graves-Basedow disease (GD) are the main autoimmune thyroid diseases in pediatric age. Both are characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function (hyperthyroidism in GD, normal function or subclinical hypothyroidism in HT with possible evolution towards manifest hypothyroidism). Celiac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects, its prevalence...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Minelli R, Gaiani F, Kayali S, Di Mario F, Fornaroli F, Leandro G, Nouvenne A, Vincenzi F, De' Angelis GL Tags: Acta Biomed Source Type: research

Growth changes after gluteen free diet in pediatric celiac patients: a literature-review.
CONCLUSIONS:   the nutritional status of celiac patients at diagnosis is variable including an increasing number of overweight and obese. GFD has a beneficial impact on growth changes determining a correction of BMI distribution towards a Gaussian shape. PMID: 30561389 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Ghiselli A, Bizzarri B, Gaiani F, Semeraro F, Iuliano S, Di Mario F, Nouvenne A, Kayali S, De 'Angelis GL Tags: Acta Biomed Source Type: research

A review of the gluten-free diet in non-celiac patients: beliefs, truths, advantages and disadvantages.
Authors: Palmieri B, Vadala' M, Laurino C Abstract A gluten-free diet is the safest treatment for the treatment of patient with celiac disease (CD) and other gluten-related disorders. However, in the last years, gluten-free diet is one of the most popular diet followed by the general population and by patients affected from others clinical conditions, such as non-celiac gluten sensitivity (NCGS), irritable bowel syndrome (IBS), autism, neurological, psychiatric and rheumatologic diseases and for improving sports practice. This review highlights some questions about the appropriateness of follow this trend answering...
Source: Minerva Gastroenterologica e Dietologica - December 16, 2018 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Efficacy of Ruxolitinib Therapy in a Patient With Severe Enterocolitis Associated With a STAT3 Gain-of-Function Mutation
Severe enterocolitis raises diagnostic and therapeutic challenges. Empirical treatment by steroids and immunosuppressive drugs is commonly used but, to date, little attempt has been made to specifically target the mechanism underlying inflammation. Possible causes of severe enterocolitis include refractory celiac disease,1 autoimmune enteropathy,2 and common variable immunodeficiency,3 the 2 latter being overlapping entities of possible monogenic inheritance. Besides FOXP3 mutations that cause immune dysregulation polyendocrinopathy X-linked syndrome,4 additional genetic causes have recently been reported. (Source: Gastroenterology)
Source: Gastroenterology - December 15, 2018 Category: Gastroenterology Authors: Marianna Parlato, Fabienne Charbit-Henrion, Elie Abi Nader, Bernadette Begue, Nicolas Guegan, Julie Bruneau, Sh érine Khater, Elizabeth Macintyre, Capucine Picard, F. Rieux-Laucat, Lionel Le Bourhis, Matthieu Allez, Olivier Goulet, Christophe Cellier, Ol Tags: Brief Communication Source Type: research

Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet
Conclusion: In CD patients, following a GFD maybe can contribute to the development of MS and HS. Patients should be informed about this possible risk.Digestion (Source: Digestion)
Source: Digestion - December 14, 2018 Category: Gastroenterology Source Type: research

Follow-up of Celiac Disease
This article deals with conventional strategies used in order to follow-up patients on treatment and aiming to obtain the best clinical outcome. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 14, 2018 Category: Gastroenterology Authors: Steffen Husby, Julio C. Bai Source Type: research

Capsule Endoscopy and Enteroscopy in Celiac Disease
Celiac disease predominantly involves the proximal small bowel, but villus atrophy can be patchy, spare the duodenum, and be present more distally. Video capsule endoscopy is more sensitive than standard endoscopy to detect villus atrophy, and can define extent of disease, though it cannot obtain biopsies. Duodenal biopsy is the gold standard for diagnosis. Video capsule endoscopy assists in special circumstances when biopsy is not possible, and in equivocal diagnosis. Video capsule endoscopy and enteroscopy are recommended for evaluating complicated celiac disease, especially refractory celiac disease type II. Future deve...
Source: Gastroenterology Clinics of North America - December 14, 2018 Category: Gastroenterology Authors: Suzanne K. Lewis, Carol E. Semrad Source Type: research

Biopsy Diagnosis of Celiac Disease
This article discusses the histopathology and differential diagnosis of celiac disease and provides the pathologist ’s perspective on biopsy adequacy, evaluation, and reporting in light of current knowledge. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 14, 2018 Category: Gastroenterology Authors: Stephen M. Lagana, Govind Bhagat Source Type: research

Nutritional Considerations of the Gluten-Free Diet
Celiac disease (CD) is an autoimmune-related disease causing inflammation in the small intestine triggered by the ingestion of gluten in the diet. The gluten-free diet (GFD) is the only treatment. Nutritional deficiencies of macronutrients and micronutrients are frequently found in untreated or newly diagnosed CD. A registered dietitian nutritionist is uniquely qualified to educate on the GFD and assess and support nutritional status at diagnosis and long term as well as helping patients with nonresponsive CD. Quality of life is important to address in individuals with CD because the GFD affects all aspects of life. (Sourc...
Source: Gastroenterology Clinics of North America - December 14, 2018 Category: Gastroenterology Authors: Melinda Dennis, Anne R. Lee, Tara McCarthy Source Type: research

Celiac Disease
The presentation in celiac disease is shifting from the classical malabsorptive presentation to more nonclassical presentations, requiring clinicians to maintain a high level of suspicion for the disease and to be aware of the possible extraintestinal manifestations. The diagnosis of celiac disease is guided by initial screening with serology, followed by confirmation with an upper endoscopy and small intestinal biopsy. In some pediatric cases, biopsy may be avoided. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Isabel A. Hujoel, Norelle R. Reilly, Alberto Rubio-Tapia Source Type: research

Celiac Disease, Gluten-Free, and Today ’s Fashionista
First described by the famous ancient Greek physician Aretaeus of Cappadocia, “celiac” and the later-described “gluten-free” have become buzz words during this millennium. Individuals claim they feel much better when consuming a gluten-free diet. Is this gluten sensitivity? Is it a real disease entity? Rigorous studies have begun to investigate this in a scientific ma nor. A famous chef in Chicago once told me a number of years ago when restaurants were forced to come out with gluten-free menus that the same individuals who requested gluten-free meals were the same ones ordering bread pudding for de...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Alan L. Buchman Tags: Foreword Source Type: research

New Developments in Celiac Disease
The world of celiac disease is changing rapidly. From the mid-twentieth century forward, celiac disease was understood as an illness primarily affecting children, exclusively affecting the small intestine, and treated by life-long gluten restriction, with no other therapies on the horizon. In recent years, these aspects of celiac disease have been upended. This issue of Gastroenterology Clinics of North America documents the current state of understanding celiac disease during this time of major change. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Benjamin Lebwohl, Peter H.R. Green Tags: Preface Source Type: research

Nonceliac Wheat Sensitivity
Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Ongoing research efforts are aimed at further characterizing the etiology, mechanism, ...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Umberto Volta, Roberto De Giorgio, Giacomo Caio, Melanie Uhde, Roberto Manfredini, Armin Alaedini Source Type: research

Nondietary Therapies for Celiac Disease
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. Gluten-free diets can be challenging because of their restrictive nature, inadvertent cross-contaminations, and the high cost of gluten-free food. Novel nondietary therapies are at the preclinical stage, clinical trial phase, or have already been developed for other indications and are now being applied to CD. These therapies include enzymatic gluten degradation, binding and sequestration of gluten, restoration of epithelial tight junction barrier function, inhibition of tissue transglutaminase –mediated potentiation of gliadin oligopeptide immunog...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Gloria Serena, Ciaran P. Kelly, Alessio Fasano Source Type: research

Refractory Celiac Disease
Refractory celiac disease (RCD) refers to persistence of malnutrition and intestinal villous atrophy for more than 1 to 2  years despite strict gluten-free diet in patients with celiac disease. Diagnosis remains difficult and impacts treatment and follow-up. RCD has been subdivided into 2 subgroups according to the normal (RCDI) or abnormal phenotype of intraepithelial lymphocytes (IELs) (RCDII). RCDII is considered a s a low-grade intraepithelial lymphoma and has a poor prognosis due to gastrointestinal and extraintestinal dissemination of the abnormal IELs, and high risk of overt lymphoma. (Source: Gastroenterology ...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Georgia Malamut, Christophe Cellier Source Type: research

The Microbiome in Celiac Disease
The healthy microbiome is necessary for normal immune development in the gut. Alterations in the microbial makeup after a critical window increase the risk of autoimmunity, including celiac disease. Although this dysbiosis has been described in adult and pediatric patients, factors leading to dysbiosis are still being elucidated. Genetics has some role in determining the microbiome makeup of the host, but other factors have yet to be determined. The microbiome remains an important therapeutic target in many autoimmune conditions, including celiac disease, however studies have yet to determine the ideal replacement therapy ...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Suneeta Krishnareddy Source Type: research

Celiac Disease in Asia
Celiac disease, once thought to be very uncommon in Asia, is now emerging in many Asian countries. Although the absolute number of patients with celiac disease at present is not very high, this number is expected to increase markedly over the next few years/decades owing to increasing awareness. It is now that the medical community across the Asia should define the extent of the problem and prepare to handle the impending epidemic of celiac disease in Asia. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Govind K. Makharia, Carlo Catassi Source Type: research

(Outcome) Measure for (Intervention) Measures
This article reviews various measures of intestinal function and nutrition, patient-reported outcome measures for symptoms and for health-related quality of life, and measures of sickness burden as they apply to intervention studies for celiac disease. A series of case studies is presented to illustrate key considerations in selecting outcome measures for dietary interventions, pharmacologic interventions, and real-world studies. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Prashant Singh, Jocelyn A. Silvester, Daniel Leffler Source Type: research

Epidemiology of Celiac Disease
Celiac disease is a common, chronic inflammatory disorder of the small intestine triggered by exposure to gluten in individuals with certain genetic types. This disorder affects people of any age or gender. Although often thought to be European in origin, it is now global in extent. Presentations are variable, from asymptomatic patients to severe malnutrition. Initial detection usually relies on celiac-specific serology, and confirmation often requires intestinal biopsy. There have been substantial increases in prevalence and incidence over the last 2 decades for reasons that are almost certainly environmental but for whic...
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Jonas F. Ludvigsson, Joseph A. Murray Source Type: research

Clinical Features and Diagnosis
The presentation in celiac disease is shifting from the classical malabsorptive presentation to more nonclassical presentations, requiring clinicians to maintain a high level of suspicion for the disease and to be aware of the possible extraintestinal manifestations. The diagnosis of celiac disease is guided by initial screening with serology, followed by confirmation with an upper endoscopy and small intestinal biopsy. In some pediatric cases, biopsy may be avoided. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - December 13, 2018 Category: Gastroenterology Authors: Isabel A. Hujoel, Norelle R. Reilly, Alberto Rubio-Tapia Source Type: research

Helicobacter pylori prevalence and risk factors among children with celiac disease.
This study included 70 patients diagnosed with CD at a tertiary referral center in Romania. Age, gender, and indicators of environmental conditions were evaluated via interviews with the childrens caretakers. A multivariable logistic regression analysis was performed to identify the independent predictors for H. pylori infection. RESULTS: Of the 70 patients, 37 (52.9%) were females, and the mean age was 4.04±3.26 years. H. pylori infection was diagnosed in 23 (32.8%) patients, of whom 12 (52.1%) were females, and the mean age was 6.2±4.5 years. Of the total number of children with CD and H. pylori infect...
Source: The Turkish Journal of Gastroenterology - December 12, 2018 Category: Gastroenterology Authors: Maxim R, Plesa A, Stanciu C, Girleanu I, Moraru E, Trifan A Tags: Turk J Gastroenterol Source Type: research

Improving Outcomes After Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): As Always, it is All About Patient Selection
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 11, 2018 Category: Cancer & Oncology Source Type: research

Inadvertent and minimal gluten intake has a negligible role in the onset of symptoms in patients with coeliac disease on a gluten-free diet.
PMID: 30526695 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - December 11, 2018 Category: Nutrition Authors: Schiepatti A, Bellani V, Perlato M, Maimaris S, Klersy C, Biagi F Tags: Br J Nutr Source Type: research

Microbial transglutaminase: A new potential player in celiac disease.
Abstract Microbial transglutaminase is heavily used in the food processing industries to improve food qualities. Being a protein's glue, by cross-linking it creates neoepitope complexes that are immunogenic and potentially pathogenic in celiac disease. Despite low sequence identity, it imitates functionally its family member, the endogenous tissue transglutaminase, which is the autoantigen of celiac disease. The present comprehensive review highlights the enzyme characteristics, endogenous and exogenous intestinal sources, its cross-talks with gluten and gliadin, its immunogenicity and potential pathogenicity and ...
Source: Clinical Immunology - December 10, 2018 Category: Allergy & Immunology Authors: Aaron L, Torsten M Tags: Clin Immunol Source Type: research

An update on the cutaneous manifestations of coeliac disease and non-coeliac gluten sensitivity.
Authors: Graziano M, Rossi M Abstract INTRODUCTION: Coeliac disease is a gluten-induced immune-mediated enteropathy, characterised by the expression of specific genotypes and the production of autoantibodies. The inflammatory process specifically targets the intestinal mucosa, but gastrointestinal and extraintestinal signs and symptoms can also be present. Non-coeliac gluten sensitivity (NCGS) can be diagnosed in individuals who have intestinal and/or extraintestinal symptoms related to the ingestion of gluten, but do not have autoantibodies and do not suffer from lesions in the duodenal mucosa. Among the extrainte...
Source: International Reviews of Immunology - December 7, 2018 Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research

Seizures as a Clinical Manifestation in Somatic Autoimmune Disorders
Publication date: Available online 5 December 2018Source: SeizureAuthor(s): Man Amanat, Roland Thijs, Mona Salehi, Josemir W. SanderAbstractThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto’s encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and ...
Source: Seizure - December 6, 2018 Category: Neurology Source Type: research

Prevalence of reduced bone mineral density in adults with coeliac disease - are we missing opportunities for detection in patients below 50 years of age?
Authors: Pritchard L, Wilson S, Griffin J, Pearce G, Murray IA, Lewis S Abstract OBJECTIVE: There are little data on the prevalence of reduced bone mineral density (BMD) in young adult patients with coeliac disease; guidelines do not support routine investigation of these patients. We assessed the prevalence of reduced BMD in our patients by age. PATIENTS AND METHODS: Prospective observational study of 260 coeliac patients having DXA one year after commencing gluten-free diet. Nonparametric tests and regression were used. RESULTS: Median age was 51years, BMI 24 and 85 (32.7%) were male. Reduced BMD was asso...
Source: Scandinavian Journal of Gastroenterology - December 6, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Duodenal villous atrophy with a negative serology induced by mycophenolate mofetil: not everything is celiac disease.
We report the case of a patient, under chronic therapy with mycophenolate mofetil , during a diagnostic workup for a chronic diarrhea, which presents a duodenal villous atrophy ( VA) with negative celiac serology, which is a diagnostic challenge. VA secondary to MMF is a very unusual adverse effect. Just a few cases have been reported in the literature. PMID: 30511578 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - December 6, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Small-intestinal TG2-specific plasma cells at different stages of coeliac disease
In coeliac disease, ingestion of gluten induces the production of transglutaminase 2 (TG2)-targeted autoantibodies by TG2-specific plasma cells present at high frequency in the small intestinal mucosa in untre... (Source: BMC Immunology)
Source: BMC Immunology - December 6, 2018 Category: Allergy & Immunology Authors: Minna Hietikko, Outi Koskinen, Kalle Kurppa, Kaija Laurila, P äivi Saavalainen, Teea Salmi, Tuire Ilus, Heini Huhtala, Katri Kaukinen and Katri Lindfors Tags: Research article Source Type: research

We might have got it wrong: modern wheat is not more toxic for celiac patients
Publication date: Available online 5 December 2018Source: Food ChemistryAuthor(s): Miguel Ribeiro, Fernando M. NunesAbstractIf there is a disease in which many myths are part of the daily lives of both patients and clinicians as well as researchers, this must be celiac disease. Here, we discuss the possibility that modern wheat varieties used by man do not have led to the increased prevalence of celiac disease. (Source: Food Chemistry)
Source: Food Chemistry - December 5, 2018 Category: Food Science Source Type: research

Testicular Acute Segmental Infarct Following Endovascular Repair of a Juxta-renal Abdominal Aortic Aneurysm: Case Report and Literature Review
A 61-year-old male presented to our Accident& Emergency department with a three-day history of nausea and vomiting. On examination, he had a soft non-tender abdomen but pronounced pulsation of his abdominal aorta. A CT angiogram revealed a 6 cm juxta-renal abdominal aortic aneurysm with thrombus within the aneurysm sac and juxta-renal neck segment. There was also moderate atherosclerotic change of the common, internal and external iliac arteries bilaterally. Given the lack of a suitable infra-renal sealing zone for the stent graft, he underwent a complex endovascular aortic aneurysm repair using a stent graft (Cook Med...
Source: Urology - December 5, 2018 Category: Urology & Nephrology Authors: Sally Zebari, Dean Y. Huang, C. Jason Wilkins, Paul S. Sidhu Source Type: research

Management of celiac disease in daily clinical practice.
Abstract Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects, expressing the HLA DQ2 and/or DQ8 genes on their antigen presenting cells. HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). This process leads to the activation of gluten reactive T cells, small bowel villous atrophy, crypt hyperplasia and intraepithelial lymphocytosis, the histological hallmarks of CD. The clinical picture of CD is extre...
Source: European Journal of Internal Medicine - December 5, 2018 Category: Internal Medicine Authors: Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D Tags: Eur J Intern Med Source Type: research

Acute Testicular Segmental Infarct Following Endovascular Repair of a Juxta-renal Abdominal Aortic Aneurysm: Case Report and Literature Review
A 61-year-old male presented to our Accident& Emergency department with a 3-day history of nausea and vomiting. On examination, he had a soft non-tender abdomen but pronounced pulsation of his abdominal aorta. A computed tomography angiogram revealed a 6 cm juxta-renal abdominal aortic aneurysm with thrombus within the aneurysm sac and juxta-renal neck segment. There was also moderate atherosclerotic change of the common, internal, and external iliac arteries bilaterally. Given the lack of a suitable infrarenal sealing zone for the stent graft, he underwent a complex endovascular aortic aneurysm repair using a stent gr...
Source: Urology - December 5, 2018 Category: Urology & Nephrology Authors: Sally Zebari, Dean Y. Huang, C. Jason Wilkins, Paul S. Sidhu Tags: Grand Rounds Source Type: research

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.
Abstract INTRODUCTION: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. METHODS: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. A meta-analysis was performed to estimate po...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Nederstigt C, Uitbeijerse B, Janssen L, Corssmit EP, de Koning E, Dekkers O Tags: Eur J Endocrinol Source Type: research

Irritable bowel syndrome and colonic diverticular disease: overlapping symptoms and overlapping therapeutic approaches
Purpose of review Irritable bowel syndrome (IBS) is a common symptomatic disorder in the Western world and colonic diverticula are also prevalent; however, relationships between IBS-type symptoms and diverticula have been a source of much debate. Our goal was to reassess these relationships in the light of new data. Recent findings On removing from consideration clinical scenarios which are directly related to diverticula (i.e., diverticulitis, diverticular hemorrhage, and complications of diverticulitis, such as stricture and fistula), relationships between IBS and diverticula can be seen to revolve around a number o...
Source: Current Opinion in Gastroenterology - November 30, 2018 Category: Gastroenterology Tags: LARGE INTESTINE: Edited by Eamonn M.M. Quigley Source Type: research

The inflammatory function of human IgA.
Abstract The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also able to actively contribute to the initiation of inflammation, both at mucosal and non-mucosal sites. This additional function of IgA is initiated by the formation of immune complexes, which trigger Fc alpha Receptor I (FcαRI) to synergize with various other receptors to amplify inflammatory responses. Recent findings have demonstrated that co-stimulation...
Source: Cellular and Molecular Life Sciences : CMLS - November 29, 2018 Category: Cytology Authors: Hansen IS, Baeten DLP, den Dunnen J Tags: Cell Mol Life Sci Source Type: research

Celiac disease presenting as motor neuron disease
Jee Eun Lee, Dong Woo Ryu, Joong Seok Kim, Jae Young AnNeurology India 2018 66(6):1810-1812 (Source: Neurology India)
Source: Neurology India - November 28, 2018 Category: Neurology Authors: Jee Eun Lee Dong Woo Ryu Joong Seok Kim Jae Young An Source Type: research

Duodenal and rectal eosinophilia are new biomarkers of non-celiac gluten sensitivity
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: M. Ellionore J ärbrink-Sehgal, Nicholas J. Talley Source Type: research

Duodenal and Rectal Eosinophilia Are New Biomarkers of Nonceliac Gluten Sensitivity
Going gluten free is thought by many in the community to be the “healthy“ option. Indeed, the gluten-free diet industry represents a $6 billion (in US$) global business.1 There continues to be heightened coverage in the mainstream and social media about gluten and health. It therefore is not surprising that in population-based studies, 7% to 15% of individua ls report symptoms related to wheat ingestion in the absence of celiac disease.2 Of those reporting symptoms related to gluten, approximately 1 in 6 have this suspicion confirmed by double-blind placebo-controlled (DBPC) wheat challenge, referred to as nonc...
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: M. Ellionore J ärbrink-Sehgal, Nicholas J. Talley Tags: Editorial Source Type: research

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture [RESEARCH ARTICLE]
This study extends previous work in flies and humans showing that diet can play a role in the health of the gut barrier. Moreover, simple models can be used to study mechanisms underlying the effects of diet on gut permeability and function. This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - November 28, 2018 Category: Biomedical Science Authors: Pereira, M. T., Malik, M., Nostro, J. A., Mahler, G. J., Musselman, L. P. Tags: Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research

Reply
We thank Dr Freeman for his interest in our systematic review and meta-analysis.1 In his letter, he refers to the study from Vancouver in which 9665 adults underwent endoscopy over 30 years and 234 (2.4%) of them showed mucosal changes compatible with celiac disease.1,2 As the author points out, those with known positive celiac serologic testing, an established diagnosis of celiac disease, and a family history of celiac disease were excluded.1,2 However, these patients were referred for upper endoscopy for evaluation of 1 or more of the following symptoms: diarrhea, abdominal pain, weight loss, dyspepsia, and so forth. (So...
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Prashant Singh, Govind K. Makharia Tags: Letter to the Editor Source Type: research

Screening for Celiac Disease in Canada
I read with interest the systematic review and meta-analysis by Singh et  al1 on the global prevalence of celiac disease. No data were provided from Canada, including prospective biopsy studies from Vancouver.2 In the Vancouver study, elective duodenal biopsy specimens were obtained in a tertiary care setting to determine if mucosal changes of celiac disease were presen t in 9665 adults seen between January 1982 and December 2011. Of these 9665 patients, 234 (or 2.4%) were positive, including 73 males (1.8%) and 161 females (2.8%). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Hugh James Freeman Tags: Letter to the Editor Source Type: research