Clustering of immune-mediated diseases in sarcoidosis
Purpose of review Sarcoidosis is an immune-mediated disease of unknown cause. Immune-mediated diseases appear to cluster in patients and in families. We review what is known on this topic for sarcoidosis, and what factors may underlie disease clustering. Recent findings In populations of patients with sarcoidosis, relative risk estimates of Sjögren's syndrome, systemic lupus erythematosus, autoimmune hepatitis, ankylosing spondylitis, multiple sclerosis (MS), celiac disease, autoimmune thyroid disease, and ulcerative colitis, varied between 2.1 and 11.6. In relatives of patients with sarcoidosis, relative risk es...
Source: Current Opinion in Pulmonary Medicine - August 2, 2019 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Jan C. Grutters and Marc A. Judson Source Type: research

Small fiber neuropathy in coeliac disease and gluten sensitivity.
CONCLUSION: SFN can be a presenting feature of CD and GS and, therefore, screening for CD and GS should be included in the diagnostic work up of patients with idiopathic SFN. PMID: 31359810 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - August 1, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Two cases of monomorphic epitheliotropic intestinal T-cell lymphoma associated with coeliac disease.
Authors: Lenti MV, Biagi F, Lucioni M, Di Sabatino A, Paulli M, Corazza GR Abstract Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive type of intestinal lymphoma which affects individuals without evidence of enteropathy. In this single-centre case series, we describe the first two cases of MEITL in Caucasian patients suffering from histologically-proven coeliac disease (CD). Original medical records were retrieved and anonymised. All biopsy and surgical MEITL specimens were reviewed by three haematopathologists. Two patients aged 63- and 55-year old at CD diagnosis, subsequently develo...
Source: Scandinavian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Is the double gene dose of DQ2.5 or DQ2.5/DQ2.2 an involved factor in the clinical features of celiac disease?
Conclusions: To date, this negative association has not been described. Further studies will be necessary to elucidate the implication of this protection factor in CD. Since, until now the association between CD and allergic diseases has been poorly studied. PMID: 31361165 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families
Wheat grains contain gluten proteins, which harbour immunogenic epitopes that trigger Coeliac disease in 1 –2% of the human population. Wheat varieties or accessions containing only safe gluten have not been id... (Source: BMC Plant Biology)
Source: BMC Plant Biology - August 1, 2019 Category: Biology Authors: Aur élie Jouanin, Jan G. Schaart, Lesley A. Boyd, James Cockram, Fiona J. Leigh, Ruth Bates, Emma J. Wallington, Richard G. F. Visser and Marinus J. M. Smulders Tags: Research article Source Type: research

[The extraintestinal spectrum of gluten sensitivity].
, Barta Z Abstract Although celiac disease (gluten-sensitive enteropathy) is a relatively well known malady, yet is surrounded by several misconceptions. It is in fact, a multi-systemic autoimmune disorder with a wide spectrum of possible presentations, though most clinicians regard it as a solely gastrointestinal disease. Another misconception that it is a disease of paediatric age group. Thus, the diagnosis of adult or elderly patients is often delayed. Recognition of the disease in the adults can be challenging, as there are less pronounced gastrointestinal symptoms, and patients present with other manifestatio...
Source: Orvosi Hetilap - August 1, 2019 Category: General Medicine Authors: Fedor I, Zöld É, Barta Z Tags: Orv Hetil Source Type: research

A Gluten-Free Diet, Not an Appropriate Choice without a Medical Diagnosis.
Authors: Diez-Sampedro A, Olenick M, Maltseva T, Flowers M Abstract In the past, only people diagnosed with celiac disease, approximately 1% of the population, avoided gluten consumption through all their meals. However, popular media often now mistakenly present gluten-free foods as being a healthier choice, and more people have now concluded that gluten is a harmful part of the diet. A review of literature on gluten-free diets, gluten sensitivity, celiac disease, and attitudes toward gluten consumption was undertaken to examine the prevalence and consequences of adopting a gluten-free diet and to provide guidance...
Source: Journal of Nutrition and Metabolism - July 31, 2019 Category: Nutrition Tags: J Nutr Metab Source Type: research

Response to Letter by Galli et al. “Do Alterations in Bone Mineral Density Go Beyond Borders in Adults with Celiac Disease”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 31, 2019 Category: Gastroenterology Authors: Marcella D. Walker, John Williams, Suzanne K. Lewis, Julio C. Bai, Benjamin Lebwohl, Peter HR. Green Source Type: research

Reply
We are grateful to Dr Galli and colleagues1 for their interest in our work demonstrating the value of bone mineral density (BMD) measurement by dual x-ray absorptiometry (DXA) in adults with celiac disease (CD).2 Our study findings highlight the importance of BMD assessment in CD, not only at the lumbar spine and hip skeletal sites but also at the distal 1/3 radius, particularly in men and patients>50 years old.2 As outlined by Galli et  al, both our study, conducted in patients at variable time points since CD diagnosis, and their recent smaller investigation in those who were newly diagnosed indicate a high preva...
Source: Clinical Gastroenterology and Hepatology - July 31, 2019 Category: Gastroenterology Authors: Marcella D. Walker, John Williams, Suzanne K. Lewis, Julio C. Bai, Benjamin Lebwohl, Peter H.R. Green Tags: Letter to the Editor Source Type: research

Autoimmunity Predisposition in Girls With Turner Syndrome
Conclusions: Our study showed a higher incidence of autoimmune diseases in TS, which is in line with the literature; however, the impact of iXq, or spontaneous / inducted puberty was not confirmed. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - July 30, 2019 Category: Endocrinology Source Type: research

Nivolumab ‐induced celiac‐like enteropathy in patient with metastatic renal cell carcinoma: Case report and review of the literature
Nivolumab may induce severe celiac ‐like enteropathy, that may appear very rapidly, after only two injections of nivolumab, and may be successfully treated with corticosteroids. This observation underlines the importance of histological analysis of duodenal biopsies and the necessity to rule out a real celiac disease in patients wi th nivolumab‐induced diarrhea. AbstractNivolumab may induce severe celiac ‐like enteropathy, that may appear very rapidly, after only two injections of nivolumab, and may be successfully treated with corticosteroids. This observation underlines the importance of histological analysis of du...
Source: Clinical Case Reports - July 28, 2019 Category: General Medicine Authors: Lucie Duval, Sarah Habes, Thierry Chatellier, Pascale Guerzider, C éline Bossard, Claude Masliah, Isabelle Archambeaud, Yann Touchefeu, Tamara Matysiak‐Budnik Tags: CASE REPORT Source Type: research

Psychological Comorbidities in Childhood Celiac Disease: A Systematic Review
Conclusions: Many existing studies have found increased prevalence of comorbid CD and psychological symptoms or diagnoses. Therefore, screening for psychological symptoms in CD and also screening for CD in psychological clinic populations is needed. We have identified the importance for further study of mechanisms and risk, and identify preliminary priorities for psychosocial research and clinical care in pediatric CD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 26, 2019 Category: Gastroenterology Tags: Review Article Source Type: research

Pediatric Nonceliac Gluten Sensitivity: A Gluten-related Disorder Treatment Center Experience
Conclusions: Even within our highly specialized population of patients with a suspected gluten-related disorder, pediatric NCGS is relatively uncommon. The estimated prevalence and clinical features mirror those previously reported in a similarly highly selective population of adults. In the absence of celiac disease, clinical suspicion for NCGS should arise in a child with gastrointestinal and/or extraintestinal complaints alleviated with gluten removal and considered in symptomatic patients with associated allergic/atopic disease. Proper and adequate exclusion of celiac disease and other potential causes of the clinica...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy
Conclusions: To our knowledge, this is the largest pediatric study to assess the histologic outcome of EoE-associated esophageal eosinophilia in response to dietary management of pediatric patients with concomitant CeD and EoE. We demonstrate that soy is well tolerated in this cohort, and suggest that reintroducing this food first, or trialing a soy-inclusive elimination diet is a viable strategy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

GSE134900 The interplay between IL-15, gluten and HLA-DQ8 drives the development of coeliac disease in mice
Contributors : Luis Barreiro ; Bana JabriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCoeliac disease (CeD) is a complex, polygenic inflammatory enteropathy with autoimmune features caused by exposure to dietary gluten that occurs in a subset of genetically susceptible HLA-DQ8 and HLA-DQ2 individuals. Attempts to develop a pathophysiologically relevant animal model that develops villous atrophy (VA) have failed. The need to develop non-dietary treatments for this common disorder is now widely recognized, but it is hampered by the lack of a preclinical model. Furthermore, while huma...
Source: GEO: Gene Expression Omnibus - July 26, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Measurements of Duodenal Mucosal Integrity are Altered in Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Dawn W. Adams, Dhyanesh Patel, Lauren Evers, James C. Slaughter, Tina Higginbotham, Michael Vaezi Source Type: research

Pseudo-obstruction, enteric dysmotility and irritable bowel syndrome
Publication date: Available online 22 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Greger LindbergAbstractNew diagnostic techniques have advanced our knowledge about the irritable bowel syndrome. The majority of patients that we believed to have a psychosomatic disorder have received other diagnoses explaining their symptoms. Endoscopy makes it possible to diagnose celiac disease before it leads to malnutrition and allows the detection of microscopic colitis as a cause of watery diarrhea. At the severe end of the symptom spectrum enteric dysmotility marks the border at which IBS ceases ...
Source: Best Practice and Research Clinical Gastroenterology - July 23, 2019 Category: Gastroenterology Source Type: research

Celiac disease: a comprehensive current review
Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. (Source: BMC Medicine)
Source: BMC Medicine - July 23, 2019 Category: Internal Medicine Authors: Giacomo Caio, Umberto Volta, Anna Sapone, Daniel A. Leffler, Roberto De Giorgio, Carlo Catassi and Alessio Fasano Tags: Review Source Type: research

Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease [Immunology and Inflammation]
B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigen-presenting cells is not well understood. We have studied the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease patients... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - July 23, 2019 Category: Science Authors: Rasmus Iversen, Bishnudeo Roy, Jorunn Stamnaes, Lene S. Hoydahl, Kathrin Hnida, Ralf S. Neumann, Ilma R. Korponay–Szabo, Knut E. A. Lundin, Ludvig M. Sollid Tags: Biological Sciences Source Type: research

Clinical and Histopathologic Predictors of Disaccharidase Deficiency in Duodenal Biopsy Specimens.
CONCLUSIONS: Utilization could be reduced by only testing cases with normal duodenal histopathology and ongoing clinical suspicion for DS deficiency after reviewing pathology. In cases with suspected celiac disease and/or mucosal injury, DS deficiency is common and likely secondary, limiting test utility. PMID: 31332425 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 23, 2019 Category: Pathology Authors: Reed RC, Pacheco MC Tags: Am J Clin Pathol Source Type: research

Adalimumab – safe and effective therapy for adolescent patient with severe psoriasis and immune thrombocytopenia.
We report the case of an adolescent with severe psoriasis and concomitant immune thrombocytopenia who obtained remission during treatment with adalimumab. Increased concentration of tumor necrosis factor- α seems to be a pathogenic linkage and therapeutic target for both diseases.  (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - July 22, 2019 Category: Dermatology Source Type: research

Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease.
Authors: Maiuri L, Raia V, Piacentini M, Tosco A, Villella VR, Kroemer G Abstract Cystic Fibrosis (CF) is the most frequent lethal monogenetic disease affecting humans. CF is characterized by mutations in cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel whose malfunction triggers the activation of transglutaminase-2 (TGM2), as well as the inactivation of the Beclin-1 (BECN1) complex resulting in disabled autophagy. CFTR inhibition, TGM2 activation and BECN1 sequestration engage in an 'infernal trio' that locks the cell in a pro-inflammatory state through anti-homeostatic feedforward lo...
Source: Oncotarget - July 21, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Lymphocytic gastritis in a patient with dyspepsia
Lymphocytic gastritis (LG) is uncommon and presents histologically with a nonspecific inflammatory pattern. It is most often associated with celiac disease andHelicobacter pylori gastritis and is rarely associated with other conditions including lymphoma. LG is of clinical importance since its recognition should prompt further clinical evaluation for other disorders. AbstractLymphocytic gastritis (LG) is uncommon and presents histologically with a nonspecific inflammatory pattern. It is most often associated with celiac disease andHelicobacter pylori gastritis and is rarely associated with other conditions including lympho...
Source: Clinical Case Reports - July 21, 2019 Category: General Medicine Authors: Katrina Collins, William N. Rezuke Tags: CLINICAL IMAGE Source Type: research

Interplay between the toxic alpha-gliadin peptide 31-43 and type 2 transglutaminase enzyme in Celiac Disease
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Gaetana Paolella, Marilena Lepretti, Stefania Martucciello, Lillà Lionetti, Carla Esposito, Ivana Caputo (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - July 20, 2019 Category: Nutrition Source Type: research

Interplay between the toxic alpha-gliadin peptide 31-43 and type 2 transglutaminase enzyme in Celiac Disease
Introduction: Celiac disease (CD) is a widespread enteropathy triggered by a diet containing cereals with gliadins in genetically predisposed individuals. Alpha-gliadin peptide 31 –43 (p31-43) is considered the main responsible of the innate immune response in CD patients and type 2 transglutaminase (TG2) enzyme is involved in CD by enhancing gliadin immunogenicity. Evidence has been reported on a role of TG2 in modulate p31-43 uptake by intestinal cells; indeed, antibodies to TG2 specifically reduced both p31-43 uptake by cells and its biological activity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Gaetana Paolella, Marilena Lepretti, Stefania Martucciello, Lill à Lionetti, Carla Esposito, Ivana Caputo Source Type: research

Survey of the initial management of celiac disease antibody tests by ordering physicians
Appropriate interpretation of a positive celiac antibody test by an ordering physician is important in order to institute proper management. We evaluated why children with an initial positive celiac serology w... (Source: BMC Pediatrics)
Source: BMC Pediatrics - July 19, 2019 Category: Pediatrics Authors: Kathryn Potter, Lawrence de Koning, J. Decker Butzner and Dominica Gidrewicz Tags: Research article Source Type: research

Efficacy of Neoadjuvant Chemotherapy in Distal Pancreatectomy with En Bloc Celiac Axis Resection (DP-CAR) for Locally Advanced Pancreatic Cancer
This study retrospectively reviewed 20 consecutive patients who underwent DP-CAR at a single institution.ResultsEleven of 20 patients (55.0%) received NAC. Their first regimens were gemcitabine (GEM) plus nab-PTX (n = 7, 63.6%), GEM plus S-1 (n = 3, 27.3%), and GEM (n = 1, 9.1%). Although two patients converted to a second regimen, none abandoned NAC due to adverse effects or could not undergo a planned procedure for disease progression. There were no significant differences in intraoperative variables, morbidity, including pancreatic fistula and delayed gas tric emptying, and mort...
Source: Journal of Gastrointestinal Surgery - July 19, 2019 Category: Surgery Source Type: research

Nutritional Intake and Bone Health Among Adults With Probable Undiagnosed, Untreated Celiac Disease: What We Eat in America and NHANES 2009 –2014
. (Source: Journal of the American College of Nutrition)
Source: Journal of the American College of Nutrition - July 19, 2019 Category: Nutrition Authors: Lara H. Sattgast Sina Gallo Cara L. Frankenfeld Alanna J. Moshfegh Margaret Slavin Source Type: research

Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond.
Abstract Few therapeutic and diagnostic tools specifically aim at T cells in autoimmune disorders, but are T cells a narrow target in these diseases? Lessons may be learned from celiac disease (CeD), one of the few autoimmune disorders where the T cell driving antigens are known, i.e. dietary gluten proteins. T cell clonotypes specific to gluten are expanded, persist for decades and express a distinct phenotype in CeD patients. Cells with this phenotype are increased also in other autoimmune conditions. Accordingly, disease-specific CD4+ T cells form an immunological scar in CeD and probably other autoimmune disor...
Source: Trends in Molecular Medicine - July 19, 2019 Category: Molecular Biology Authors: Christophersen A, Risnes LF, Dahal-Koirala S, Sollid LM Tags: Trends Mol Med Source Type: research

Nutritional Intake and Bone Health Among Adults With Probable Undiagnosed, Untreated Celiac Disease: What We Eat in America and NHANES 2009 –2014
. (Source: Journal of the American College of Nutrition)
Source: Journal of the American College of Nutrition - July 19, 2019 Category: Nutrition Authors: Lara H. Sattgast Sina Gallo Cara L. Frankenfeld Alanna J. Moshfegh Margaret Slavin Source Type: research

Genetic and Environmental Contributors for Celiac Disease
AbstractPurpose of ReviewCeliac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.Recent FindingsWe reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of...
Source: Current Allergy and Asthma Reports - July 18, 2019 Category: Allergy & Immunology Source Type: research

Quinoa protein: Composition, structure and functional properties
Publication date: 30 November 2019Source: Food Chemistry, Volume 299Author(s): Samira Dakhili, Leyla Abdolalizadeh, Seyede Marzieh Hosseini, Saeedeh Shojaee-Aliabadi, Leila MirmoghtadaieAbstractQuinoa (Chenopodium quinoa willd.) is an annual herbaceous flowering plant showing appropriate nutritional and functional properties due to its high quality protein with a wide amino acid spectrum, particularly rich in lysine. The mature quinoa seed predominantly consists of 11S-type globulin called chenopodin, comprising about 37% of the total protein, and also 2S albumin accounting for 35% of the seed protein both stabilized throu...
Source: Food Chemistry - July 17, 2019 Category: Food Science Source Type: research

Celiac disease in the East and the West: Bridging the gaps between the guidelines and their implementation in daily practice is mandatory
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - July 17, 2019 Category: Gastroenterology Source Type: research

Challenges to drug discovery for celiac disease and approaches to overcome them
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - July 17, 2019 Category: Drugs & Pharmacology Authors: Luis Vaquero David Bernardo Francisco Le ón Laura Rodr íguez-Martín Bego ña Alvarez-Cuenllas Santiago Vivas Source Type: research

Hematologic Manifestations in Celiac Disease-A Practical Review.
Abstract Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scena...
Source: Medicina (Kaunas) - July 15, 2019 Category: Universities & Medical Training Authors: Balaban DV, Popp A, Ionita Radu F, Jinga M Tags: Medicina (Kaunas) Source Type: research

HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo.
Authors: Ramosaj-Morina A, Burek Kamenaric M, Azemi M, Spahiu L, Grubic Z, Zunec R Abstract Genetic predisposition to celiac disease (CD) is strongly associated with the presence of HLA alleles in the individual genotype encoding HLA-DQ2 and/or HLA-DQ8 heterodimers. The main aim of this study was to analyze the HLA-A, -B, -DRB1, and -DQ allele and five-locus haplotype frequencies in 60 Albanian pediatric CD patients and 124 non-CD children from Kosovo. The most prevalent haplotype in patients was the ancestral AH 8.1 haplotype present in 22.5% of the cases compared to 2.8% of the controls (P
Source: Gastroenterology Research and Practice - July 12, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Phenotypic Expression of Autoimmunity in Children With Autoimmune Thyroid Disorders
Autoimmune thyroid diseases (AITDs), including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), tend to aggregate with other non-thyroidal autoimmune diseases (NTADs). Aim of this Mini-review is to report the most recent insights concerning the clustering of NTADs in pediatric patients with either HT or GD, the pathophysiology of AITDs and the metamorphic thyroid autoimmunity. A systematic literature research of the last fifteen years, according to EQUATOR statement, was carried out through MEDLINE via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) Embase, CINAHL, Cochrane Library, based on the following ...
Source: Frontiers in Endocrinology - July 12, 2019 Category: Endocrinology Source Type: research

Lupus anticoagulant remission after gluten-free diet in a coeliac pregnant woman.
PMID: 31299883 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - July 12, 2019 Category: Rheumatology Authors: Tabacco S, Garufi C, Giannini A, Lanzone A, Benedetti Panici P, Rizzo F, Salvi S, De Carolis S Tags: Lupus Source Type: research

Effect of Bletilla striata on the Prevention of Postoperative Peritoneal Adhesions in Abrasion-Induced Rat Model.
Authors: Liu B, Zhang Q, Wu X, Fu Y, Wang H, Guan Y, Yang S, Liu Y, Cao W, Wang J Abstract Postoperative peritoneal adhesions (PPAs) constitute a common complication of abdominal surgery with a high incidence. Bletilla striata (BS) is an important hemostatic drug used in China for nearly 2000 years. The purpose of this study was to investigate the effect of Bletilla striata on postoperative intestinal adhesion in rats. PPA was induced by cecal wall abrasion, and Bletilla striata was injected to observe its effect on adhesion in rats. The adhesion and inflammation score were assessed through visual observation and h...
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Celiac disease in type 1 diabetes mellitus in the Kingdom of Saudi Arabia. Characterization and meta-analysis.
Conclusion: The prevalence of biopsy-proven CD among T1DM patients in Kingdom of Saudi Arabia (12.0%) was double the global prevalence (6.0%), and much higher than the normal Saudi population (1.4%). The female-to-male ratio (2:1) of CD patients in T1DM was the same as in the normal population in Kingdom of Saudi Arabia. No significant difference was detected between the reported serologically-proven rates and the reported biopsy-proven rates (p=0.093). PMID: 31287124 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - July 11, 2019 Category: Middle East Health Tags: Saudi Med J Source Type: research

[Analysis of the gluten-free menus served in school canteens: are they balanced?]
CONCLUSIONS: school menus adapted for children conform to the recommendations, although they should be limited to intake. PMID: 31291737 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - July 11, 2019 Category: Nutrition Authors: García Soto L, Martín-Masot R, Nestares MT, Maldonado J Tags: Nutr Hosp Source Type: research

Risk of fractures in dermatitis herpetiformis and coeliac disease: a register-based study.
Conclusion: The incidence of hip fracture is not increased in treated DH or coeliac disease in an area with high awareness and dietary compliance rates. However, patients with DH seem to have a lower risk for fractures overall compared to coeliac disease. PMID: 31280614 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 10, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Dietary Factors and Mucosal Immune Response in Celiac Disease Patients Having Persistent Symptoms Despite a Gluten-free Diet
Conclusions: Low fiber intake may predispose patients to persistent symptoms in celiac disease. There were no differences between the groups in the markers of innate immunity, epithelial stress or epithelial integrity. A higher number of IELs in asymptomatic subjects may indicate that the association between symptoms and mucosal inflammation is more complicated than previously thought. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Link Between Celiac Disease and Inflammatory Bowel Disease
Conclusions: The data are consistent with the notion that celiac disease is a risk factor for IBD and to lesser degree patients with IBD have an increased risk of celiac disease. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Diagnostic Accuracy of Point of Care Tests for Diagnosing Celiac Disease: A Systematic Review and Meta-Analysis
Conclusions: The pooled sensitivity and specificity of POCTs in diagnosing CD are high. POCTs may be used to screen for CD, especially in areas with limited access to laboratory-based testing. Further research assessing the diagnostic accuracy of individual POCTs and comparing it with other available POCTs is needed. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Duodenal Biopsy Rate Differences Among Endoscopists and its Impact on Celiac Disease Diagnosis and Management
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 10, 2019 Category: Gastroenterology Tags: LETTERS TO THE EDITOR Source Type: research

Should the clinical significance of supraclavicular and celiac lymph node metastasis in thoracic esophageal cancer be reevaluated?
ConclusionsThese results provide preliminary evidence that the clinical significance of supraclavicular and celiac lymph node metastasis should be reevaluated in thoracic esophageal cancer with different prognostic information according to the primary sites. (Source: Thoracic Cancer)
Source: Thoracic Cancer - July 10, 2019 Category: Cancer & Oncology Authors: Junmiao Wen, Donglai Chen, Ting Zhao, Jiayan Chen, Yuhuan Zhao, Di Liu, Wenjia Wang, Xinyan Xu, Min Fan, Chang Chen, Yongbing Chen Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study
Journal of Clinical Pediatric Dentistry,Volume 43, Issue 4, Page 274-280, 2019. (Source: Journal of Clinical Pediatric Dentistry)
Source: Journal of Clinical Pediatric Dentistry - July 8, 2019 Category: Dentistry Authors: Michail Zoumpoulakis Maria Fotoulaki Vasiliki Topitsoglou Panagiota Lazidou Lambros Zouloumis Nikolaos Kotsanos Source Type: research