Are the Latin American recommendations for the management of patients infected with COVID -19 on hemodialysis realistic in health systems with limited resources?
Authors: Herrera-Añazco P, Rabanal CL, Benites-Zapata VA PMID: 32941592 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 18, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Screening of family members of chronic kidney disease patients with Fabry disease mutations: a very important and underrated task.
CONCLUSION: We found a prevalence of Fabry disease in 9.47% of relatives of CKD patients with this condition, remarkably with a 66.1% predominance of women, which contrasts with previous reports. The screening of family members of FD patients is important, since it can lead to early diagnosis and treatment, thus allowing better quality of life and improved clinical outcomes for these individuals. PMID: 32930322 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 17, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Vitamin D-dependent rickets (VDDR) type 1: case series of two siblings with a CYP27B1 mutation and review of the literature.
Authors: Dhull RS, Jain R, Deepthi B, Cheong HI, Saha A, Mehndiratta M, Basu S Abstract Two siblings presented with clinical and biochemical features of rickets, initially suspected as hypophosphatemic rickets. There was no improvement initially, hence the siblings were reinvestigated and later diagnosed as having vitamin D-dependent rickets (VDDR) type 1 due to a rare mutation in the CYP27B1 gene encoding the 1α-hydroxylase enzyme. Both siblings improved with calcitriol supplementation. The initial presentation of VDDR is often confusing and algorithmic evaluation helps in diagnosis. We also present a brief ...
Source: Jornal Brasileiro de Nefrologia - September 15, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Biomarkers of acute kidney injury in patients with nephrotic syndrome.
CONCLUSIONS: Neutrophil gelatinase associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) estimates correlated with histological signs of ATN and were able to discriminate patients with AKI even in conditions of NS. Furthermore, urinary levels of NGAL and KIM-1 may be useful in the differential diagnosis of acute tubular necrosis and exudative glomerulonephritis in patients with nephrotic syndrome. PMID: 32926065 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 15, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Post-antibiotic era in hemodialysis? Two case reports of simultaneous colonization and bacteremia by multidrug-resistant bacteria.
We report the simultaneous colonization and bacteremia by multidrug-resistant bacteria in two hemodialysis patients. The first patient was colonized by carbapenem- and colistin-resistant Klebsiella pneumoniae, carbapenem-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (MRSA). The patient had a bacteremia by MRSA, and molecular typing methods confirmed the colonizing isolate was the same strain that caused infection. The second case is of a patient colonized by extended-spectrum beta-lactamases (ESBL)-producing Escherichia coli and carbapenem-resistant Pseudomonas aeruginosa. During the fol...
Source: Jornal Brasileiro de Nefrologia - September 15, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Making a case for the combined use of SGLT2 inhibitors and GLP1 receptor agonists for cardiorenal protection.
Authors: Sridhar VS, Dubrofsky L, Boulet J, Cherney DZ Abstract Sodium glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RA) were initially approved to improve glycemic control in the treatment of type 2 diabetes. Clinical trials have also demonstrated beneficial effects with regards to cardiovascular and renal parameters. Beyond improving glycemic control, these therapies promote weight loss and lower blood pressure when used individually, and in an additive manner when used together. Accordingly, taking advantage of complementary mechanisms of action with the combined ...
Source: Jornal Brasileiro de Nefrologia - September 15, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Regional differences in Acute Kidney Injury incidence and mortality in developing countries: recent trends.
Authors: Macedo E, Mehta RL PMID: 32926068 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 15, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Kidney supportive care: an update of the current state of the art of palliative care in CKD patients.
Authors: Tavares APDS, Santos CGDS, Tzanno-Martins C, Barros Neto J, Silva AMMD, Lotaif L, Souza JVL Abstract Chronic kidney disease (CKD) has become a public health burden worldwide for its increasing incidence and prevalence, high impact on the health related quality of life (HRQoL) and life expectancy, and high personal and social cost. Patients with advanced CKD, in dialysis or not, suffer a burden from symptoms very similar to other chronic diseases and have a life span not superior to many malignancies. Accordingly, in recent years, renal palliative care has been recommended to be integrated in the traditiona...
Source: Jornal Brasileiro de Nefrologia - September 10, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

X-linked hypophosphatemic rickets: a new mutation.
Authors: Maio P, Mano L, Rocha S, Baptista RB, Francisco T, Sousa H, Freixo JP, Abranches M Abstract Phosphopenic rickets may be caused by mutations in the PHEX gene (phosphate regulating endopeptidase homolog X-linked). Presently, more than 500 mutations in the PHEX gene have been found to cause hypophosphatemic rickets. The authors report a clinical case of a 4-year-old girl with unremarkable family history, who presented with failure to thrive and bowing of the legs. Laboratory tests showed hypophosphatemia, elevated alkaline phosphatase, normal calcium, mildly elevated PTH and normal levels of 25(OH)D and 1.25(...
Source: Jornal Brasileiro de Nefrologia - September 10, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The disparity of measuring bone mineral content using bioimpedance and dual-energy absorptiometry in the context of hyperparathyroidism.
DISCUSSION: BIA should be interpreted with caution in patients with SHPT due to a loss of accuracy, which can compromise the interpretation of body composition. PMID: 32877488 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The Brazilian Society of Nephrology and the Covid-19 Pandemic.
Authors: Abreu AP, Riella MC, Nascimento MMD PMID: 32877489 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Recommendations from the Brazilian Society of Nephrology for approaching Covid-19 Diagnostic Testing in Dialysis Units.
Authors: Moura-Neto JA, Palma LMP, Marchiori GF, Stucchi RSB, Misael AM, D'Avila R, Silva DRD, Andreoli MCC, Kraychete A, Bastos K, Nascimento MMD Abstract The Covid-19 pandemic brought several challenges to the healthcare system: diagnosis, treatment and measures to prevent the spread of the disease. With the greater availability and variety of diagnostic tests, it is essential to properly interpret them. This paper intends to help dialysis units concerning the use of clinical criteria and diagnostic tests for decision making regarding the discontinuation of isolation of patients with suspected or confirmed Covid-...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Recommendations from the Brazilian Society of Nephrology regarding the use of cloth face coverings, by chronic kidney patients in dialysis, during the new coronavirus pandemic (Covid-19).
Authors: Abreu AP, Moura Neto JA, Delfino VDA, Palma LMP, Nascimento MMD Abstract These recommendations were created after the publication of informative note 3/2020- CGGAP/DESF/SAPS/MS, of April 4, 2020, in which the Brazilian Ministry of Health recommended the use of a cloth mask by the population, in public places. Taking into account the necessary prioritization of the provision of Personal Protective Equipment (PPE) for patients with suspected or confirmed disease, as well as for healthcare professionals, the SBN is favorable concerning the wear of cloth masks by chronic kidney patients in dialysis, in public ...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Covid-19 (Sars-Cov-2 Infection) Information for Patients with Predialytic Chronic Kidney Disease.
Authors: Delfino VDA, Nascimento MMD, Barros Neto JR Abstract Patients with Chronic Kidney Disease are among those individuals at increased risk for developing more serious forms of Covid-19. This increased risk starts in the pre-dialysis phase of the disease. Providing useful information for these patients, in language that facilitates the understanding of the disease, can help nephrologists and other healthcare professionals to establish a more effective communication with these patients and help minimize contagion and the risks of serious illness in this population. PMID: 32877492 [PubMed - in process] (Sour...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Good Practice Recommendations from the Brazilian Society of Nephrology to Dialysis Units Concerning the Pandemic of the New Coronavirus (Covid-19).
Authors: Moura-Neto JA, Abreu AP, Delfino VDA, Misael AM, D'Avila R, Silva DRD, Andreoli MCC, Kraychete A, Bastos K, Nascimento MMD Abstract Dialysis units are environments potentially prone to the spread of Covid-19. Patients cannot suspend treatment, and they often have comorbidities, which assigns them a higher risk and worse prognosis. The Brazilian Society of Nephrology prepared this document of good practices, whose technical recommendations deal with general measures that can be implemented to reduce the risk of transmission and prevent the spread of the disease in the unit. PMID: 32877493 [PubMed - in p...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Good practices recommendations from the Brazilian Society of Nephrology to Peritoneal Dialysis Services related to the new coronavirus (Covid-19) epidemic.
Authors: Calice-Silva V, Cabral AS, Bucharles S, Moura-Neto JA, Figueiredo AE, Franco RP, Abreu AP, Nascimento MMD Abstract Considering the new coronavirus epidemic (Covid-19), the Brazilian Society of Nephrology, represented by the Peritoneal Steering Committee, in agreement with the and the Dialysis Department, developed a series of recommendations for good clinical practices for peritoneal dialysis (PD) clinics, to be considered during the period of the Covid-19 epidemic. We aim to minimize the disease spread, protecting patients and staff, and ensuring the quality of the treatment provided and adequate follow-u...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine.
Authors: Suassuna JHR, Lima EQ, Rocha E, Castro A, Burdmann EA, Carmo LPFD, Yu L, Ibrahim MY, Betônico GN, Cuvello Neto AL, Ávila MON, Gonçalvez ARR, Costa CBS, Bresolin NL, Abreu AP, Lobo SMA, Nascimento MMD Abstract We produced this document to bring pertinent information to the practice of nephrology, as regards to the renal involvement with COVID-19, the management of acute kidney injury cases, and practical guidance on the provision of dialysis support.As information on COVID-19 evolves at a pace never before seen in medical science, these recommendations, although based on recent scientifi...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Recommendations Of The Brazilian Society Of Nephrology Regarding Pediatric Patients On Renal Replacement Therapy During The Covid-19 Pandemic.
We present the recommendations of the Brazilian Society of Nephrology regarding the treatment of pediatric patients with kidney diseases during the COVID-19 pandemic. METHODS: Articles and documents from medical societies and government agencies on specific recommendations for children on RRT in relation to COVID-19 as well as those focused on epidemiological aspects of this condition in Brazil Were evaluated and analyzed. RESULTS: We present recommendations on outpatient care, transportation to dialysis centers, peritoneal dialysis, hemodialysis, and kidney transplantation in children and adolescents during the CO...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

COMDORA-SBN recommendations for patients with rare kidney diseases in relation to the Covid-19 pandemic.
Authors: Colares VS, Miranda SM, Andrade LGM, Palma LMP, Castro MCR, Silva CAB, Penido MGMG, Sobral R, Vaisbich MH Abstract During the Covid-19 pandemic, the issue is how to maintain adequate care for people with other diseases. In this document, the SBN Rare Diseases Committee (COMDORA) gives some guidelines on the care of patients with rare kidney diseases. These patients should follow the recommendations for the general population, bearing in mind that, as they have chronic kidney disease, they are included in the risk group for more serious outcomes if they develop Covid-19. Non-essential decision-making proced...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Hemodialysis Vascular access maintenance in the Covid-19 pandemic: Positioning paper from the Interventional Nephrology Committee of the Brazilian Society of Nephrology.
Authors: Franco RP, Costa CBS, Sousa CS, Rodrigues AT, Neves PDMM, Chula DC Abstract Vascular accesses for hemodialysis are considered the patient's lifeline and their maintenance is essential for treatment continuity. Following the example of institutions in other countries affected by the Covid-19 pandemic, the Brazilian Society of Nephrology developed these guidelines for healthcare services, elaborating on the importance of carrying out procedures for the preparation and preservation of vascular accesses. Creating definitive accesses for hemodialysis, grafts and arteriovenous fistulas are non-elective procedure...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Palliative Renal Care and the Covid-19 Pandemic.
CONCLUSION: The principles of palliative care are essential to face the challenges of a planet-wide crisis, which raises human suffering in all dimensions, and which requires the construction of strategies that can keep patients assisted, comfortable and with measures proportional to their clinical condition and preferences. PMID: 32877499 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Position Paper of the Department of Hypertension of the Brazilian Society of Nephrology: Use of renin-angiotensin system blockers during the course of Covid-19 infection.
Authors: Rodrigues CIS Abstract This position statement of the Department of Hypertension of the Brazilian Society of Nephrology (SBN) addresses the controversy surrounding the use or suspension/replacement of the renin-angiotensin-aldosterone system blockers (particularly inhibitors of the angiotensin-converting enzyme or angiotensin II AT1 receptor blockers) prophylactically in individuals using these drugs, due to the possibility of allegedly worsening the prognosis of hypertensive patients infected with SARS-CoV-2. The SBN Hypertension Department recommends individualizing treatment and maintaining these medica...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Position statement from the Brazilian Society of Nephrology regarding chloroquine and hydroxychloroquine drug dose adjustment according to renal function.
Authors: Moura-Neto JA, Misael AM, Silva DRD, D'Avila R, Andreoli MCC, Kraychete A, Bastos K, Nascimento MMD Abstract Chloroquine and hydroxychloroquine have shown promising preliminary results and have been discussed as therapeutic options for patients with Covid-19. Despite the lack of robust evidence demonstrating the benefits and justifying the use of one of these drugs, the final decision is the responsibility of the attending physician and should be individualized and shared, whenever possible. This position statement recommends dosage adjustment for these drugs in the context of renal impairment. PMID: 3...
Source: Jornal Brasileiro de Nefrologia - September 4, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Covid-19 pandemic: from carnival masks to surgical masks.
Authors: Tzanno-Martins C Abstract Given the high transmissibility of SARS-CoV-2, COVID-19 pandemic has a huge impact on our health system. Even in developed countries, strategic resources soon become insufficient. Although people over 60 and with comorbidities are at greater risk of developing severe forms, younger people may also require precious and scarce care. Hence, the World Health Organization recommend tests - PCR and serological tests - for detecting infected people on a large scale. The most common symptoms are fever, fatigue, dry cough, anorexia, myalgia, and dyspnea, with tomographic pulmonary findings...
Source: Jornal Brasileiro de Nefrologia - September 2, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The conundrum of parathyroidectomy vs cinacalcet for treatment of post-transplant hyperparathyroidism.
Authors: Patel R, Santos RD PMID: 32840556 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 26, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Urine hepcidin, netrin-1, neutrophil gelatinase-associated lipocalin and C-C motif chemokine ligand 2 levels in multicystic dysplastic kidney.
CONCLUSIONS: MCP-1/CCL-2 may play a role in the development of proteinuria in MCDK. Netrin-1 may be a protective factor against proteinuria-induced renal injury. Urine hepcidin/Cr may reflect proximal tubule damage in MCDK. Urine NGAL/Cr may be a predictor of tubule damage by proteinuria. PMID: 32818222 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 22, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Nephrotic syndrome after insect sting: a case report.
We present a case report of a woman with new onset of nephrotic syndrome after a non-hymenoptera insect sting, with biopsy-proven minimal change disease, that was accompanied by a pulmonary thromboembolism process. Complete remission with glucocorticoid therapy was observed, with sustained response for 6 months after discontinuation. A new exposure to insect sting in the same geographical region and season triggered a nephrotic syndrome relapse. Subsequent avoidance of the place resulted in a sustained remission for more than 4 years. PMID: 32818223 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 22, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO.
CONCLUSION: Hospitalization or death was not influenced by the type of RO, Al accumulation, or TMV classification. An elevated prevalence of osteoporosis and Al accumulation was detected. PMID: 32756862 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Idiopathic nodular glomerulosclerosis and differential diagnosis.
CONCLUSIONS: ING is a rare disease with a poor renal prognosis and wide diagnostic approach; we highlight the importance of analyzing every piece of detail together to reach a definitive diagnosis. PMID: 32776085 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pregnancy and dialysis.
Authors: Ribeiro CI, Silva N Abstract The pregnancy rate of women on dialysis is still very low when compared to that of the remaining population. However, recent years have seen an increase in the success rates of these pregnancies. Among the main precautions that must be taken with pregnant women on dialysis are the maintenance of low levels of pre-dialysis urea, the adequacy of the tension profile, the control of anemia and care to avoid infections, nutritional deficits, changes in phosphorus-calcium metabolism and electrolytic fluctuations. It is also necessary to strictly monitor fetal growth and development. ...
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Non-adherence to hemodialysis, perception of the illness, and severity of advanced nephropathy.
Authors: Dantas LG, Rocha MS, Cruz CMS Abstract INTRODUCTION: Hemodialysis (HD) is a complex therapy that imposes several changes in the patient's life. Failure to follow therapy recommendations is called non-adherence (NA). The patient's illness perception, severity of chronic kidney disease, and individual strategies for coping with HD can have an impact on NA to the demands of therapy. METHODS: This was a cross-sectional study with end-stage renal disease patients on conventional HD in Salvador, Bahia. We evaluated attendance to treatment and interdialytic weight gain (IDWG) as parameters of NA to HD, and in...
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Intraoperative oliguria does not predict postoperative acute kidney injury in major abdominal surgery: a cohort analysis.
CONCLUSION: In this cohort of patients we demonstrated that intraoperative oliguria does not predict postoperative AKI in major abdominal surgery. PMID: 32779689 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Case reports of hypercalcemia and chronic renal disease due to cosmetic injections of polymethylmethacrylate (PMMA).
Authors: Manfro AG, Lutzky M, Dora JM, Kalil MAS, Manfro RC Abstract Cosmetic injections of fillers are common plastic surgery procedures worldwide. Polymethylmethacrylate (PMMA) is a filler approved only for minimally invasive procedures in facial tissue and is among the most frequently used injectable substances for cosmetic purposes. Injection of a large volume of PMMA may lead to the development of severe hypercalcemia and chronic kidney damage in a probably underestimated frequency. In such cases, hypercalcemia develops due to a granulomatous foreign body reaction with extrarenal production of calcitriol. In t...
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Nephrotic syndrome associated with primary atypical hemolytic uremic syndrome.
We present here a pediatric patient diagnosed with primary atypical hemolytic-uremic syndrome associated with nephrotic syndrome who responded to eculizumab treatment. PMID: 32779691 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Metabolic acidosis in patients with kidney disease.
Authors: Leon SJ, Tangri N PMID: 32779692 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 13, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Non-recovery of renal function is a strong independent risk factor associated with mortality in AKI patients.
Authors: Santos RPD, Carvalho ARDS, Peres LAB, Delfino VDA, Grion CMC Abstract INTRODUCTION: Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes. OBJECTIVE: To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU. METHODS: The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December 2016 of at least 18 years old upon admission and who remained in the ICU at least 48 hours. Comparisons between selected characteristics of survivo...
Source: Jornal Brasileiro de Nefrologia - July 30, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Association between interleukin-6 gene polymorphism and iron regulation in hemodialysis patients infected with HCV.
CONCLUSIONS: Our study indicated that IL-6 -174 G/C and -597 G/A polymorphisms may play a role in HCV susceptibility in HD patients. Additional prospective studies on a larger population are needed to confirm our findings. PMID: 32720970 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 30, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Therapy for persistent hypercalcemic hyperparathyroidism post-renal transplant: cinacalcet versus parathyroidectomy.
Authors: Rivelli GG, Lima ML, Mazzali M Abstract BACKGROUND: Persistent hyperparathyroidism post-transplant is associated with increases in the incidence of cardiovascular events, fractures, and deaths. The aim of this study was to compare both therapeutic options available: parathyroidectomy (PTX) and the calcimimetic agent cinacalcet. METHODS: A single center retrospective study including adult renal transplant recipients who developed hypercalcemia due to persistent hyperparathyroidism. Inclusion criteria: PTH> 65 pg/mL with serum calcium> 11.5 mg/dL at any time after transplant or serum calcium persis...
Source: Jornal Brasileiro de Nefrologia - July 30, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Influence of socioeconomic disparities, temperature and humidity in kidney stone composition.
Authors: Cunha TDS, Rodriguez A, Heilberg IP Abstract INTRODUCTION: Large variations in demographic, economic and environmental factors might influence the worldwide distribution of urolithiasis, but scarce data are available concerning their associations with stone composition. We aimed to evaluate the frequency and composition of kidney stones and their associations with temperature, humidity, and human development index (HDI). MATERIALS AND METHODS: A total of 1,158 stones from distinct patients (47±14 years old, male/female 2:1) were included. The mean annual temperature and relative humidity of each...
Source: Jornal Brasileiro de Nefrologia - July 29, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Prevalence of abnormalities in electrocardiogram conduction in dialysis patients: a comparative study.
CONCLUSION: To our knowledge, this is the first study to report that ECG conduction intervals are significantly longer as one progresses from CKD Stage 1 and 2, to PD, to HD. These and other data support the need for future research to utilize ECG conduction times to identify dialysis patients who could potentially benefit from proactive cardiac evaluations and risk reduction. PMID: 32716472 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 29, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effect of febuxostat on renal function in patients from South China with CKD3 diabetic nephropathy.
Authors: Wen H, Yongling Z, Shuying Z, Jiali W, Yanling Z Abstract OBJECTIVE: To investigate the efficacy and safety of febuxostat on renal function in CKD stage 3 diabetic nephropathy patients. METHODS: Patients in our hospital with chronic kidney disease (CKD) stage 3 diabetic nephropathy (DN) complicated by high serum uric acid (360 µmol/L) were recruited. Patients were then divided into treatment group and control group according to the random number table method. All the patients received low purine diet, renin-angiotensin-aldosterone system (RAAS) inhibitors, and adequate routine hypoglycemic treatm...
Source: Jornal Brasileiro de Nefrologia - July 25, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Handgrip strength as an instrument for assessing the risk of malnutrition and inflammation in hemodialysis patients.
Authors: Sostisso CF, Olikszechen M, Sato MN, Oliveira MASC, Karam S Abstract INDRODUCTION: Establishing which parameters to use for diagnosing malnutrition in hemodialysis patients is a challenge in clinical practice. The handgrip strength (HGS) has stood out as a method of assessing nutritional status. Thus, the aim of this study was to determine the cut-off point for HGS in the assessment of the risk of malnutrition and inflammation in HD patients, and its association with other parameters. METHODS: Study carried out in hemodialysis units in the city of Curitiba, Brazil. We obtained the cut-off point of the ...
Source: Jornal Brasileiro de Nefrologia - July 17, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Twin pregnancy after kidney transplantation: case report and systematic review.
CONCLUSION: Twin pregnancies after kidney transplantation are rare, and it is most frequently associated with preterm birth. We reported a successful twin pregnancy after kidney transplantation, with good perinatal and maternal outcomes, and without graft rejection or dysfunction. PMID: 32672328 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 17, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Multiple extremity necrosis in fatal calciphylaxis: Case report.
CONCLUSION: The preventive strategy is fundamental, since the therapy is complex with poorly validated effectiveness. PMID: 32645129 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 10, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Conventional physical examination extended by bedside ultrasound: a new paradigm in nephrological practice.
We report the case of a patient with nephrotic syndrome secondary to amyloidosis, previously diagnosed by renal biopsy, who was oligosymptomatic when seen the an outpatient clinic, where the POCUS, focused on the heart, lung and abdomen, revealed anasarca, pulmonary congestion and cardiac changes suggestive of cardiac amyloidosis. After evaluation by the cardiology and hematology services, the diagnosis of AL amyloidosis with cardiac involvement was confirmed. This case emphasizes the importance of extending the physical examination using POCUS, which, ideally, should not be restricted to the urinary tract. PMID: 32645...
Source: Jornal Brasileiro de Nefrologia - July 10, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Urgent vs. early-start peritoneal dialysis: patients' profile and outcomes.
CONCLUSION: Fifty five percent of our sample started PD less than 72 hours after catheter insertion. The lack of difference in the measured outcomes compared to patients that had therapy initiated after this period encourages the use of urgent PD when needed. PMID: 32602882 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 2, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Rapidly progressive glomerulonephritis and acute kidney injury associated with cocaine use - Case report.
We report a case of a 38-year-old man chronic user of cocaine, alcohol, and cigarettes who had red urine, oliguria, swollen legs and eyelids, as well as the uremic symptoms anorexia, emesis, and mental confusion. He was admitted with acute kidney injury and performed six hemodialysis sessions during the first 16 days of hospitalization and then was transferred to a tertiary hospital for diagnostic investigation. Tests of ANF (antinuclear factor), ANCA, anti-DNA, serology for hepatitis B, C, and HIV virus were negative. A renal percutaneous biopsy revealed crescentic glomerulonephritis with mild tubular atrophy. The patient...
Source: Jornal Brasileiro de Nefrologia - June 25, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Dietary pattern analysis among stone formers: resemblance to a DASH-style diet.
Authors: Rodrigues FG, Lima TM, Zambrano L, Heilberg IP Abstract Recent epidemiological studies have shown that dietary patterns may have a more persistent impact on the risk of stone formation than single nutrients of the diet. Dietary Approaches to Stop Hypertension (DASH), a low-sodium and fruits/vegetables-rich diet, has been associated with a lower risk of nephrolithiasis, due to altered urinary biochemistry. This observational study aimed to investigate whether the dietary pattern of stone formers (SF) resembled a DASH-diet and its influence on urinary lithogenic parameters. Anthropometric data, fasting serum...
Source: Jornal Brasileiro de Nefrologia - June 6, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pharmacotherapy assessment in chronic kidney disease: validation of the pair instrument for use in Brazil.
Authors: Marquito AB, Pinheiro HS, Fernandes NMDS, Paula RB Abstract Individuals with chronic kidney disease (CKD) use polypharmacy, which, in combination with renal impairment, exposes them to the risk of drug-related problems (DRPs). There are no available tools in Brazil to systematically assess the pharmacotherapy and management of DRPs in this population. Therefore, the objective of this work was to validate the PAIR instrument (Pharmacotherapy Assessment in Chronic Renal Disease) for use in Brazilian Portuguese. This is a retrospective longitudinal observational study. Medical records from 100 CKD patients un...
Source: Jornal Brasileiro de Nefrologia - June 6, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pre-formed DSA and kidney allograft outcomes.
Authors: Yeung MY PMID: 32495816 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 6, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research