The role of C-peptide in the attenuation of outcomes of diabetic kidney disease: a systematic review and meta-analysis.
CONCLUSION: The results of the studies included in the systematic review diverged. However, the meta-analysis showed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels. PMID: 30106427 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 16, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Perioperative factors associated with delayed graft function in renal transplant patients.
CONCLUSIONS: Combined anesthesia technique, dialysis for more than 60 months, basiliximab, and cold ischemia time> 12 hours are risk factor for DGF, while liberal fluid regimens and kidneys from living donors are protective factors. PMID: 30106428 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 16, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The specific impact of uremic toxins upon cognitive domains: a review.
Authors: Franco ÁO, Starosta RT, Roriz-Cruz M Abstract One of the mechanisms proposed for chronic kidney disease (CKD)-related cognitive impairment is the accumulation of uremic toxins due to the deterioration of the renal clearance function. Cognition can be categorized into five major domains according to its information processing functions: memory, attention, language, visual-spatial, and executive. We performed a review using the terms 'uric acid', 'indoxyl sulfate', 'p-cresyl sulfate', 'homocysteine', 'interleukins' and 'parathyroid hormone'. These are the compounds that were found to be strongly assoc...
Source: Jornal Brasileiro de Nefrologia - August 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

ANCA associated vasculitis: experience of a tertiary care referral center.
Authors: Chaudhry R, Bilal A, Austin A, Mehta S, Salman L, Foulke L, Feustel P, Zuckerman R, Asif A Abstract BACKGROUND AND OBJECTIVES: Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis is a small vessel vasculitis with insufficient epidemiologic estimates in the United States. We aimed to determine demographic and clinical features of ANCA associated vasculitis patients presenting to a large tertiary care referral center in Upstate New York. Design, setting, participants, and measurements: A retrospective analysis of cases with pauci-immune GN on renal biopsy and clinical diagnosis of ANCA va...
Source: Jornal Brasileiro de Nefrologia - August 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The impact of dialysis on critically ill elderly patients with acute kidney injury: an analysis by propensity score matching.
CONCLUSIONS: The data suggested that dialysis did not seem to impact the death rates of critically ill patients with AKI aged 70+ years. PMID: 30080913 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Evaluation of variables associated with the patency of arteriovenous fistulas for hemodialysis created by a nephrologist.
CONCLUSION: Hemoglobin level in the recommended range has a favorable impact on late AVF patency and elevated blood pressure during surgery on the lower number of vascular accesses per patient. The high success rate indicates that it can be placed by trained nephrologists. PMID: 30080914 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Cerebral Venous Sinus Thrombosis in a Child with Idiopathic Nephrotic Syndrome: a case report.
This report describes the case of a 5-year-old girl with NS for the first time presenting with severe hypoalbuminemia (
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effectiveness of the monitoring program for ensuring the quality of water treated for dialysis in the state of S ão Paulo.
CONCLUSION: The design adopted in the state monitoring program is highly effective based on new collections after the joint actions of the Sanitary Surveillance System and the State Dialysis Services. PMID: 30080916 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

APOL1 risk variants and kidney disease: what we know so far.
Authors: Siemens TA, Riella MC, Moraes TP, Riella CV Abstract There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carrie...
Source: Jornal Brasileiro de Nefrologia - July 28, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Conservative management for patients with chronic kidney disease refusing dialysis.
Authors: Castro MCM Abstract Estimates suggest that 20-30% of the deaths of patients with chronic kidney disease with indication to undergo dialysis occur after refusal to continue dialysis, discontinuation of dialysis or inability to offer dialysis on account of local conditions. Contributing factors include aging, increased comorbidity associated with chronic kidney disease, and socioeconomic status. In several occasions nephrologists will intervene, but at times general practitioners or family physicians are on their own. Knowledge of the main etiologies of chronic kidney disease and the metabolic alterations an...
Source: Jornal Brasileiro de Nefrologia - July 27, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.
We describe a 54-year-old liver transplant patient that was admitted with flaccid muscle weakness associated with plasma potassium level of 9.25 mEq/L. Additional investigation revealed type 4 renal tubular acidosis and marked hypomagnesemia with high fractional excretion of magnesium. Relevant past medical history included a recent diagnosis of Paracoccidioidomycosis, a systemic fungal infection that is endemic in some parts of South America, and his outpatient medications contained trimethoprim-sulfamethoxazole, tacrolimus, and propranolol. In the present acid-base and electrolyte case study, we discuss a clinical approa...
Source: Jornal Brasileiro de Nefrologia - July 27, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report.
CONCLUSIONS: Although the lesions are mostly benign, they may increase the morbidity and mortality of these patients, so a proper diagnosis and early treatment are extremely important. PMID: 30010691 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The relationship between proton pump inhibitors and renal disease.
Authors: Morschel CF, Mafra D, Eduardo JCC Abstract Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze re...
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients.
Authors: Lopez ED, Córdova-Cázarez C, Valdez-Ortiz R, Cardona-Landeros CM, Gutiérrez-Rico MF Abstract AIM: To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients. METHODS: Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The intricate relationship between gut and kidney.
Authors: Cunha RS, Stinghen AEM PMID: 29958303 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Probiotics in the treatment of chronic kidney disease: a systematic review.
This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included a...
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The impact of surgical intervention on renal function in cystinuria.
CONCLUSIONS: Surgical interventions for urinary stones are commonly required in patients with cystinuria. Renal scarring is a prevalent finding in cystinuric patients. Surgical interventions have no negative impact on eGFR in patients with cystinuria according to the present study. PMID: 29958305 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effects of Low-Protein Diet on lipid and anthropometric profiles of patients with chronic kidney disease on conservative management.
CONCLUSION: LPD prescribe to non-dialysis CKD patients for six months was able to improve some cardiovascular risk factors as overweight and plasma lipid profile, suggesting that LPD can be also an important tool for protection against cardiovascular diseases in these patients. PMID: 29944154 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Understanding the causes of mortality post-transplantation - there is more than meets the eye.
Authors: Riella LV PMID: 29944155 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

High Flow and volume overload: The saga continues.
Authors: Cheng J, Costanzo EJ, Vachharajani TJ, Asif A PMID: 29944156 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Solitary functioning kidney in children: clinical implications.
CONCLUSION: Children with SFK have high morbidity especially when associated with ipsilateral CAKUT. Long-term periodical follow up is essential in these patients to improve clinical outcome. PMID: 29944157 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The importance of histopathology in the diagnosis of isolated renal sarcoidosis: a case report.
CONCLUSIONS: The use of histopathology together with clinical and laboratory data to diagnose isolated renal sarcoidosis, rule out other etiologies and introduce early treatment is of paramount importance. PMID: 29944158 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis.
Authors: Gonsalez SR, Ferrão FM, Souza AM, Lowe J, Morcillo LDSL Abstract Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the mol...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases.
Authors: Pereira C, Gil J, Leal I, Costa-Reis P, Silva JEED, Stone R Abstract Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosis. Urinary β2-microglobulin levels may be particularly useful. Uveitis, mostly anterior, nongranulomatous and bilateral, occurs usually after the onset of nephritis. Treatment includes corticosteroids and, eventually, other immunosuppressant agents...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder.
CONCLUSION: parathyroidectomy is a safe and reproducible surgical procedure even in the absence of adjuvant techniques. PMID: 29944161 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

In vitro effect of uremic serum on barrier function and inflammation in human colonocytes.
Authors: Andrade LS, Dalboni MA, Carvalho JTG, Grabulosa CC, Pereira NBF, Aoike DT, Cuppari L Abstract INTRODUCTION: In chronic kidney disease (CKD), it has been suggested that alterations within the gut are associated with an inflammatory state and uremic toxicity. Studies suggest that uremia may impair the function of the intestinal barrier via the promotion of increased intestinal permeability. To understand the mechanisms that are involved in intestinal barrier damage in the setting of uremia, we evaluated the in vitro effect of uremic serum on transepithelial electrical resistance (TER), inflammation, and apop...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review.
Authors: Balbino KP, Hermsdorff HHM, Bressan J Abstract Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular cal...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

NOS3 Polymorphisms and Chronic Kidney Disease.
Authors: Medina AM, Zubero EE, Jiménez MAA, Barragan SAA, García CAL, Ramos JJG, Gutierrez JFS, Castillo ZG Abstract Chronic kidney disease (CKD) is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized b...
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Validated registry of pre-dialysis chronic kidney disease: description of a large cohort.
CONCLUSION: Validated data are of vital importance for health managers to monitor users. The population of this study is predominantly elderly, obese, requiring multi-professional care to slow the progression of the disease and decrease morbidity and mortality. PMID: 29927457 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The influence of clinical, environmental, and socioeconomic factors on five-year patient survival after kidney transplantation.
CONCLUSION: This analysis confirmed that in this population, infection is the leading cause of mortality over the first 5 years after kidney transplantation. Several demographic and socioeconomic risk factors were associated with death, most of which are not readily modifiable. PMID: 29927458 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Evaluation of the 1000 renal transplants carried out at the University Hospital of the Botucatu Medical School (HCFMB) - UNESP and their evolution over the years.
CONCLUSION: There was a significant increase in the number of transplants, with evolution in graft survival, despite the worsening in the profiles of recipients and donors. PMID: 29927459 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Are high flow arteriovenous accesses associated with worse haemodialysis?
CONCLUSION: Our results suggest that patients with HFA have higher risk of volume overload. However, contrarily to what has been postulated, HFA was not associated with less efficient dialysis, measured by Kt/V. Randomized controlled trials are needed to clarify these questions. PMID: 29927460 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The enigma of aluminum deposition in bone tissue from a patient with chronic kidney disease: a case report.
The objective of this case report is to alert the medical community about a potential high prevalence of Al deposition in bone tissue and to discuss the possible sources of contamination in patients with chronic kidney disease (CKD). PMID: 29927461 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

CD77 levels over enzyme replacement treatment in Fabry Disease Family (V269M).
CONCLUSION: The increased CD77 levels in the phagocytes of Fabry carriers together with the decrease in CD77 levels throughout ERT suggest that measuring CD77 levels in phagocytes is a promising tool for monitoring the response to ERT in FD. PMID: 29927462 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Expenses of the Brazilian Public Healthcare System with chronic kidney disease.
CONCLUSION: Renal diseases and some of the main related diseases corresponded to 12.97% of the expenses in the triennium 2013-2015, and RRT to more than 5% of the SUS expenses with medium and high complexity healthcare. Such high expenses determine great concerns on the future maintenance of treatment for stage-5 CKD in Brazil and countries in similar or worse conditions of development. PMID: 29927463 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers.
CONCLUSION: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. These data indicate the need for better compliance with clinical guidelines and public policies on the supply of drugs associated with CKD-MBD. PMID: 29796575 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Clinical and laboratory features of urinary tract infections in young infants.
CONCLUSIONS: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI. PMID: 29796576 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Sepsis-like histoplasmosis in a kidney transplant patient.
Authors: Fernandes AR, Viana LA, Mansur JB, Françoso MM, Santos DWCL, Silva HT, Pestana JOM Abstract Histoplasmosis is a fungus infection that mainly affects immunosuppressed patients. The authors present a case of a kidney transplant recipient who developed sepsis-like histoplasmosis, na atypical but severe manifestation of the disease. The fungus was found in blood and in a skin biopsy, and the treatment with liposomal amphotericin resulted in hepatotoxicity. PMID: 29796577 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Quantitative detection of BK virus in kidney transplant recipients: a prospective validation study.
CONCLUSION: Our study shows that marked variability occurs in BKV viral load when different qPCR methodologies are used. The in-house qPCR assay proved clinically useful, a cheaper option in comparison to commercial qPCR kits. There is an urgent need to make BKV standards available to the international community. PMID: 29796578 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report.
We present a case report of an asymptomatic renal oncocytoma in a kidney transplant recipient presenting persistent hematuria. The features of computed tomography and contrast-enhanced ultrasound (CEUS) are presented. This was the first time we used CEUS in a transplant kidney recipient presenting a renal mass, allowing the real-time visualization of contrast-enhancement patterns during all vascular phases for the differential diagnosis of renal tumors. Although the pattern of intense vascularization could mislead to an early judgment as a malignant lesion, it could help to exclude other renal lesions without inducing neph...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study.
CONCLUSION: These data suggest that intense intradialytic strength exercise was unable to increase the circulating concentration of irisin in HD patients. Moreover, our data show that after one hour of dialysis session, irisin plasma levels may be reduced. PMID: 29796580 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Complement activation in atypical hemolytic uremic syndrome and scleroderma renal crisis: a critical analysis of pathophysiology.
This article reviews the role of complement system in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis, and calls for heightened awareness to the development of thrombotic angiopathy in patients with scleroderma. PMID: 29796581 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Oral infection by Pseudomonas aeruginosa in patient with chronic kidney disease - a case report.
Authors: Souza LCD, Lopes FF, Bastos EG, Alves CMC Abstract Chronic renal patients are more susceptible to hospital complications and infections such as urinary tract infections, peritonitis, surgery infections, and bacteremia, which are often caused by Pseudomonas aeruginosa. A case of a HIV-positive girl with chronic kidney disease and with serious oral lesions due to P. aeruginosa septic shock is presented. The patient showed necrotic lesions in the oral mucosa, pathological tooth mobility, bone loss, and hematogenous osteomyelitis in the maxilla. The patient was submitted to systemic antibiotic therapy based on...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Influence of nutritional status, laboratory parameters and dietary patterns upon urinary acid excretion in calcium stone formers.
CONCLUSION: The endogenous production of OA and not an acidogenic diet were found to be independently predictive factors for lower urinary pH levels in calcium stone formers. Hypercalciuric and/or hyperuricosuric patients presented higher OA levels and lower levels of urinary pH. PMID: 29796583 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion.
CONCLUSION: Low intake of BN prior to IR-induced kidney injury improves renal function by inhibition of macrophage infiltration and oxidative stress. PMID: 29796584 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Posterior reversible leukoencephalopathy syndrome (PRES) after kidney transplantation: a case report.
CONCLUSION: PRES is an unusual complication after organ transplantation and should be considered in the appropriate clinical setting. Physicians must be aware of this condition in order to provide early detection and appropriate treatment since delay in removing the cause may lead to permanent sequelae. PMID: 29796585 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
CONCLUSIONS: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients. PMID: 29796586 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

First stages chronic kidney disease have mild effects on cognitive performance. Results of a 15,105 brazilian adult baseline cohort.
Authors: Passos VMA, Ladeira RM, Souza CCV, Santos IS, Barreto SM Abstract INTRODUCTION: The aging of the population may lead to an increased prevalence of dementia and chronic kidney disease (CKD) and their overlap. OBJECTIVE: We investigated the association between CKD and cognitive performance among Brazilian adults (35-74 years). METHODS: Baseline data analysis of the Longitudinal Study of Adults (ELSA-Brasil), a multicenter cohort comprising 15,105 civil servants, was performed. Kidney function was defined by the CKD-Epi-estimated GRF and albumin creatinin ratio (ACR). Cognitive performance was measure...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

CKD-MBD in Brazil: the gap between reality and the recommended guidelines.
Authors: Custódio MR PMID: 29796588 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

IgA Nephropathy in Salvador, Brazil. Clinical and laboratory presentation at diagnosis.
CONCLUSION: The prevalence of IgAN was lower in Salvador than other regions of Brazil. Chronic histological lesions and laboratory markers of severe disease were frequent. M1 and T2 MEST-C scores were correlated with markers of renal dysfunction. PMID: 29782630 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research