Development and validation of a multicenter Cox regression model to predict all-cause mortality in patients with renal masses suspicious for renal cancer
CONCLUSIONS: For patients with localized renal masses, accurate determination of life expectancy is essential for decision-making regarding intervention vs. active surveillance as a primary treatment modality. We have made available a simple tool for this purpose.PMID:38704319 | DOI:10.1016/j.urolonc.2024.04.007 (Source: Urologic Oncology)
Source: Urologic Oncology - May 4, 2024 Category: Urology & Nephrology Authors: Brian R Lane Joseph G Cheaib Dennis Boynton Phillip Pierorazio Sabrina L Noyes Henry Peabody Nirmish Singla Anna Johnson Khurshid R Ghani Andrew Krumm Karandeep Singh Source Type: research
Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk
Exp Mol Pathol. 2024 May 3;137:104895. doi: 10.1016/j.yexmp.2024.104895. Online ahead of print.ABSTRACTLipidome perturbation occurring during meta-inflammation is associated to left ventricle (LV) remodeling though the activation of the NLRP3 inflammasome, a key regulator of chronic inflammation in obesity-related disorders. Little is known about phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as DAMP-induced NLRP3 inflammasome. Our study is aimed to evaluate if a systemic reduction of PC/PE molar ratio can affect NLRP3 plasma levels in cardiovascular disease (CVD) patients with insulin resistance (IR) risk. For...
Source: Experimental and Molecular Pathology - May 4, 2024 Category: Pathology Authors: Elena Vianello Federico Ambrogi Marta Kalousov á Julietta Badalyan Elena Dozio Lorenza Tacchini Gerd Schmitz Tom áš Zima Gregory J Tsongalis Massimiliano M Corsi-Romanelli Source Type: research
Determinants of uptake of influenza, zoster and pneumococcal vaccines in patients with cardiovascular diseases
CONCLUSION: Influenza, pneumococcal and zoster vaccine uptake among cardiac patients was low. Encouraging physician recommendations for vaccination for cardiac patients under 65 years of age and addressing vaccination challenges among people from culturally and linguistically diverse backgrounds and pharmacy, workplace, and hospital vaccination may help increase vaccination uptake among cardiac patients.PMID:38704255 | DOI:10.1016/j.vaccine.2024.04.031 (Source: Herpes)
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: Elizabeth Benedict Kpozehouen C Raina Macintyre Timothy C Tan Source Type: research
Antiretroviral Stewardship: Top 10 Questions Encountered by Stewardship Teams and Solutions to Optimize Therapy
Clin Ther. 2024 May 3:S0149-2918(24)00081-X. doi: 10.1016/j.clinthera.2024.04.002. Online ahead of print.ABSTRACTPURPOSE: Infectious disease pharmacists and physicians overseeing antimicrobial stewardship programs possess expertise and often advanced certification in management of antiretrovirals to treat HIV. Stewardship programs are responsible for managing facility formularies and must stay up to date with the latest antiretrovirals, including once daily formulations and depot injectables. Furthermore, stewardship program members need to understand drug-interactions, short-, and long-term toxicities of these regimens, i...
Source: Clinical Therapeutics - May 4, 2024 Category: Drugs & Pharmacology Authors: Mei H Chang Yi Guo Antoinette Acbo Hongkai Bao Terrence McSweeney Christopher A Vo Priya Nori Source Type: research
Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway
Biomed Pharmacother. 2024 May 3;175:116689. doi: 10.1016/j.biopha.2024.116689. Online ahead of print.ABSTRACTIschemic heart disease invariably leads to devastating damage to human health. Nicotinamide ribose (NR), as one of the precursors of NAD+ synthesis, has been discovered to exert a protective role in various neurological and cardiovascular disorders. Our findings demonstrated that pretreatment with 200 mg/kg NR for 3 h significantly reduced myocardial infarct area, decreased levels of CK-MB and LDH in serum, and improved cardiac function in the rats during myocardial ischemia-reperfusion (I/R) injury. Meanwhile, 0.5 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Kai Zhao Jie Tang Hong Xie Lin Liu Qin Qin Bo Sun Zheng-Hong Qin Rui Sheng Jiang Zhu Source Type: research
Development and validation of a multicenter Cox regression model to predict all-cause mortality in patients with renal masses suspicious for renal cancer
CONCLUSIONS: For patients with localized renal masses, accurate determination of life expectancy is essential for decision-making regarding intervention vs. active surveillance as a primary treatment modality. We have made available a simple tool for this purpose.PMID:38704319 | DOI:10.1016/j.urolonc.2024.04.007 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Brian R Lane Joseph G Cheaib Dennis Boynton Phillip Pierorazio Sabrina L Noyes Henry Peabody Nirmish Singla Anna Johnson Khurshid R Ghani Andrew Krumm Karandeep Singh Source Type: research
The Association Between Adverse Cardiovascular Outcomes in Celiac Disease and the Role of Inflammation: Retrospective Analysis Using the National Inpatient Sample
Curr Probl Cardiol. 2024 May 2:102612. doi: 10.1016/j.cpcardiol.2024.102612. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease with patients being prone to a proinflammatory state. With recent studies showing an association between adverse cardiovascular events in patients with CD, we aim to further elucidate this relationship. Furthermore, when risk-stratifying patients with cardiovascular disease (CVD), chronic inflammatory conditions such as CD are not included in these calculations. We conducted a retrospective analysis using the National Inpatient Sample database from 2016 to 2019 to inve...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Rabab Elsadek Zeeshan Ismail Raghav Bassi Anuoluwa Oyetoran Yaseen Perbtani Tony Brar Suzanne Zentko Source Type: research
Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis
CONCLUSION: Hysterectomy, even with ovarian preservation, may be independently associated with a higher risk of metabolic syndrome. If other studies confirm these findings, screening and preventive strategies focused on females with ovary-sparing hysterectomy and the mechanisms underpinning these associations may be explored.PMID:38703940 | DOI:10.1016/j.ajog.2024.04.035 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Eric K Broni Justin B Echouffo Tcheugui Anna Palatnik Ernest M Graham Ruth-Alma Turkson-Ocran Yvonne Commodore-Mendah Chiadi E Ndumele Erin D Michos Source Type: research
Alterations in the gut mycobiome with coronary artery disease severity
In conclusion, the structure and composition of the gut fungal community differed from healthy controls to various subtypes of CAD, revealing key fungi taxa alterations linked to the onset and progression of CAD. Our study highlights the potential role of gut fungi in CAD and may facilitate the development of novel biomarkers and therapeutic targets for CAD.FUNDING: This work was supported by the grants from the National Natural Science Foundation of China (No. 82170302, 92168117, 82370432), National clinical key specialty construction project- Cardiovascular Surgery, the Reform and Development Program of Beijing Institute...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Kun An Yanxiong Jia Boqia Xie Jie Gao Yihang Chen Wen Yuan Jiuchang Zhong Pixiong Su Xiaoyan Liu Source Type: research
Insulin resistance in the adipose tissue predicts future vascular resistance: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
CONCLUSIONS: Future vascular resistance was predicted by insulin resistance in the adipose tissue. After glucose intake, serum FFA levels may significantly impact vascular resistance development.PMID:38703418 | DOI:10.1016/j.atherosclerosis.2024.117547 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Nobuo Sasaki Yoshitaka Ueno Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research
Atopic dermatitis is associated with an increased risk of cardiovascular diseases: A large-scale, propensity-matched US-based retrospective study
CONCLUSION: Atopic dermatitis is associated with an increased risk for multiple cardiovascular diseases.PMID:38703379 | DOI:10.1093/ced/llae164 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Henner Zirpel Sascha St änder Alicja Fr ączek Henning Olbrich Ralf J Ludwig Diamant Tha çi Source Type: research
Dapagliflozin and quality of life measured using the EuroQol 5 ‐dimension questionnaire in patients with heart failure with reduced and mildly reduced/preserved ejection fraction
ConclusionsBoth higher (better) EQ-5D-5L VAS and index scores were associated with better outcomes. Dapagliflozin treatment improved EQ-5D-5L VAS and index scores, irrespective of ejection fraction. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - May 4, 2024 Category: Cardiology Authors: Mingming Yang,
Toru Kondo,
Atefeh Talebi,
Pardeep S. Jhund,
Kieran F. Docherty,
Brian L. Claggett,
Muthiah Vaduganathan,
Erasmus Bachus,
Adrian F. Hernandez,
Carolyn S.P. Lam,
Silvio E. Inzucchi,
Felipe A. Martinez,
Rudolf A. de Boer,
Mikhail Tags: Research Article Source Type: research
Change in Body Mass Index and Cardiovascular Outcomes in Patients With Cancer
To investigate the association between body mass index (BMI) changes and the risk of cardiovascular disease (CVD) in patients with cancer. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 4, 2024 Category: Internal Medicine Authors: Kensuke Ueno, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Katsuhito Fujiu, Taisuke Jo, Norifumi Takeda, Kentaro Kamiya, Junya Ako, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro Tags: Original article Source Type: research
Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms
European Journal of Clinical Nutrition, Published online: 04 May 2024; doi:10.1038/s41430-024-01442-8Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - May 4, 2024 Category: Nutrition Authors: Emilia Ruggiero Augusto Di Castelnuovo Simona Costanzo Simona Esposito Amalia De Curtis Mariarosaria Persichillo Chiara Cerletti Maria Benedetta Donati Giovanni de Gaetano Licia Iacoviello Marialaura Bonaccio Source Type: research
FGF21 Agonists: An Emerging Therapeutic for Metabolic Dysfunction-Associated Steatohepatitis and Beyond
The worldwide epidemics of obesity, hypertriglyceridemia, dyslipidemia, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD) / metabolic dysfunction-associated steatohepatitis (MASH) represents a major economic burden on healthcare systems. At-risk MASH patients, defined as MASH with moderate or significant fibrosis are at higher risk of comorbidity / mortality with a significant risk of cardiovascular diseases and/or major adverse liver outcomes. Despite a high unmet medical need, there is no approved therapy to date. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 4, 2024 Category: Gastroenterology Authors: Stephen A. Harrison, Tim Rolph, Maddie Knot, Julie Dubourg Source Type: research
