Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - March 7, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Significant Weight Loss In A Patient Taking Olmesartan: An Unusual Case Report.
Abstract OBJECTIVE: Olmesartan-induced enteropathy consists a syndrome that mimics celiac disease both clinically and histologically. Cases of this entity have sporadically been reported since 2012 and are usually characterized by severe diarrhea and malabsorption, followed by significant weight loss. CASE REPORT: Herein, we report an uncommon case of this syndrome, where weight loss preceded several months the onset of gastrointestinal symptoms. Physicians should be aware of unexplained weight loss in patients taking olmesartan, as prompt discontinuation of the drug may prevent the deleterious consequences o...
Source: Current Drug Safety - March 7, 2019 Category: Drugs & Pharmacology Authors: Makri A, Florentin M, Elisaf MS, Liamis G Tags: Curr Drug Saf Source Type: research

The role of interleukin-13 in chronic inflammatory intestinal disorders
Publication date: Available online 4 March 2019Source: Autoimmunity ReviewsAuthor(s): Paolo Giuffrida, Flavio Caprioli, Federica Facciotti, Antonio Di SabatinoAbstractInterleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some intestinal disorders. IL-13 is produced by Th2 cells, natural killer T cell, innate lymphoid cells and innate immune cells, which contribute to trigger and maintain a chronic idiopathic intestinal inflammation. In murine models IL-13 exerts pleiotropic functions, playing either pathogenic or protective roles according to the different e...
Source: Autoimmunity Reviews - March 5, 2019 Category: Allergy & Immunology Source Type: research

Overview in the clinical management of patients with seronegative villous atrophy
Differential diagnosis and management of enteropathies found in the context of seronegative villous atrophy (VA) are still a clinical challenge. Although seronegative coeliac disease may be the most frequent cause of serology-negative VA, other conditions must be taken into account in the differential diagnosis of seronegative VA. The rarity of these enteropathies with frequent overlapping of histological features may result in misclassification of such patients as affected by a seronegative or a refractory form of coeliac disease with consequent inappropriate treatments and long-term morbidity. The aim of this review is t...
Source: European Journal of Gastroenterology and Hepatology - March 5, 2019 Category: Gastroenterology Tags: Review Articles Source Type: research

Coeliac disease and obstetric and gynaecological disorders: where are we now?
Coeliac disease (CD) is a chronic gluten-dependent enteropathy very common in the general population and characterized by an extremely heterogeneous clinical picture. Although its prevalence is growing worldwide, case-finding strategy remains the mainstay to diagnosis. Thus, correct identification of high-risk categories of patients who need to be tested for CD is an essential part of medical knowledge to a large number of specialists and primary care providers. In this regard, although CD might have a serious effect on women’s reproductive health, a widespread consensus is lacking on which categories of obstetric an...
Source: European Journal of Gastroenterology and Hepatology - March 5, 2019 Category: Gastroenterology Tags: Review Articles Source Type: research

Thymic stromal lymphopoietin levels are increased in patients with celiac disease.
In this study, we evaluated serum TSLP levels in patients with celiac disease (CD). The prospective study was conducted at a gastroenterology outpatient clinic between March 2018 and August 2018. Eighty-nine participants aged between 18 and 75 years were classified into following groups: 22 patients with newly diagnosed CD; 20 patients with CD who were compliant with a gluten-free diet (GFD); 32 patients with CD who were not compliant with a GFD; and 15 healthy controls. Demographic characteristics, disease duration, and selected biochemical and hematologic parameters were recorded and compared between groups. Median serum...
Source: Bosnian Journal of Basic Medical Sciences - March 5, 2019 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Compliance with gluten-free diet in a selected group of celiac children in the Slovak Republic.
CONCLUSIONS: Our study confirmed important factors influencing adherence to the GF diet, which are connected to the symptoms and consequences of CD. The assessment of parents' opinions and burden on the families of children with celiac disease should be also reflected in the evaluation of patient's status. Important is also the role of parents in order to facilitate and support clinical interventions and prevention of CD. PMID: 30817868 [PubMed - in process] (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - March 4, 2019 Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research

Celiac disease and severe vitamin D deficiency: the case for anti-tissue transglutaminase antibody screening
AbstractSummaryVitamin D-deficient Saudi adolescent girls were screened for anti-tissue transglutaminase (IgA-tTG) antibodies to determine whether the presence of severe vitamin D deficiency was associated with celiac disease. All 9 participants who were positive for IgA-tTG antibodies had severe vitamin D deficiency (25(OH)D
Source: Archives of Orthopaedic and Trauma Surgery - March 4, 2019 Category: Orthopaedics Source Type: research

Common causes of iron deficiency anaemia in gastroenterology patients
Gastroenterological disorders frequently lead to anaemia as a result of blood loss, inflammation, malabsorption or drug therapies. With malignancy or inflammatory bowel disease, the causes are often multifactorial. Aside from iron deficiency, other conditions resulting in vitamin B12 or folate deficiency can lead to anaemia. Here, coeliac disease, inflammatory bowel disease and surgical resection are particular risk factors. The approach to anaemia in the gastroenterology patient should focus on establishing and managing the underlying cause while supplementing any deficiencies to correct the anaemia. (Source: Medicine)
Source: Medicine - March 4, 2019 Category: Internal Medicine Authors: Edward A. Dickson, Matthew J. Brookes Tags: Symptoms and signs Source Type: research

The roles of autonomous motivation and self-control lapses in concurrent adherence to a gluten-free diet and a self-chosen weight loss plan in adults with coeliac disease
. (Source: Psychology and Health)
Source: Psychology and Health - March 4, 2019 Category: Psychiatry & Psychology Authors: Sandro Voi Kirby Sainsbury Source Type: research

Association Between Antibiotics in the First Year of Life and Celiac Disease
The intestinal microbiota is thought to be involved in pathogenesis of celiac disease, along with genetic variants and dietary gluten. The gut microbiota is strongly influenced by systemic antibiotics —especially in early life. We explored the association between exposure to a systemic antibiotic in the first year of life and risk of diagnosed celiac disease. (Source: Gastroenterology)
Source: Gastroenterology - March 2, 2019 Category: Gastroenterology Authors: Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Joseph A. Murray, Øystein Karlstad, Steffen Husby, Ketil Størdal Source Type: research

[Cold urticaria and coeliac disease in a paediatric patient].
ra MA, Fernández González P PMID: 30837113 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - March 2, 2019 Category: Pediatrics Authors: Méndez Sánchez A, Pascual Pérez AI, Vázquez Piñera MA, Fernández González P Tags: An Pediatr (Barc) Source Type: research

Diagnosis and Treatment Patterns in Celiac Disease
The objective of this study was to describe the current state of CD diagnosis and treatment patterns. A targeted review of literature from MEDLINE, Embase, the Cochrane Library, and screening of relevant conference abstracts was performed. The generally recommended diagnostic approach is GI endoscopy with small bowel biopsy; however, in selected patients, biopsy may be avoided and diagnosis based on positive serology and clinical symptoms. Diagnosis often is delayed; the average diagnostic delay after symptom onset is highly variable and can last up to 12  years. Barriers to accurate and timely diagnosis include atypi...
Source: Digestive Diseases and Sciences - March 1, 2019 Category: Gastroenterology Source Type: research

The Liver and Celiac Disease
Celiac disease is a multisystem disorder. Celiac hepatitis characterized by gluten-responsive mild elevation of transaminases is the more common liver manifestation of celiac disease. Celiac disease may also be associated or coexist with other chronic liver disorders. Shared genetic risk and increased intestinal permeability have been suggested to be the most relevant events in the pathogenesis of liver injury in celiac disease. The aim of this article is to review the full spectrum of liver disorders in patients with celiac disease. (Source: Clinics in Liver Disease)
Source: Clinics in Liver Disease - March 1, 2019 Category: Gastroenterology Authors: Alberto Rubio-Tapia, Joseph A. Murray Source Type: research

Risk of bacterial pneumonia and pneumococcal infection in youths with celiac disease — A population-based study
Assess the risk of hospitalizations for bacterial pneumonia or pneumococcal infections, in a cohort of young individuals with celiac disease (CD) compared to matched References (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 1, 2019 Category: Gastroenterology Authors: Cristina Canova, Jonas Ludvigsson, Vincenzo Baldo, Claudio Barbiellini Amidei, Loris Zanier, Fabiana Zingone Tags: Alimentary Tract Source Type: research

Gas, Bloating, and Belching: Approach to Evaluation and Management.
Abstract Gas, bloating, and belching are associated with a variety of conditions but are most commonly caused by functional gastrointestinal disorders. These disorders are characterized by disordered motility and visceral hypersensitivity that are often worsened by psychological distress. An organized approach to the evaluation of symptoms fosters trusting therapeutic relationships. Patients can be reliably diagnosed without exhaustive testing and can be classified as having gastric bloating, small bowel bloating, bloating with constipation, or belching disorders. Functional dyspepsia, irritable bowel syndrome, an...
Source: American Family Physician - February 28, 2019 Category: Primary Care Authors: Wilkinson JM, Cozine EW, Loftus CG Tags: Am Fam Physician Source Type: research

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - February 26, 2019 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research

Effects of the Gluten-free Diet on Body Mass Indexes in Pediatric Celiac Patients
Conclusions: Although overall we observed no significant changes in BMI before and after 2011, we did notice that in adolescent celiac patients there was a trend toward a higher postdiagnosis BMI in the years after 2011. We speculate that teenagers may be especially vulnerable to choosing quick and easy processed gluten-free options over more healthy, natural alternatives leading to a rise in their BMIs after the 2011 surge in production of processed gluten-free foods on the market. Therefore, special attention must be paid to this population to insure ongoing healthy food choices even after many years on the GFD. (Sourc...
Source: Journal of Pediatric Gastroenterology and Nutrition - February 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Intracellular Localization of Microbial Transglutaminase and Its Influence on the Transport of Gliadin in Enterocytes
Conclusions: mTG and gliadin are transported to the ER of enterocytes and to a greater extent to the ER of RACE cells, suggesting cross-presentation of exogenous antigens. The strong localization of mTG at the basolateral membrane and the lamina propria may also indicate a potential antigenic interaction with cells of the immune system. Since mTG may not only been taken up with food stuffs but could also be released by bacteria within the intestinal microbiota, further investigations are needed regarding the role of mTG in CD pathogenesis. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - February 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Prevalence of Celiac Disease in a Long-term Study of a Spanish At-genetic-risk Cohort From the General Population
Conclusions: A repeated screening of at-risk children during their follow-up allowed us to diagnose new CD cases. In our cohort, HLA- DQ2.5 trans genotype conferred a higher risk in the development of CD than HLA- DQ2.5/DQ2.2. The majority of children with potential CD and CD autoimmunity at 10 years of age remained healthy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - February 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease
AbstractPurpose of reviewThe aim of this paper was to overview the current literature in order to establish the available treatment options for the neurological manifestations of gluten-related disorders (serologically confirmed gluten sensitivity and coeliac disease).Recent findingsA range of debilitating neurological manifestations is increasingly being recognized in patients with gluten sensitivity with and without enteropathy even in the absence of gastrointestinal symptoms. Ataxia is the commonest neurological manifestation, followed by peripheral neuropathy. Epilepsy, headache, encephalopathy, various movement disord...
Source: Current Treatment Options in Neurology - February 26, 2019 Category: Neurology Source Type: research

Sequence of acquisition of self-management skills to follow a gluten-free diet by adults with celiac disease
Celiac disease (CD) treatment is lifelong adherence to a gluten-free diet (GFD), requiring mastery of numerous skills to maintain health. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - February 26, 2019 Category: Gastroenterology Authors: Emma M. Clerx, Jocelyn Silvester, Daniel Leffler, Maya DeGroote, Laurie N. Fishman Tags: Alimentary Tract Source Type: research

Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease.
Abstract PURPOSE OF REVIEW: The aim of this paper was to overview the current literature in order to establish the available treatment options for the neurological manifestations of gluten-related disorders (serologically confirmed gluten sensitivity and coeliac disease). RECENT FINDINGS: A range of debilitating neurological manifestations is increasingly being recognized in patients with gluten sensitivity with and without enteropathy even in the absence of gastrointestinal symptoms. Ataxia is the commonest neurological manifestation, followed by peripheral neuropathy. Epilepsy, headache, encephalopathy, var...
Source: Epilepsy Curr - February 26, 2019 Category: Neurology Authors: Zis P, Hadjivassiliou M Tags: Curr Treat Options Neurol Source Type: research

Prevalence of autoimmune diseases and clinical significance of autoantibody profile: data from National Institute of Hygiene in Rabat, Morocco.
CONCLUSION: Our study shows the diagnostic value of auto antibodies in AIDs. It would be interesting to carry out prospective studies on each pathology separately, in order to fill the classic vagaries of the retrospective study and objectively estimate the prevalence in different AIDs. These data on the prevalence of each autoimmune disease are valuable for the public health system. PMID: 30807792 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - February 23, 2019 Category: Allergy & Immunology Authors: Missoum H, Alami M, Aouad RE, Bakri Y Tags: Hum Immunol Source Type: research

Celiac Disease Screening in Infertile Women: Is It Worth It?
Authors: Petrarca L, Pontone S, Nenna R PMID: 30784566 [PubMed - in process] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - February 22, 2019 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa
. (Source: Journal of the American College of Nutrition)
Source: Journal of the American College of Nutrition - February 22, 2019 Category: Nutrition Authors: Ilaria Russo Chiara Del Giorno Ivana Giangrieco Najla Hajji Maria Antonietta Ciardiello Paola Iovino Carolina Ciacci Source Type: research

Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins
Wheat-related disorders, a spectrum of conditions induced by the ingestion of gluten-containing cereals, have been increasing in prevalence. Patients with celiac disease have gluten-specific immune responses, but the contribution of non-gluten proteins to symptoms in patients with celiac disease or other wheat-related disorders is controversial. (Source: Gastroenterology)
Source: Gastroenterology - February 22, 2019 Category: Gastroenterology Authors: Alberto Caminero, Justin L. McCarville, Victor F. Zevallos, Marc Pigrau, Xuechen B. Yu, Jennifer Jury, Heather J. Galipeau, Alexandra V. Clarizio, Javier Casqueiro, Joseph A. Murray, Stephen M. Collins, Armin Alaedini, Premysl Bercik, Detlef Schuppan, Ele Source Type: research

A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa
. (Source: Journal of the American College of Nutrition)
Source: Journal of the American College of Nutrition - February 22, 2019 Category: Nutrition Authors: Ilaria Russo Chiara Del Giorno Ivana Giangrieco Najla Hajji Maria Antonietta Ciardiello Paola Iovino Carolina Ciacci Source Type: research

Prognostic impact of celiac lymph node involvement in patients after frontline treatment for advanced ovarian cancer
ConclusionCLN involvement and high preoperative tumor burden are independently associated with decreased survival after complete cytoreduction for OC. CLN involvement is a marker of diffuse disease and an independent risk factor for early recurrent disease. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - February 19, 2019 Category: Surgery Source Type: research

Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain
Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis based on clinical tests and biological parameters, NCGS is a more difficult diagnosis, especially in children with functional gastrointestinal (GI) complaints. NCGS is considered a syndrome of intestinal but also extraintestinal symptoms occurring...
Source: Annals of Nutrition and Metabolism - February 19, 2019 Category: Nutrition Source Type: research

Tailoring the immune response to wheat gliadin by enzymatic transamidation.
Abstract Enzymatic transamidation of wheat gliadin by microbial transglutaminase inhibits IFN-γ secretion by intestinal T cell lines from celiac disease (CD) patients. Here, we analysed its effects on intestinal biopsies from CD patients and studied the underlying mechanisms in HLA-DQ8 transgenic (tg) mice, a model of T-cell mediated gluten sensitivity. In vitro challenge with a soluble form of transamidated gliadin (spf) upregulated IL-10 transcript levels in human biopsy samples. Furthermore, the ratio of IL-10/IFN-γ transcripts was significantly increased following treatment with spf. In DQ8 tg mice...
Source: Cytokine - February 18, 2019 Category: Molecular Biology Authors: Luongo D, Bonavita R, Rossi S, Rotondi Aufiero V, Feliciello NR, Maurano F, Iaquinto G, Mazzarella G, Rossi M Tags: Cytokine Source Type: research

Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: acute randomized controlled trial
People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excursions in individuals with diabetes. Thus, we evaluated the acute effect of fibre-enriched buckwheat (FBP) and corn pasta (CP) on postprandial blood glucose response (PP-BGR). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 16, 2019 Category: Endocrinology Authors: Claudia Vetrani, Lutgarda Bozzetto, Marisa Giorgini, Luisa Cavagnuolo, Elpidio Di Mattia, Paola Cipriano, Anna Mangione, Annamaria Todisco, Giovanna Inghilterra, Angela Giacco, Giovanni Annuzzi, Angela A. Rivellese Source Type: research

Coeliac disease detection with an IgA/IgG-deamidated gliadin peptide based point of care test in community pharmacies
Conclusion It was feasible to use the C-test as a case finding tool in pharmacies. There was good uptake for the C-test, although the case detection rate and the test specificity were low. Based on this, the C-test has a limited role in case finding in a community pharmacy setting. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - February 16, 2019 Category: Drugs & Pharmacology Source Type: research

Addison's disease and hypertransaminasemia.
Authors: Kalambokis G, Milionis HJ Abstract Endocrine diseases, such as diabetes mellitus and thyroid dysfunction, have been rarely associated with increased serum transaminase activity. The association of Addison's disease with abnormal liver function tests has received less attention. Addison's disease as a part of autoimmune polyglandular syndrome-1 may be associated with autoimmune hepatitis. Addison's disease may also coexist with celiac disease, an autoimmune disorder commonly associated with hypertransaminasemia. On the other hand, a number of case reports have suggested hypertransaminasemia to be one of the...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall.
Abstract Physiologically-based pharmacokinetic (PBPK) models provide a framework for in vitro-in vivo extrapolation of metabolic drug clearance. Many of the concepts in PBPK can have consequential impact on more mechanistic systems pharmacology models. In the gut wall, turnover of enzymes and enterocytes are typically lumped into one rate constant that describes the time dependent enzyme activity. This assumption may influence predictability of any sustained and dynamic effects such as mechanism-based inhibition (MBI), particularly when considering translation from healthy to gut disease. A novel multi-level syste...
Source: European Journal of Pharmaceutical Sciences - February 15, 2019 Category: Drugs & Pharmacology Authors: Darwich AS, Burt HJ, Rostami-Hodjegan A Tags: Eur J Pharm Sci Source Type: research

Overlap of Characteristic Serological Antibodies in Rheumatoid Arthritis and Wheat-Related Disorders.
Conclusions: Our data presents an apparent trend of overlapped serological antibody biomarker positivity in RA and wheat-related disorders. PMID: 30755781 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 14, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Immune mediated diseases in patients with celiac disease and their relatives: a comparative study of age and sex
ABSTRACT BACKGROUND: Up to 15% of other immune-mediated diseases (IMDs) can occur in patients with CD throughout their lives and are associated with multiple factors, including sex and sex hormone levels. Moreover, sex is associated with differences in clinical presentation, onset, progression, and outcomes of disorders. OBJECTIVE: To investigate the prevalence of IMDs at diagnosis in patients with celiac disease (CD) and their first-degree relatives and to compare the findings between female and male patients of different age. METHODS: A retrospective study including Brazilian patients with CD who visited the same doctor ...
Source: Arquivos de Gastroenterologia - February 14, 2019 Category: Gastroenterology Source Type: research

Irritable bowel syndrome, food intolerance and non- celiac gluten sensitivity. a new clinical challenge
The objective of the present review is to provide an overview highlighting the interaction between IBS, food intolerance and NCGS in order to unravel whether gluten/wheat/FODMAP sensitivity represents ‘ facts ’ and not ‘ fiction ’ in IBS symptoms.RESUMO Cerca de 80% dos pacientes com s índrome do intestino irritável (SII) relatam que seus sintomas são desencadeados após a ingestão de um ou grupos específicos de alimentos. Nesse grupo, glúten, trigo e proteínas relacionadas (como inibidores de amilase-tripsina e oligo-di-mono-sacarídeos e...
Source: Arquivos de Gastroenterologia - February 14, 2019 Category: Gastroenterology Source Type: research

Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort
(Source: BMJ)
Source: BMJ - February 14, 2019 Category: General Medicine Source Type: research

Celiac Disease: Beyond Genetic Susceptibility and Gluten. A Narrative Review.
Authors: Pes GM, Bibbò S, Dore MP Abstract CONTEXT: Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals. However, only a small proportion of subjects harbouring CD-related genetic risk develop the disease. Among the environmental factors that may influence CD risk, pre- and perinatal factors, delivery methods, parental lifestyle, infant feeding practices, seasonality, dietary factors, drug use, childhood infections and variability in gut microbiota are those most widely studied regarding the risk to develop CD. Although for many of th...
Source: Annals of Medicine - February 13, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

A New Generation Plant For The Conventional Cuisine: Quinoa (Chenopodium Quinoa Willd.)
Publication date: Available online 11 February 2019Source: Trends in Food Science & TechnologyAuthor(s): Aybuke Ceyhun Sezgin, Nevin SanlierAbstractBackgroundThe quinoa herb belongs to the family of Chenopodiaceae where spinach and beet are also found. It is a kind of herb that is native to South America and there are about 250 kinds of Chenopodium species worldwide. It is considered a sacred herb by humans due to the high level of protein in its composition and its content of essential amino acids in a balanced manner. In addition, due to the fact that quinoa has a high value of energy and nutrients and because of its...
Source: Trends in Food Science and Technology - February 13, 2019 Category: Food Science Source Type: research

Immunoreactive cereal proteins in wheat allergy, non-celiac gluten/wheat sensitivity (NCGS) and celiac disease
Publication date: Available online 11 February 2019Source: Current Opinion in Food ScienceAuthor(s): Katharina Anne ScherfWheat is one of the major sources of nutrients for the world population, but its consumption may cause inflammatory immune reactions such as wheat allergy, celiac disease or non-celiac gluten/wheat sensitivity in predisposed individuals. Various wheat proteins including gluten and non-gluten proteins have been identified as triggering factors. With mounting evidence pointing to an increasing prevalence of adverse reactions to wheat, recent research efforts aim at elucidating the underlying causes. Multi...
Source: Current Opinion in Food Science - February 12, 2019 Category: Food Science Source Type: research

Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial
Goals: The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). Background: About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. Study: CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study. A 6-week treatment period was preceded by a 2-week run-in and fol...
Source: Journal of Clinical Gastroenterology - February 12, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Chronic Pancreatitis is a Common Finding in Celiac Patients Who Undergo Endoscopic Ultrasound
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: LETTERS TO THE EDITOR Source Type: research

Insights into Cardiovascular Risk and Nutritional Status in Subjects with Wheat-related Disorders.
CONCLUSION: Subjects with positive serology for Wheat Zoomer have deranged blood lipid profiles but did not show any significant micronutrient deficiency. Hence, our results showcase a significant association of wheat-related disorders to cardiovascular risk. PMID: 30734586 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Comparison of Small Gut and Whole Gut Microbiota of First-Degree Relatives With Adult Celiac Disease Patients and Controls
Rahul Bodkhe, Sudarshan A. Shetty, Dhiraj P. Dhotre, Anil K. Verma, Khushbo Bhatia, Asha Mishra, Gurvinder Kaur, Pranav Pande, Dhinoth K. Bangarusamy, Beena P. Santosh, Rajadurai C. Perumal, Vineet Ahuja, Yogesh S. Shouche, Govind K. Makharia (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 8, 2019 Category: Microbiology Source Type: research

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease
Publication date: Available online 7 February 2019Source: CellAuthor(s): Toufic Mayassi, Kristin Ladell, Herman Gudjonson, James E. McLaren, Dustin G. Shaw, Mai T. Tran, Jagoda J. Rokicka, Ian Lawrence, Jean-Christophe Grenier, Vincent van Unen, Cezary Ciszewski, Matthew Dimaano, Hoda E. Sayegh, Vinod Kumar, Cisca Wijmenga, Peter H.R. Green, Ranjana Gokhale, Hilary Jericho, Carol E. Semrad, Stefano GuandaliniSummaryTissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), wh...
Source: Cell - February 8, 2019 Category: Cytology Source Type: research

Defective proteostasis in celiac disease as a new therapeutic target
Defective proteostasis in celiac disease as a new therapeutic target, Published online: 08 February 2019; doi:10.1038/s41419-019-1392-9Defective proteostasis in celiac disease as a new therapeutic target (Source: Cell death and disease)
Source: Cell death and disease - February 8, 2019 Category: Internal Medicine Authors: Luigi Maiuri Valeria R Villella Mauro Piacentini Valeria Raia Guido Kroemer Source Type: research

Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease
Conclusions: Our data indicate that PEDF levels are significantly higher in CD patients than those in the healthy controls. This result suggests that PEDF negatively affects angiogenesis in CD. Although we did not observe any differences of PEDF levels among celiac patients, additional studies including more patients could clarify this issue. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 7, 2019 Category: Internal Medicine Source Type: research