Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research

Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research

Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients
AbstractCeliac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with tryptophan (Trp) and its metabolite, kynurenic acid (KYNA), are known to influence the immune function of DCs and enhance their tolerogenicity. This research aims to assess the impact of gliadin on DC maturation and the potential of vitamin A and tryptophan to induce immune tolerance in DCs. The monocyte cells obtained from peripheral blood mononuclear cells (PBMCs) of celiac d...
Source: Inflammation - March 16, 2024 Category: Allergy & Immunology Source Type: research

Italian guidelines for the management of irritable bowel syndrome in children and adolescents
AbstractThe irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and e...
Source: Italian Journal of Pediatrics - March 14, 2024 Category: Pediatrics Source Type: research

Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India
ConclusionSame HLA genes provide susceptibility for both T1D and CD. Non-HLA genes CTLA4, PTPN22 and INS provide further susceptibility while different polymorphisms in PTPN22 and INS can discriminate between T1D and T1D  + CD. Epitope homology between autoantigens of two diseases further encourages the two diseases to occur together. The T1D + CD being more common in females along with co-existence of thyroid autoimmunity, and have more immune dysregulated state than T1D alone. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 14, 2024 Category: Endocrinology Source Type: research

The role of antral histopathology in diagnosing paediatric celiac disease
Pol J Pathol. 2023;74(4):256-264. doi: 10.5114/pjp.2023.134290.ABSTRACTThe aim of this study was to evaluate the diagnostic potential of gastric antrum histology in children suspected of having celiac disease (CD). The present retrospective study was performed on 224 patients who were suspected of having CD and had several duodenal and one gastric antrum biopsies. They were divided into 2 groups based on the definite diagnosis of CD. The statistical analysis was performed using SPSS version 22 software. Receiver operating characteristic (ROC) curves were drown and the area under the curves (AUCs) was calculated. Article au...
Source: Polish Journal of Pathology - March 13, 2024 Category: Pathology Authors: Zahra Heidari Manijeh Khalili Hamidreza Mahmoudzadeh Sagheb Mahdi Afshari Fateme Parooie Iraj Shahramian Fateme Sargazi Alireza Aminisefat Mahdi Shirdel Kahkha Zhale Ali Mansuri Source Type: research