Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases
Front Pharmacol. 2024 Apr 17;15:1398381. doi: 10.3389/fphar.2024.1398381. eCollection 2024.ABSTRACTCardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all global deaths. With an aging population and changing lifestyles, CVDs pose a major threat to human health. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are communication platforms between cellular organelles and regulate cellular physiological functions, including apoptosis, autophagy, and programmed necrosis. Further research has sh...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Yanqiu Ding Nanyang Liu Dawu Zhang Lijun Guo Qinghua Shang Yicheng Liu Gaocan Ren Xiaochang Ma Source Type: research
Needs-based considerations for the role of low-dose aspirin along the CV risk continuum
Am J Prev Cardiol. 2024 Apr 15;18:100675. doi: 10.1016/j.ajpc.2024.100675. eCollection 2024 Jun.ABSTRACTCardiovascular disease (CVD) remains the leading cause of death worldwide. The risk of a cardiovascular (CV) event is not static and increases along a continuum, making identification and management complex. Aspirin has been the cornerstone of antiplatelet therapy in CV risk reduction and remains the only antiplatelet agent with current guideline recommendations throughout the CV risk continuum. In light of recent trials, the role of aspirin in CVD prevention in asymptomatic patients has been downgraded in clinical guide...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Francesca Santilli Gerhard Albrecht Michael Blaha Angel Lanas Li Li Dirk Sibbing Source Type: research
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease
CONCLUSION: The gut microbiota is emerging as a potential therapeutic target for CVD prevention and management. However, current research has limitations, including the need for larger and more diverse studies, the challenges of establishing causality, and concerns regarding the long-term consequences and safety of gut microbiota modulation. Despite these limitations, understanding the gut-heart axis holds promise for the development of personalized therapies and interventions for cardiovascular health. Further research is needed to expand our knowledge and address the ethical and safety issues associated with gut microbio...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Sanobar Shariff Alicia Kwan Su Huey Nishant Parag Soni Amer Yahia Doha Hammoud Abubakar Nazir Olivier Uwishema Magda Wojtara Source Type: research
Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR(-/-) Hamsters
In this study, CHL was induced in low-density lipoprotein receptor-deficient (LDLR-/-) hamsters through an 8-week high-fat and high-cholesterol (HFHC) diet or a 4-month high-cholesterol (HC) diet. Placebo or antibiotics were administered through separate or cohousing approaches. Analysis through 16S rDNA sequencing revealed that intermittent antibiotic treatment and the cohousing approach effectively modulated the gut microbiota community without impacting its overall abundance in LDLR-/- hamsters exhibiting severe CHL. Antibiotic treatment mitigated HFHC diet-induced obesity, hyperglycemia, and hyperlipidemia, enhancing t...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Guolin Miao Jiabao Guo Wenxi Zhang Pingping Lai Yitong Xu Jingxuan Chen Lianxin Zhang Zihao Zhou Yufei Han Gonglie Chen Jinxuan Chen Yijun Tao Lemin Zheng Ling Zhang Wei Huang Yuhui Wang Xunde Xian Source Type: research
Carotid intimamedia thickness in patients with severe hypertriglyceridemia
CONCLUSIONS: Our findings suggest that extreme TG elevations in severe HTG patients are not significantly associated with carotid IMT, in contrast to the increased IMT seen in FH patients. These findings add perspective to the complex relationship between severe HTG and ASCVD risk.PMID:38694144 | PMC:PMC11060956 | DOI:10.1016/j.athplu.2024.04.001 (Source: Atherosclerosis)
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Maud Ahmad Brooke A Kennedy Surim Son Adam D McIntyre Julieta Lazarte Jian Wang Robert A Hegele Source Type: research
IL-1 β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
CONCLUSIONS: Taken together, IL-1β appears to be required for the maintenance of standard laboratory diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.PMID:38695167 | DOI:10.1161/ATVBAHA.124.320800 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Santosh Karnewar Vaishnavi Karnewar Rebecca Deaton Laura S Shankman Ernest D Benavente Corey M Williams Xenia Bradley Gabriel F Alencar Gamze B Bulut Sara Kirmani Richard A Baylis Eli R Zunder Hester M den Ruijter Gerard Pasterkamp Gary K Owens Source Type: research
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
CONCLUSIONS: Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.PMID:38695168 | DOI:10.1161/ATVBAHA.123.320387 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Gissette Reyes-Soffer Anastasiya Matveyenko James Lignos Nelsa Matienzo Leinys S Santos Baez Antonio Hernandez-One Lau Yung Renu Nandakumar Sasha A Singh Masanori Aikawa Richard George Henry N Ginsberg Source Type: research
Evinacumab and Cardiovascular Outcome in Patients With Homozygous Familial Hypercholesterolemia
CONCLUSIONS: Real-life, long-term evinacumab adjunctive to lipid-lowering therapy including lipoprotein apheresis led to sustained low-density lipoprotein cholesterol lowering and improved cardiovascular event-free survival of patients with HoFH.PMID:38695169 | DOI:10.1161/ATVBAHA.123.320609 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Sophie B éliard Samir Saheb St éphanie Litzler-Renault Alexandre Vimont Ren é Valero Éric Bruckert Michel Farnier Antonio Gallo Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Should varicocele screening be conducted in men diagnosed with chronic venous insufficiency? A prospective study
CONCLUSIONS: There is a significant association between left GSV diameter and varicocele (p = 0.004). Varicocele screening can be carried out with 71.4% sensitivity in adult male patients with a left GSV diameter of 5.35 cm and above. Both cardiovascular surgeons and radiologists can conduct varicocele screening by measuring pampiniform veins in patients with a left GSV diameter of 5.35 cm and above. This approach has the potential to reduce the incidence of varicocele and associated infertility.PMID:38693978 | PMC:PMC11059024 | DOI:10.5114/kitp.2024.138486 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ferit Çetinkaya Kamil Do ğan Ay şe Taş Source Type: research
Contemporary trends of leadless pacemaker implantation in the United States
ConclusionThe contemporary US practice has shown significantly increased implantation rates of LPM since its approval with reduced rates of inpatient mortality. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - May 2, 2024 Category: Cardiology Authors: Muhammad Z. Khan,
Sameh Nassar,
Amanda Nguyen,
Muhammad Usman Khan,
Yasar Sattar,
Waleed Alruwaili,
Karthik Gonuguntla,
Haitham Mazek,
Zain Ul Abideen Asad,
Siddharth Agarwal,
Sameer Raina,
Sudarshan Balla,
Bao Nguyen,
Dali Fan,
Douglas Dard Tags: ORIGINAL ARTICLE Source Type: research
GSE232168 Dissecting the Mechanisms of Transcriptional Synergy in Response to Proinflammatory Cytokines in Endothelial Cells
Contributors : Ronan Bracken ; Joey Stolze ; Quanhu Sheng ; Jonathan D BrownSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCombinatorial cytokine signaling is implicated in the pathogenesis of diseases of the cardiovascular system ranging from acute combinatorial cytokine signaling observed in complications from SARS-COVID19 infection to chronic combinatorial cytokine signaling observed in atherosclerosis. There remains a large gap of our understanding how combinatorial cytokine signaling interface to drive proinflammatory programs. We hypothesize that stimulation of...
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Seafarers ’ attitudes and chances to improve the nutrition on merchant ships from the crews’ and cooks’ perspective
Seafarers ’ diets are often high in fat, sugar and calories, thus contributing to an increased risk of obesity, metabolic syndrome and cardiovascular disease. The multitude of obstacles to healthy eating in the... (Source: Journal of Occupational Medicine and Toxicology)
Source: Journal of Occupational Medicine and Toxicology - May 2, 2024 Category: Occupational Health Authors: Felix Alexander Neumann, Lukas Belz, Dorothee Dengler, Volker Harth, Chiara Reck, Marcus Oldenburg and Birgit-Christiane Zyriax Tags: Research Source Type: research
LUNet: deep learning for the segmentation of arterioles and venules in high resolution fundus images
This study aims to automate the segmentation of retinal arterioles and venules (A/V) from digital fundus images (DFI), as changes in the spatial distribution of retinal microvasculature are indicative of cardiovascular diseases, positioning the eyes as windows to cardiovascular health. Approach. We utilized active learning to create a new DFI dataset with 240 crowd-sourced manual A/V segmentations performed by 15 medical students and reviewed by an ophthalmologist. We then developed LUNet, a novel deep learning architecture optimized for high-resolution A/V segmentation. The LUNet model features a double dilated convolutio...
Source: Physiological Measurement - May 2, 2024 Category: Physiology Authors: Jonathan Fhima, Jan Van Eijgen, Marie-Isaline Billen Moulin-Roms ée, Heloïse Brackenier, Hana Kulenovic, Valérie Debeuf, Marie Vangilbergen, Moti Freiman, Ingeborg Stalmans and Joachim A Behar Source Type: research
Associations between pinch strength, cardiovascular events and all-cause mortality in patients undergoing maintenance hemodialysis
Patients undergoing maintenance hemodialysis (MHD) experience increased mortality and cardiovascular disease (CVD) risks; however, the potential connection between pinch strength (PS) and the prognosis of thes... (Source: BMC Nephrology)
Source: BMC Nephrology - May 2, 2024 Category: Urology & Nephrology Authors: Yaqi Yang, Lin Liu, Yuzhuo Li, Rongshao Tan, Xiaoshi Zhong, Yun Liu and Yan Liu Tags: Research Source Type: research
