Macroscopic hematuria as presenting symptom of celiac disease.
Abstract A 47-year old man was admitted for macroscopic hematuria and spontaneous hematomas. Laboratory results showed a prolonged partial thromboplastin time (PTT), a prolonged activated partial thromboplastin time (APTT) and a severe vitamin K deficiency. The underlying cause proved to be vitamin K malabsorption due to previously undiagnosed celiac disease, possibly provoked by oral antibiotic administration. PMID: 30895932 [PubMed - in process] (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - February 1, 2019 Category: General Medicine Authors: Duetz C, Houtenbos I, de Roij van Zuijdewijn CLM Tags: Neth J Med Source Type: research

Celiac Disease
GASTROENTEROLOGY CLINICS OF NORTH AMERICA (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - January 31, 2019 Category: Gastroenterology Authors: Benjamin Lebwohl, Peter H.R. Green Source Type: research

Celiac disease prevalence in a large series of patients with Beh çet's disease
ConclusionAlthough BD and CD share many similar clinical manifestations, our results did not support a possible association between these two diseases. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - January 25, 2019 Category: Rheumatology Authors: Erdem Ko çak, Erdem Akbal, Yavuz Beyazit, Bilal Ergül, Arzu Karataş, Seyfettin Köklü, H. Meral Ekşioğlu Tags: Original Article Source Type: research

Red Spot Lesions in the Duodenal Bulb Are a Highly Specific Endoscopic Sign of Celiac Disease: A Prospective Study
We have recognized red spot lesions (RSLs) in the duodenal bulb in children with celiac disease (CD) and believe they may represent an underappreciated and distinct endoscopic sign of CD. A total of 171 pediatric patients undergoing esophagogastroduodenoscopy with duodenal biopsy for symptoms consistent with CD were prospectively recruited. There were 75 patients who met criteria for CD and the remaining 96 patients served as symptomatic controls. As compared to endoscopic markers frequently mentioned in literature, RSLs had comparable sensitivity, specificity, positive predictive value, and negative predictive value of 31...
Source: Journal of Pediatric Gastroenterology and Nutrition - January 24, 2019 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Celiac Disease Source Type: research

Lactation and maternal cardiovascular disease risk in later life
Lactation is the process of secretion of milk from the mammary glands as well as the period when the mother lactates to feed her offspring. In humans, lactation (also called breastfeeding or nursing) is recommended for at least the first 6 months of the infant ’s life [1], with introduction of the appropriate complementary foods whilst breastfeeding until 1 year or longer, as mutually desired by the mother and the infant. Breastfeeding is beneficial for both child and maternal health. The short-term advantages for the infant include the decrease in th e incidence of respiratory tract infections and otitis medi...
Source: Maturitas - January 23, 2019 Category: Primary Care Authors: Georgia Zachou, Eleni Armeni, Irene Lambrinoudaki Source Type: research

Exit Gluten-Free and Enter Low FODMAPs: A Novel Dietary Strategy to Reduce Gastrointestinal Symptoms in Athletes
AbstractExercise-associated physiological disturbances alter gastrointestinal function and integrity. These alterations may increase susceptibility to dietary triggers, namely gluten and a family of short-chain carbohydrates known as FODMAPs (fermentable oligo-, di-, monosaccharides and polyols). A recent surge in the popularity of gluten-free diets (GFDs) among athletes without celiac disease has been exacerbated by unsubstantiated commercial health claims and high-profile athletes citing this diet to be the secret to their success. Up to 41% of athletes at least partially adhere to a GFD diet, with the belief that gluten...
Source: Sports Medicine - January 22, 2019 Category: Sports Medicine Source Type: research

Commentary: Midaortic syndrome —What is the skinny?
Midaortic syndrome (MAS) is characterized by narrowing of the descending aorta between the distal aortic arch and the aortic bifurcation. The narrowing may be focal and discrete, or it may be more diffuse along the course of the descending aorta (Figure  1). Not infrequently, the disease process may also extend into visceral arterial branches, such as the celiac, mesenteric, or renal vessels. Most cases of MAS are idiopathic, and the underlying pathogenesis remains poorly understood. In select instances, a link has been established with such condi tions as inflammatory arteritis, mucopolysaccharidosis, fibromuscular d...
Source: The Journal of Thoracic and Cardiovascular Surgery - January 22, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Demetrios N. Mallios, S. Ram Kumar Tags: Commentary Source Type: research

Allergen-specific CD8+ T cells in peanut-allergic individuals
CD8+ T cells are uncommonly thought to be involved in IgE-mediated food allergy, but there are reasons to reconsider their role in this condition.1 CD8+ T cells are present in skin, and in the respiratory and gut mucosae, where they may modulate the immune response in atopic conditions such as asthma and atopic dermatitis.2-4 In mice, CD8+ T cells attenuate food allergy in some experimental models, whereas in humans, CD8+ T cells have been shown to expand in response to wheat ingestion in celiac disease. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 22, 2019 Category: Allergy & Immunology Authors: Wong Yu, Xiaoying Zhou, Diane Dunham, Shu Chen Lyu, Monali Manohar, Wenming Zhang, Fan Zhao, Mark M. Davis, Kari Nadeau Tags: Letter to the Editor Source Type: research

Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes [Protein Structure and Folding]
This study underscores the ability of TCRs to recognize subtle differences in the peptide–HLA-II landscape in a human disease setting. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - January 18, 2019 Category: Chemistry Authors: Shiva Dahal–Koirala, Laura Ciacchi, Jan Petersen, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbȷorn Christophersen, Knut E. A. Lundin, Hugh H. Reid, Shuo–Wang Qiao, Jamie Rossȷohn, Ludvig M. Sollid Tags: Immunology Source Type: research

A rare case of an enlarged celiac lymph node diagnosed as an epidermal inclusion cyst.
PMID: 30654604 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 18, 2019 Category: Internal Medicine Authors: Kim SB, Kim KH, Kim TN, Cho CW, Choi JH Tags: Korean J Intern Med Source Type: research

Celiac ganglia: can they be misinterpreted on multimodal: 68: Ga-PSMA-11 PET/MR?
Conclusion Frequently observed, the nodular, oval and longitudinal (nodular, thick or with oval parts) shape of CG, especially of the thicker left CG, on MR scans may cause mistaking them for lymph nodes, even abnormal or metastatic. On whole-body PET/MRI, evident and sometimes high 68Ga-PSMA-11 uptake in CG increases the risk of a misinterpretation of them as metastases. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Resolution of celiac disease, IgA deficiency and platelet refractoriness after allogeneic bone marrow transplantation for acute leukemia.
Abstract PMID: 30655374 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - January 17, 2019 Category: Hematology Authors: Zandi S, Kanfar S, Cserti-Gazdewich C, Lipton JH, Pendergrast J Tags: Haematologica Source Type: research

Risk of Venous Thromboembolism for Patients with Pancreatic Ductal Adenocarcinoma Undergoing Preoperative Chemotherapy Followed by Surgical Resection
ConclusionsVenous thromboembolism during neoadjuvant therapy and the subsequent perioperative period is common and has a significant impact on outcome. Further study into novel thromboprophylaxis measures or protocols during neoadjuvant treatment and the perioperative period is warranted. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 16, 2019 Category: Cancer & Oncology Source Type: research

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial stress and innate immune activation are essential for breaking oral tolerance to the gluten component gliadin. How gliadin subverts host intestinal mucosal defenses remains elusive. Here, we show that the α-gliadin-derived LGQQQPFPPQQPY peptide (P31–43) inhibits the function of cystic&nbs...
Source: EMBO Journal - January 15, 2019 Category: Molecular Biology Authors: Villella, V. R., Venerando, A., Cozza, G., Esposito, S., Ferrari, E., Monzani, R., Spinella, M. C., Oikonomou, V., Renga, G., Tosco, A., Rossin, F., Guido, S., Silano, M., Garaci, E., Chao, Y.-K., Grimm, C., Luciani, A., Romani, L., Piacentini, M., Raia, Tags: Immunology, Membrane & Intracellular Transport, Molecular Biology of Disease Articles Source Type: research

CFTR is not a gluten lover either
Coeliac disease (CD) is an inflammatory autoimmune disease caused by ingestion of gluten proteins, mainly gliadin. Undigested gliadin proline-rich peptides trigger the innate and adaptive immune response, resulting in intestinal cell stress and damage. A new study by Villella et al (2019) addressing the unclear primary cause of intestinal cell stress reports that gliadin peptides inhibit the function of the chloride and bicarbonate channel CFTR, causing intestinal cell stress, which is sufficient to trigger CD symptoms. Notably, CFTR potentiators used to treat cystic fibrosis effectively rescue CFTR function and marke...
Source: EMBO Journal - January 15, 2019 Category: Molecular Biology Authors: Vachel, L., Muallem, S. Tags: Immunology, Membrane & Intracellular Transport, Molecular Biology of Disease News [amp ] Views Source Type: research

Overview of Deep Learning in Gastrointestinal Endoscopy.
Authors: Min JK, Kwak MS, Cha JM Abstract Artificial intelligence is likely to perform several roles currently performed by humans, and the adoption of artificial intelligence-based medicine in gastroenterology practice is expected in the near future. Medical image-based diagnoses, such as pathology, radiology, and endoscopy, are expected to be the first in the medical field to be affected by artificial intelligence. A convolutional neural network, a kind of deep-learning method with multilayer perceptrons designed to use minimal preprocessing, was recently reported as being highly beneficial in the field of endosc...
Source: Gut and Liver - January 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Autoimmunity in celiac disease: Extra-intestinal manifestations
Publication date: Available online 11 January 2019Source: Autoimmunity ReviewsAuthor(s): Lerner Aaron, Matthias Torsten, Wusterhausen PatriciaAbstractCeliac disease is an autoimmune condition of the small intestine caused by prolamins in genetically susceptible individuals evoked by multiple environmental factors. The pathological luminal intricate eco-events produce multiple signals that irradiate the entire body, resulting in a plethora of extra-intestinal manifestations. Nutrients, dysbiosis, dysbiotic components and their mobilome, post-translational modification of naive proteins, inter-enterocyte's tight junction dys...
Source: Autoimmunity Reviews - January 12, 2019 Category: Allergy & Immunology Source Type: research

Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients
Refractory celiac disease (RCD) is a rare condition, usually managed at specialized centers. However, gastroenterologists and pathologists in general practices are often the first to consider a diagnosis of RCD in celiac patients with persistent symptoms. The distinction between type I and type II RCD is crucial as patients with RCD II have a shortened life expectancy. The diagnosis of RCD II requires the demonstration of abnormal intraepithelial lymphocytes and/or monoclonal T-cell populations in duodenal biopsies, typically assessed in formalin-fixed paraffin-embedded tissue. We investigated the clinical significance of ...
Source: The American Journal of Surgical Pathology - January 12, 2019 Category: Pathology Tags: Original Articles Source Type: research

Assessment of Quality of Life, Anxiety and Depressive Symptoms in Serbian Children with Celiac Disease and their Parents
AbstractObjectivesTo evaluate the level of health-related quality of life (QoL) and presence of anxiety and depressive symptoms in Serbian children with celiac disease from the perspective of patients and their parents.MethodsThis cross-sectional study investigated the group of children and adolescents with celiac disease aged 5 –18 y, and at least one parent of each patient with celiac disease. The patients and their parents were recruited at the Institute of Mother and Child Health of Serbia and the University Children’s Hospital in Belgrade. The instruments used in this study were child-self and parent-proxy...
Source: Indian Journal of Pediatrics - January 12, 2019 Category: Pediatrics Source Type: research

Letter: Celiac Disease Presenting After a Single Anastomosis Duodeno-Ileal Bypass and Sleeve Gastrectomy
(Source: Obesity Surgery)
Source: Obesity Surgery - January 12, 2019 Category: Surgery Source Type: research

Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence.
Abstract The current prevalence of pediatric Celiac Disease (CD) is estimated to be around 1% in the general population, worldwide. However, according to the geographic area, a great variability of CD prevalence has been described. Whereas a number of studies are available from Europe, North and South America, Australia, South-West Asia, and North Africa, the knowledge and awareness of CD in large parts of the remaining world areas is definitively poor. In several countries of Central and East Asia, the consumption of wheat is consistent and/or has significantly increased in recent decades, and CD is supposed to b...
Source: Medicina (Kaunas) - January 12, 2019 Category: Universities & Medical Training Authors: Poddighe D, Rakhimzhanova M, Marchenko Y, Catassi C Tags: Medicina (Kaunas) Source Type: research

The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series
Publication date: Available online 11 January 2019Source: Autoimmunity ReviewsAuthor(s): Silvia Martina Ferrari, Poupak Fallahi, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Salvatore Benvenga, Alessandro AntonelliAbstractGraves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Here, we review...
Source: Autoimmunity Reviews - January 11, 2019 Category: Allergy & Immunology Source Type: research

Single-Port Thoracoscopic Minimally Invasive Esophagectomy for Esophageal Cancer
ConclusionsOur preliminary results demonstrate that this technique is safe and feasible for treating esophageal cancer within an acceptable length of operation time, which does not compromise the surgical radicality. (Source: World Journal of Surgery)
Source: World Journal of Surgery - January 11, 2019 Category: Surgery Source Type: research

Covering the Cover
Immune reactivity against synthesized neoepitopes can be used to diagnosis and monitor disease status in patients with celiac disease. (Source: Gastroenterology)
Source: Gastroenterology - January 11, 2019 Category: Gastroenterology Authors: Andrew T. Chan, Christopher S. Williams Tags: Covering the Cover Source Type: research

Celiac disease among at-risk individuals in Saudi Arabia.
Conclusion: Both the prevalence of biopsy-proven CD (10.6%) and seroprevalence (15.6%) were higher than those we previously reported in the normal population (1.4% and 2.7%). The female-to-male ratio (1.9/1) of CD patients was the same in normal and at-risk populations in SA. Meta-analysis for prevalence of CD in DM, SS, and DS separately in SA is recommended. PMID: 30617375 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - January 10, 2019 Category: Middle East Health Tags: Saudi Med J Source Type: research

Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease
Conclusions: A duodenal biopsy is more likely to be performed in younger patients, females, and for key indications such as weight loss, diarrhea, and anemia. Providers varied widely in the performance of duodenal biopsy. Further study is warranted to better understand the decision to perform duodenal biopsy and to determine the optimal scenarios for its performance. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - January 10, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

[ASAP] Metabolic Signature of Primary Biliary Cholangitis and Its Comparison with Celiac Disease
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.8b00849 (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - January 10, 2019 Category: Biochemistry Authors: Alessia Vignoli, Beatrice Orlandini, Leonardo Tenori, Maria Rosa Biagini, Stefano Milani, Daniela Renzi, Claudio Luchinat, Antonino Salvatore Calabr ò Source Type: research

Clinical Characteristics of Japanese Patients with Palmoplantar Pustulosis
AbstractPalmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles. The purpose of this review was to describe the characteristics of Japanese PPP patients as PPP is frequently observed within the Japanese population. Most Japanese dermatologists consider PPP a distinct entity, and co-existence of PPP and psoriasis is rare; however, outside Japan, PPP is often considered to be palmoplantar psoriasis, and an extra-palmoplantar lesion associated with PPP is considered to be psoriasis. PPP frequently develops or exacerbates following focal inf...
Source: Clinical Drug Investigation - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

An unusual Chinese case of celiac disease presenting as hypocalcemia and low bone density
(Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 10, 2019 Category: Orthopaedics Source Type: research

Effects of dipyrone on the digestive tract.
Abstract Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. In rats, in contrast to non...
Source: Braz J Med Biol Res - January 10, 2019 Category: Research Authors: Collares EF, Troncon LEA Tags: Braz J Med Biol Res Source Type: research

Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis
ConclusionsWhen performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 4, 2019 Category: Cancer & Oncology Source Type: research

Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis.
CONCLUSIONS: When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. PMID: 30610560 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 4, 2019 Category: Cancer & Oncology Authors: Klompmaker S, Peters NA, van Hilst J, Bassi C, Boggi U, Busch OR, Niesen W, Van Gulik TM, Javed AA, Kleeff J, Kawai M, Lesurtel M, Lombardo C, Moser AJ, Okada KI, Popescu I, Prasad R, Salvia R, Sauvanet A, Sturesson C, Weiss MJ, Zeh HJ, Zureikat AH, Yamau Tags: Ann Surg Oncol Source Type: research

Validating microscopic colitis (MC) in Swedish pathology registers.
CONCLUSIONS: This study found a high validity for MC as recorded in Swedish pathology registers. PMID: 30600733 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - January 3, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Coeliac disease and neuromyelitis optica: a rare but possible association
Publication date: Available online 31 December 2018Source: Neurología (English Edition)Author(s): A. Díaz Díaz, M. Hervás García, A. Muñoz García, F. Romero Santana, G. Pinar Sedeño, J.R. García Rodríguez (Source: Neurologia)
Source: Neurologia - January 1, 2019 Category: Neurology Source Type: research

Current Evidence in the Diagnosis and Treatment of Children With Celiac Disease
Recent statistics report that 3 million people, or 1% of the population in the United States (U.S.), are affected by celiac disease (CD). In addition, in the U.S., as many as 1 in 80 children is affected with CD. However, CD can be challenging to diagnose and many children are not correctly diagnosed or live without a diagnosis for several years. Symptoms, if present, are often nonspecific and may be common manifestations of many pediatric illnesses. The purpose of this review is to examine the current evidence regarding incidence, pathophysiology, diagnosis, and treatment of a child with CD. Clinical implications for nurs...
Source: Gastroenterology Nursing - January 1, 2019 Category: Nursing Tags: Features Source Type: research

Current Evidence in the Diagnosis and Treatment of Children With Celiac Disease
No abstract available (Source: Gastroenterology Nursing)
Source: Gastroenterology Nursing - January 1, 2019 Category: Nursing Tags: CE Tests Source Type: research

Is Adherence to a Gluten-Free Diet by Adult Patients With Celiac Disease Influenced by Their Knowledge of the Gluten Content of Foods?
The aim of this study was to investigate adherence to a gluten-free diet and potentially associated factors, focusing on the relationship between adherence and knowledge of the gluten content of foods and of celiac disease in general. A questionnaire was completed by adult patients diagnosed with celiac disease including demographics, dietary practices, sources of information, and attitude to the disease. Their knowledge of disease and gluten-free diet was assessed using a newly developed scale comprising 31 statements on celiac disease in general and foods appropriate in a gluten-free diet. A validated questionnaire was u...
Source: Gastroenterology Nursing - January 1, 2019 Category: Nursing Tags: Features Source Type: research

Role of anti-tissue transglutaminase IgA+IgG antibodies in detection of potential celiac disease in patients with type 1 diabetes.
This study was aimed to evaluate five commercially available anti-tissue transglutaminase (tTG) ELISA kits with distinct formats for the detection of CD and potential CD in T1D patients. Clinical and demographic profiles of the patients with different disease subsets were also studied. Methods: : Fifty T1D patients with classical and non-classical symptoms of CD and 100 T1D patients without any symptoms of CD were included in this study. Anti-tTG autoantibody levels were estimated by five ELISA kits followed by histological examination of duodenal biopsy. HLA DQ2-DQ8 and DRB1-DQB1 typing was done, and serum levels for...
Source: Indian J Med Res - January 1, 2019 Category: Research Authors: Kaur N, Minz RW, Bhadada SK, Saikia B, Dayal D, Anand S, Joshi N, Singh J, Thapa BR, Kochhar RK, Vaiphei K Tags: Indian J Med Res Source Type: research

Celiac disease & type 1 diabetes: A double burden.
Celiac disease & type 1 diabetes: A double burden. Indian J Med Res. 2019 Jan;149(1):5-7 Authors: Bhatia E PMID: 31115368 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - January 1, 2019 Category: Research Authors: Bhatia E Tags: Indian J Med Res Source Type: research

2019 Preview: Experimental vaccine could let coeliacs eat gluten
A vaccine that teaches a person's immune system to see gluten as harmless could enable some people with coeliac disease to eat bread and pasta made from wheat (Source: New Scientist - Health)
Source: New Scientist - Health - December 30, 2018 Category: Consumer Health News Source Type: research

In Screening for Celiac Disease, Deamidated Gliadin Rarely Predicts Disease When Tissue Transglutaminase Is Normal
Conclusions: In isolation, DGP positive serology has a poor positive predictive value for celiac disease in children, especially in IgA sufficient individuals. Our findings suggest that DGP IgG testing should not be completed as part of the initial screening for celiac disease in the pediatric population as it does not effectively differentiate between individuals with and without the disease. Further research is needed to clarify to role of DGP IgG in children under the age of 2 and those with IgA deficiency. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - December 29, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Contribution of Oral Hygiene and Cosmetics on Contamination of Gluten-free Diet: Do Celiac Customers Need to Worry About?
Conclusions: Gluten contamination is currently not an issue in a wide array of cosmetic and oral hygiene products that are commonly in the market. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - December 29, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Cancers, Vol. 11, Pages 31: Small Bowel Carcinomas Associated with Immune-Mediated Intestinal Disorders: The Current Knowledge
tonio Di Sabatino Small bowel carcinomas (SBC) are uncommon neoplasms, whose predisposing conditions include hereditary syndromes and immune-mediated intestinal disorders including coeliac disease (CD) and Crohn’s disease (CrD). Although both CD-associated SBC (CD-SBC) and CrD-associated SBC (CrD-SBC) arise from an inflammatory background, they differ substantially in tumour cell phenotype, frequency of microsatellite instability and nuclear β-catenin expression, as well as in prognosis. For these patients, high tumour-infiltrating lymphocyte density and glandular/medullary histotype represen...
Source: Cancers - December 29, 2018 Category: Cancer & Oncology Authors: Paolo Giuffrida Alessandro Vanoli Giovanni Arpa Arturo Bonometti Ombretta Luinetti Enrico Solcia Gino Roberto Corazza Marco Paulli Antonio Di Sabatino Tags: Review Source Type: research

Lack of Follow Up of Pediatric Patients With Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 28, 2018 Category: Gastroenterology Authors: Bradley A. Blansky, Zackary J. Hintze, Eaman Alhassan, Alan M. Leichtner, Dascha C. Weir, Jocelyn A. Silvester Source Type: research

Management of celiac disease in daily clinical practice: do not forget depression!
PMID: 30598247 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - December 28, 2018 Category: Internal Medicine Authors: Mirijello A, d'Angelo C, De Cosmo S, Gasbarrini A, Addolorato G Tags: Eur J Intern Med Source Type: research

Lack of Follow-up of Pediatric Patients With Celiac Disease
Celiac disease (CD) is often diagnosed in childhood, and the treatment is a lifelong gluten-free diet (GFD).1,2 It may take several years to gain competence in the skills required to follow a GFD successfully. Inadequately treated CD is associated with bone fractures, nutritional deficiencies, and lymphoma.3,4 Healthcare providers are key resources for patients with CD. Consultation with a dietitian with GFD expertise at diagnosis and annual disease-specific follow-up care are recommended.2,5 The primary objective of this study was to evaluate adherence to guidelines for dietitian consultation and follow-up for children wi...
Source: Clinical Gastroenterology and Hepatology - December 28, 2018 Category: Gastroenterology Authors: Bradley A. Blansky, Zackary J. Hintze, Eaman Alhassan, Alan M. Leichtner, Dascha C. Weir, Jocelyn A. Silvester Tags: Research Correspondence Source Type: research

Plasma Cells are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Development of celiac disease is believed to involve the transglutaminase-dependent response of CD4+ T cells toward deamidated gluten peptides in the intestinal mucosa of individuals with specific HLA-DQ haplotypes. We investigated the antigen presentation process during this mucosal immune response. (Source: Gastroenterology)
Source: Gastroenterology - December 26, 2018 Category: Gastroenterology Authors: Lene St økken Høydahl, Lisa Richter, Rahel Frick, Omri Snir, Kristin Støen Gunnarsen, Ole JB. Landsverk, Rasmus Iversen, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Elin Bergseng, Stian Foss, Shuo-Wang Qiao, Knut EA. Lundin, Jørgen Jahnsen, Frode L. Jahns Source Type: research

165: Maternal celiac disease and long-term gastrointestinal morbidity of the offspring
The development and availability of diagnosis made the prevalence of celiac disease to increase over the past 20 years. Celiac disease has been associated with adverse short-term perinatal outcomes such as low birth- weight and preterm delivery. The aim of the present study was to determine whether being born to a mother with celiac disease increases the risk for long-term gastrointestinal morbidity of the offspring. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Gali Pariente, Tamar Wainstock, Eyal Sheiner Tags: Poster Session I Source Type: research

853: Perinatal outcome of women with known celiac disease
Celiac disease shows an increased prevalence in female, particularly during reproductive years. The purpose of the current study was to evaluate perinatal outcome of women with celiac disease (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Gali Pariente, Tamar Wainstock, Eyal Sheiner Tags: Poster Session IV Source Type: research

Novel screening test for celiac disease using peptide functionalised gold nanoparticles.
CONCLUSION: The study demonstrates the potential of gold nanoparticle-peptide based approach to be adapted for developing a screening assay for celiac disease diagnosis. The assay could be a part of an exclusion based diagnostic strategy and prove particularly useful for testing high celiac disease risk populations. PMID: 30598582 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2018 Category: Gastroenterology Authors: Kaur A, Shimoni O, Wallach M Tags: World J Gastroenterol Source Type: research