Identification of a γc Receptor Antagonist that Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21
Gamma chain ( γc) cytokines (interleukin 2 [IL2], IL4, IL7, IL9, IL15 and IL21) signal via a common γc receptor. IL2 regulates the immune response, whereas IL21 and IL15 contribute to development of autoimmune disorders, including celiac disease. We investigated whether BNZ-2, a peptide designed to inhibit IL15 and IL21, blocks these cytokines selectively and its effects on intraepithelial cytotoxic T cells. (Source: Gastroenterology)
Source: Gastroenterology - October 14, 2019 Category: Gastroenterology Authors: Cezary Ciszewski, Valentina Discepolo, Alain Pacis, Nick Doerr, Olivier Tastet, Toufic Mayassi, Mariantonia Maglio, Asjad Basheer, Laith Q. Al-Mawsawi, Peter Green, Renata Auricchio, Riccardo Troncone, Thomas A. Waldmann, Nazli Azimi, Yutaka Tagaya, Luis Source Type: research

Nutritional and dietary strategy in the clinical care of inflammatory bowel disease.
Abstract The incidence and prevalence of inflammatory bowel disease have been increasing for decades and IBD has become a worldwide disease. Epidemiology studies demonstrated higher incidence rates in the more westernized countries. The change of habitual diets in these countries is perceived as the reason for the development of IBD. Besides, molecular biological studies showed some pathogenic substances produced after digestion of daily diet decrease the diversity of intestinal microbiota and cause dysbiosis of microbiome. Then, chronic inflammation occurs in some genetically susceptible subjects and IBD develope...
Source: J Formos Med Assoc - October 14, 2019 Category: General Medicine Authors: Hsieh MS, Hsu WH, Wang JW, Wang YK, Hu HM, Chang WK, Chen CY, Wu DC, Kuo FC, Su WW Tags: J Formos Med Assoc Source Type: research

The effect of self-efficacy expectations in the adherence to a gluten free diet in celiac disease
. (Source: Psychology and Health)
Source: Psychology and Health - October 14, 2019 Category: Psychiatry & Psychology Authors: Ricardo Fueyo-D íaz Rosa Magall ón-Botaya Santiago Gasc ón-Santos Ángela Asensio-Martínez Guillermo Palacios-Navarro Juan J. Sebasti án-Domingo Source Type: research

Celiac disease in the context of airborne allergen-associated chronic vulvo-vaginitis.
We present a woman with a three-year history of severe chronic urticaria and recurrent vulvo-vaginal Candidiasis in the setting of seasonal allergic rhinitis. Her past medical history was significant only for Bell's palsy in her childhood. Her review of systems was otherwise negative (specifically: no history of diarrhea, weight loss, malabsorption, anemia, nor eczema). Extensive testing revealed seasonal sensitivities to outdoor allergens and celiac disease. Repeating the evaluation six months after initiating a wheat-free diet, her vulvo-vaginal symptoms resolved. PMID: 31599434 [PubMed - in process] (Source: Europea...
Source: European Review for Medical and Pharmacological Sciences - October 12, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Molecules, Vol. 24, Pages 3665: Assessing the Utility of Multiplexed Liquid Chromatography-Mass Spectrometry for Gluten Detection in Australian Breakfast Food Products
Colgrave Coeliac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten that is associated with gastrointestinal issues, including diarrhea, abdominal pain, and malabsorption. Gluten is a general name for a class of cereal storage proteins of wheat, barley, and rye that are notably resistant to gastrointestinal digestion. After ingestion, immunogenic peptides are subsequently recognized by T cells in the gastrointestinal tract. The only treatment for CD is a life-long gluten-free diet. As such, it is critical to detect gluten in diverse food types, including those where one would not expect to fi...
Source: Molecules - October 11, 2019 Category: Chemistry Authors: Li Bose Stockwell Howitt Colgrave Tags: Article Source Type: research

Autoimmune and Allergic Disorders are More Common in People With Celiac Disease or on a Gluten-free Diet in the United States
Conclusions: Our study confirms that CD and PWAG share comorbidities of autoimmune nature. PWAG had more autoimmune/allergy-related disorders that may be associated with non-celiac gluten sensitivity a self-justifiable reason to be on the diet. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

IJERPH, Vol. 16, Pages 3798: Neighborhood Deprivation and Risks of Autoimmune Disorders: A National Cohort Study in Sweden
Conclusion: This study is the largest to date analyzing the potential influence of neighborhood deprivation on ADs. Our results indicate that neighborhood deprivation may affect risk of ADs, independent of individual level sociodemographic characteristics. For health care policies, both individual and neighborhood level approaches seem to be of importance. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - October 9, 2019 Category: Environmental Health Authors: Xinjun Li Jan Sundquist Tsuyoshi Hamano Kristina Sundquist Tags: Article Source Type: research

Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease
European Journal of Human Genetics, Published online: 07 October 2019; doi:10.1038/s41431-019-0520-4Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - October 7, 2019 Category: Genetics & Stem Cells Authors: Isis Rica ño-Ponce Javier Gutierrez-Achury Ana Florencia Costa Patrick Deelen Alexander Kurilshikov Maria Magdalena Zorro Mathieu Platteel Adriaan van der Graaf Emilia Sugai Mar ía L. Moreno Horacio V ázquez Elsa Barrientos Eduardo Mauri ño Martin Tal Source Type: research

[Prevalence of an association between coeliac disease and vitiligo].
Authors: Henker J, Hartmann A Abstract Coeliac disease and vitiligo are immune-mediated disorders that are often associated with other immune-mediated disorders. In a prospective study we included 174 patients with vitiligo between the ages of 3 and 79 years (mean 38.2 years) to investigate whether there is an increased risk for coeliac disease in patients with vitiligo. We determined immunoglobulin A and IgA- and IgG-antibodies against tissue transglutaminase, while also optionally measuring blood count, ferritin, and endomysial-IgA-antibodies. In 3 of 174 (1.7%) vitiligo patients, coeliac...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - October 6, 2019 Category: Dermatology Tags: Hautarzt Source Type: research

Anthropometric Parameters in Celiac Disease: A Review on the Different Evaluation Methods and Disease Effects.
Authors: Costa A, Brito GAP Abstract This review compiled anthropometric data from 29 original articles, published between 1995 and 2015, corresponding to a total sample of 6368 celiac disease subjects. Body mass index was the main parameter for measuring anthropometry (82.1%), followed by body mass (78.6%), body fat (51.7%), bone mineral density and bone mineral content (46.4%), and fat-free mass (44.8%). The main evaluation method was dual x-ray absorptiometry (83.3%), followed by bioimpedance (16.6%), skinfold thickness (16.6%), and isotope dilution (5.5%). This compilation suggests that celiac disease patients ...
Source: Journal of Nutrition and Metabolism - October 6, 2019 Category: Nutrition Tags: J Nutr Metab Source Type: research

Diagnostic Yield of Malignancy and Coeliac Disease in Biopsies at Upper Gastrointestinal Endoscopy in Patients with Iron Deficiency Anaemia (IDA)
Publication date: November 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 11Author(s): Stephen Stonelake, Jessica Wilkinson, Sevim Gulmez, Edmund Leung (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 5, 2019 Category: Surgery Source Type: research

A TRAV26-1-encoded recognition motif focuses the biased T-cell response in celiac disease.
This article is protected by copyright. All rights reserved. PMID: 31580480 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - October 3, 2019 Category: Allergy & Immunology Authors: Frick R, Gunnarsen KS, Dahal-Koirala S, Risnes LF, Sollid LM, Sandlie I, Høydahl LS, Løset GÅ Tags: Eur J Immunol Source Type: research

ASSOCIATIONS OF IL-6 -174G>C AND IL-10 -1082A>G POLYMORPHISMS WITH SUSCEPTIBILITY TO CELIAC DISEASE: EVIDENCE FROM A META-ANALYSIS AND LITERATURE REVIEW
CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease. Our results suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease.RESUMO CONTEXTO: H á poucas evidências para sugerir que os IL-6 -174G>C e IL-10 -1082A>G polimorf...
Source: Arquivos de Gastroenterologia - October 1, 2019 Category: Gastroenterology Source Type: research

Erratum
CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease. Our results suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease.RESUMO CONTEXTO: H á poucas evidências para sugerir que os IL-6 -174G>C e IL-10 -1082A>G polimorf...
Source: Arquivos de Gastroenterologia - October 1, 2019 Category: Gastroenterology Source Type: research

The Vagus Nerve and the Celiaco-mesenteric Ganglia Participate in the Feeding Responses Evoked by Non-sulfated Cholecystokinin-8 in Male Sprague Dawley Rats
. (Source: Endocrine Research)
Source: Endocrine Research - October 1, 2019 Category: Endocrinology Authors: Amged I. Dafalla Thaer R. Mhalhal Kenneth Hiscocks John Heath Ayman I. Sayegh Source Type: research

P.93Small fiber neuropathy underlying autoinflammatory syndromes in children
Small fiber neuropathy affecting the small A δ and C fibers is rare in children. Few data have been published on the etiology of small fiber neuropathy in the pediatric population. Metabolic, infectious, and toxic causes were described. It has been associated with several autoimmune disorders such as Sjogren disease, fibromyalgia and celiac d isease, but there are no reports of an autoinflammatory etiology. The aim of the present study was to highlight the potential etiologic role of autoinflammatory syndromes, particularly familial Mediterranean fever, in small fiber neuropathy and erythromelalgia in the pediatric p...
Source: Neuromuscular Disorders - October 1, 2019 Category: Neurology Authors: I. Shinkarevsy, I. Nevo, L. Harel, G. Amarilyo, A. Dori, N. Agmon-Levin, L. Kachko, R. Dabby, M. Rabie, S. Aharoni Source Type: research

The Vagus Nerve and the Celiaco-mesenteric Ganglia Participate in the Feeding Responses Evoked by Non-sulfated Cholecystokinin-8 in Male Sprague Dawley Rats
. (Source: Endocrine Research)
Source: Endocrine Research - October 1, 2019 Category: Endocrinology Authors: Amged I. Dafalla Thaer R. Mhalhal Kenneth Hiscocks John Heath Ayman I. Sayegh Source Type: research

Triple Diagnosis of Crohn's Disease, Celiac Disease, and Eosinophilic Esophagitis in a Child With Siderius-Hamel Syndrome.
Abstract Siderius-Hamel syndrome is a rare condition characterized by intellectual disability and distinct facial features. Crohn's disease-related eosinophilic esophagitis (EoE) has been reported; however, an association between celiac disease and EoE remains controversial. We present a case of a child with Siderius-Hamel syndrome who had characteristic findings of all these conditions-Crohn's disease, celiac disease, and EoE-an occurrence that to our knowledge has not been reported previously. The purpose of this report is to make physicians aware of this rare occurrence, so that it can be kept in mind while eva...
Source: WMJ - October 1, 2019 Category: General Medicine Authors: Ahlawat R, Parikh NS, Jhaveri A Tags: WMJ Source Type: research

Evaluation and comparison of short chain fatty acids composition in gut diseases.
CONCLUSION: Analysis of fecal SCFAs shows the potential to provide a non-invasive means of diagnosis to detect patients with CRC and AP, while CD patients cannot be discriminated from healthy subjects. PMID: 31576099 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 28, 2019 Category: Gastroenterology Authors: Niccolai E, Baldi S, Ricci F, Russo E, Nannini G, Menicatti M, Poli G, Taddei A, Bartolucci G, Calabrò AS, Stingo FC, Amedei A Tags: World J Gastroenterol Source Type: research

The intestinal expansion of TCR γδ+ and disappearance of IL4+ T cells suggest their involvement in the evolution from potential to overt celiac disease.
This article is protected by copyright. All rights reserved. PMID: 31553811 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - September 25, 2019 Category: Allergy & Immunology Authors: Vitale S, Santarlasci V, Camarca A, Picascia S, Pasquale AD, Maglio M, Maggi E, Cosmi L, Annunziato F, Troncone R, Auricchio R, Gianfrani C Tags: Eur J Immunol Source Type: research

Molecular Mechanisms of 33-mer Gliadin Peptide Oligomerisation
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02338K, PaperMar ía Julia Amundarain, Maria Georgina Herrera, Fernando Zamarreño, Juan F Viso, Marcelo D Costabel, Veronica I Dodero The proteolytical resistant 33-mer gliadin peptide is the immunodominant fragment in gluten and responsible for celiac disease, and other gluten-related disorders. Meanwhile, the primary structure of 33-mer is associated with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 24, 2019 Category: Chemistry Authors: Mar ía Julia Amundarain Source Type: research

Preparation of Gluten-Free Foods Alongside Gluten-Containing Food May Not Always Be as Risky for Celiac Patients as Diet Guides Suggest
(Source: Gastroenterology)
Source: Gastroenterology - September 24, 2019 Category: Gastroenterology Authors: Vanessa M. Weisbrod, Jocelyn A. Silvester, Catherine Raber, Joyana McMahon, Shayna S. Coburn, Benny Kerzner Source Type: research

Community-based Study of Celiac Disease Autoimmunity Progression in Adults
Celiac disease can develop at any age, but outcomes of adults with positive results from serologic tests for tissue transglutaminase antibodies (tTGA) without endoscopic determination of celiac disease (called celiac autoimmunity) have not been thoroughly evaluated. We investigated the proportion of adults with celiac autoimmunity at a community medical center and their progression to celiac disease. (Source: Gastroenterology)
Source: Gastroenterology - September 24, 2019 Category: Gastroenterology Authors: Rok Seon Choung, Shahryar Khaleghi, Amanda K. Cartee, Eric V. Marietta, Joseph J. Larson, Katherine S. King, Otto Savolainen, Alastair B. Ross, S. Vincent Rajkumar, Michael J. Camilleri, Alberto Rubio-Tapia, Joseph.A. Murray Source Type: research

Linear growth of children with celiac disease after the first two years on gluten- free diet: a controlled study.
Abstract BACKGROUND: Celiac disease (CD) is a lifelong disorder with gluten-induced manifestations in different organs especially growth. Gluten free diet (GFD) is required to achieve remission and prevent abnormal growth. Study reports on growth of children with celiac disease on long-term GFD are not consistent. OBJECTIVE: We evaluated the effect of GFD on growth of children with the classical form of CD (diagnosed by serology and small intestine mucosal biopsy) on log-term GFD (>2 years). METHODS: We studied growth parameters (weight gain/day, BMI and BMI-SDS, height growth velocity, Ht-SDS) and la...
Source: Acta Bio-Medica : Atenei Parmensis - September 23, 2019 Category: General Medicine Authors: Soliman AT, Laham M, Jour C, Shaat M, Souikey F, Itani M, Al-Safi A, Karmallah A, Qudaisat A, Alarabi Z, Hassan A, Quraan E, Al-Naimi N, Alsaadi RK, De Sanctis V Tags: Acta Biomed Source Type: research

The Risk of Autoimmune Disorders in Treated Celiac Disease Patients in Olmsted County, Minnesota
Background: Patients with autoimmune disorders (ADs) are at increased risk for celiac disease (CD), but data are conflicting on the risk of ADs in treated patients with CD. We aimed to assess the incidence of ADs in treated patients with CD. Methods: Using the Rochester Epidemiology Project, we retrospectively searched for the medical records at Mayo Clinic and Olmsted Medical Center from January 1997 to December 2015 for patients with CD who met accepted diagnostic criteria. For each patient with CD, we identified 2 age and sex-matched controls during the same study period. The incidence rate of AD diagnosis 5 years ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Diagnostic Delays in Children With Coeliac Disease in the Central European Region
Objectives: Coeliac disease (CD) is a systemic autoimmune disorder affecting about 1% of the population. Many patients remain undiagnosed or are diagnosed with substantial delay. We assessed diagnostic delays in symptomatic CD children in Central Europe (CE). Methods: Paediatric gastroenterologists in 5 CE countries retrospectively reported data of their patients diagnosed in 2016. Age at first CD-related symptom(s), first visit to paediatric gastroenterologist and confirmed diagnosis were used to determine diagnostic delays. Results: Data from 393 children (65% girls, median age 7 years, range 7 months to 18.5 yea...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Should We Assess Vitamin D Status in Pediatric Patients With Celiac Disease?
Objectives: Screening for vitamin D status in celiac disease (CD) has been recommended but the literature provides varying support. We sought to assess the vitamin D status in newly diagnosed children with CD and in a non-CD control population and relate them to vitamin D intake. Methods: In a cross-sectional study, serum 25-hydroxyvitamin D (25-OHD) levels were drawn in children with newly diagnosed CD and compared with pediatric outpatients with functional abdominal complaints. Anthropometric data as well as vitamin D intake based on milk and multivitamin ingestion were collected. Results: Thirty-eight newly diag...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Modulation of in vitro digestibility and physical characteristics of protein enriched gluten free breads by defining hydration
Publication date: January 2020Source: LWT, Volume 117Author(s): Marta Sahagún, Yaiza Benavent-Gil, Cristina M. Rosell, Manuel GómezAbstractThe association of diabetes on celiac disease together with the high glycemic index of gluten-free breads makes necessary the pursuit of a solution to reduce this glycemic response. Protein enrichment and changes on hydration level may be tools to get it. Thus, the aim of this study was to analyze the effect of two proteins (pea and egg white) on the digestibility and physical characteristics of gluten-free breads, with either the same hydration or specific volume. Protein...
Source: LWT Food Science and Technology - September 20, 2019 Category: Food Science Source Type: research

A Cooking-Based Intervention Promotes Gluten-Free Diet Adherence and Quality of Life for Adults with Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 20, 2019 Category: Gastroenterology Authors: Randi L. Wolf, Mary Morawetz, Anne R. Lee, Pamela Koch, Isobel R. Contento, Patricia Zybert, Peter HR. Green, Benjamin Lebwohl Source Type: research

Prevalence of anti-tissue transglutaminase antibodies in patients with irritable bowel syndrome in Duhok city
ConclusionThe prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.ResumoIntroduçãoA síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII.Pacientes e MétodosEste estudo transvers...
Source: Journal of Coloproctology - September 14, 2019 Category: Gastroenterology Source Type: research

Gut microbiome investigation in celiac disease: from methods to its pathogenetic role
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - September 10, 2019 Category: Laboratory Medicine Source Type: research

Intra-arterial infusion chemotherapy versus isolated upper abdominal perfusion for advanced pancreatic cancer: a retrospective cohort study on 454 patients
ConclusionsResponsiveness of pancreatic cancer to regional chemotherapy is drug exposure dependent. The isolated perfusion procedure is superior to intra-arterial infusion in survival times. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 10, 2019 Category: Cancer & Oncology Source Type: research

The Skin in Celiac Disease Patients: The Other Side of the Coin.
e; SP Abstract Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every as...
Source: Medicina (Kaunas) - September 9, 2019 Category: Universities & Medical Training Authors: Abenavoli L, Dastoli S, Bennardo L, Boccuto L, Passante M, Silvestri M, Proietti I, Potenza C, Luzza F, Nisticò SP Tags: Medicina (Kaunas) Source Type: research

Effect of celiac disease on maternal and neonatal outcomes of pregnancy
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - September 6, 2019 Category: Perinatology & Neonatology Authors: Brittney Elliott Nicholas Czuzoj-Shulman Andrea R. Spence Daniel S. Mishkin Haim Arie Abenhaim Source Type: research

Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome
ConclusionSID was found in 35% of patients with presumed IBS-D/M and should be considered in the differential diagnosis of patients presenting with abdominal pain, diarrhea, or bloating. Further studies should better characterize the clinical features of SID and investigate the effects of dietary modification in this group of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 6, 2019 Category: Gastroenterology Source Type: research

Effect of celiac disease on maternal and neonatal outcomes of pregnancy
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - September 6, 2019 Category: Perinatology & Neonatology Authors: Brittney Elliott Nicholas Czuzoj-Shulman Andrea R. Spence Daniel S. Mishkin Haim Arie Abenhaim Source Type: research

EFSUMB Gastrointestinal Ultrasound (GIUS) Task Force Group: Celiac sprue and other rare gastrointestinal diseases ultrasound features.
Authors: Dietrich CF, Hollerweger A, Dirks K, Higginson A, Serra C, Calabrese E, Dong Y, Hausken T, Maconi G, Mihmanli I, Nürnberg D, Nylund K, Pallotta N, Ripollés T, Romanini L, Săftoiu A, Sporea I, Wüstner M, Maaser C, Gilja OH Abstract Transabdominal gastrointestinal ultrasound (GIUS) is unique in its capacity to examine the bowel non-invasively and in its physiological condition, including extra-intestinal features such as the splanchnic vessels, mesentery, omentum and lymph nodes- even at the bedside. Despite this, and its extensive documentation for its usefulness, it has only been fully im...
Source: Medical Ultrasonography - September 4, 2019 Category: Radiology Tags: Med Ultrason Source Type: research

Cancer of the oesophagus and lymph nodes management in the neoadjuvant or definitive radiochemotherapy setting.
nat S Abstract Despite representing a 1% of diagnosed cancer cases in the USA and up to 5% in eastern Asia and Africa, oesophageal cancer still holds numerous questions concerning the best therapeutic management. For squamous cell carcinoma, while radiochemotherapy has proven itself to be the gold standard as part of the trimodality or alone as a definitive treatment, radiotherapy modalities are still debated especially regarding lymph node irradiation. Involved nodes irradiation was developed with the aim of maintaining clinical outcomes and enhancing quality of life but lacks grade 1 evidence. In this article, w...
Source: Cancer Radiotherapie - September 3, 2019 Category: Cancer & Oncology Authors: Bourbonné V, Pradier O, Schick U, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

Neuropsychiatric manifestations in celiac disease
Publication date: October 2019Source: Epilepsy & Behavior, Volume 99Author(s): Chiara Maria Trovato, Umberto Raucci, Francesco Valitutti, Monica Montuori, Maria Pia Villa, Salvatore Cucchiara, Pasquale ParisiAbstractCeliac disease (CD) is a systemic, chronic immune-mediated disorder elicited by gluten and related prolamines in genetically susceptible subjects. Main manifestations of CD involve the digestive tract; however, a growing body of evidence supports the theory that symptoms may occur in every part of the body. It is known that some patients with CD can be asymptomatic, and additionally, the incidence of &ldquo...
Source: Epilepsy and Behavior - September 1, 2019 Category: Neurology Source Type: research

Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?
Authors: Popp A, Kivelä L, Fuchs V, Kurppa K Abstract Celiac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnostic yield substantially. Many recent guidelines recommend screening of at least selected risk groups, but more wide-scale screening remains controversial. The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a grad...
Source: Gastroenterology Research and Practice - September 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

112 Substantially increased risk of dermatitis herpetiformis in children and adolescents with atopic dermatitis
Atopic dermatitis (AD) is an eczematous inflammatory skin disease being the most common skin disease in children. AD is associated with an increased risk for several atopic, somatic and psychiatric comorbidities. Recent epidemiological data suggests that AD patients are at risk for autoimmune diseases, but the risk of celiac disease (CD) in children and adolescents with AD has shown conflicting results. Dermatitis herpetiformis (DH) is a rare autoimmune bullous skin disease with worldwide highest prevalence in Finland. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: S. Kauppi, J. Jokelainen, M. Timonen, K. Tasanen, L. Huilaja Tags: Clinical Research and Epidemiology Source Type: research

089 Atopic Dermatitis Is Associated With an Increased Risk of Autoimmune Diseases: A Population-Based Cohort Study Using UK Primary Care Data
Atopic dermatitis (AD) is associated with a wide range of comorbidities, particularly allergies, but its association with nonatopic autoimmune disease is less well defined. Recent genome-wide association studies have reported shared genetic loci between AD and autoimmune diseases. In the UK, most patients with these conditions are managed in primary care, meaning general practice (GP) databases provide a rich data source for studying AD. A retrospective cohort study was undertaken to examine the association between AD and the following autoimmune diseases (rheumatoid arthritis [RA], ulcerative colitis [UC], Crohn ’s ...
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: H. Alexander, S. de Lusignan, S. Mashayekhi, C. Feeney, C. Flohr Tags: Clinical Research and Epidemiology Source Type: research

Gastrointestinal findings in 26 adults with common variable immunodeficiency: The fickle nature of the disease manifests in gastrointestinal biopsies.
avşargil B Abstract BACKGROUND/AIMS: The aim of the present study was to demonstrate the histopathological findings in gastrointestinal (GI) biopsies in adults with common variable immunodeficiency (CVID). MATERIALS AND METHODS: A total of 172 GI biopsies of 26 patients with CVID obtained over a 16-year period were reevaluated. Findings were analyzed using descriptive analyzes and χ2 test. RESULTS: Female-to-male ratio was 1.36. The median age at diagnosis was 36±13.94 (16-72) years. Chronic esophagitis was noted in 3 patients. The absence of plasma cells in the stomach, duodenum, and colon w...
Source: The Turkish Journal of Gastroenterology - September 1, 2019 Category: Gastroenterology Authors: Pehlivanoğlu B, Ardeniz Ö, Hassoy H, Sezak M, Özdemir H, Ünal NG, Onay H, Doğanavşargil B Tags: Turk J Gastroenterol Source Type: research

Does celiac disease cause autoimmune sensorineural hearing loss?
CONCLUSION: In this study with a higher number of CD patients when compared with the previous studies, it has been shown that CD does not appear to cause autoimmune sensorineural hearing loss. In addition, the status of the patients regarding the activeness or the remission of CD did not display a differ between the CD patients in terms of hearing levels. PMID: 31530521 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - September 1, 2019 Category: Gastroenterology Authors: Yazıcı A, Yıldırım AE, Konduk BT Tags: Turk J Gastroenterol Source Type: research

Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx?
Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx? J Fam Pract. 2019 Sep;68(7):E9-E11 Authors: Bray SC, Carek PJ PMID: 31532821 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - September 1, 2019 Category: Practice Management Authors: Bray SC, Carek PJ Tags: J Fam Pract Source Type: research

An association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten
Celiac disease (CD) is characterized histologically by inflammation and villous atrophy. Villous atrophy is thought to result from a disruption of epithelial cellular proliferation and death. Epithelial cells ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 31, 2019 Category: Pathology Authors: Michael Lee, Shane Betman, Alina Iuga, Hui-Min Yang, Jude Fleming, Peter H. R. Green, Benjamin Lebwohl and Stephen M. Lagana Tags: Research Source Type: research

Neuropsychiatric manifestations in celiac disease.
Abstract Celiac disease (CD) is a systemic, chronic immune-mediated disorder elicited by gluten and related prolamines in genetically susceptible subjects. Main manifestations of CD involve the digestive tract; however, a growing body of evidence supports the theory that symptoms may occur in every part of the body. It is known that some patients with CD can be asymptomatic, and additionally, the incidence of "nonclassical" CD with extraintestinal presentation is apparently increasing. We aimed to perform a thorough review of existing evidence for neurological manifestations of CD, providing an up-to-dat...
Source: Epilepsy and Behaviour - August 31, 2019 Category: Neurology Authors: Trovato CM, Raucci U, Valitutti F, Montuori M, Villa MP, Cucchiara S, Parisi P Tags: Epilepsy Behav Source Type: research

Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.
Abstract Trials of antigen-specific tolerance have been undertaken in the clinic for over fifty years and the results of these antigen-specific clinical trials are described in this review. Antigen-specific tolerization of the immune system in protein replacement therapy for hemophilia A is an accepted treatment. Clinical trials are ongoing for autoimmune conditions such as type 1 diabetes, multiple sclerosis, neuromyelitis optica, and rheumatoid arthritis with various antigen-specific strategies. Trials for tolerization in celiac disease aim for antigen specific tolerance to gluten, an environmental trigger, whic...
Source: Current Opinion in Immunology - August 30, 2019 Category: Allergy & Immunology Authors: Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P Tags: Curr Opin Immunol Source Type: research

Are Viruses and Parasites linked to Celiac Disease? A question that still has no definite answer.
Abstract Celiac disease is a complex autoimmune enteropathy of the small intestine that commonly occurs in genetically predisposed individuals due to intake of gluten and related proteins. Gluten consumption, duration of breast-feeding, various infections, especially frequent intestine infections, vaccinations and use of antibiotics can be linked to celiac disease. It is predicted that it affects 1% of the global population and its incidence rate is increasing. Celiac disease is closely related to Turner's syndrome, type I diabetes mellitus, Down's syndrome, and other autoimmune conditions and most people with the...
Source: Current Pharmaceutical Biotechnology - August 28, 2019 Category: Biotechnology Authors: Shariati A, Aslani HR, Shayesteh MRH, Taghipour A, Nasser A, Safari H, Alizade-Sani M, Dehghan A, Azimi T Tags: Curr Pharm Biotechnol Source Type: research

Common Problems Found in the Methodological Approach to Small Bowel Biopsies in the Diagnosis of Celiac Disease
Small bowel biopsy (SBB) is not always helpful to establish celiac disease diagnosis. Hence we have conducted a retrospective study to know the amount of SBB in our center that was not optimal for this purpose. Histological findings were not appropriate for diagnosis in 3.56% (34 out of 955). The main problem encountered was inadequate sample cutting, although this could be solved by a new recut in almost 30% of cases. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2019 Category: Gastroenterology Tags: Short Communication: Gastroenterology Celiac Disease Source Type: research