Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway
Cardiovasc Toxicol. 2024 May 1. doi: 10.1007/s12012-024-09863-4. Online ahead of print.ABSTRACTVascular lesions frequently arise as complication in patients diagnosed with diabetes mellitus (DM). Presently, percutaneous coronary intervention (PCI) and antithrombotic therapy serve as primary treatments. However, in-stent restenosis persists as a challenging clinical issue following PCI, lacking sustained and effective treatment. Linarin (LN) exhibits diverse pharmacological activities and is regarded as a potential drug for treating various diseases, including DM. But its specific role in restenosis after vascular injury in...
Source: Cardiovascular Toxicology - May 1, 2024 Category: Cardiology Authors: Aihua Jiang Lin Liu Jianping Wang Yinglan Liu Shanshan Deng Tao Jiang Source Type: research
USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway
Cardiovasc Toxicol. 2024 Apr 30. doi: 10.1007/s12012-024-09860-7. Online ahead of print.ABSTRACTHypertension is a pathological state of the metabolic syndrome that increases the risk of cardiovascular disease. Managing hypertension is challenging, and we aimed to identify the pathogenic factors and discern therapeutic targets for metabolic hypertension (MHR). An MHR rat model was established with the combined treatment of a high-sugar, high-fat diet and ethanol. Histopathological observations were performed using hematoxylin-eosin and Sirius Red staining. Transcriptome sequencing was performed to screen differentially expr...
Source: Cardiovascular Toxicology - May 1, 2024 Category: Cardiology Authors: Zhihong Xie Mingshan Huang Wang Xu Fuwei Liu Donghua Huang Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
The cardiovascular system at high altitude: A bibliometric and visualization analysis
CONCLUSION: Over the past 32 years, research on the cardiovascular system in high-altitude regions has been steadily increasing. Future research in this field may focus on areas such as hypoxia adaptation, metabolism, and cardiopulmonary exercise. Strengthening interdisciplinary and multi-team collaborations will facilitate further exploration of the pathophysiological mechanisms underlying cardiovascular changes in high-altitude environments and provide a theoretical basis for standardized disease diagnosis and treatment.PMID:38690218 | PMC:PMC11056872 | DOI:10.4330/wjc.v16.i4.199 (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Mao-Lin Zhao Zhong-Jie Lu Li Yang Sheng Ding Feng Gao Yuan-Zhang Liu Xue-Lin Yang Xia Li Si-Yi He Source Type: research
Hypoxia-inducible factor-1 α in myocardial infarction
World J Cardiol. 2024 Apr 26;16(4):181-185. doi: 10.4330/wjc.v16.i4.181.ABSTRACTHypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthe...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Ivana Škrlec Sergey N Kolomeichuk Source Type: research
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia
Exp Cell Res. 2024 Apr 29:114061. doi: 10.1016/j.yexcr.2024.114061. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is a prevalent cardiovascular disease with high morbidity and mortality rates worldwide. Pyroptosis is an inflammatory form of programmed cell death that has been linked to various pathological conditions. However, its exact contribution to the onset and progression of heart injury in AMI has not yet fully elucidated. Herein, we established mouse AMI model by ligating the left anterior descending artery and performed transcriptome analysis during the early phase of AMI. Mouse HL-1 and human AC...
Source: Experimental Cell Research - May 1, 2024 Category: Cytology Authors: Xing Ye Zi-Jie Lin Guang-Hui Hong Zhi-Min Wang Run-Ting Dou Jun-Yi Lin Jian-Hui Xie Yi-Wen Shen Source Type: research
miR-92b-3p Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting MAP3K2 in a Mouse Model
CONCLUSION: This research suggests that miR-92b-3p protects against myocardial I/R injury by inhibiting MAP3K2, which may provide novel candidates for treatment of myocardial I/R injury.PMID:38692270 | DOI:10.1055/s-0044-1786528 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - May 1, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Kun Zhao Mei Wang Source Type: research
Update in genetic and epigenetic causes of hypertension
Cell Mol Life Sci. 2024 Apr 30;81(1):201. doi: 10.1007/s00018-024-05220-4.ABSTRACTHypertension is a heritable disease that affects one-fourth of the population and accounts for about 50% of cardiovascular deaths. The genetic basis of hypertension is multifaceted, involving both monogenic and most commonly complex polygenic forms. With the advent of the human genome project, genome-wide association studies (GWAS) have identified a plethora of loci linked to hypertension by examining common genetic variations. It's notable, however, that the majority of these genetic variants do not affect the protein-coding sequences, posin...
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Arya Mani Source Type: research
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration
CONCLUSION: These data indicate that supraphysiological levels of Testo increase the endothelial expression and activity of NOX4 to counterbalance the deleterious effects caused by Testo in endothelial function.PMID:38690939 | DOI:10.1152/ajpendo.00365.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Juliano V Alves Rafael M da Costa Wanessa M C Awata Ariane Bruder-Nascimento Shubhnita Singh Rita C Tostes Thiago Bruder-Nascimento Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
Persistence and Adherence to PCSK9 Inhibitor Monoclonal Antibodies Versus Ezetimibe in Real-World Settings
CONCLUSIONS: These data suggest approaches to increase persistence and adherence to PCSK9i mAb and ezetimibe should be implemented prior to or within 182 days following treatment initiation.PMID:38691317 | DOI:10.1007/s12325-024-02868-z (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Paul Muntner Lama Ghazi Jenna Jones Nafeesa Dhalwani Bharat Poudel Ying Wen Ligong Chen Zhixin Wang Vera Bittner Bethany Kalich Michael E Farkouh Mark Woodward Lisandro D Colantonio Robert S Rosenson Source Type: research
Mortality, bone density and grip strength: lessons from the past and hope for the future?
CONCLUSION: We report strong relationships between grip strength and mortality compared with BMD. We hypothesize that this may reflect better recognition and treatment of low BMD in this cohort.PMID:38690291 | PMC:PMC11057971 | DOI:10.1093/rap/rkae046 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Leo D Westbury Faidra Laskou Harnish P Patel Cyrus Cooper Elaine M Dennison Source Type: research
Effectiveness of Applying Green Heart, a Smartphone-Based Self-management Intervention to Control Smoking: A Randomized Clinical Trial
CONCLUSION: Our results confirmed that complete adherence to the app for at least 24 weeks was linked to alterations in cigarette smoking behavior among CAD patients. Trial Registration Number: IRCT20221016056204N1.PMID:38690792 | DOI:10.34172/aim.2024.37 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Mojgan Ghavami Alireza Abdshah Ayat Ahmadi Diba Akbarzadeh Ali Mofidi Mahnaz Ashoorkhani Saeed Sadeghian Source Type: research
Identifying Risk Indicators of Cardiovascular Disease in Fasa Cohort Study (FACS): An Application of Generalized Linear Mixed-Model Tree
CONCLUSION: Given the superior performance of the GLMM tree compared with the standard tree and the lack of significant difference with the GLMM, using this model is suggested due to its simpler interpretation and fewer assumptions. Using updated statistical models for more accurate CVD prediction can result in more precise frameworks to aid in proactive patient detection planning.PMID:38690790 | DOI:10.34172/aim.2024.35 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Fariba Asadi Reza Homayounfar Mojtaba Farjam Yaser Mehrali Fatemeh Masaebi Farid Zayeri Source Type: research
The relationship between muscle strength and epicardial fat in healthy adults
CONCLUSIONS: The relationship between epicardial fat and muscle strength is inverse and independent. Implementation of HGS measurement may be useful for the identification of subjects with excessive epicardial fat and cardiovascular risk. Measurement of epicardial fat could be helpful in the early detection of physical decline associated to ageing.PMID:38692441 | DOI:10.1016/j.exger.2024.112447 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 1, 2024 Category: Geriatrics Authors: Klara Komici Leonardo Bencivenga Caterina Arganese Giuseppe Rengo Germano Guerra Source Type: research
