Competency Based Assessment in Pediatrics for the New Undergraduate Curriculum
Indian Pediatr. 2021 Apr 20:S097475591600315. Online ahead of print.ABSTRACTMedical Council of India (MCI) implemented competency-based curriculum for undergraduate medical education nationwide in 2019, with assessment of competencies being its integral component. The curriculum has outlined some broad principles and components of assessment, but the process and schedule for formative and summative assessment is to be decided by the universities and institutions. In this document, we summarize the recommendations for the subject of Pediatrics, and propose an assessment model for summative assessment that can be adapted/ ad...
Source: Indian Pediatrics - April 20, 2021 Category: Pediatrics Authors: Piyush Gupta Dheeraj Shah Tejinder Singh Source Type: research

Publication Ethics
Indian Pediatr. 2021 Apr 20:S097475591600316. Online ahead of print.ABSTRACTPublications in the field of medical literature are a matter of prestige and fame for doctors. While genuine research contributes to the existing scientific knowledge, fraudulent data make publication unreliable, demeans the credibility of the author and reduces faith in science. Research misconduct includes the three cardinal sins fabrication, falsification and plagiarism. To promote highest standards in publication ethics, Committee on Publication Ethics provides advice and guidance to journals and publishers. Investigators should abide by ethica...
Source: Indian Pediatrics - April 20, 2021 Category: Pediatrics Authors: Kirtisudha Mishra Aashima Dabas Source Type: research

Study Designs: Diagnostic Studies
Indian Pediatr. 2021 Apr 20:S097475591600317. Online ahead of print.ABSTRACTDiagnostic tests are evolving with betterment of technology, quest for patient safety with less invasive medicine, and evolution of new diseases. It is important to assess diagnostic accuracy of a new test, and clinical impact of introduction of new test on outcomes and cost. A diagnostic study is planned for the index test based on place of new test in diagnostic pathway (screening, triage, diagnostic or add-on test) and established information of the test. A reference standard is used to classify population into diseased and healthy, and the disc...
Source: Indian Pediatrics - April 20, 2021 Category: Pediatrics Authors: Nitin Dhochak Rakesh Lodha Source Type: research

Basics of Statistical Comparisons
Indian Pediatr. 2021 Apr 20:S097475591600318. Online ahead of print.ABSTRACTAll study designs in medical research, barring descriptive studies, involve comparative analysis to achieve its objective/s. Comparisons between groups based on outcomes, or risk factors, or interventions, are the basis of hypotheses in evidence-based medicine. Statistical tests support in making criterion-based decisions about the validity of the hypothesis. A basic knowledge of statistical comparisons helps medical researchers to apply valid statistical tests. Novice medical researchers struggle to decide when, and which statistical test must be ...
Source: Indian Pediatrics - April 20, 2021 Category: Pediatrics Authors: Amir Maroof Khan Ashish Goel Source Type: research

Clinical Profile and Short-Term Outcome of Children with SARS-CoV-2 Related Multisystem Inflammatory Syndrome(MIS-C) Treated with Pulse Methylprednisolone
CONCLUSIONS: In patients with SARS-CoV-2 related MIS-C, methylprednisolone pulse therapy was associated with favorable short-term outcomes.PMID:33876782 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 20, 2021 Category: Pediatrics Authors: Sheeja Sugunan S Bindusha S Geetha H R Niyas A Santhosh Kumar Source Type: research

Clinical Profile of Adolescents With Delayed Puberty
Indian Pediatr. 2021 Apr 17:S097475591600309. Online ahead of print.ABSTRACTOne year study on forty-eight adolescents with delayed puberty revealed etiology of constitutional delay, hypogonadotrophic hypogonadism (HH), hypergonadotrophic hypogonadism, chronic systemic disease, hypothyroidism and sex reversal in 14(29.2%), 13 (27%), 12 (25%), 5 (10.4%), 3 (6.3%) and 1 (2.1 %) cases, respectively. Earlier presentation, male preponderance, significant normal variants and utility of GnRH analogue testing observed.PMID:33864448 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Aarthe Selvaraj Hemchand Krishna Prasad Kannan Narayanasamy Anand Thiagarajan Nedunchelian Krishnamoorthy Source Type: research

Gastric Lavage for Prevention of Feeding Intolerance in Neonates Delivered Through Meconium-Stained Amniotic Fluid: A Systematic Review and Meta-Analysis
This study evaluated the effects of gastric lavage, compared to no- gastric lavage, on the incidences of feeding intolerance, respiratory distress, meconium aspiration syndrome, time to establish breastfeeding, hospitalization and procedure-related complications in late-preterm and term neonates delivered through meconium-stained amniotic fluid.DESIGN: Systematic review and meta-analysis.DATA SOURCES AND SELECTION CRITERIA: MEDLINE, EMBASE, CENTRAL, and other databases were searched for randomized controlled trials and quasi randomized controlled trials using search terms: neonate OR newborn infant, meconium OR meconium-st...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Poonam Singh Manish Kumar Sriparna Basu Source Type: research

Prognostic Value of Amplitude Integrated Electroencephalography in Term Neonates With Encephalopathy
CONCLUSIONS: Abnormal aEEG had good sensitivity but low specificity to predict primary outcome in term neonates with encephalopathy.PMID:33864450 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Giriraj Kumar Sharma Chandra Kumar Natarajan Vaanathi Hementhakumar Shanmuga Sundaram Shyam Sundar Sharma Source Type: research

Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children with Cerebral Palsy
Indian Pediatr. 2021 Apr 17:S097475591600312. Online ahead of print.ABSTRACTOBJECTIVES: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.METHODS: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.RESULTS: Z scores of BMD [-1.80 (1.03), -2.12 (0.85) Vs -1.40 (0.90); P
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Namita Gwasikoti Kapil Bhalla Jaya Shankar Kaushik Veena Singh Ghalaut Zile Singh Kundu Source Type: research

Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Retrospective Cohort Study From Argentina
Indian Pediatr. 2021 Apr 17:S097475591600313. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the differential characteristics of SARS-COV-2 associated inflammatory multisystem syndrome (MIS-C) in children.METHODS: A retrospective cohort study was conducted. The definition of MIS- C was based on WHO criteria. Temporally related COVID-19 patients were included as controls.RESULTS: 25 patients with MIS-C and 75 controls were included. Multivariate multiple logistic regression model of variables that showed to be significant in univariate analysis revealed that age ≥2 years (OR 24.7; 95% CI 1.03 -592.4; P=0.048), lym...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Maria Teresa Rosanova Guadalupe Perez Maria Martha Katsicas Ana Paula Arias Micaela Picollo Marcela Palladino Claudia Gonzalez Natalia Veliz Ana Buchovsky Roberto Lede Rosa Bologna Source Type: research

Framework to Incorporate Leadership Training in Competency-based Undergraduate Curriculum for the Indian Medical Graduate
We describe the rationale for incorporating formal leadership training in the new competency-based undergraduate curriculum and propose a longitudinal curricular template utilizing a mixed/multi-modality approach to teach and apply leadership competencies.PMID:33864453 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Sumita Sethi Henal Shah Avinash Supe Source Type: research

Clinical Profile of Adolescents With Delayed Puberty
Indian Pediatr. 2021 Apr 17:S097475591600309. Online ahead of print.ABSTRACTOne year study on forty-eight adolescents with delayed puberty revealed etiology of constitutional delay, hypogonadotrophic hypogonadism (HH), hypergonadotrophic hypogonadism, chronic systemic disease, hypothyroidism and sex reversal in 14(29.2%), 13 (27%), 12 (25%), 5 (10.4%), 3 (6.3%) and 1 (2.1 %) cases, respectively. Earlier presentation, male preponderance, significant normal variants and utility of GnRH analogue testing observed.PMID:33864448 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Aarthe Selvaraj Hemchand Krishna Prasad Kannan Narayanasamy Anand Thiagarajan Nedunchelian Krishnamoorthy Source Type: research

Gastric Lavage for Prevention of Feeding Intolerance in Neonates Delivered Through Meconium-Stained Amniotic Fluid: A Systematic Review and Meta-Analysis
This study evaluated the effects of gastric lavage, compared to no- gastric lavage, on the incidences of feeding intolerance, respiratory distress, meconium aspiration syndrome, time to establish breastfeeding, hospitalization and procedure-related complications in late-preterm and term neonates delivered through meconium-stained amniotic fluid.DESIGN: Systematic review and meta-analysis.DATA SOURCES AND SELECTION CRITERIA: MEDLINE, EMBASE, CENTRAL, and other databases were searched for randomized controlled trials and quasi randomized controlled trials using search terms: neonate OR newborn infant, meconium OR meconium-st...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Poonam Singh Manish Kumar Sriparna Basu Source Type: research

Prognostic Value of Amplitude Integrated Electroencephalography in Term Neonates With Encephalopathy
CONCLUSIONS: Abnormal aEEG had good sensitivity but low specificity to predict primary outcome in term neonates with encephalopathy.PMID:33864450 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Giriraj Kumar Sharma Chandra Kumar Natarajan Vaanathi Hementhakumar Shanmuga Sundaram Shyam Sundar Sharma Source Type: research

Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children with Cerebral Palsy
Indian Pediatr. 2021 Apr 17:S097475591600312. Online ahead of print.ABSTRACTOBJECTIVES: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.METHODS: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.RESULTS: Z scores of BMD [-1.80 (1.03), -2.12 (0.85) Vs -1.40 (0.90); P
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Namita Gwasikoti Kapil Bhalla Jaya Shankar Kaushik Veena Singh Ghalaut Zile Singh Kundu Source Type: research

Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Retrospective Cohort Study From Argentina
Indian Pediatr. 2021 Apr 17:S097475591600313. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the differential characteristics of SARS-COV-2 associated inflammatory multisystem syndrome (MIS-C) in children.METHODS: A retrospective cohort study was conducted. The definition of MIS- C was based on WHO criteria. Temporally related COVID-19 patients were included as controls.RESULTS: 25 patients with MIS-C and 75 controls were included. Multivariate multiple logistic regression model of variables that showed to be significant in univariate analysis revealed that age ≥2 years (OR 24.7; 95% CI 1.03 -592.4; P=0.048), lym...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Maria Teresa Rosanova Guadalupe Perez Maria Martha Katsicas Ana Paula Arias Micaela Picollo Marcela Palladino Claudia Gonzalez Natalia Veliz Ana Buchovsky Roberto Lede Rosa Bologna Source Type: research

Framework to Incorporate Leadership Training in Competency-based Undergraduate Curriculum for the Indian Medical Graduate
We describe the rationale for incorporating formal leadership training in the new competency-based undergraduate curriculum and propose a longitudinal curricular template utilizing a mixed/multi-modality approach to teach and apply leadership competencies.PMID:33864453 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Sumita Sethi Henal Shah Avinash Supe Source Type: research

Clinical Profile of Adolescents With Delayed Puberty
Indian Pediatr. 2021 Apr 17:S097475591600309. Online ahead of print.ABSTRACTOne year study on forty-eight adolescents with delayed puberty revealed etiology of constitutional delay, hypogonadotrophic hypogonadism (HH), hypergonadotrophic hypogonadism, chronic systemic disease, hypothyroidism and sex reversal in 14(29.2%), 13 (27%), 12 (25%), 5 (10.4%), 3 (6.3%) and 1 (2.1 %) cases, respectively. Earlier presentation, male preponderance, significant normal variants and utility of GnRH analogue testing observed.PMID:33864448 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Aarthe Selvaraj Hemchand Krishna Prasad Kannan Narayanasamy Anand Thiagarajan Nedunchelian Krishnamoorthy Source Type: research

Gastric Lavage for Prevention of Feeding Intolerance in Neonates Delivered Through Meconium-Stained Amniotic Fluid: A Systematic Review and Meta-Analysis
This study evaluated the effects of gastric lavage, compared to no- gastric lavage, on the incidences of feeding intolerance, respiratory distress, meconium aspiration syndrome, time to establish breastfeeding, hospitalization and procedure-related complications in late-preterm and term neonates delivered through meconium-stained amniotic fluid.DESIGN: Systematic review and meta-analysis.DATA SOURCES AND SELECTION CRITERIA: MEDLINE, EMBASE, CENTRAL, and other databases were searched for randomized controlled trials and quasi randomized controlled trials using search terms: neonate OR newborn infant, meconium OR meconium-st...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Poonam Singh Manish Kumar Sriparna Basu Source Type: research

Prognostic Value of Amplitude Integrated Electroencephalography in Term Neonates With Encephalopathy
CONCLUSIONS: Abnormal aEEG had good sensitivity but low specificity to predict primary outcome in term neonates with encephalopathy.PMID:33864450 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Giriraj Kumar Sharma Chandra Kumar Natarajan Vaanathi Hementhakumar Shanmuga Sundaram Shyam Sundar Sharma Source Type: research

Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children with Cerebral Palsy
Indian Pediatr. 2021 Apr 17:S097475591600312. Online ahead of print.ABSTRACTOBJECTIVES: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.METHODS: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.RESULTS: Z scores of BMD [-1.80 (1.03), -2.12 (0.85) Vs -1.40 (0.90); P
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Namita Gwasikoti Kapil Bhalla Jaya Shankar Kaushik Veena Singh Ghalaut Zile Singh Kundu Source Type: research

Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Retrospective Cohort Study From Argentina
Indian Pediatr. 2021 Apr 17:S097475591600313. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the differential characteristics of SARS-COV-2 associated inflammatory multisystem syndrome (MIS-C) in children.METHODS: A retrospective cohort study was conducted. The definition of MIS- C was based on WHO criteria. Temporally related COVID-19 patients were included as controls.RESULTS: 25 patients with MIS-C and 75 controls were included. Multivariate multiple logistic regression model of variables that showed to be significant in univariate analysis revealed that age ≥2 years (OR 24.7; 95% CI 1.03 -592.4; P=0.048), lym...
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Maria Teresa Rosanova Guadalupe Perez Maria Martha Katsicas Ana Paula Arias Micaela Picollo Marcela Palladino Claudia Gonzalez Natalia Veliz Ana Buchovsky Roberto Lede Rosa Bologna Source Type: research

Framework to Incorporate Leadership Training in Competency-based Undergraduate Curriculum for the Indian Medical Graduate
We describe the rationale for incorporating formal leadership training in the new competency-based undergraduate curriculum and propose a longitudinal curricular template utilizing a mixed/multi-modality approach to teach and apply leadership competencies.PMID:33864453 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 17, 2021 Category: Pediatrics Authors: Sumita Sethi Henal Shah Avinash Supe Source Type: research

Relationship of Maternal and Neonatal Variables With Breastmilk Sodium
CONCLUSION: Breastmilk sodium shows a steady decline in the first 72 hours after delivery. Feeding ≤8 times per day is associated high breastmilk sodium at 72 hours of age.PMID:33772530 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Mary Veena Mathew K Peter Prasanth Kumar R Sivaa Satish Kuruvilla K Ravichandran Lalitha Krishnan Source Type: research

Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600304. Online ahead of print.ABSTRACTOBJECTIVES: To study vitamin C levels in children with transfusion-dependent b-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients.METHODS: This case-control study enrolled 100 children with transfusion-dependent b-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels.RESULTS: 81/95 (85.3%) study subjects Vs no...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: K Vasudeva Bhat Ratna A Sharma Sujata M Sharma Priyanka Joshi Bina F Dias Nikita Shah Maninder Setia Mamta V Manglani Source Type: research

Adverse Drug Reactions Following Propranolol in Infantile Hemangioma
CONCLUSIONS: Young children with low body weight were at higher risk for adverse effects of propranolol.PMID:33772532 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Vaibhav Pandey Preeti Tiwari Mohammed Imran Akash Mishra Deepak Kumar S P Sharma Source Type: research

Pubertal Development and its Determinants in Adolescents With Transfusion-Dependent Thalassemia
CONCLUSIONS: A significant proportion of adolescents with TDT continue to have pubertal arrest/failure. High systemic iron load is the key determinant for this.PMID:33772533 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Preeti Singh Sukla Samaddar Nupur Parakh Jagdish Chandra Anju Seth Source Type: research

Agreement Between Oscillatory and Invasive Intra-Arterial Blood Pressure in the Pediatric Cardiac Critical Care Unit
CONCLUSIONS: NIBP cannot replace but can supplement IBP in the pediatric cardiac critical care setting.PMID:33772534 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Amit Kumar Jigar P Thacker Manoj Chaudhary Ajay G Phatak Somashekhar M Nimbalkar Source Type: research

Gene Therapies for Transfusion-dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600302. Online ahead of print.ABSTRACTβ-Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of b-globin, a component of adult hemoglobin (a2b2), leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene-editing strategies now allow for efficient ex-vivo genetic manipulation of human hematopoietic stem cells that can lead to a meaningful clinical benefit in thalassemia patients. In this perspective, the status of the gene-therapy approac...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Sandeep Soni Source Type: research

Macrophage Activation Syndrome in Children: Diagnosis and Management
Indian Pediatr. 2021 Mar 26:S097475591600308. Online ahead of print.ABSTRACTMacrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.PMID:33772536 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Narendra Kumar Bagri Latika Gupta Ethan S Sen A V Ramanan Source Type: research

Relationship of Maternal and Neonatal Variables With Breastmilk Sodium
CONCLUSION: Breastmilk sodium shows a steady decline in the first 72 hours after delivery. Feeding ≤8 times per day is associated high breastmilk sodium at 72 hours of age.PMID:33772530 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Mary Veena Mathew K Peter Prasanth Kumar R Sivaa Satish Kuruvilla K Ravichandran Lalitha Krishnan Source Type: research

Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600304. Online ahead of print.ABSTRACTOBJECTIVES: To study vitamin C levels in children with transfusion-dependent b-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients.METHODS: This case-control study enrolled 100 children with transfusion-dependent b-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels.RESULTS: 81/95 (85.3%) study subjects Vs no...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: K Vasudeva Bhat Ratna A Sharma Sujata M Sharma Priyanka Joshi Bina F Dias Nikita Shah Maninder Setia Mamta V Manglani Source Type: research

Adverse Drug Reactions Following Propranolol in Infantile Hemangioma
CONCLUSIONS: Young children with low body weight were at higher risk for adverse effects of propranolol.PMID:33772532 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Vaibhav Pandey Preeti Tiwari Mohammed Imran Akash Mishra Deepak Kumar S P Sharma Source Type: research

Pubertal Development and its Determinants in Adolescents With Transfusion-Dependent Thalassemia
CONCLUSIONS: A significant proportion of adolescents with TDT continue to have pubertal arrest/failure. High systemic iron load is the key determinant for this.PMID:33772533 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Preeti Singh Sukla Samaddar Nupur Parakh Jagdish Chandra Anju Seth Source Type: research

Agreement Between Oscillatory and Invasive Intra-Arterial Blood Pressure in the Pediatric Cardiac Critical Care Unit
CONCLUSIONS: NIBP cannot replace but can supplement IBP in the pediatric cardiac critical care setting.PMID:33772534 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Amit Kumar Jigar P Thacker Manoj Chaudhary Ajay G Phatak Somashekhar M Nimbalkar Source Type: research

Gene Therapies for Transfusion-dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600302. Online ahead of print.ABSTRACTβ-Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of b-globin, a component of adult hemoglobin (a2b2), leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene-editing strategies now allow for efficient ex-vivo genetic manipulation of human hematopoietic stem cells that can lead to a meaningful clinical benefit in thalassemia patients. In this perspective, the status of the gene-therapy approac...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Sandeep Soni Source Type: research

Macrophage Activation Syndrome in Children: Diagnosis and Management
Indian Pediatr. 2021 Mar 26:S097475591600308. Online ahead of print.ABSTRACTMacrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.PMID:33772536 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Narendra Kumar Bagri Latika Gupta Ethan S Sen A V Ramanan Source Type: research

Relationship of Maternal and Neonatal Variables With Breastmilk Sodium
CONCLUSION: Breastmilk sodium shows a steady decline in the first 72 hours after delivery. Feeding ≤8 times per day is associated high breastmilk sodium at 72 hours of age.PMID:33772530 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Mary Veena Mathew K Peter Prasanth Kumar R Sivaa Satish Kuruvilla K Ravichandran Lalitha Krishnan Source Type: research

Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600304. Online ahead of print.ABSTRACTOBJECTIVES: To study vitamin C levels in children with transfusion-dependent b-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients.METHODS: This case-control study enrolled 100 children with transfusion-dependent b-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels.RESULTS: 81/95 (85.3%) study subjects Vs no...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: K Vasudeva Bhat Ratna A Sharma Sujata M Sharma Priyanka Joshi Bina F Dias Nikita Shah Maninder Setia Mamta V Manglani Source Type: research

Adverse Drug Reactions Following Propranolol in Infantile Hemangioma
CONCLUSIONS: Young children with low body weight were at higher risk for adverse effects of propranolol.PMID:33772532 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Vaibhav Pandey Preeti Tiwari Mohammed Imran Akash Mishra Deepak Kumar S P Sharma Source Type: research

Pubertal Development and its Determinants in Adolescents With Transfusion-Dependent Thalassemia
CONCLUSIONS: A significant proportion of adolescents with TDT continue to have pubertal arrest/failure. High systemic iron load is the key determinant for this.PMID:33772533 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Preeti Singh Sukla Samaddar Nupur Parakh Jagdish Chandra Anju Seth Source Type: research

Agreement Between Oscillatory and Invasive Intra-Arterial Blood Pressure in the Pediatric Cardiac Critical Care Unit
CONCLUSIONS: NIBP cannot replace but can supplement IBP in the pediatric cardiac critical care setting.PMID:33772534 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Amit Kumar Jigar P Thacker Manoj Chaudhary Ajay G Phatak Somashekhar M Nimbalkar Source Type: research

Gene Therapies for Transfusion-dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600302. Online ahead of print.ABSTRACTβ-Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of b-globin, a component of adult hemoglobin (a2b2), leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene-editing strategies now allow for efficient ex-vivo genetic manipulation of human hematopoietic stem cells that can lead to a meaningful clinical benefit in thalassemia patients. In this perspective, the status of the gene-therapy approac...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Sandeep Soni Source Type: research

Macrophage Activation Syndrome in Children: Diagnosis and Management
Indian Pediatr. 2021 Mar 26:S097475591600308. Online ahead of print.ABSTRACTMacrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.PMID:33772536 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Narendra Kumar Bagri Latika Gupta Ethan S Sen A V Ramanan Source Type: research

Relationship of Maternal and Neonatal Variables With Breastmilk Sodium
CONCLUSION: Breastmilk sodium shows a steady decline in the first 72 hours after delivery. Feeding ≤8 times per day is associated high breastmilk sodium at 72 hours of age.PMID:33772530 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Mary Veena Mathew K Peter Prasanth Kumar R Sivaa Satish Kuruvilla K Ravichandran Lalitha Krishnan Source Type: research

Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600304. Online ahead of print.ABSTRACTOBJECTIVES: To study vitamin C levels in children with transfusion-dependent b-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients.METHODS: This case-control study enrolled 100 children with transfusion-dependent b-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels.RESULTS: 81/95 (85.3%) study subjects Vs no...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: K Vasudeva Bhat Ratna A Sharma Sujata M Sharma Priyanka Joshi Bina F Dias Nikita Shah Maninder Setia Mamta V Manglani Source Type: research

Adverse Drug Reactions Following Propranolol in Infantile Hemangioma
CONCLUSIONS: Young children with low body weight were at higher risk for adverse effects of propranolol.PMID:33772532 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Vaibhav Pandey Preeti Tiwari Mohammed Imran Akash Mishra Deepak Kumar S P Sharma Source Type: research

Pubertal Development and its Determinants in Adolescents With Transfusion-Dependent Thalassemia
CONCLUSIONS: A significant proportion of adolescents with TDT continue to have pubertal arrest/failure. High systemic iron load is the key determinant for this.PMID:33772533 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Preeti Singh Sukla Samaddar Nupur Parakh Jagdish Chandra Anju Seth Source Type: research

Agreement Between Oscillatory and Invasive Intra-Arterial Blood Pressure in the Pediatric Cardiac Critical Care Unit
CONCLUSIONS: NIBP cannot replace but can supplement IBP in the pediatric cardiac critical care setting.PMID:33772534 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Amit Kumar Jigar P Thacker Manoj Chaudhary Ajay G Phatak Somashekhar M Nimbalkar Source Type: research

Gene Therapies for Transfusion-dependent β-Thalassemia
Indian Pediatr. 2021 Mar 26:S097475591600302. Online ahead of print.ABSTRACTβ-Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of b-globin, a component of adult hemoglobin (a2b2), leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene-editing strategies now allow for efficient ex-vivo genetic manipulation of human hematopoietic stem cells that can lead to a meaningful clinical benefit in thalassemia patients. In this perspective, the status of the gene-therapy approac...
Source: Indian Pediatrics - March 27, 2021 Category: Pediatrics Authors: Sandeep Soni Source Type: research