Italian guidelines for the management of irritable bowel syndrome in children and adolescents
AbstractThe irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and e...
Source: Italian Journal of Pediatrics - March 14, 2024 Category: Pediatrics Source Type: research
Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India
ConclusionSame HLA genes provide susceptibility for both T1D and CD. Non-HLA genes CTLA4, PTPN22 and INS provide further susceptibility while different polymorphisms in PTPN22 and INS can discriminate between T1D and T1D + CD. Epitope homology between autoantigens of two diseases further encourages the two diseases to occur together. The T1D + CD being more common in females along with co-existence of thyroid autoimmunity, and have more immune dysregulated state than T1D alone. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 14, 2024 Category: Endocrinology Source Type: research
The role of antral histopathology in diagnosing paediatric celiac disease
Pol J Pathol. 2023;74(4):256-264. doi: 10.5114/pjp.2023.134290.ABSTRACTThe aim of this study was to evaluate the diagnostic potential of gastric antrum histology in children suspected of having celiac disease (CD). The present retrospective study was performed on 224 patients who were suspected of having CD and had several duodenal and one gastric antrum biopsies. They were divided into 2 groups based on the definite diagnosis of CD. The statistical analysis was performed using SPSS version 22 software. Receiver operating characteristic (ROC) curves were drown and the area under the curves (AUCs) was calculated. Article au...
Source: Polish Journal of Pathology - March 13, 2024 Category: Pathology Authors: Zahra Heidari Manijeh Khalili Hamidreza Mahmoudzadeh Sagheb Mahdi Afshari Fateme Parooie Iraj Shahramian Fateme Sargazi Alireza Aminisefat Mahdi Shirdel Kahkha Zhale Ali Mansuri Source Type: research
