Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers.
CONCLUSION: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. These data indicate the need for better compliance with clinical guidelines and public policies on the supply of drugs associated with CKD-MBD. PMID: 29796575 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Clinical and laboratory features of urinary tract infections in young infants.
CONCLUSIONS: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI. PMID: 29796576 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Sepsis-like histoplasmosis in a kidney transplant patient.
Authors: Fernandes AR, Viana LA, Mansur JB, Françoso MM, Santos DWCL, Silva HT, Pestana JOM Abstract Histoplasmosis is a fungus infection that mainly affects immunosuppressed patients. The authors present a case of a kidney transplant recipient who developed sepsis-like histoplasmosis, na atypical but severe manifestation of the disease. The fungus was found in blood and in a skin biopsy, and the treatment with liposomal amphotericin resulted in hepatotoxicity. PMID: 29796577 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Quantitative detection of BK virus in kidney transplant recipients: a prospective validation study.
CONCLUSION: Our study shows that marked variability occurs in BKV viral load when different qPCR methodologies are used. The in-house qPCR assay proved clinically useful, a cheaper option in comparison to commercial qPCR kits. There is an urgent need to make BKV standards available to the international community. PMID: 29796578 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report.
We present a case report of an asymptomatic renal oncocytoma in a kidney transplant recipient presenting persistent hematuria. The features of computed tomography and contrast-enhanced ultrasound (CEUS) are presented. This was the first time we used CEUS in a transplant kidney recipient presenting a renal mass, allowing the real-time visualization of contrast-enhancement patterns during all vascular phases for the differential diagnosis of renal tumors. Although the pattern of intense vascularization could mislead to an early judgment as a malignant lesion, it could help to exclude other renal lesions without inducing neph...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study.
CONCLUSION: These data suggest that intense intradialytic strength exercise was unable to increase the circulating concentration of irisin in HD patients. Moreover, our data show that after one hour of dialysis session, irisin plasma levels may be reduced. PMID: 29796580 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Complement activation in atypical hemolytic uremic syndrome and scleroderma renal crisis: a critical analysis of pathophysiology.
This article reviews the role of complement system in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis, and calls for heightened awareness to the development of thrombotic angiopathy in patients with scleroderma. PMID: 29796581 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Oral infection by Pseudomonas aeruginosa in patient with chronic kidney disease - a case report.
Authors: Souza LCD, Lopes FF, Bastos EG, Alves CMC Abstract Chronic renal patients are more susceptible to hospital complications and infections such as urinary tract infections, peritonitis, surgery infections, and bacteremia, which are often caused by Pseudomonas aeruginosa. A case of a HIV-positive girl with chronic kidney disease and with serious oral lesions due to P. aeruginosa septic shock is presented. The patient showed necrotic lesions in the oral mucosa, pathological tooth mobility, bone loss, and hematogenous osteomyelitis in the maxilla. The patient was submitted to systemic antibiotic therapy based on...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Influence of nutritional status, laboratory parameters and dietary patterns upon urinary acid excretion in calcium stone formers.
CONCLUSION: The endogenous production of OA and not an acidogenic diet were found to be independently predictive factors for lower urinary pH levels in calcium stone formers. Hypercalciuric and/or hyperuricosuric patients presented higher OA levels and lower levels of urinary pH. PMID: 29796583 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion.
CONCLUSION: Low intake of BN prior to IR-induced kidney injury improves renal function by inhibition of macrophage infiltration and oxidative stress. PMID: 29796584 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Posterior reversible leukoencephalopathy syndrome (PRES) after kidney transplantation: a case report.
CONCLUSION: PRES is an unusual complication after organ transplantation and should be considered in the appropriate clinical setting. Physicians must be aware of this condition in order to provide early detection and appropriate treatment since delay in removing the cause may lead to permanent sequelae. PMID: 29796585 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
CONCLUSIONS: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients. PMID: 29796586 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

First stages chronic kidney disease have mild effects on cognitive performance. Results of a 15,105 brazilian adult baseline cohort.
Authors: Passos VMA, Ladeira RM, Souza CCV, Santos IS, Barreto SM Abstract INTRODUCTION: The aging of the population may lead to an increased prevalence of dementia and chronic kidney disease (CKD) and their overlap. OBJECTIVE: We investigated the association between CKD and cognitive performance among Brazilian adults (35-74 years). METHODS: Baseline data analysis of the Longitudinal Study of Adults (ELSA-Brasil), a multicenter cohort comprising 15,105 civil servants, was performed. Kidney function was defined by the CKD-Epi-estimated GRF and albumin creatinin ratio (ACR). Cognitive performance was measure...
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

CKD-MBD in Brazil: the gap between reality and the recommended guidelines.
Authors: Custódio MR PMID: 29796588 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 30, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

IgA Nephropathy in Salvador, Brazil. Clinical and laboratory presentation at diagnosis.
CONCLUSION: The prevalence of IgAN was lower in Salvador than other regions of Brazil. Chronic histological lesions and laboratory markers of severe disease were frequent. M1 and T2 MEST-C scores were correlated with markers of renal dysfunction. PMID: 29782630 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Reflections on end-of-life dialysis.
In this study, we discuss dialysis in the final phase of life and present a systematic way to address this dilemma. PMID: 29782631 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Prevalence of clinically validated primary causes of end-stage renal disease (ESRD) in a State Capital in Northeastern Brazil.
CONCLUSION: The data contradicted national studies reporting primary hypertension as the main cause of chronic kidney disease (CKD). A high rate of unknown causes and categorization bias were observed mainly in relation to primary hypertension as a cause of CKD, which affects the overall prevalence of causes of ESRD in patients on dialysis. PMID: 29782632 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Macrothrombocytopenia, renal dysfunction and nephrotic syndrome in a young male patient: a case report of MYH9-related disease.
Authors: Sevignani G, Pavanelli GM, Milano SS, Ferronato BR, Pachaly MA, Ii Cheong H, Carvalho M, Barreto FC Abstract MYH9-related disease is an autosomal dominant disorder caused by mutations of the MYH9 gene, which encodes the non-muscle myosin heavy chain IIA on chromosome 22q12. It is characterized by congenital macrothrombocytopenia, bleeding tendency, hearing loss, and cataracts. Nephropathy occurs in approximately 30% of MYH9-related disease in a male patient carrier of a de novo missense mutation in exon 1 of the MYH9 gene [c.287C> T; p.Ser(TCG)96(TTG)Leu]. He presented all phenotypic manifestations of t...
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia.
CONCLUSIONS: in preeclampsia patients, postpartum urinary podocalyxin decreased before proteinuria. After three years, serum creatinine, urinary podocalyxin, and protein tended to normalize, although some patients still had proteinuria. PMID: 29782634 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 22, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Upper gastrointestinal alterations in kidney transplant candidates.
CONCLUSION: Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter. PMID: 29771269 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 21, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients.
CONCLUSION: Our study did not show viral load decrease after conversion to EVR with maintenance of antiproliferative therapy. PMID: 29771270 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 21, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Association between glomerular filtration rate (measured by high-performance liquid chromatography with iohexol) and plasma oxalate.
Authors: Selistre LS, Cochat P, Rech DL, Parant F, Souza VC, Dubourg L Abstract INTRODUCTION: Secondary hyperoxalemia is a multifactorial disease that affects several organs and tissues in patients with native or transplanted kidneys. Plasma oxalate may increase during renal failure because it is cleared from the body by the kidneys. However, there is scarce evidence about the association between glomerular filtration rate and plasma oxalate, especially in the early stages of chronic kidney disease (CKD). METHODS: A case series focuses on the description of variations in clinical presentation. A pilot study was...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Polyomavirus infection: can early diagnosis prevent development of associated allograft nephropathy?
Authors: Mazzali M PMID: 29738023 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Urinary pH in calcium oxalate stone formers: does it matter?
Authors: Carvalho M PMID: 29738024 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Oral infection by Pseudomonas aeruginosa in patient with chronic kidney disease - a case report.
Authors: Souza LCD, Lopes FF, Bastos EG, Alves CMC Abstract Chronic renal patients are more susceptible to hospital complications and infections such as urinary tract infections, peritonitis, surgery infections, and bacteremia, which are often caused by Pseudomonas aeruginosa. A case of a HIV-positive girl with chronic kidney disease and with serious oral lesions due to P. aeruginosa septic shock is presented. The patient showed necrotic lesions in the oral mucosa, pathological tooth mobility, bone loss, and hematogenous osteomyelitis in the maxilla. The patient was submitted to systemic antibiotic therapy based on...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Posterior reversible leukoencephalopathy syndrome (PRES) after kidney transplantation: a case report.
CONCLUSION: PRES is an unusual complication after organ transplantation and should be considered in the appropriate clinical setting. Physicians must be aware of this condition in order to provide early detection and appropriate treatment since delay in removing the cause may lead to permanent sequelae. PMID: 29738026 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis.
Authors: Zuckerman R, Patel M, Costanzo EJ, Dounis H, Haj RA, Seyedali S, Asif A Abstract Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension. ANCA serology wa...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Quantitative detection of BK virus in kidney transplant recipients: a prospective validation study.
CONCLUSION: Our study shows that marked variability occurs in BKV viral load when different qPCR methodologies are used. The in-house qPCR assay proved clinically useful, a cheaper option in comparison to commercial qPCR kits. There is an urgent need to make BKV standards available to the international community. PMID: 29738028 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Sepsis-like histoplasmosis in a kidney transplant patient.
Authors: Fernandes AR, Viana LA, Mansur JB, Françoso MM, Santos DWCL, Silva HT, Pestana JOM Abstract Histoplasmosis is a fungus infection that mainly affects immunosuppressed patients. The authors present a case of a kidney transplant recipient who developed sepsis-like histoplasmosis, na atypical but severe manifestation of the disease. The fungus was found in blood and in a skin biopsy, and the treatment with liposomal amphotericin resulted in hepatotoxicity. PMID: 29738029 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report.
We present a case report of an asymptomatic renal oncocytoma in a kidney transplant recipient presenting persistent hematuria. The features of computed tomography and contrast-enhanced ultrasound (CEUS) are presented. This was the first time we used CEUS in a transplant kidney recipient presenting a renal mass, allowing the real-time visualization of contrast-enhancement patterns during all vascular phases for the differential diagnosis of renal tumors. Although the pattern of intense vascularization could mislead to an early judgment as a malignant lesion, it could help to exclude other renal lesions without inducing neph...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Influence of nutritional status, laboratory parameters and dietary patterns upon urinary acid excretion in calcium stone formers.
CONCLUSION: The endogenous production of OA and not an acidogenic diet were found to be independently predictive factors for lower urinary pH levels in calcium stone formers. Hypercalciuric and/or hyperuricosuric patients presented higher OA levels and lower levels of urinary pH. PMID: 29738031 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study.
CONCLUSION: These data suggest that intense intradialytic strength exercise was unable to increase the circulating concentration of irisin in HD patients. Moreover, our data show that after one hour of dialysis session, irisin plasma levels may be reduced. PMID: 29738032 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

CKD-MBD in Brazil: the gap between reality and the recommended guidelines.
Authors: Custódio MR PMID: 29738033 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers.
CONCLUSION: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. These data indicate the need for better compliance with clinical guidelines and public policies on the supply of drugs associated with CKD-MBD. PMID: 29738034 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion.
CONCLUSION: Low intake of BN prior to IR-induced kidney injury improves renal function by inhibition of macrophage infiltration and oxidative stress. PMID: 29738035 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

First stages chronic kidney disease have mild effects on cognitive performance. Results of a 15,105 brazilian adult baseline cohort.
Authors: Passos VMA, Ladeira RM, Souza CCV, Santos IS, Barreto SM Abstract INTRODUCTION: The aging of the population may lead to an increased prevalence of dementia and chronic kidney disease (CKD) and their overlap. OBJECTIVE: We investigated the association between CKD and cognitive performance among Brazilian adults (35-74 years). METHODS: Baseline data analysis of the Longitudinal Study of Adults (ELSA-Brasil), a multicenter cohort comprising 15,105 civil servants, was performed. Kidney function was defined by the CKD-Epi-estimated GRF and albumin creatinin ratio (ACR). Cognitive performance was measure...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Clinical and laboratory features of urinary tract infections in young infants.
CONCLUSIONS: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI. PMID: 29738037 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
CONCLUSIONS: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients. PMID: 29738038 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Homemade ultrasound phantom for simulation of hydronephrosis.
Authors: Novaes AKB, Dalamura R, Menon T, Pazeli JM, Bastos MG Abstract In this article, we describe the development of a simple and inexpensive simulation phantom as a surrogate of human hydronephrosis for the identification of urinary tract obstruction at bedside to be used in undergraduate training of medical students. PMID: 29738039 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Nephrologists between power and vulnerability in times of technology.
Authors: Obregón JMV, Anjos MF Abstract The doctor-patient relationship is often discussed from the perspective of patient vulnerability. Little attention is given to the vulnerability of nephrologists in their professional practice, a reality often affected by profound cultural transformation arising from technological development. Nephrology is based on research and procedure instrumentalization, both permeated with technology. In addition, the relationship between nephrologists and institutions is governed by market rules. Recent data showed a shortage of new nephrologists and the need to improve the tech...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study.
Authors: Santos EMD, Brito DJA, França AKDCT, Lages JS, Santos AMD, Salgado Filho N Abstract INTRODUCTION: Excessive salt intake is a risk factor for the development of chronic kidney disease (CKD). OBJECTIVE: To evaluate the association between estimated glomerular filtration rate (eGFR) and sodium excretion in urine samples of Brazilians of African ancestry. METHODS: Cross-sectional, population-based study of 1,211 Brazilians of African ancestry living in Alcântara City, Maranhão, Brazil. Demographic, nutritional, clinical, and laboratory data were analyzed. The urinary excretion of so...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Biomarkers of cardio-renal syndrome in uremic myocardiopathy animal model.
CONCLUSIONS: TnI seems to reflect cardiac injury as a consequence of the CKD however nt-proBNP did not change because it reflects stretching. TNF-α characterized an inflammatory peak and fibrosis increased over time in a process connecting heart and kidneys. The angiotensin showed increased activity of the renin-angiotensin axis and corroborates the hypothesis that the inflammatory process and its involvement with CRS4. Therefore, this animal study reinforces the need for renin-angiotensin blockade strategies and the control of CKD to avoid the development of CRS4. PMID: 29738042 [PubMed - as supplied by publishe...
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Complement activation in atypical hemolytic uremic syndrome and scleroderma renal crisis: a critical analysis of pathophysiology.
This article reviews the role of complement system in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis, and calls for heightened awareness to the development of thrombotic angiopathy in patients with scleroderma. PMID: 29738043 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - May 10, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Quality of life in the treatment of chronic kidney disease: a challenge.
Authors: Chiloff CLM, Cerqueira ATAR, Balbi AL PMID: 29319757 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Cytomegalovirus infection after transplantation: prevention is still the challenge.
Authors: Reusing Junior JO, David-Neto E PMID: 29319758 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Transthoracic pulmonary ultrasonography: looking inside the lungs to better treat the dialysis patient.
Authors: Bastos MG, Pazeli Junior JM, Fernandes NMDS PMID: 29319759 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Acute kidney injury in critically ill obstetric patients: a cross-sectional study in an intensive care unit in Northeast Brazil.
Authors: Silva Junior GBD, Saintrain SV, Castelo GC, Vasconcelos VR, Oliveira JGR, Rocha AMT, Vasconcelos Júnior AG, Saintrain MVL, Daher EF Abstract INTRODUCTION: Acute kidney injury (AKI) is a complication still poorly studied in the setting of obstetric patients, which is associated with increased mortality. Objective: The aim of this study was to investigate the frequency and risk factors of AKI among critically ill obstetric patients. METHODS: A cross-sectional study was conducted with all patients admitted to an intensive care unit (ICU) due to obstetric complications, in Fortaleza, Brazil, in the ...
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Isotonic sports drink promotes rehydration and decreases proteinuria following karate training.
Authors: Geraldini S, Cruz IF, Romero A, Fonseca FLA, Campos MP Abstract INTRODUCTION: Adequate hydration status in the sport is essential for good health, yet the relationship between hydration, proteinuria and sports is little studied. OBJECTIVE: To analyze the influence of an isotonic sports drink as rehydration strategy on the hydration status and proteinuria after karate training. METHODS: Ten athletes participated in this study. In the first session of standard training, called observation training session (STO), the athletes hydrated themselves according to their habits, and in the second session of ...
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Complement System and C4d expression in cases of Membranous nephropathy.
CONCLUSION: C4d was associated with increased interstitial fibrosis, but not with clinical markers of poor prognosis. Through the deposition of C4d and C1q we demonstrated that all complement pathways may be involved in MN, highlighting the lectin pathway. The presence of C4d has been associated with severe tubulointerstitial lesions, but not with clinical markers, or can be taken as a universal marker of all cases of MN. PMID: 29319762 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Current distribution pattern of biopsy-proven glomerular disease in Salvador, Brazil, 40 years after an initial assessment.
In this study, we investigate the potential changes in the distribution of glomerular diseases after a period of important epidemiological transition in Brazil. METHODS: Pathology reports of all patients subjected to kidney biopsy from 2003 to 2015 in a referral nephrology service were reviewed. Clinical, laboratorial and pathological diagnoses were collected for analysis. Histological slides of the biopsies performed between 2003 and 2006 were reviewed to examine the accuracy of the estimates based on the pathology reports. RESULTS: Among the biopsies performed during the time period, 1,312 met the inclusion crite...
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research