Hemophagocytic lymphohistiocytosis, a rare condition in renal transplant - a case report.
We report a case of a 50-year-old renal transplant female admitted with fever and malaise 3 months post-transplant and presenting anemia, fever, hypertriglyceridemia, high levels of serum ferritin, and positive CMV antigenemia. Urine was positive for decoy cells and BKV-DNA. Graft biopsy showed CMV nephritis. Both blood and urine cultures where positive for E. coli. Hemophagocytosis was confirmed by bone marrow aspiration. Immunosuppression was reduced, and the patient received high-dose intravenous immunoglobulin and dexamethasone, with complete response after 3 weeks. We highlight the importance of early diagnosis and pr...
Source: Jornal Brasileiro de Nefrologia - October 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Albuminuria and glomerular filtration rate in obese children and adolescents.
CONCLUSION: Albuminuria, although frequent in children and adolescents with obesity, was not associated with other morbidities and the glomerular filtration rate in these patients. PMID: 30328467 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - October 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Long-term effects of delayed graft function duration on function and survival of deceased donor kidney transplants.
Authors: Helfer MS, Pompeo JC, Costa ORS, Vicari AR, Ribeiro AR, Manfro RC Abstract INTRODUCTION: Delayed graft function (DGF) is a frequent complication after deceased donor kidney transplantation with an impact on the prognosis of the transplant. Despite this, long-term impact of DGF on graft function after deceased donor kidney transplantation has not been properly evaluated. OBJECTIVE: The main objective of this study was to evaluate risk factors for DGF and the impact of its occurrence and length on graft survival and function. METHODS: A retrospective cohort study was performed in 517 kidney transplan...
Source: Jornal Brasileiro de Nefrologia - October 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Translumbar hemodialysis long-term catheters: an alternative for vascular access failure.
CONCLUSION: TLDC is an option for patients with VA failure, improving survival and acting as a bridge for renal transplantation. PMID: 30281060 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Successful multiple-exchange peritoneal dialysis in a patient with severe hematological toxicity by methotrexate: case report and literature review.
We present the case of a 68-year-old man with chronic, end-stage renal disease associated with ANCA vasculitis, under treatment with peritoneal dialysis, who received the medication at a low dose, indicated by disease activity, which presented as a complication with severe pancytopenia with mucositis that improved with support measures and multiple-exchange peritoneal dialysis. We reviewed 20 cases published to date of pancytopenia associated with methotrexate in patients on dialysis and found high morbidity and mortality, which is why its use in this type of patient is not recommended. However, when this complication occu...
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs.
Authors: Lucas GNC, Leitão ACC, Alencar RL, Xavier RMF, Daher EF, Silva Junior GBD Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-related nephrotoxicity. The main mechanism of NSAID action is cyclooxygenase (COX) enzyme inhibition, interfering on arachidonic acid conversion into E2 prostaglandins E2, prostacyclins and thromboxanes. Within the kidneys, pro...
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Reversible posterior encephalopathy syndrome in a 10-year-old child.
CONCLUSION: PRES is associated with acute hypertension. Early diagnosis and proper management may determine a better prognosis and minimize the severity of the clinical course. PMID: 30281063 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Thumb adductor muscle thickness used in the nutritional assessment of chronic kidney disease patients under conservative treatment.
Authors: Pereira PML, Soares ÍT, Bastos MG, Cândido APC Abstract INTRODUCTION: Evaluate the association between the thumb adductor muscle thickness and the patient's nutritional status, and propose cutoff points for muscle mass depletion in elderly patients with chronic kidney disease (CKD) under conservative treatment. Epidemiological and cross-sectional study, including patients with CKD stages 3 to 5, older than 60 years. Socioeconomic, clinical, physical activity and anthropometric data was obtained. TAMT was described and compared according to CKD stage, socioeconomic data, physical activity, nutr...
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

IgA nephropathy in Salvador, Brazil: a more aggressive disease?
Authors: Barros RT PMID: 30281065 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - October 5, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The effect of music therapy on hemodialysis patients' quality of life and depression symptoms.
This study evaluated the effect of music therapy on QOL and depressive symptoms in hemodialysis patients. METHOD: This was a music therapy intervention study in which 23 patients were evaluated regarding QOL and depression symptoms at two distinct stages - before and after the intervention. Eight sessions of music therapy were conducted, with two weekly sessions and an average duration of 75 minutes. The intervention was conducted by the music therapist herself, using specific music therapy techniques, besides voice and guitar to conduct harmonic and rhythmic support for the groups' sound-music production. RESULTS:...
Source: Jornal Brasileiro de Nefrologia - September 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Renal histological findings in a patient with acute renal injury associated with purpura fulminans: a case report.
CONCLUSION: When thrombotic and hemorrhagic phenomena overlap, obtaining a renal biopsy can be difficult. However, in the presented case, the biopsy allowed the exclusion of AKI caused by TMA, presenting for the first time, histological findings compatible with PF. PMID: 30222177 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Cognition and renal function: findings from a Brazilian population.
Authors: Chaiben VBO, Silveira TBD, Guedes MH, Fernandes JPA, Ferreira JHF, Beltrão J, Leal GF, Erbano LHO, Bosch NL, Pecoits Filho R, Moraes TP, Baena CP Abstract INTRODUCTION: The prevalence of chronic kidney disease (CKD) is increasing, with a potential impact in the risk of acceleration of dementia. The potential association between glomerular filtration rate (eGFR) and cognitive performance was scarcely studied. The aim of this study was to evaluate cognitive performance levels across different degrees of kidney function. METHODS: We analyzed 240 outpatients in a nephrology service, classified accor...
Source: Jornal Brasileiro de Nefrologia - September 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Salvage of thrombosed arteriovenous fistulae of patients on hemodialysis: report on the experience of a Brazilian center.
CONCLUSION: The majority of thrombosed accesses can be successfully treated, maintaining its long-term patency. The need of repeated intervention is frequent. PMID: 30207374 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 14, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Reflections on End-of-Life Dialysis.
Authors: Tzanno-Martins C PMID: 30199557 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

A teenage patient with autosomal recessive polycystic kidney disease, a splenorenal shunt, and congenital hepatic fibrosis: a case report.
Authors: Scarioti VD, Oliveira LT, Mattiello AC, Gomes NDS Abstract A 16-year-old female patient previously diagnosed with autosomal recessive polycystic kidney disease (ARPKD) presented with acute bilateral pneumonia, upper gastrointestinal bleeding caused by ruptured esophageal varices, ascites, and lower limb edema. She required intensive care and an endoscopic procedure to treat the gastrointestinal bleeding. The analysis of the differential diagnosis for chronic liver disease indicated she had a spontaneous splenorenal shunt. Ultrasound-guided biopsy revealed the patient had cirrhosis, as characteristically se...
Source: Jornal Brasileiro de Nefrologia - September 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Oral manifestations of renal tubular acidosis associated with secondary rickets: case report.
This report describes the oral manifestations of renal tubular acidosis (RTA) associated with secondary rickets and discusses the biological plausibility of these findings. The characteristic electrolyte changes during RTA or genetic mutations that trigger RTA may be responsible for impaired amelogenesis, dental malocclusion, impacted teeth, and absent lamina dura. This report reinforces the possibility of an association between RTA and the oral manifestations described. PMID: 30199559 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Anca-associated crescentic glomerulonephritis in a child with isolated renal involvement.
We report a case of a 7-year-old girl who presented with malaise and mildly elevated creatinine diagnosed as ANCA-associated pauci-immune crescentic glomerulonephritis with crescents in 20 of 25 glomeruli (80%). Of these 20 crescents, 12 were cellular, 4 fibrocellular, and 4 globally sclerotic. She did not have purpura, arthritis, or systemic symptoms and she responded well to initial immunosuppressive treatment despite relatively severe histopathology. The patient was given three pulses of intravenous methylprednisolone (30 mg/kg on alternate days) initially and continued with cyclophosphamide (CYC; 2 mg/kg per day) orall...
Source: Jornal Brasileiro de Nefrologia - September 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pure red cell aplasia and anti-erythropoietin antibodies in patients on hemodialysis: a report of two cases and a literature review.
CONCLUSION: PRCA is a rare condition among patients on dialysis treated with rhEPO and should be considered as a possible cause of refractory anemia. Treating patients with PRCA may be challenging, since the specific management and diagnostic procedures needed in this condition are not always readily available. PMID: 30160771 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 1, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Acute renal failure by rapidly progressive glomerulonephritis with IgA deposition in a patient concomitantly diagnosed with multibacillary Hansen's disease: a case report.
Authors: Parente YDM, Castro AL, Araújo FB, Teixeira AC, Lima ÍC, Daher EF Abstract Rapidly progressive glomerulonephritis (RPGN) is a renal disease with an extensive differential diagnosis. This paper reports the case of a 55-year-old female patient diagnosed with Hansen's disease with acute progressive renal impairment after developing lower limb pyoderma. The association between Hansen's and kidney disease has been well documented, with glomerulonephritis (GN) ranked as the most common form of renal involvement. Post-infectious glomerulonephritis (PIGN) in adults has been associated with a number o...
Source: Jornal Brasileiro de Nefrologia - September 1, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

An atypical presentation of a severe and massive atheroembolic disease.
Authors: Falcão LP, Fernandes S, Costa AC, Teixeira C, Raimundo M, Silva S, Miranda M, Almeida E Abstract Atheroembolic renal disease (AERD) is a kidney manifestation of atherosclerosis as a systemic disease. AERD is defined as a renal impairment secondary to embolization of cholesterol crystals with consequent occlusion of renal vascularization. The current case report describes one patient with multiple risk factors but without any inciting event history who presents a very atypical clinical course of a severe and massive atheroembolic disease that developed spontaneously and silently. PMID: 30129967 [...
Source: Jornal Brasileiro de Nefrologia - August 23, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

TpTe and TpTe/QT: novel markers to predict sudden cardiac death in ESRD?
CONCLUSIONS: In ESRD patients on hemodialysis, prolonged TpTe or TpTe/QT was not associated with a significant increase in SCD or all-cause mortality. PMID: 30118535 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion.
CONCLUSION: In experimental IR, the damage can be minimized with a prior low-dose intake of BN, improving inflammation, injury, and cell death. PMID: 30118536 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 19, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The role of C-peptide in the attenuation of outcomes of diabetic kidney disease: a systematic review and meta-analysis.
CONCLUSION: The results of the studies included in the systematic review diverged. However, the meta-analysis showed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels. PMID: 30106427 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 16, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Perioperative factors associated with delayed graft function in renal transplant patients.
CONCLUSIONS: Combined anesthesia technique, dialysis for more than 60 months, basiliximab, and cold ischemia time> 12 hours are risk factor for DGF, while liberal fluid regimens and kidneys from living donors are protective factors. PMID: 30106428 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 16, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The specific impact of uremic toxins upon cognitive domains: a review.
Authors: Franco ÁO, Starosta RT, Roriz-Cruz M Abstract One of the mechanisms proposed for chronic kidney disease (CKD)-related cognitive impairment is the accumulation of uremic toxins due to the deterioration of the renal clearance function. Cognition can be categorized into five major domains according to its information processing functions: memory, attention, language, visual-spatial, and executive. We performed a review using the terms 'uric acid', 'indoxyl sulfate', 'p-cresyl sulfate', 'homocysteine', 'interleukins' and 'parathyroid hormone'. These are the compounds that were found to be strongly assoc...
Source: Jornal Brasileiro de Nefrologia - August 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

ANCA associated vasculitis: experience of a tertiary care referral center.
Authors: Chaudhry R, Bilal A, Austin A, Mehta S, Salman L, Foulke L, Feustel P, Zuckerman R, Asif A Abstract BACKGROUND AND OBJECTIVES: Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis is a small vessel vasculitis with insufficient epidemiologic estimates in the United States. We aimed to determine demographic and clinical features of ANCA associated vasculitis patients presenting to a large tertiary care referral center in Upstate New York. Design, setting, participants, and measurements: A retrospective analysis of cases with pauci-immune GN on renal biopsy and clinical diagnosis of ANCA va...
Source: Jornal Brasileiro de Nefrologia - August 12, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The impact of dialysis on critically ill elderly patients with acute kidney injury: an analysis by propensity score matching.
CONCLUSIONS: The data suggested that dialysis did not seem to impact the death rates of critically ill patients with AKI aged 70+ years. PMID: 30080913 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Evaluation of variables associated with the patency of arteriovenous fistulas for hemodialysis created by a nephrologist.
CONCLUSION: Hemoglobin level in the recommended range has a favorable impact on late AVF patency and elevated blood pressure during surgery on the lower number of vascular accesses per patient. The high success rate indicates that it can be placed by trained nephrologists. PMID: 30080914 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Cerebral Venous Sinus Thrombosis in a Child with Idiopathic Nephrotic Syndrome: a case report.
This report describes the case of a 5-year-old girl with NS for the first time presenting with severe hypoalbuminemia (
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effectiveness of the monitoring program for ensuring the quality of water treated for dialysis in the state of S ão Paulo.
CONCLUSION: The design adopted in the state monitoring program is highly effective based on new collections after the joint actions of the Sanitary Surveillance System and the State Dialysis Services. PMID: 30080916 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 7, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

APOL1 risk variants and kidney disease: what we know so far.
Authors: Siemens TA, Riella MC, Moraes TP, Riella CV Abstract There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carrie...
Source: Jornal Brasileiro de Nefrologia - July 28, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Conservative management for patients with chronic kidney disease refusing dialysis.
Authors: Castro MCM Abstract Estimates suggest that 20-30% of the deaths of patients with chronic kidney disease with indication to undergo dialysis occur after refusal to continue dialysis, discontinuation of dialysis or inability to offer dialysis on account of local conditions. Contributing factors include aging, increased comorbidity associated with chronic kidney disease, and socioeconomic status. In several occasions nephrologists will intervene, but at times general practitioners or family physicians are on their own. Knowledge of the main etiologies of chronic kidney disease and the metabolic alterations an...
Source: Jornal Brasileiro de Nefrologia - July 27, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.
We describe a 54-year-old liver transplant patient that was admitted with flaccid muscle weakness associated with plasma potassium level of 9.25 mEq/L. Additional investigation revealed type 4 renal tubular acidosis and marked hypomagnesemia with high fractional excretion of magnesium. Relevant past medical history included a recent diagnosis of Paracoccidioidomycosis, a systemic fungal infection that is endemic in some parts of South America, and his outpatient medications contained trimethoprim-sulfamethoxazole, tacrolimus, and propranolol. In the present acid-base and electrolyte case study, we discuss a clinical approa...
Source: Jornal Brasileiro de Nefrologia - July 27, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report.
CONCLUSIONS: Although the lesions are mostly benign, they may increase the morbidity and mortality of these patients, so a proper diagnosis and early treatment are extremely important. PMID: 30010691 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The relationship between proton pump inhibitors and renal disease.
Authors: Morschel CF, Mafra D, Eduardo JCC Abstract Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze re...
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients.
Authors: Lopez ED, Córdova-Cázarez C, Valdez-Ortiz R, Cardona-Landeros CM, Gutiérrez-Rico MF Abstract AIM: To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients. METHODS: Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR
Source: Jornal Brasileiro de Nefrologia - July 17, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The intricate relationship between gut and kidney.
Authors: Cunha RS, Stinghen AEM PMID: 29958303 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Probiotics in the treatment of chronic kidney disease: a systematic review.
This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included a...
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The impact of surgical intervention on renal function in cystinuria.
CONCLUSIONS: Surgical interventions for urinary stones are commonly required in patients with cystinuria. Renal scarring is a prevalent finding in cystinuric patients. Surgical interventions have no negative impact on eGFR in patients with cystinuria according to the present study. PMID: 29958305 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effects of Low-Protein Diet on lipid and anthropometric profiles of patients with chronic kidney disease on conservative management.
CONCLUSION: LPD prescribe to non-dialysis CKD patients for six months was able to improve some cardiovascular risk factors as overweight and plasma lipid profile, suggesting that LPD can be also an important tool for protection against cardiovascular diseases in these patients. PMID: 29944154 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Understanding the causes of mortality post-transplantation - there is more than meets the eye.
Authors: Riella LV PMID: 29944155 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

High Flow and volume overload: The saga continues.
Authors: Cheng J, Costanzo EJ, Vachharajani TJ, Asif A PMID: 29944156 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Solitary functioning kidney in children: clinical implications.
CONCLUSION: Children with SFK have high morbidity especially when associated with ipsilateral CAKUT. Long-term periodical follow up is essential in these patients to improve clinical outcome. PMID: 29944157 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

The importance of histopathology in the diagnosis of isolated renal sarcoidosis: a case report.
CONCLUSIONS: The use of histopathology together with clinical and laboratory data to diagnose isolated renal sarcoidosis, rule out other etiologies and introduce early treatment is of paramount importance. PMID: 29944158 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis.
Authors: Gonsalez SR, Ferrão FM, Souza AM, Lowe J, Morcillo LDSL Abstract Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the mol...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases.
Authors: Pereira C, Gil J, Leal I, Costa-Reis P, Silva JEED, Stone R Abstract Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosis. Urinary β2-microglobulin levels may be particularly useful. Uveitis, mostly anterior, nongranulomatous and bilateral, occurs usually after the onset of nephritis. Treatment includes corticosteroids and, eventually, other immunosuppressant agents...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder.
CONCLUSION: parathyroidectomy is a safe and reproducible surgical procedure even in the absence of adjuvant techniques. PMID: 29944161 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

In vitro effect of uremic serum on barrier function and inflammation in human colonocytes.
Authors: Andrade LS, Dalboni MA, Carvalho JTG, Grabulosa CC, Pereira NBF, Aoike DT, Cuppari L Abstract INTRODUCTION: In chronic kidney disease (CKD), it has been suggested that alterations within the gut are associated with an inflammatory state and uremic toxicity. Studies suggest that uremia may impair the function of the intestinal barrier via the promotion of increased intestinal permeability. To understand the mechanisms that are involved in intestinal barrier damage in the setting of uremia, we evaluated the in vitro effect of uremic serum on transepithelial electrical resistance (TER), inflammation, and apop...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review.
Authors: Balbino KP, Hermsdorff HHM, Bressan J Abstract Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular cal...
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

NOS3 Polymorphisms and Chronic Kidney Disease.
Authors: Medina AM, Zubero EE, Jiménez MAA, Barragan SAA, García CAL, Ramos JJG, Gutierrez JFS, Castillo ZG Abstract Chronic kidney disease (CKD) is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized b...
Source: Jornal Brasileiro de Nefrologia - June 24, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research