Observing the Clinical Course of Duchenne Muscular Dystrophy in Medicaid Real-World Healthcare Data
ConclusionsThis study is the first to use diagnosis and procedure codes from real-world Medicaid claims to document the clinical course in DMD. Findings were consistent with previously published estimates from commercially insured populations and clinical registries; and contribute to the expanding body of real-world evidence around clinical progression of patients with DMD. (Source: Advances in Therapy)
Source: Advances in Therapy - May 2, 2024 Category: Drugs & Pharmacology Source Type: research
Social and Structural Determinants of Cardiovascular Complications of Diabetes
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of mortality in people who have diabetes. Racial and ethnic minorities with diabetes have suboptimal management of cardiovascular risk factors, leading to higher mortality. Social and structural determinants of health are external factors that influence an individual ’s ability to choose positive health behaviors. In this review, we will discuss cardiovascular complications in people who have diabetes and their relationship to social determinants of health (SDOH).Recent FindingsRecent innovations in diabetes treatment, including new devices and me...
Source: Current Diabetes Reports - May 2, 2024 Category: Endocrinology Source Type: research
Sexual dimorphism in atherosclerotic plaques of aged Ldlr −/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaq... (Source: Immunity and Aging)
Source: Immunity and Aging - May 2, 2024 Category: Geriatrics Authors: Virginia Smit, Jill de Mol, Mireia N. A. Bernab é Kleijn, Marie A. C. Depuydt, Menno P. J. de Winther, Ilze Bot, Johan Kuiper and Amanda C. Foks Tags: Research Source Type: research
Performance of the 2019 ESC pre-test probability model in predicting obstructive coronary artery disease in a Chinese population using coronary computed tomography angiography outcomes
This study aimed to validate the 2019 ESC-PTP model in predicting CAD using coronary computed tomography angiography (CCTA) outcomes in a Chinese population. (Source: Journal of Cardiovascular Computed Tomography)
Source: Journal of Cardiovascular Computed Tomography - May 2, 2024 Category: Radiology Authors: Jianan Zheng, Zhihui Hou, Weihua Yin, Yang Gao, Yanan Ma, Bin Lu Tags: Research paper Source Type: research
Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis
AbstractPurpose of ReviewSince obesity is a major risk factor for many different types of cancer, examining one of the most closely associated comorbidities, such as hypercholesterolemia, is crucial to understanding how obesity causes cancer. Hypercholesterolemia is usually associated with many cardiovascular complications such as hypertension, angina, and atherosclerosis. In addition, cholesterol may be a major factor in increasing cancer risk. Cancer patients who received statins, an anti-hypercholesteremic medicine, demonstrated improved prognosis possibly through its effect on tumor proliferation, apoptosis, and oxidat...
Source: Current Nutrition Reports - May 2, 2024 Category: Nutrition Source Type: research
Advanced Cardiovascular Magnetic Resonance Imaging in Takotsubo Syndrome: Update on Feature Tracking and Tissue Mapping
AbstractBackgroundsTakotsubo syndrome (TTS) is an intriguing clinical entity characterized by transient myocardial dysfunction. The precise pathophysiological mechanism of TTS is still unknown, but recent evidence suggests a central role of systemic inflammation associated with adrenergic discharge. Although initially considered benign, TTS has shown several potential short-term and long-term complications and adverse outcomes. To improve understanding and management, advanced cardiovascular magnetic resonance (CMR) techniques, such as feature tracking (FT) and parametric mapping, have gained attention.Purpose of ReviewThe...
Source: Current Cardiovascular Imaging Reports - May 2, 2024 Category: Radiology Source Type: research
Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies
Conclusion
We found consistent evidence that high CRF is strongly associated with lower risk for a variety of mortality and incident chronic conditions in general and clinical populations. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - May 2, 2024 Category: Sports Medicine Authors: Lang, J. J., Prince, S. A., Merucci, K., Cadenas-Sanchez, C., Chaput, J.-P., Fraser, B. J., Manyanga, T., McGrath, R., Ortega, F. B., Singh, B., Tomkinson, G. R. Tags: Open access, BJSM Reviews with MCQs, BJSM Systematic review Source Type: research
Infographic. All health professionals should talk about physical activity with patients
Regular physical activity contributes to the prevention and management of non-communicable diseases, including cardiovascular disease, stroke, diabetes and cancer, as well as improved mental health, sleep and cognitive function.1 Despite these benefits, populations worldwide are insufficiently active.2 Enabling people with the lowest levels of physical activity to become more active is where the greatest gains to public health will be achieved.3 Researchers, practitioners and policymakers are increasingly advocating for a systems approach to physical activity promotion. This should involve stakeholders across diverse secto...
Source: British Journal of Sports Medicine - May 2, 2024 Category: Sports Medicine Authors: Milton, K., Morris, J. L., McLaughlin, M., Cameron, A., Dewhurst, S., Gardner, S., Gomersall, S., Blackshaw, J. Tags: BJSM Infographic Source Type: research
Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’
Nature Reviews Cardiology, Published online: 02 May 2024; doi:10.1038/s41569-024-01029-7Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’ (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 2, 2024 Category: Cardiology Authors: Azita H. Talasaz Behnood Bikdeli Source Type: research
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease
Nature Reviews Cardiology, Published online: 02 May 2024; doi:10.1038/s41569-024-01028-8Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 2, 2024 Category: Cardiology Authors: Jonatan W ärme Martin O. Sundqvist Stefan James Robin Hofmann Source Type: research
Molecules, Vol. 29, Pages 2100: Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases
This article reviews the main pharmacological effects and clinical research of A. sinensis on cardiovascular and cerebrovascular diseases in recent years, explores the effect of its chemical components on cardiovascular and cerebrovascular diseases by regulating the expression of functional proteins and inhibiting inflammation, anti-apoptosis, and antioxidant mechanisms. It provides a reference for further research on A. sinensis and the development of related drugs. It provides a new reference direction for the in-depth research and application of A. sinensis in the prevention, improvement, and treatment of cardiovascular...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Linlin Chen Bei Fan Fengzhong Wang Yang Song Xizhi Wang Ying Meng Yumin Chen Qing Xia Jing Sun Tags: Review Source Type: research
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Theresa Failer, Michael Amponsah-Offeh, Aleš Neuwirth, Ioannis Kourtzelis, Pallavi Subramanian, Peter Mirtschink, Mirko Peitzsch, Klaus Matschke, Sems M. Tugtekin, Tetsuhiro Kajikawa, Xiaofei Li, Anne Steglich, Florian Gembardt, Annika C. Wegner, Christi Source Type: research
Frailty Assessment and Perioperative Adverse Cardiovascular Events After Noncardiac Surgery
Dr. Chandler
Clinical question: Can a frailty assessment tool be used to identify patients at higher risk for major adverse cardiac events (MACE) prior to noncardiac surgery?
Background: Studies have outlined the risk of increasing frailty on overall health outcomes and hospitalizations and as a possible risk factor for complications after noncardiac surgery. The association between frailty scores and perioperative MACE is limited.
Study design: Retrospective cohort study
Setting: Administrative data of patients aged ≥45 hospitalized for noncardiac surgeries between 2004 and 2014 in the U.S.
Synopsis: Using the Nati...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Cardiology In the Literature Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration
CONCLUSION: These data indicate that supraphysiological levels of Testo increase the endothelial expression and activity of NOX4 to counterbalance the deleterious effects caused by Testo in endothelial function.PMID:38690939 | DOI:10.1152/ajpendo.00365.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Juliano V Alves Rafael M da Costa Wanessa M C Awata Ariane Bruder-Nascimento Shubhnita Singh Rita C Tostes Thiago Bruder-Nascimento Source Type: research
