Prospective Deep Learning-based Quantitative Assessment of Coronary Plaque by CT Angiography Compared with Intravascular Ultrasound
CONCLUSIONS: Artificial intelligence enabled CCTA quantification and characterization of atherosclerosis demonstrated strong agreement with IVUS reference standard measurements. This tool may prove effective for accurate evaluation of coronary atherosclerotic burden and cardiovascular risk assessment.[ClinicalTrails.gov identifier: NCT05138289].PMID:38700097 | DOI:10.1093/ehjci/jeae115 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Jagat Narula Thomas D Stuckey Gaku Nakazawa Amir Ahmadi Mitsuaki Matsumura Kersten Petersen Saba Mirza Nicholas Ng Sarah Mullen Michiel Schaap Jonathan Leipsic Campbell Rogers Charles A Taylor Harout Yacoub Himanshu Gupta Hitoshi Matsuo Sarah Rinehart Aki Source Type: research
Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth
ACS Appl Mater Interfaces. 2024 May 3. doi: 10.1021/acsami.4c00999. Online ahead of print.ABSTRACTAtherosclerosis is the main risk factor for cardiovascular disease, which accounts for the majority of mortality worldwide. A significantly increased plasma level of low-density lipoprotein cholesterol (LDL-C), surrounded by a monolayer of phospholipids, free cholesterol, and one apolipoprotein B-100 (ApoB-100) in the blood, plays the most significant role in driving the development of atherosclerosis. Commercially available cholesterol-lowering drugs are not sufficient for preventing recurrent cardiovascular events. Developin...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Zhenzhou Li Yi Zhou Manlin Lai Jingna Luo Fei Yan Source Type: research
Palm oil as part of a high-fat diet: advances and challenges, or possible risks of pathology?
Nutr Rev. 2024 May 2:nuae038. doi: 10.1093/nutrit/nuae038. Online ahead of print.ABSTRACTNutritional status disorders have the most significant impact on the development of cardiovascular and oncologic diseases; therefore, the interest in the study of palm oil as among the leading components of nutrition has been increasing. The data examined in this review were sourced from the Scopus, SCIE (Web of Science), PubMed and PubMed Central, MEDLINE, CAPlus/SciFinder, and Embase databases; experts in the field; bibliographies; and abstracts from review analyses from the past 15 years. This review summarizes recent research data ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Natalia Kurhaluk Source Type: research
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions
Front Immunol. 2024 Apr 18;15:1377470. doi: 10.3389/fimmu.2024.1377470. eCollection 2024.ABSTRACTAtherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory cells within the damaged walls of arterial vessels. It is a significant independent risk factor for ischemic cardiovascular disease, ischemic stroke, and peripheral arterial disease. Despite the availability of current treatments such as statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and lifestyle modifications for prevention, AS remains a leading cause of morbidity and ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Li Wang Shenyi Huang Xiaolun Liang Junliang Zhou Yifan Han Jiangshan He Danping Xu Source Type: research
Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis
Cardiovasc Toxicol. 2024 May 3. doi: 10.1007/s12012-024-09866-1. Online ahead of print.ABSTRACTAnthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfunction in patients treated with anthracyclines can help detect subclinical cardiac dysfunction early and help initiate interventions to protect these patients. Among parameters of myocardial measure, cardiac magnetic resonance (CMR)-me...
Source: Cardiovascular Toxicology - May 3, 2024 Category: Cardiology Authors: Amira A Mohamed Layla Y Elmancy Sara M Abulola Sara A Al-Qattan Mohamed Izham Mohamed Ibrahim Zaid H Maayah Source Type: research
Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry
CONCLUSION: Cardiovascular symptoms were more prevalent in the ANCA-negative subset than in the MPO-ANCA-positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.PMID:38699219 | PMC:PMC11065486 | DOI:10.1155/2024/4283928 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - May 3, 2024 Category: Allergy & Immunology Authors: Anna Drynda Agnieszka Padjas Krzysztof W ójcik Rados ław Dziedzic Grzegorz Biedro ń Katarzyna Wawrzycka-Adamczyk Anna W łudarczyk Joanna Wila ńska Jacek Musia ł Zbigniew Zdrojewski Zenobia Czuszy ńska Anna Masiak Maria Majdan Rados ław Jeleniewicz Source Type: research
Mesenteric Ischemia after Cardiac Surgery
CONCLUSION: The prognosis of Me-Is following cardiac surgery is poor-independently from diagnostic or treatment patterns. There exists a significant asymptomatic time period postoperatively, in which pathophysiologic processes seem to cross the Rubicon. After clinical demarcation, the further course can almost no longer be influenced.PMID:38701840 | DOI:10.1055/s-0044-1786183 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Asen Petrov Ali Taghizadeh-Waghefi Fabio Hotz Christian Georgi Klaus Ehrhard Matschke Albert Busch Manuel Wilbring Source Type: research
Cool-shot Technique to Protect Spinal Cord During Thoracoabdominal Aortic Replacement
Thorac Cardiovasc Surg. 2024 May 3. doi: 10.1055/a-2318-5855. Online ahead of print.ABSTRACTDeep hypothermia helps protect the spinal cord, but is invasive. Here, we present a method to avoid reperfusion injury by selectively circulating cold blood under high pressure to the intercostal artery during reperfusion after intercostal artery reconstruction. Of the 23 patients who underwent thoracoabdominal aortic aneurysm open repair, one died. The motor evoked potential disappeared during aortic clamping in nine patients. Six patients recovered completely from aortic clamping release, two showed recovery >50% and one achiev...
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Taira Yamamoto Daisuke Endo Yasutaka Yokoyama Minoru Tabata Source Type: research
Pulmonary Arterial Anatomical Patterns: a Classification Scheme Based on Lobectomy and 3D-CTBA
CONCLUSION: The 3D-CTBA technique enables us to adequately assess the anatomy of the pulmonary arteries. Moreover, we provide a practical classification scheme of pulmonary arterial anatomical patterns based on lobectomy and 3D-CTBA. Our data can be used by clinicians in the teaching of pulmonary artery anatomy and the preoperative preparation for anatomical lobectomy.PMID:38698602 | DOI:10.1055/s-0044-1786195 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Zhuolin Xie Xinyu Zhu Feifei Li Jun Zhao Chang Li Source Type: research
The Incidence of Winged Scapula after Thoracic Cancer Surgery: A Prospective Cohort Study
CONCLUSION: The incidence of WS was similar to the literature. As WS incidence is underdiagnosed, assessment and correct education about possible deficits or impairments should be improved. Moreover, when a minimally invasive approach is not planned, it is a good clinical practice to discuss surgical strategies with surgeons to reduce this deficit.PMID:38698601 | DOI:10.1055/s-0044-1786196 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Luiz Felipe Nevola Teixeira Fabio Sandrin Ruy Fernando Kuenzer Caetano da Silva Francesco Petrella Luca Bertolaccini Maria Claudia Simoncini Lorenzo Spaggiari Source Type: research
Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness
Cell Metab. 2024 Apr 24:S1550-4131(24)00130-X. doi: 10.1016/j.cmet.2024.04.010. Online ahead of print.ABSTRACTPerivascular collagen deposition by activated fibroblasts promotes vascular stiffening and drives cardiovascular diseases such as pulmonary hypertension (PH). Whether and how vascular fibroblasts rewire their metabolism to sustain collagen biosynthesis remains unknown. Here, we found that inflammation, hypoxia, and mechanical stress converge on activating the transcriptional coactivators YAP and TAZ (WWTR1) in pulmonary arterial adventitial fibroblasts (PAAFs). Consequently, YAP and TAZ drive glutamine and serine c...
Source: Cell Metabolism - May 3, 2024 Category: Cytology Authors: Nesrine S Rachedi Ying Tang Yi-Yin Tai Jingsi Zhao Caroline Chauvet Julien Grynblat Kouam é Kan Firmin Akoumia Leonard Estephan St éphanie Torrino Chaima Sbai Amel Ait-Mouffok Joseph D Latoche Yassmin Al Aaraj Frederic Brau Sophie Ab élanet Stephan Cla Source Type: research
Androgen Deprivation Therapy/Androgen Receptor Signaling Inhibitor Treatments for Prostate Cancer: Pathophysiology and Review of Effects on Cardiovascular Disease
This article critically reviews the associations between androgen deprivation therapy, androgen receptor signaling inhibitors, and cardiovascular complications such as prolonged QT interval, atrial fibrillation, heart failure, atherosclerosis, coronary heart disease, venous thromboembolism, and peripheral arterial occlusive disease. These unfavorable outcomes reinforce the need for regular cardiovascular screening of patients undergoing androgen deprivation for the management of prostate cancer.PMID:38701845 | DOI:10.14423/SMJ.0000000000001687 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Richard Orji Alicia Morgans Eiman Jahangir Favor Markson Ayodeji Ilelaboye Alan Tan Tochukwu M Okwuosa Source Type: research
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00020.2024. Online ahead of print.ABSTRACTPreeclampsia is a risk factor for future cardiovascular diseases. However, the mechanisms underlying this association remain unclear, limiting effective prevention strategies. Blood pressure responses to acute stimuli may reveal cardiovascular dysfunction not apparent at rest, identifying individuals at elevated cardiovascular risk. Therefore, we compared blood pressure responsiveness to acute stimuli between previously preeclamptic (PPE) women (34±5yr, 13±6 months postpartum) and women following healthy pregnanci...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Danielle E Berbrier Tessa E Adler Cheryl A Leone Michael J Paidas Nina S Stachenfeld Charlotte W Usselman Source Type: research
Lepodisiran, an siRNA targeting lipoprotein(a) for the potential future treatment of cardiovascular disease
Expert Opin Investig Drugs. 2024 May 3. doi: 10.1080/13543784.2024.2352129. Online ahead of print.NO ABSTRACTPMID:38699928 | DOI:10.1080/13543784.2024.2352129 (Source: Expert Opinion on Investigational Drugs)
Source: Expert Opinion on Investigational Drugs - May 3, 2024 Category: Drugs & Pharmacology Authors: P Mihika S Fernando Amanda J Hooper John R Burnett Source Type: research
