From Editor's desk.
PMID: 31611433 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Agrawal R Tags: Indian J Pathol Microbiol Source Type: research

p16 as an independent marker for detection of high-risk HPV in oral submucous fibrosis and oral squamous cell carcinoma.
Abstract Background: An alarming increase in incidence of high-risk human papillomavirus (HPV) positive tumors in head and neck squamous cell carcinoma (HNSCC) by 25% and 70% in oropharyngeal HNSCC cannot be ignored. The early oncogenes of HPV, E6, and E7 play a key role in carcinogenesis. HPV associated tumors have a better clinical outcome and a favorable prognosis. The p16 expression has high concordance with other methods of HPV detection, ascertaining p16 as a surrogate marker for HPV. Objective: To assess the immunohistochemical expression of p16 in oral submucous fibrosis (OSF) and oral squamous cell c...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Sudhakaran A, Hallikeri K, Babu B Tags: Indian J Pathol Microbiol Source Type: research

Omics data-driven analysis identifies laminin-integrin-mediated signaling pathway as a determinant for cell differentiation in oral squamous cell carcinoma.
Conclusion: This study serves as a proof-of-principle for the mining of multiple omics datasets coupled with selection of functionally important group of molecules to provide novel insights into tumorigenesis and cancer progression. PMID: 31611435 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Kulkarni S, Abdulla R, Jose M, Adyanthaya S, B Rex DA, Patil AH, Pinto SM, Subbannayya Y Tags: Indian J Pathol Microbiol Source Type: research

Collagen fibers in oral submucous fibrosis - A polarizing microscopy study using two special stains.
Conclusion: Picrosirius red was found to be a better stain. Histopathological grading and polarization colors showed no association with each other. Collagen fibers were more thickly and tightly packed in the submucosa indicating that the process of fibrosis began there. The increase in perpendicular type III fibers with advancing histopathological grades suggested their role in fibrosis. PMID: 31611436 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Nishat R, Kumar H Tags: Indian J Pathol Microbiol Source Type: research

Risk of malignancy in Thyroid "Atypia of undetermined significance/Follicular lesion of undetermined significance" and its subcategories - A 5-year experience.
Conclusions: The sub-classification of AUS/FLUS into subcategories as recommended by TBSRTC, 2017 may better stratify the malignancy risk and guide future management guidelines. PMID: 31611437 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Thakur A, Sarin H, Kaur D, Sarin D Tags: Indian J Pathol Microbiol Source Type: research

Loss of c-Cbl expression correlates with de-differentiation status and lymphatic metastasis in gastric cancer.
In this study, we aimed to assess the correlation between the expression of c-Cbl and clinicopathological parameters and explored the role of c-Cbl in the development and progression of GC. Settings and Design: This is a Pilot study. Methods and Materials: In total, 84 tissue samples including 44 gastric cancers (GC) and 40 matched adjacent normal tissues were collected after surgery. Then tissue microarray (TMA) and immunohistochemistry (IHC) technology were combined to detect the protein expression of c-Cbl. Statistical Analysis Used: Statistical analysis was performed using SPSS 22.0 (IBM Corporation, Arm...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Chen C, Hui Y, Chen Y, Qian C, Sun M Tags: Indian J Pathol Microbiol Source Type: research

Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India.
Conclusion: Our study is significant with respect to the information on PRETEXT staging, risk status, and histological favorability. In developing countries with limited resources and low-socioeconomic status, it is important to have a multidisciplinary team approach and tailor treatment to manage these patients effectively and improve the overall survival. PMID: 31611439 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Archana B, Thanka J, Sneha LM, Xavier Scott JJ, Arunan M, Agarwal P Tags: Indian J Pathol Microbiol Source Type: research

The role of p53, Ki-67 and laminin expression in the differential diagnosis of keratoacanthoma and well-differentiated SCC.
This study totally included 46 cases consisting of 23 cases with keratoacanthoma and 23 with SCC. As well as age, gender, localization, and diameter of the lesion, the expression of p53, Ki-67 and laminin was evaluated. Results: No statistically significant difference was found between KA and well-differentiated SCC in terms of diameter, age, and localization. There was a statistically significant difference between KA and well-differentiated SCC in terms of p53 and Ki-67 staining (P
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Turan G, Altun E, Aslan F, Kulahci O Tags: Indian J Pathol Microbiol Source Type: research

Morphological characterization and molecular profiling of malignant pericardial effusion in patients with pulmonary adenocarcinoma.
Conclusions: MPCE shows micropapillary and solid cytological patterns predominant with mucin secretion. MPCE are suitable to analyze oncogenic mutations and to develop targeted therapy for patients with pulmonary adenocarcinoma. Further molecular investigations may reveal novel molecular alterations. PMID: 31611441 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Zhou B, Li L, Shi D, Jiang T, Xue G, Xiong J Tags: Indian J Pathol Microbiol Source Type: research

Evaluation of high-fluorescence body fluid (HF-BF) parameter as a screening tool of malignancy in body fluids.
This study was done to analyze the high-fluorescence (HF)-BF parameter generated on Sysmex XN-1000 and study its correlation with the presence of malignant cells in the body fluids. A correlation between manual and automated differential counts was also done. Materials and Methods: A total of 1985 samples including 797 ascitic fluids (AF), 532 pleural fluids (PF), and 656 cerebrospinal fluids (CSF) were run on Sysmex XN-1000 in BF mode and cytopathology was available for 924 BFs including 389 AF, 379 PF, and 156 CSF. Both manual and automated methods were used for cell differential and cell morphology. Results: O...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Rastogi L, Dass J, Arya V, Kotwal J Tags: Indian J Pathol Microbiol Source Type: research

Role of procalcitonin, Il-6 and C- reactive protein in suspected cases of sepsis.
Abstract Objectives: To study the role of serum procalcitonin as a diagnostic biomarker in sepsis and to compare it with other sepsis markers (IL-6, CRP) in patients of suspected sepsis. Materials and Methods: A total of 80 patients were included in this study from ICU and each patient was investigated for serum Procalcitonin, Interleukin-6 and C-reactive protein levels by ELISA along with blood cultures by BacT/Alert system. Result: Procalcitonin along with CRP is a better diagnostic tool for sepsis. PMID: 31611443 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Sharma S, Duggal N Tags: Indian J Pathol Microbiol Source Type: research

Metastatic hepatocellular carcinoma to the parotid gland: A diagnostic dilemma with review of the literature.
We report a case of a rare metastasis of HCC to the parotid gland. Furthermore, the present case demonstrates the importance of tissue biopsy and immunohistochemistry for obtaining an accurate final diagnosis. PMID: 31611444 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Aiyer HM, Deb S, Rawat G Tags: Indian J Pathol Microbiol Source Type: research

Primary epiglottic follicular variant of peripheral T-cell lymphoma.
Abstract The follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise specified in a 44-year-old Chinese man, who presented with a tumor in the middle of the epiglottis tongue surface. Microscopically, the tumor had a vague nodular growth pattern and the morphology of the nodules was different from each other at low power. Atypical lymphoid cells were medium to large in size and ...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Kong J, Zhong L, Gao X, Qi W, Zhang L, Lin Z Tags: Indian J Pathol Microbiol Source Type: research

Fever work-up unfolds a rare diagnosis of native valve endocarditis caused by Mycobacterium abscessus.
Abstract Endocarditis caused by Mycobacterium abscessus is rare and often missed without appropriate blood cultures. It does not respond to standard antitubercular treatment and is also resistant to many other antibiotics. The course of the disease may be indolent and often results in a fatal outcome. Accurate identification and sensitivity, combination therapy, and prolonged duration of antibiotics are, therefore, important for a successful outcome. PMID: 31611446 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Sharma A, Mundi I, Behal K, Kaur N, Singh P, Mahant M Tags: Indian J Pathol Microbiol Source Type: research

Sympathetic ophthalmia with incidental finding of chicken pox supported by histopathology and immunohistochemistry.
We present a case of a 24-year-old female with clinical diagnosis of SO with an atypical past history of chicken pox in that eye and residual corneal opacity. PMID: 31611447 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Das D, Krishnakumar S, Biswas J Tags: Indian J Pathol Microbiol Source Type: research

Type I pleuropulmonary blastoma presenting as congenital pulmonary airway malformation: A report of two cases.
Abstract Pleuropulmonary blastoma (PPB) is a rare aggressive intrathoracic tumor which is believed to originate from embryonic uncommitted lung mesenchymal cells, which are important for developing the lung. Type I PPB is cystic, type II is cystic and solid, while type III is predominantly solid. Diagnosing type 1 PPB is a challenge for both radiologists as well as pathologists. Owing to its purely cystic nature, type I PPB it is often mistaken for unrelated entities such as congenital pulmonary airway malformation and congenital lobar emphysema which delays surgical intervention. Here, we report two such cases pr...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Kumari K, Longchar M, Gunathilaka G, Narange P, Aggarwal S, Arava S Tags: Indian J Pathol Microbiol Source Type: research

Cardiac myxoma with cartilaginous differentiation-An uncommon variant presented as mitral stenosis.
Abstract The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30-year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Jagtap SV, Salunkhe P, Mane A, Kumbhar S, Mayekar P, Boral S Tags: Indian J Pathol Microbiol Source Type: research

Myeloid sarcoma of bile ducts presenting as obstructive jaundice - A case report.
Abstract Myeloid sarcoma is an extra medullary manifestation of acute myeloid leukemia (AML). Primary involvement of the biliary tract with myeloid sarcoma presenting as obstructive jaundice without evidence of leukemia is very rare. Here we present a case of 72 year old lady, who initially presented with features of biliary obstruction and was clinically considered as cholangiocarcinoma. She was diagnosed as myeloid sarcoma involving right and left hepatic duct, common bile duct (CBD) on histopathological and immunohistochemistry (IHC) examination after surgical resection. Since she did not show evidence of leuke...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Agarwal A, Dadu T, Bhalla VP, Malhotra V Tags: Indian J Pathol Microbiol Source Type: research

Primary epithelial splenic cyst: A rare encounter.
We report a case of 30-year-old female presenting with left upper abdominal pain and heaviness. Computed tomography revealed a multiloculated cyst in spleen. Hydatid serology was negative. Total splenectomy was done. Histopathological evaluation was done and a diagnosis of primary epithelial splenic cyst was given. PMID: 31611451 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Kala PS, Azad S, Sharma T, Acharya S Tags: Indian J Pathol Microbiol Source Type: research

"Endolymphatic sac tumour": A case report with review of literature.
"Endolymphatic sac tumour": A case report with review of literature. Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):608-610 Authors: Rajeshwari B, Shanmugam S, Sadiya N, Mitra G, Chendilnathan B Abstract Endolymphatic sac tumour (ELST) is a non-metastasizing low grade adenocarcinoma of endolymphatic sac origin. It is also known as Heffner tumour, low grade adenocarcinoma of endolymphatic sac origin and aggressive papillary middle ear tumour. These tumours are closely associated with Von Hippel Lindau (VHL) disease. Here we report a case of Endolymphatic sac tumour in a 63 yr old lady who pres...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Rajeshwari B, Shanmugam S, Sadiya N, Mitra G, Chendilnathan B Tags: Indian J Pathol Microbiol Source Type: research

Tale of a mermaid.
Abstract Sirenomelia is a rare congenital anomaly characterized by the presence of a median single lower appendage. The affected fetus is popularly referred to as a "Mermaid baby," due to the uncanny resemblance to the fictious fable character. The manifestation is a result of the merger of the lower limbs with variable fusion or complete absence of bones. Sirenomelia is universally fatal due to the associated lethal anomalies involving the internal organs, which are usually part of the VACTER or VACTERL complex. However, this sirenomelia-afflicted fetus is unique in being associated with VACTERL as well...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Vasisht P, Madakshira MG, Kakkar N, Singla V, Jain V Tags: Indian J Pathol Microbiol Source Type: research

FLI1 and MIC2 expression in precursor B-lymphoblastic leukemia with Burkitt-like morphology and extensive extramedullary involvement: A diagnostic challenge in pediatric small round cell tumor.
Abstract Pediatric small round cell tumors (PSRCTs) constitute a large proportion of childhood malignancies with overlapping diagnostic and clinical features but radically different therapies. Here, we report a case of 16-year-old male child presenting with diffuse abdominal and mediastinal mass, axillary lymphadenopathy, and pleural effusion. Bone marrow aspirate showed near total replacement by small round malignant cells. The bone marrow biopsy showed interstitial infiltration by malignant cells, which were CD45- CD3- CD20- MIC2+ FLI1+ and diagnosis of Ewing's sarcoma was established. In contrast, flowcytometri...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Das N, Thakral D, Singh G, Malhotra A, Phulware RH, Gogia A, Gupta R Tags: Indian J Pathol Microbiol Source Type: research

Invasive, gangrenous mucormycosis of arm: A fatal opportunistic infection in a highly immunocompromised host.
We report a case of posttraumatic, highly lethal, angioinvasive, and gangrenous type of CM of the arm in an IC patient. Diabetic ketoacidosis and cirrhosis due to chronic alcoholic liver disease were the risk factors. PMID: 31611455 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Kanagaraju V, Narayanasamy VK, Sukumaran S, Moorthy U, Sundar VS, Lakshmi SV Tags: Indian J Pathol Microbiol Source Type: research

A case report of Nocardia cyriacigeorgica presenting as cellulitis with multiple discharging sinuses.
Abstract Nocardia spp. are filamentous Gram positive bacteria that are ubiquitous soil saprophytes. The majority of nocardial infections occur in severely immunocompromised patients who are particularly susceptible to pulmonary disease and dissemination. Extrapulmonary nocardiosis is relatively common and can occur through hematogenous dissemination or a contiguous spread of necrotizing pneumonitis. Primary cutaneous and soft tissue nocardiosis can result from traumatic injury to the skin that involves contamination with soil. After skin inoculation, a superficial abscess or localized cellulitis can develop. Co-tr...
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Bora A, Rathore L, Khatri PK, Chattopadhyay CS Tags: Indian J Pathol Microbiol Source Type: research

Solid pseudopapillary neoplasm of pancreas metastasizing to spleen in a post menopausal female.
PMID: 31611457 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Singla T, Ahluwalia C, Singla G, Kolte S, Singla S, Arora R Tags: Indian J Pathol Microbiol Source Type: research

Incidentally detected acalculous tubercular cholecystitis: A rare case report with a comprehensive review of literature.
PMID: 31611458 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Chaudhary D, Kaur N, Mandal S, Khurana N, Singh CB Tags: Indian J Pathol Microbiol Source Type: research

Primary actinomycosis of anterior abdominal wall: A rare occurrence, diagnosed on fine needle aspiration cytology.
We report a case of primary actinomycosis of anterior abdominal wall, diagnosed on fine needle aspiration cytology (FNAC). Identifying fluffy colonies and branching swirling filaments positive for fungal and Gram stain on cytology smears aid correct diagnosis. FNAC is an effective and reliable tool for early diagnosis of actinomycosis. The treatment is centered around antibiotics, and thus it is essential to diagnose accurately and avoid unnecessary surgery. PMID: 31611459 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Agnihotri M, Kothari K, Naik L Tags: Indian J Pathol Microbiol Source Type: research

Cavernous hemangioma of uvula: A rare site.
PMID: 31611460 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Rane S, Parkhi MV, Agrawal G, Ghodke A Tags: Indian J Pathol Microbiol Source Type: research

EBV positive mucocutaneous ulcer of palate: A mimicker of malignancy.
PMID: 31611461 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Goel D, Singh M Tags: Indian J Pathol Microbiol Source Type: research

Carancular mass- Always take with a pinch of salt!
PMID: 31611462 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Basa D, Balijepalli P, Mulay K Tags: Indian J Pathol Microbiol Source Type: research

Localized intrapulmonary mesothelioma presenting with a pulmonary mass.
PMID: 31611463 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Wang T, Cui M, Thakur A Tags: Indian J Pathol Microbiol Source Type: research

Extensive gastrointestinal amyloidosis due to multiple myeloma mimicking inflammatory bowel disease in a young male.
PMID: 31611464 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Ahuja A, Sharma V, Bhardwaj M, Marwah S, Lamoria S Tags: Indian J Pathol Microbiol Source Type: research

Primary melanoma of cecum: A diagnostic challenge.
PMID: 31611465 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Alwani NM, Fatima S, Adiga BK, Haider N Tags: Indian J Pathol Microbiol Source Type: research

Recurrent monophasic synovial sarcoma in a child.
PMID: 31611466 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Chaudhuri PM, Islam N, Das M, Chatterjee U, Datta C Tags: Indian J Pathol Microbiol Source Type: research

Acute myeloid leukemia presenting as fissure-in-ano: A unique case of histologically proven anodermal leukemia cutis.
PMID: 31611467 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2019 Category: Pathology Authors: Gaur K, Puri V, Jain M, Hooda S, Sharma S, Andley M Tags: Indian J Pathol Microbiol Source Type: research

From Editor's desk.
PMID: 31361220 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Agrawal R Tags: Indian J Pathol Microbiol Source Type: research

Biomarker for colorectal carcinoma -ERCC1-New kid on the block.
PMID: 31361221 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Bansal N Tags: Indian J Pathol Microbiol Source Type: research

Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study.
Conclusion: Detection of the primary site in metastatic CNS tumors is possible by adopting this simple and effective diagnostic approach at centers/hospitals having cost and other constraints. PMID: 31361222 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Gupta A, Chaturvedi S, Jha D, Chaturvedi M Tags: Indian J Pathol Microbiol Source Type: research

Akt and estrogen receptor expression in nasal polyps.
In this study, it showed the effect of estrogen on the activation of Akt signaling pathway in nasal polyps. Mann- Whitney-U test was applied to evaluate the statistical differences between nasal polyp and control group, (P
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Bahçeci S, Şimşek F, Eren E, Aladaǧ I Tags: Indian J Pathol Microbiol Source Type: research

A cytohistological correlation in salivary gland swelling with special reference to the proposed Milan system.
Conclusions: The six-tier diagnostic categories of the Milan classification scheme help in segregating patients with salivary gland lesions into the management categories of follow-up, conservative surgery, and radical surgery with/without chemotherapy. PMID: 31361224 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Mishra S, Ray S, Sengupta M, Sengupta A Tags: Indian J Pathol Microbiol Source Type: research

Clinicopathological correlation of cancer stem cell markers Oct-4 and CD133 expression as prognostic factor in malignant lesions of gallbladder: An immunohistochemical study.
Abstract Background: Gallbladder cancer (GBC) is the most frequent biliary tract cancer, with high morbidity and poor prognosis, and shows early metastasis and invasiveness. No reliable biomarkers are available for detection of GBC progression. Aim: To investigate the immunohistochemical expression of Oct-4 and CD133 in malignant and nonneoplastic lesions of gallbladder and to analyze the clinical significance of the expressions related to clinicopathological parameters. Settings and Design: This is a prospective case control study, conducted in medical college background. Materials and Methods: A t...
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Fatima N, Srivastava AN, Nigam J, Tandon N, Ahmad R, Kumar V Tags: Indian J Pathol Microbiol Source Type: research

Development of an efficient in vivo cell-based assay system for monitoring hepatitis C virus genotype 4a NS3/4A protease activity.
Conclusions: We successfully developed an efficient cell-based system based on the blue/white selection of bacterial cells that are able to express functional/nonfunctional β-galactosidase enzyme. PMID: 31361226 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Naguib MM, Mohamed MR, M Ali MA, Karim AM Tags: Indian J Pathol Microbiol Source Type: research

Duodenal mucosal immune cells in treatment-naive adult patients with celiac disease having different histological grades and controls.
Conclusion: Our finding in this observational study generates interest to study the local intestinal mucosal immunity in CeD in detail. A study to prove the failure of CD4+ FoxP3+ Treg cell recruitment in CeD and its direct functional impact may yield valuable information regarding loss of mucosal tolerance. PMID: 31361227 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: S Gahlot GP, Das P, Baloda V, Singh A, Vishnubhatla S, Gupta SD, Makharia GK Tags: Indian J Pathol Microbiol Source Type: research

Role of ERCC1 expression in colorectal adenoma-carcinoma sequence and relation to other mismatch repair proteins expression, clinicopathological features and prognosis in mucinous and non-mucinous colorectal carcinoma.
Conclusion: this study is the first to investigate the relation between MMR status and ERCC1 expression in colorectal MA and NMA. ERCC1 expression was significantly related to MMR status only in NMA cases. Hence, the current study emphasizes that further research about the relation between various DNA repair pathways is needed. PMID: 31361228 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Mohammad Foda AA, Palicelli A, Shebl A, Boldorini R, Elnaghi K, ElHawary AK Tags: Indian J Pathol Microbiol Source Type: research

Assessment of appendix carcinoid tumors: A retrospective study.
This study aimed to analyze the frequency of carcinoid tumor, the applied treatments to cure it, and the survival periods of the patients thereafter in a city located in the west of Turkey, Balıkesir. Materials and Methods: The data for this study were gathered by the careful retrospective analysis of 6369 files of patients who underwent an appendectomy operation during the time span of January 2011 and December 2017 in Balıkesir Atatürk City Hospital. Results: The results revealed that among the patients who underwent appendectomy, 17 carcinoid tumor cases, 16 of which with combine classic carcinoid and 1...
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Kocaöz S, Turan G Tags: Indian J Pathol Microbiol Source Type: research

Role of CD71 in acute leukemia- An immunophenotypic marker for erythroid lineage or proliferation?
Conclusions: Surface CD71 expression is not only found in erythroid lineage cells, but also in proliferating cells. CD71 MFI is highest in T lymphoblasts followed by leukemic erythroblasts, myeloblasts and least in B lymphoblasts. PMID: 31361230 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Acharya S, Kala PS Tags: Indian J Pathol Microbiol Source Type: research

A novel approach to decalcification in histopathology laboratory: An adaptation from the Hammersmith protocol.
Conclusion: This novel and modified method has circumvented the common problems of overdecalcification, preserved morphology, and produced consistent results without interfering with special stains and immunohistochemistry. PMID: 31361231 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Pradhan P, Rajesh NG, Badhe BA, Ilanchezian K, Manimehalai D, Jyothish A Tags: Indian J Pathol Microbiol Source Type: research

Thoracopagus: Autoptic and radiologic study of 2 cases.
Abstract Conjoined twins are a very rare complication of monozygotic twinning, most common being thoracopagus. Here we report about two cases of thoracopagus male twins illustrating the autopsy details of one case and the prenatal magnetic resonance imaging (MRI) details of another case. While the first case was misdiagnosed as separate twins on antenatal USG, only to be later confirmed as thoracopagus twins after birth, the antenatal MRI done in the second case helped in accurate detection of thoracopagus twins. Bilateral peripheral cortical cysts with dysplasia was noted in one of the twins of the first case, wh...
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Mandal B, Islam N, Mukherjee S, Chatterjee U Tags: Indian J Pathol Microbiol Source Type: research

ROS-1 re-arrangements and c-MET amplifications in adenocarcinoma lung: A tertiary care center study from North India.
Conclusion: This is the first study from the Indian subcontinent to identify the frequency of ROS-1 re-arrangements and MET amplification in the Indian population. The availability of targeted therapy that has a significant impact on survival makes it essential to detect these less frequent mutations. PMID: 31361233 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Shukla S, Pandey RK, Kant S, Garg R, Husain N Tags: Indian J Pathol Microbiol Source Type: research

Kimura disease with nephrotic syndrome in a child- A rare association.
Abstract Lymphadenopathy along with various systemic manifestations is commonly encountered in pediatric patients, tuberculosis being the commonest etiology. Occasional patients may present a diagnostic conundrum. Here, the authors report an unusual manifestation of Kimura disease (KD) presenting as nephrotic syndrome associated with mesenteric lymphadenitis in an 11-year-old male child. KD is a chronic inflammatory disorder of unknown etiology. It typically affects young adult males in the age range of 27-40 years and usually presents as painless itchy nodular masses in the head and neck region. The involvement o...
Source: Indian Journal of Pathology and Microbiology - July 1, 2019 Category: Pathology Authors: Majumder A, Sen D Tags: Indian J Pathol Microbiol Source Type: research