Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00020.2024. Online ahead of print.ABSTRACTPreeclampsia is a risk factor for future cardiovascular diseases. However, the mechanisms underlying this association remain unclear, limiting effective prevention strategies. Blood pressure responses to acute stimuli may reveal cardiovascular dysfunction not apparent at rest, identifying individuals at elevated cardiovascular risk. Therefore, we compared blood pressure responsiveness to acute stimuli between previously preeclamptic (PPE) women (34±5yr, 13±6 months postpartum) and women following healthy pregnanci...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Danielle E Berbrier Tessa E Adler Cheryl A Leone Michael J Paidas Nina S Stachenfeld Charlotte W Usselman Source Type: research
TwinsMX: Exploring the Genetic and Environmental Influences on Health Traits in the Mexican Population
Twin Res Hum Genet. 2024 May 3:1-12. doi: 10.1017/thg.2024.18. Online ahead of print.ABSTRACTTwinsMX registry is a national research initiative in Mexico that aims to understand the complex interplay between genetics and environment in shaping physical and mental health traits among the country's population. With a multidisciplinary approach, TwinsMX aims to advance our knowledge of the genetic and environmental mechanisms underlying ethnic variations in complex traits and diseases, including behavioral, psychometric, anthropometric, metabolic, cardiovascular and mental disorders. With information gathered from over 2800 t...
Source: Twin Research and Human Genetics - May 3, 2024 Category: Genetics & Stem Cells Authors: Brisa Garc ía-Vilchis Talia V Rom án-López Diego Ram írez-González Xanat J L ópez-Camaño Vanessa Murillo-Lechuga X óchitl Díaz-Téllez C Itzamn á Sánchez-Moncada Ian M Espinosa-M éndez Diego Zenteno-Morales Zaida X Espinosa-Valdes Sofia Pradel Source Type: research
Polymorphic transposable elements provide new insights on high-altitude adaptation in the Tibetan Plateau
Genomics. 2024 May 1;116(3):110854. doi: 10.1016/j.ygeno.2024.110854. Online ahead of print.ABSTRACTSeveral studies demonstrated that populations living in the Tibetan plateau are genetically and physiologically adapted to high-altitude conditions, showing genomic signatures ascribable to the action of natural selection. However, so far most of them relied solely on inferences drawn from the analysis of coding variants and point mutations. To fill this gap, we focused on the possible role of polymorphic transposable elements in influencing the adaptation of Tibetan and Sherpa highlanders. To do so, we compared high-altitud...
Source: Genomics - May 3, 2024 Category: Genetics & Stem Cells Authors: Giorgia Modenini Paolo Abondio Marco Sazzini Alessio Boattini Source Type: research
Pediatric hypertension as an early manifestation of cardiovascular disease in children
J Bras Nefrol. 2024 May 3;46(4):e20230159. doi: 10.1590/2175-8239-JBN-2023-0159en. eCollection 2024.ABSTRACTIn adults, cardiovascular events associated with arterial hypertension (AH) have a major impact on morbidity and mortality. In light of recent findings, AH in children has been interpreted as early cardiovascular disease (CVD), while exposure to CV risk factors in children proves to be a predictor of subclinical CVD in adults. The American College of Cardiology/American Heart Association has recently updated the classifications for measuring blood pressure (BP) in adults and children. Primary AH in children is genera...
Source: Jornal Brasileiro de Nefrologia - May 3, 2024 Category: Urology & Nephrology Authors: Vera Hermina Kalika Koch Erika Arai Furusawa Source Type: research
Severe heart failure and intracardiac thrombosis: going beyond the appearance for diagnosis and treatments
We describe the case of a 45-year-old female affected by asthma and nasal polyposis who presented to the emergency department because of worsening dyspnea and paresthesia of the left lower limb. Comprehensive instrumental examinations revealed the presence of severe left ventricle dysfunction, intra-cardiac thrombus, deep vein thrombosis, pulmonary embolism, lung infiltrates, polyserositis, and neurological involvements. Finally, the patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, a rare vasculitis of small-medium blood vessels with several organ involvement...
Source: Monaldi Archives for Chest Disease - May 3, 2024 Category: Respiratory Medicine Authors: Andrea Segreti Sara Mastroberardino Lorenzo Frau Alessandro Appetecchia Luca D'Antonio Danilo Ricciardi Gian Paolo Ussia Francesco Grigioni Source Type: research
The current paradigm of cardiac troponin increase among athletes
Monaldi Arch Chest Dis. 2024 Apr 30. doi: 10.4081/monaldi.2024.2878. Online ahead of print.ABSTRACTAlthough it is known that exercise improves cardiovascular health and extends life expectancy, a significant number of people may also experience an elevation in cardiac troponin levels as a result of exercise. For many years, researchers have argued whether exercise-induced cardiac troponin rises are a consequence of a physiological or pathological reaction and whether they are clinically significant. Differences in cardiac troponin elevation and cardiac remodeling can be seen between athletes participating in different type...
Source: Monaldi Archives for Chest Disease - May 3, 2024 Category: Respiratory Medicine Authors: Mihail Celeski Andrea Segreti Mariagrazia Piscione Luigi Maria Monticelli Giuseppe Di Gioia Chiara Fossati Gian Paolo Ussia Fabio Pigozzi Francesco Grigioni Source Type: research
The burden of alcohol-related cardiovascular complications in young and middle-aged adults: rising burden of atrial fibrillation and hypertensive heart disease
CONCLUSIONS: The impact of alcohol-associated atrial fibrillation and hypertensive heart disease has increased over the last decades. Regarding region, the burden in Europe and the rising burden in Asia, require immediate public health policy to lessen these cardiovascular complications from alcohol in young and middle-aged adults.PMID:38699921 | DOI:10.1080/00015385.2024.2346872 (Source: Acta Cardiologica)
Source: Acta Cardiologica - May 3, 2024 Category: Cardiology Authors: Pojsakorn Danpanichkul Phuuwadith Wattanachayakul Kwanjit Duangsonk Sorawit Ongsupankul Adivitch Sripusanapan Ekdanai Uawithya Juthipong Benjanuwattra Angkawipa Trongtorsak Surakit Nathisuwan Leenhapong Navaravong Source Type: research
Increased risk of renal events in people with diabetic foot disease: a longitudinal observational study
CONCLUSION: The risk of renal events was increased in people with T2DM and DFD.PMID:38701944 | DOI:10.1016/j.diabet.2024.101536 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 3, 2024 Category: Endocrinology Authors: Fadi Alkhami S ébastien Rubin Gauthier Borderie Ninon Foussard Alice Larroumet Laurence Blanco Marie-Am élie Barbet-Massin Fr édéric Domenge Kamel Mohammedi Vincent Rigalleau Source Type: research
Age-specific and cause-specific mortality contributions to the socioeconomic gap in life expectancy in Germany, 2003-21: an ecological study
We examined how age-specific and cause-specific mortality contributions to the socioeconomic gap in life expectancy have changed at the area level in Germany over time.METHODS: In this ecological study, official German population and cause-of-death statistics provided by the Federal Statistical Office of Germany for the period Jan 1, 2003, to Dec 31, 2021, were linked to district-level data of the German Index of Socioeconomic Deprivation. Life-table and decomposition methods were applied to calculate life expectancy by area-level deprivation quintile and decompose the life-expectancy gap between the most and least deprive...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Fabian Tetzlaff Markus Sauerberg Pavel Grigoriev Juliane Tetzlaff Michael M ühlichen Jens Baumert Niels Michalski Annelene Wengler Enno Nowossadeck Jens Hoebel Source Type: research
Androgen Deprivation Therapy/Androgen Receptor Signaling Inhibitor Treatments for Prostate Cancer: Pathophysiology and Review of Effects on Cardiovascular Disease
This article critically reviews the associations between androgen deprivation therapy, androgen receptor signaling inhibitors, and cardiovascular complications such as prolonged QT interval, atrial fibrillation, heart failure, atherosclerosis, coronary heart disease, venous thromboembolism, and peripheral arterial occlusive disease. These unfavorable outcomes reinforce the need for regular cardiovascular screening of patients undergoing androgen deprivation for the management of prostate cancer.PMID:38701845 | DOI:10.14423/SMJ.0000000000001687 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Richard Orji Alicia Morgans Eiman Jahangir Favor Markson Ayodeji Ilelaboye Alan Tan Tochukwu M Okwuosa Source Type: research
Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness
Cell Metab. 2024 Apr 24:S1550-4131(24)00130-X. doi: 10.1016/j.cmet.2024.04.010. Online ahead of print.ABSTRACTPerivascular collagen deposition by activated fibroblasts promotes vascular stiffening and drives cardiovascular diseases such as pulmonary hypertension (PH). Whether and how vascular fibroblasts rewire their metabolism to sustain collagen biosynthesis remains unknown. Here, we found that inflammation, hypoxia, and mechanical stress converge on activating the transcriptional coactivators YAP and TAZ (WWTR1) in pulmonary arterial adventitial fibroblasts (PAAFs). Consequently, YAP and TAZ drive glutamine and serine c...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Nesrine S Rachedi Ying Tang Yi-Yin Tai Jingsi Zhao Caroline Chauvet Julien Grynblat Kouam é Kan Firmin Akoumia Leonard Estephan St éphanie Torrino Chaima Sbai Amel Ait-Mouffok Joseph D Latoche Yassmin Al Aaraj Frederic Brau Sophie Ab élanet Stephan Cla Source Type: research
Clinical characterization and detection of subclinical atherosclerosis in subjects with extreme hyperalphalipoproteinemia
CONCLUSIONS: Men had a higher prevalence of CVRF than women, except for dyslipidemia. Subclinical atherosclerosis occurred in more than half of the series. Age, alcohol consumption and smoking were independently associated with the presence of plaque, however, our data do not show a significant influence of HDL-C levels.PMID:38702206 | DOI:10.1016/j.arteri.2024.03.005 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Javier Esp íldora-Hernández Tania D íaz-Antonio Jes ús Olmedo-Llanes Jes ús Zarzuela León Jos é Rioja Pedro Valdivielso Miguel Ángel Sánchez-Chaparro Mar ía José Ariza Source Type: research
Androgen Deprivation Therapy/Androgen Receptor Signaling Inhibitor Treatments for Prostate Cancer: Pathophysiology and Review of Effects on Cardiovascular Disease
This article critically reviews the associations between androgen deprivation therapy, androgen receptor signaling inhibitors, and cardiovascular complications such as prolonged QT interval, atrial fibrillation, heart failure, atherosclerosis, coronary heart disease, venous thromboembolism, and peripheral arterial occlusive disease. These unfavorable outcomes reinforce the need for regular cardiovascular screening of patients undergoing androgen deprivation for the management of prostate cancer.PMID:38701845 | DOI:10.14423/SMJ.0000000000001687 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Richard Orji Alicia Morgans Eiman Jahangir Favor Markson Ayodeji Ilelaboye Alan Tan Tochukwu M Okwuosa Source Type: research
Early detection of severe hypertriglyceridemia using teleconsultation in a clinical laboratory setting
CONCLUSION: This extensive study has identified a family at high risk of cardiovascular disease and acute pancreatitis. These findings can help maximize lifestyle changes and improve the clinical management of their dyslipidemia.PMID:38702205 | DOI:10.1016/j.arteri.2024.03.004 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Teresa Arrobas-Velilla Mar ía José Ariza Miguel Ángel Rico-Corral Pedro Valdivielso Source Type: research
Metabolic dysfunction-associated steatotic liver disease and atherosclerosis
Curr Diab Rep. 2024 May 3. doi: 10.1007/s11892-024-01542-6. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To update information about the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis. This review emphasizes the potential mechanisms linking MASLD with atherosclerosis and the possible causal relationships between these conditions.RECENT FINDINGS: An increased risk of cardiovascular disease is related to MASLD. Several molecular, cellular, and metabolic mechanisms have been described to explain the development of atherothrombosis in MASLD patients. These include ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Yulino Castillo-N úñez Paloma Almeda-Valdes Guillermo Gonz ález-Gálvez Mar ía Del Rosario Arechavaleta-Granell Source Type: research
