Evinacumab and Cardiovascular Outcome in Patients With Homozygous Familial Hypercholesterolemia
CONCLUSIONS: Real-life, long-term evinacumab adjunctive to lipid-lowering therapy including lipoprotein apheresis led to sustained low-density lipoprotein cholesterol lowering and improved cardiovascular event-free survival of patients with HoFH.PMID:38695169 | DOI:10.1161/ATVBAHA.123.320609 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Sophie B éliard Samir Saheb St éphanie Litzler-Renault Alexandre Vimont Ren é Valero Éric Bruckert Michel Farnier Antonio Gallo Source Type: research
IL-1 β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
CONCLUSIONS: Taken together, IL-1β appears to be required for the maintenance of standard laboratory diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.PMID:38695167 | DOI:10.1161/ATVBAHA.124.320800 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Santosh Karnewar Vaishnavi Karnewar Rebecca Deaton Laura S Shankman Ernest D Benavente Corey M Williams Xenia Bradley Gabriel F Alencar Gamze B Bulut Sara Kirmani Richard A Baylis Eli R Zunder Hester M den Ruijter Gerard Pasterkamp Gary K Owens Source Type: research
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
CONCLUSIONS: Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.PMID:38695168 | DOI:10.1161/ATVBAHA.123.320387 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Gissette Reyes-Soffer Anastasiya Matveyenko James Lignos Nelsa Matienzo Leinys S Santos Baez Antonio Hernandez-One Lau Yung Renu Nandakumar Sasha A Singh Masanori Aikawa Richard George Henry N Ginsberg Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Should varicocele screening be conducted in men diagnosed with chronic venous insufficiency? A prospective study
CONCLUSIONS: There is a significant association between left GSV diameter and varicocele (p = 0.004). Varicocele screening can be carried out with 71.4% sensitivity in adult male patients with a left GSV diameter of 5.35 cm and above. Both cardiovascular surgeons and radiologists can conduct varicocele screening by measuring pampiniform veins in patients with a left GSV diameter of 5.35 cm and above. This approach has the potential to reduce the incidence of varicocele and associated infertility.PMID:38693978 | PMC:PMC11059024 | DOI:10.5114/kitp.2024.138486 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ferit Çetinkaya Kamil Do ğan Ay şe Taş Source Type: research
Drivers of access to cardiovascular health care for rural Indigenous Peoples: a scoping review
CONCLUSION: The findings are consistent with other literature exploring access to health care for rural Indigenous Peoples. This review offers a novel approach to summarising literature by situating the themes within the context of equity and rights for Indigenous Peoples. This review also highlighted the need for further research in this area to be conducted in the context of Aotearoa New Zealand.PMID:38697785 | DOI:10.22605/RRH8674 (Source: Rural and Remote Health)
Source: Rural and Remote Health - May 2, 2024 Category: Rural Health Authors: T āria Tane Vanessa Selak Kyle Eggleton Matire Harwood Source Type: research
Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury
In this study we show in vitro and in vivo that Park7 has a crucial role in protection from AKI, and upregulated peroxisome activity. These data in combination with published results of Park7's protective role in cardiovascular damage and chronic kidney disease lead us to hypothesize that succinylation of Park7 may ameliorate oxidative damage resulting from AKI and prevent disease progression. This novel mechanism provides a potential therapeutic mechanism that can be targeted.PMID:38695076 | DOI:10.1152/ajprenal.00062.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - May 2, 2024 Category: Physiology Authors: Katherine Pfister Victoria Young Brendon Frankel Anne Silva Barbosa Jordan Burton Joanna Bons Bob Zhang Takuto Chiba Rebecca Uhlean Eric Goetzman Birgit Schilling Sunder Sims-Lucas Source Type: research
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease
Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00383.2023. Online ahead of print.ABSTRACTAccording to the Developmental Origins of Health and Disease (DOHaD) hypothesis, exposure to certain environmental influences during early life may be a key determinant of fetal development and short- and long-term offspring health. Indeed, adverse conditions encountered during the fetal, perinatal, and early childhood stages can alter normal development and growth, as well as put the offspring at elevated risk of developing long-term health conditions in adulthood, including chronic kidney disease (CKD) and cardiovascul...
Source: American Journal of Physiology. Renal Physiology - May 2, 2024 Category: Physiology Authors: Zo é Oulerich Amanda N Sferruzzi-Perri Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Should varicocele screening be conducted in men diagnosed with chronic venous insufficiency? A prospective study
CONCLUSIONS: There is a significant association between left GSV diameter and varicocele (p = 0.004). Varicocele screening can be carried out with 71.4% sensitivity in adult male patients with a left GSV diameter of 5.35 cm and above. Both cardiovascular surgeons and radiologists can conduct varicocele screening by measuring pampiniform veins in patients with a left GSV diameter of 5.35 cm and above. This approach has the potential to reduce the incidence of varicocele and associated infertility.PMID:38693978 | PMC:PMC11059024 | DOI:10.5114/kitp.2024.138486 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ferit Çetinkaya Kamil Do ğan Ay şe Taş Source Type: research
Computed Tomography-Assessed Sarcopenia Predicts Mortality in Kidney Transplant Candidates
CONCLUSIONS: Sarcopenia was ~5 times more frequent in patients with end-stage renal disease than in healthy controls and was positively correlated with the prognostic nutritional index. Sarcopenia was an independent risk factor for mortality in patients on transplant waiting lists.PMID:38695590 | DOI:10.6002/ect.2023.0050 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Harun Coban Dilek Barutcu Atas Murat Tugcu Meltem Kursun Canan Cimsit Ebru Asicioglu Hakki Arikan Serhan Tuglular Arzu Velioglu Source Type: research
Clinicopathologic Spectrum and Outcomes of Infections Diagnosed on Graft Biopsies and Nephrectomy in Live Renal Allograft Recipients: An Institutional Experience
CONCLUSIONS: BK polyoma virus infection was the most common infection affecting the renal allograft in our study. Although fungal infections caused the highest mortality among our patients, bacterial graft pyelonephritis was responsible for maximum graft failure. Correctly identifying infections on histology is important so that graft and patient life can be prolonged.PMID:38695589 | DOI:10.6002/ect.2023.0200 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Pallav Gupta Vinant Bhargava Manish Malik Anurag Gupta A K Bhalla Ashwani Gupta Vaibhav Tiwari Shiv Chadha D S Rana Source Type: research
Regulatory bodies and health care systems should systematically evaluate the safety and cost-effectiveness of new cardiovascular treatments in health care registries using prospectively designed protocols
Scand Cardiovasc J. 2024 Dec;58(1):2343383. doi: 10.1080/14017431.2024.2343383. Epub 2024 May 2.NO ABSTRACTPMID:38695202 | DOI:10.1080/14017431.2024.2343383 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 2, 2024 Category: Cardiology Authors: Bj örn Redfors Source Type: research
Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study
Conclusion. New-onset atrial fibrillation during 30 days of follow-up was rare after percutaneous coronary intervention but common after coronary artery bypass grafting. A prolonged uninterrupted heart rhythm monitoring strategy identified additional patients in both groups with new-onset atrial fibrillation after discharge.PMID:38695238 | DOI:10.1080/14017431.2024.2347297 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 2, 2024 Category: Cardiology Authors: Anders Wickbom Espen Fengsrud Joakim Alfredsson Johan Engdahl Torbj örn Kalm Anders Ahlsson Source Type: research
Interplay between Hypoxia Inducible Factor-1 and mitochondria in cardiac diseases
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00426-X. doi: 10.1016/j.freeradbiomed.2024.04.239. Online ahead of print.ABSTRACTIschemic heart diseases and cardiomyopathies are characterized by hypoxia, energy starvation and mitochondrial dysfunction. HIF-1 acts as a cellular oxygen sensor, tuning the balance of metabolic and oxidative stress pathways to provide ATP and sustain cell survival. Acting on mitochondria, HIF-1 regulates different processes such as energy substrate utilization, oxidative phosphorylation and mitochondrial dynamics. In turn, mitochondrial homeostasis modifications impact HIF-1 activity. This under...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Jeanne Mialet-Perez Elise Belaidi Source Type: research
