Retinoic acid-loaded liposomes induce human mucosal CD103 < sup > + < /sup > dendritic cells that inhibit Th17 cells and drive regulatory T-cell development in vitro
Eur J Immunol. 2024 Mar 2:e2350839. doi: 10.1002/eji.202350839. Online ahead of print.ABSTRACTThe active vitamin A metabolite, all-trans-retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103+ DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles carrying tolerogenic adjuvants and disease-specific antigens is a valuable treatment strategy to induce antigen-specific mucosal tolerance in vivo. Here, we investigate...
Source: European Journal of Immunology - March 2, 2024 Category: Allergy & Immunology Authors: No émi Anna Nagy Florianne M J Hafkamp Rinske Sparrius Rico Bas Fernando Lozano Vigario Toni M M van Capel Ronald van Ree Teunis B H Geijtenbeek Bram Sl ütter Sander W Tas Esther C de Jong Source Type: research
Retinoic acid-loaded liposomes induce human mucosal CD103 < sup > + < /sup > dendritic cells that inhibit Th17 cells and drive regulatory T-cell development in vitro
Eur J Immunol. 2024 Mar 2:e2350839. doi: 10.1002/eji.202350839. Online ahead of print.ABSTRACTThe active vitamin A metabolite, all-trans-retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103+ DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles carrying tolerogenic adjuvants and disease-specific antigens is a valuable treatment strategy to induce antigen-specific mucosal tolerance in vivo. Here, we investigate...
Source: European Journal of Immunology - March 2, 2024 Category: Allergy & Immunology Authors: No émi Anna Nagy Florianne M J Hafkamp Rinske Sparrius Rico Bas Fernando Lozano Vigario Toni M M van Capel Ronald van Ree Teunis B H Geijtenbeek Bram Sl ütter Sander W Tas Esther C de Jong Source Type: research
Retinoic acid-loaded liposomes induce human mucosal CD103 < sup > + < /sup > dendritic cells that inhibit Th17 cells and drive regulatory T-cell development in vitro
Eur J Immunol. 2024 Mar 2:e2350839. doi: 10.1002/eji.202350839. Online ahead of print.ABSTRACTThe active vitamin A metabolite, all-trans-retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103+ DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles carrying tolerogenic adjuvants and disease-specific antigens is a valuable treatment strategy to induce antigen-specific mucosal tolerance in vivo. Here, we investigate...
Source: European Journal of Immunology - March 2, 2024 Category: Allergy & Immunology Authors: No émi Anna Nagy Florianne M J Hafkamp Rinske Sparrius Rico Bas Fernando Lozano Vigario Toni M M van Capel Ronald van Ree Teunis B H Geijtenbeek Bram Sl ütter Sander W Tas Esther C de Jong Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Lipopolysaccharide-producing Veillonella infantium and Escherichia fergusonii cause vagus nerve-mediated cognitive impairment in mice
In conclusion, LPS-producing NK2001 and NK2002 and LPS-nonproducing NK2003 may induce NF-κB-mediated neuroinflammation through the translocation of byproducts such as LPS and peptidoglycan into the brain through gut-blood/vagus nerve-brain and gut-blood-brain pathways, respectively, resulting in cognitive impairment.PMID:38428648 | DOI:10.1016/j.bbi.2024.02.031 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 1, 2024 Category: Neurology Authors: Xiaoyang Ma Jeon-Kyung Kim Yoon-Jung Shin Hee-Seo Park Dong-Yun Lee Sung-Vin Yim Dong-Hyun Kim Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research
