Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Measurement of Forearm Bone Density by Dual Energy X-ray Absorptiometry Increases the Prevalence of Osteoporosis in Men with Celiac Disease
Guidelines advise measurement of bone mineral density (BMD) in patients with a diagnosis of celiac disease. The lumbar spine (LS) and hip sites are usually measured. Although skeletal sites rich in trabecular bone are believed to be vulnerable to osteoporosis in patients with celiac disease, most studies have not measured the cortical distal 1/3-radius. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 10, 2019 Category: Gastroenterology Authors: Marcella D. Walker, John Williams, Suzanne K. Lewis, Julio C. Bai, Benjamin Lebwohl, Peter HR. Green Source Type: research

Non-Celiac Wheat/Gluten Sensitivity
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 9, 2019 Category: Gastroenterology Authors: Anam Khan, Milena Gould Suarez, Joseph A. Murray Source Type: research

Progression of Celiac Disease in Children With Antibodies Against Tissue Transglutaminase and Normal Duodenal Architecture
Potential celiac disease is characterized by positive results from serologic tests for tissue transglutaminase antibodies (anti-TG2) but normal duodenal architecture (Marsh stages 0 –1). There is controversy over the best way to manage these patients. We investigated risk factors associated with the development of villous atrophy in children with potential celiac disease. (Source: Gastroenterology)
Source: Gastroenterology - April 9, 2019 Category: Gastroenterology Authors: R. Auricchio, R. Mandile, M.R. Del Vecchio, S. Scapaticci, M. Galatola, M.A. Maglio, V. Discepolo, E. Miele, D. Cielo, R. Troncone, L. Greco Source Type: research

Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring
ConclusionIf confirmed, our results suggest that the maternal variants related to celiac disease may be involved in the risk of NTDs. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - April 9, 2019 Category: Genetics & Stem Cells Authors: Thanh T. Hoang, Yunping Lei, Laura E. Mitchell, Shreela V. Sharma, Michael D. Swartz, D. Kim Waller, Richard H. Finnell, Renata H. Benjamin, Marilyn L. Browne, Mark A. Canfield, Philip J. Lupo, Paige McKenzie, Gary M. Shaw, A. J. Agopian, Th Tags: ORIGINAL ARTICLE Source Type: research

Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring.
CONCLUSION: If confirmed, our results suggest that the maternal variants related to celiac disease may be involved in the risk of NTDs. PMID: 30968606 [PubMed - as supplied by publisher] (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2019 Category: Molecular Biology Authors: Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw GM, Agopian AJ, National Birth Defects Prevention Study Tags: Mol Genet Genomic Med Source Type: research

Effects of duration of initial treatment on postoperative complications in pancreatic cancer
AbstractBackgroundWe analyzed the clinical impact of chemotherapy or chemoradiotherapy as initial treatment (IT), focusing on treatment duration, on morbidity and mortality in patients with resected pancreatic ductal adenocarcinoma.MethodsWe enrolled 509 consecutive patients, with 417 in the upfront surgery group and 92 in the IT group. The IT group was subdivided into 72 patients treated for
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 9, 2019 Category: Gastroenterology Authors: Suguru Yamada, Hideki Takami, Fuminori Sonohara, Masamichi Hayashi, Tsutomu Fujii, Yasuhiro Kodera Tags: Original Article Source Type: research

Nonceliac Gluten and Wheat Sensitivity
Non-celiac gluten and/or wheat sensitivity (NCGS) is thought to be an immune-mediated reaction to gluten or other components of wheat (eg, fructans or amylase trypsin inhibitors) with intestinal and extraintestinal symptoms which improve once gluten and/or wheat is eliminated from the diet and after a diagnosis of celiac disease and wheat allergy have been excluded with appropriate testing. However, there is a great deal of skepticism within the scientific community questioning the existence of NCGS as a distinct clinical disorder. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 9, 2019 Category: Gastroenterology Authors: Anam Khan, Milena Gould Suarez, Joseph A. Murray Source Type: research

Symptoms Prompting Interest in Celiac Disease and the Gluten-Free Diet: Analysis of Internet Search Term Data
Conclusions: We found an increase in antecedent searches for symptoms known to be associated with celiac disease, a rise in searches for depression and anxiety, and an increase in symptoms that are associated with celiac disease but may not be reported to health care providers. The protean clinical manifestations of celiac disease are reflected in the diffuse nature of antecedent internet queries of those interested in celiac disease, underscoring the challenge of effective case-finding strategies. (Source: Journal of Medical Internet Research)
Source: Journal of Medical Internet Research - April 8, 2019 Category: General Medicine Authors: Benjamin Lebwohl Elad Yom-Tov Source Type: research

The overlap of irritable bowel syndrome and noncoeliac gluten sensitivity
Purpose of review There has been significant interest in gluten over the last decade, with an increase in interest of gluten-related disorders outside coeliac disease. Particularly, there has been a focus on the role of gluten in noncoeliac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS). There is significant overlap between both of these conditions, with the aim of this review to explore their complex relationship. Recent findings Gluten has been demonstrated to generate symptoms in individuals with NCGS. However, there appears to be an increasing role for gluten in symptom generation in patients with IB...
Source: Current Opinion in Gastroenterology - April 6, 2019 Category: Gastroenterology Tags: SMALL INTESTINE: Edited by Reena Sidhu Source Type: research

Intraoperative Neurophysiologic Testing of the Perigastric Vagus Nerve Branches to Evaluate Viability and Signals along Nerve Pathways during Gastrectomy.
Conclusions: Intraoperative neurophysiologic testing seems to be a feasible methodology for monitoring the perigastric vagus nerves. Innervation of the duodenum via the celiac branch and postoperative preservation of the function of the vagus nerves were confirmed in most patients. Trial Registration: Clinical Research Information Service Identifier: KCT0000823. PMID: 30944758 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

The Celiac Disease Patients' Ability to Experience Pleasure.
Authors: Zingone F, Siniscalchi M, Carpinelli L, Iovino P, Zingone L, Ciacci C Abstract The motivation or ability to experience pleasure has been scarcely studied in celiac disease (CeD). We aimed to investigate the hedonistic feelings/anhedonia and sexual pleasure in CeD patients on a gluten-free diet (GFD) compared to controls. We recruited adult CeD patients at follow-up consecutively visited from April 2017 to April 2018 and controls from the hospital staff and friends of CeD patients. Participants completed the Snaith-Hamilton Pleasure Scale, measuring the levels of anhedonia, and answered three questions abou...
Source: Gastroenterology Research and Practice - April 6, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Molecules, Vol. 24, Pages 1341: The Profile of Urinary Headspace Volatile Organic Compounds After 12-Week Intake of Oligofructose-Enriched Inulin by Children and Adolescents with Celiac Disease on a Gluten-Free Diet: Results of a Pilot, Randomized, Placebo-Controlled Clinical Trial
Kozak The concentration of volatile organic compounds (VOCs) can inform about the metabolic condition of the body. In the small intestine of untreated persons with celiac disease (CD), chronic inflammation can occur, leading to nutritional deficiencies, and consequently to functional impairments of the whole body. Metabolomic studies showed differences in the profile of VOCs in biological fluids of patients with CD in comparison to healthy persons; however, there is scarce quantitative and nutritional intervention information. The aim of this study was to evaluate the effect of the supplementation of a gluten-free diet...
Source: Molecules - April 5, 2019 Category: Chemistry Authors: Natalia Drabi ńska El żbieta Jarocka-Cyrta Norman Mark Ratcliffe Urszula Krupa-Kozak Tags: Article Source Type: research

Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study
Conclusion: This feasibility study suggests that removal of gluten from the diet is associated with improvement in psychiatric and gastrointestinal symptoms in people with schizophrenia or schizoaffective disorder. PMID: 30938127 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 3, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The Significant Psychological Burden of a Celiac Family: Overlooked and Untreated
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - April 3, 2019 Category: Pediatrics Source Type: research

Coeliac disease
(CD) is a common, chronic, immune-mediated small bowel enteropathy resulting from gluten exposure in genetically susceptible individuals. Considerable clinical and immunopathological heterogeneity is seen in newly diagnosed patients, and the diagnosis is not always straightforward even for experienced physicians. Population screening using tissue transglutaminase 2 has revealed a higher prevalence of seropositivity than previously appreciated. There is a wide differential diagnosis for mucosal villous atrophy, crypt hyperplasia and increased intraepithelial lymphocyte concentrations. (Source: Medicine)
Source: Medicine - April 3, 2019 Category: Internal Medicine Authors: Jeffrey Butterworth, Louis Los Tags: Malabsorption Source Type: research

Serologic Diagnosis of Celiac Disease
Most patients affected by celiac disease (CD) are asymptomatic or hyposymptomatic and undiagnosed, and are at risk of preventable complications. Therefore, early diagnosis is highly recommended. Multiple diagnostic antibodies are available; the most frequently used is IgA to tissue transglutaminase (IgA-tTg). It may yield false results and, alone, does not address IgA deficiency. Recently, a new generation of anti-neo-epitope tTg check (IgG  + IgA) has become available. It is highly sensitive and specific, covers IgA-deficient patients with CD, reflects intestinal damage, and has predictive potential in the diagn...
Source: Gastroenterology Clinics of North America - April 1, 2019 Category: Gastroenterology Authors: Aaron Lerner, Ajay Ramesh, Torsten Matthias Source Type: research

HLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey.
CONCLUSION: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degree relatives. PMID: 30945642 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2019 Category: Gastroenterology Authors: Özgenel ŞM, Temel T, Üsküdar Teke H, Yıldız P, Korkmaz H, Özakyol A Tags: Turk J Gastroenterol Source Type: research

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features
Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 27, 2019 Category: Gastroenterology Authors: Giacomo Caio, Umberto Volta, Francesco Ursini, Roberto Manfredini and Roberto De Giorgio Tags: Research article Source Type: research

Effects of duration of initial treatment on postoperative complications in pancreatic cancer
AbstractBackgroundWe analyzed the clinical impact of chemotherapy or chemoradiotherapy as initial treatment (IT), focusing on treatment duration, on morbidity and mortality in patients with resected pancreatic ductal adenocarcinoma.MethodsWe enrolled 509 consecutive patients, with 417 in the upfront surgery group and 92 in the IT group. The IT group was subdivided into 72 patients treated for
Source: Journal of Hepato-Biliary-Pancreatic Sciences - March 27, 2019 Category: Gastroenterology Authors: Suguru Yamada, Hideki Takami, Fuminori Sonohara, Masamichi Hayashi, Tsutomu Fujii, Yasuhiro Kodera Tags: Original Article Source Type: research

Changing Epidemiology of Liver Involvement in Children With Celiac Disease
Conclusions: Liver involvement in celiac children is now less frequent than previously reported, possibly due to changing CD epidemiology. Younger age is the only risk factor. Associated autoimmune liver disease is rare. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - March 26, 2019 Category: Gastroenterology Tags: Original Article: Gastroenterology: Celiac Disease Source Type: research

Transient Exocrine Pancreatic Insufficiency in Children: An Existing Entity?
Objectives: Pancreatic insufficiency in children is usually associated with diseases such as cystic fibrosis, Shwachman-Diamond syndrome, or chronic pancreatitis. Fecal elastase-1 is a reliable laboratory test for the diagnosis of exocrine pancreatic insufficiency (EPI). Transient pancreatic insufficiency has been rarely described and data on this entity are lacking in the medical literature. In this retrospective study we report 17 cases of transient pancreatic insufficiency presented mainly with failure to thrive and/or diarrhea. Methods: We followed 43 children (age range 1 month–18 years) with low fecal elas...
Source: Journal of Pediatric Gastroenterology and Nutrition - March 26, 2019 Category: Gastroenterology Tags: Original Articles: Pancreatology Source Type: research

P.06.14 dietary assessment in celiac disease patients under a gluten-free diet and following a low-fodmap diet
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: L. Roncoroni, K. Bascu ñán, N. Pellegrini, A. Scricciolo, V. Lombardo, L. Doneda, M. Vecchi, L. Elli Tags: Posters Source Type: research

P.06.13 fecal gluten immunogenic peptides: could be considered as possible markers in the evaluation of adherence to gluten free diet in celiac disease patients?
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: M. Marini, B. Porcelli, I. Biviano, A. Santini, L. Terzuoli, M. Vascotto, E. Grande, F. Quagliarella, F. Ferretti Tags: Posters Source Type: research

P.06.11 metabolic alterations in celiac disease occurring after following a gluten-free diet
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: A. Ciccone, D. Gabrieli, R. Cardinale, M. Di Ruscio, F. Vernia, G. Stefanelli, S. Necozione, D. Melideo, A. Viscido, G. Frieri, G. Latella Tags: Posters Source Type: research

P.06.8 evaluation of alarm symptoms at time of diagnosis of coeliac disease identifies patients eligible to a biopsy-avoidance diagnostic strategy
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: A. Schiepatti, S. Maimaris, M. Costetti, S. Costa, G.M. Gabrielli, F. Biagi Tags: Posters Source Type: research

P.06.7 rectal mucosa inflammation and eosinophils infiltration in non-celiac wheat sensitivity patients as possible biomarkers for diagnosis
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: A. Carroccio, G. Giannone, P. Mansueto, M. Soresi, F. La Blasca, F. Fayer, G. Geraci, T. Catalano, A. Arini, A. D'Alcamo, V. Villanacci, A.M. Florena Tags: Posters Source Type: research

P.06.2 in adult coeliac disease histological follow-up seems to be satisfactory after 2 years of gluten free diet
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: G. Galli, L. Conti, G. Esposito, E. Pilozzi, B. Annibale, E. Lahner Tags: Posters Source Type: research

P.05.3 the role of capsule enteroscopy in coeliac disease: results of a prospective study in a tertiary referral center
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: B. Marinoni, M. Topa, L. Roncoroni, M. Vecchi, L. Elli Tags: Posters Source Type: research

Oc.10.2 risk of bacterial pneumonia and pneumococcal infection in youths with coeliac disease – a population-based study
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: C. Canova, J. Ludvigsson, C. Barbiellini Amidei, L. Zanier, F. Zingone Tags: Oral Communications Source Type: research

Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - March 24, 2019 Category: Laboratory Medicine Source Type: research

Pachychoroid Pigment Epitheliopathy and Choroidal Thickness Changes in Coeliac Disease.
Authors: Bolukbasi S, Erden B, Cakir A, Bayat AH, Elcioglu MN, Yurttaser Ocak S, Gokden Y, Adas M, Asik ZN Abstract Purpose: To evaluate choroidal thickness in patients with coeliac disease (CD) using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes. Methods: Seventy patients with CD and 70 healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500 μm, 1000 μm, and 1500 μm), and temporal (temporal distan...
Source: Journal of Ophthalmology - March 23, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Volume: 57 Issue: 8 Pages: 1207-1217 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - March 23, 2019 Category: Laboratory Medicine Source Type: research

Headache in Patients with Celiac Disease and Its Response to the Gluten-Free Diet.
CONCLUSION: These results suggest that strict compliance to the GFD could improve headache in celiac patients with headache, even in those without gastrointestinal symptoms. This observation could provide an additional factor when convincing patients to follow a GFD, thus reducing the morbidity related to CD. PMID: 30893404 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - March 22, 2019 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Molecules, Vol. 24, Pages 1142: Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review
enugopal Gangur The prevalence of wheat allergy has reached significant levels in many countries. Therefore, wheat is a major global food safety and public health issue. Animal models serve as critical tools to advance the understanding of the mechanisms of wheat allergenicity to develop preventive and control methods. A comprehensive review on the molecular mechanisms of wheat allergenicity using animal models is unavailable at present. There were two major objectives of this study: To identify the lessons that animal models have taught us regarding the molecular mechanisms of wheat allergenicity and to identify the s...
Source: Molecules - March 22, 2019 Category: Chemistry Authors: Yining Jin Harini G. Acharya Devansh Acharya Rick Jorgensen Haoran Gao James Secord Perry K. W. Ng Venugopal Gangur Tags: Review Source Type: research

Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets
Conclusions: tTGIgA were increasingly tested, while the rate of positive results decreased in recent years, possibly reflecting the impact of current alimentary trends on clinical practice. Associated autoimmune disease was frequently found in CD. High levels of tTGIgA accurately predicted CD diagnosis. WA was rarely investigated and deserves more attention, in particular in children with atopic background. WA does not seem to be associated with CD.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 21, 2019 Category: Allergy & Immunology Source Type: research

The Nutritional and Social Contexts of Celiac Disease in Women: A Qualitative Study
Conclusions/Implications for Practice: This study shows that celiac disease and its treatment reduce mental and social quality of life in women. Organizations and public institutions should carry out public awareness campaigns targeting celiac disease and promote quality of life in sufferers of celiac disease in general. (Source: Journal of Nursing Research)
Source: Journal of Nursing Research - March 21, 2019 Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research

Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study.
This study evaluates hepatitis B virus (HBV) vaccination response in children with celiac disease (CD). Response in initial non-responders after a single booster vaccination as well as factors influencing HBV vaccination response were evaluated. METHODOLOGY: Anti-hepatitis B surface antibodies (a-HBsAB) were checked in all children with CD and a documented complete HBV vaccination. An a-HBsAB
Source: Acta Gastro-Enterologica Belgica - March 21, 2019 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research

GSE112102 First Degree Relatives (FDRs) of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect Them from Enterocyte Damage
Contributors : Rajesh Pandey ; Govind K Makharia ; Rintu KutumSeries Type : Expression profiling by arrayOrganism : Homo sapiensPatients with Celiac Disease, first degree relatives of celiac patients and control groups displayed significant differential gene expression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease
Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatenin... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 21, 2019 Category: Pediatrics Authors: Luigi Maiuri, Valeria R. Villella, Valeria Raia and Guido Kroemer Tags: Commentary Source Type: research

Viruses, Vol. 11, Pages 288: Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles
Risco Dermody Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation of cell-intrinsic defenses, and coordinate the release of progeny particles. Reoviruses are common pathogens of mammals that have been linked to celiac disease and show promise for oncolytic applications. These viruses form nonenveloped, double-shelled virions that contain ten segments of double-stranded RNA. Replication organelles in reovirus-infect...
Source: Viruses - March 21, 2019 Category: Virology Authors: Tenorio Fern ández de Castro Knowlton Zamora Sutherland Risco Dermody Tags: Review Source Type: research

Efficacy of Enteric-Release Oral Budesonide in Treatment of Acute Reactions to Gluten in Patients With Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2019 Category: Gastroenterology Authors: Amelie Therrien, Jocelyn A. Silvester, Daniel A. Leffler, Ciaran P. Kelly Source Type: research

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease
AbstractFamilial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-derived peptide (P31 –43) can cause CFTR inhibition in intestinal epithelial cells, thus causing a local stress response that contributes to the immunopathology of celiac disease (CD). Accordingly, an increased prevalence of CD has been observed in several cohorts of CF patients. CD is characterized by a permanent int...
Source: Italian Journal of Pediatrics - March 21, 2019 Category: Pediatrics Source Type: research

Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients.
CONCLUSION: GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple home-based method for self-assessment of dietary indiscretions. PMID: 30918433 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Costa AF, Sugai E, Temprano MP, Niveloni SI, Vázquez H, Moreno ML, Domínguez-Flores MR, Muñoz-Suano A, Smecuol E, Stefanolo JP, González AF, Cebolla-Ramirez A, Mauriño E, Verdú EF, Bai JC Tags: World J Gastroenterol Source Type: research

[Dermatitis herpetiformis].
Authors: Juratli HA, Görög A, Sárdy M Abstract Dermatitis herpetiformis (DH) is a genetically determined, gluten sensitive autoimmune bullous dermatosis related to celiac disease in which granular, insoluble aggregates in the papillary dermis of epidermal transglutaminase (TG3), immunoglobulin A (IgA), and fibrinogen are present. Detection of the dermal IgA-TG3 immune complex is the gold standard of diagnosis. DH develops in a subpopulation of patients with gluten sensitive enteropathy, characterized by itching, erythematous, excoriated papules showing characteristic distribution ove...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - March 16, 2019 Category: Dermatology Tags: Hautarzt Source Type: research

Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease are Frequent and Linked With Autoimmunity to TG6
Celiac disease is an autoimmune disorder induced by ingestion of gluten that affects 1% of the population and is characterized by gastrointestinal symptoms, weight loss, and anemia. We evaluated the presence of neurologic deficits and investigated whether the presence of antibodies to TG6 increases the risk of neurologic defects in patients with a new diagnosis of celiac disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 15, 2019 Category: Gastroenterology Authors: Marios Hadjivassiliou, Iain D. Croall, Panagiotis Zis, Ptolemaios G. Sarrigiannis, David S. Sanders, Pascale Aeschlimann, Richard A. Gr ünewald, Paul A. Armitage, Daniel Connolly, Daniel Aeschlimann, Nigel Hoggard Source Type: research

Benefits From and Barriers to Portable Detection of Gluten, Based on a Randomized Pilot Trial of Patients with Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 15, 2019 Category: Gastroenterology Authors: Randi L. Wolf, Peter H.R. Green, Anne R. Lee, Norelle R. Reilly, Patricia Zybert, Benjamin Lebwohl Source Type: research

Improving gluten free diet adherence by youth with celiac disease
Authors: Sample, Dory / Turner, Justine (Source: International Journal of Adolescent Medicine and Health)
Source: International Journal of Adolescent Medicine and Health - March 15, 2019 Category: Pediatrics Source Type: research

Excess weight and gastrointestinal symptoms in Chilean celiac patients at the time of diagnosis.
CONCLUSIONS: further studies are needed to jointly assess energy intake and intestinal absorption in these patients, in order to explain the high rate of excess weight. PMID: 30859843 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - March 14, 2019 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Reliability of coeliac serology in monitoring dietary adherence in children with coeliac disease on a gluten-free diet.
This study aimed to determine the utility of coeliac serology for monitoring dietary adherence in coeliac disease. Serum anti-tTg IgA and anti-DGP IgG levels of 42 newly diagnosed patients were measured at diagnosis and at intervals of three, six and 12 months after starting a gluten-free diet. Both anti-tTg and anti-DGP antibodies decreased in all patients. The decline in the former was significantly greater at 3-12 months throughout, while in the latter the decline was seen only at three months but not subsequently. Serial measurement of coeliac serology may help in monitoring adherence to a gluten-free diet. PMID: ...
Source: Tropical Doctor - March 14, 2019 Category: Tropical Medicine Authors: Jain R, Kumar P, Kapoor S, Basu S, Lomash A, Rohatgi S Tags: Trop Doct Source Type: research