IL-1beta Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
CONCLUSIONS: Taken together, IL-1β appears to be required for the maintenance of standard laboratory diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.PMID:38695167 | DOI:10.1161/ATVBAHA.124.320800 (Source: Atherosclerosis)
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Santosh Karnewar Vaishnavi Karnewar Rebecca Deaton Laura S Shankman Ernest D Benavente Corey M Williams Xenia Bradley Gabriel F Alencar Gamze B Bulut Sara Kirmani Richard A Baylis Eli R Zunder Hester M den Ruijter Gerard Pasterkamp Gary K Owens Source Type: research
Genetic and inflammatory factors underlying gestational diabetes mellitus: a review
Front Endocrinol (Lausanne). 2024 Apr 17;15:1399694. doi: 10.3389/fendo.2024.1399694. eCollection 2024.ABSTRACTGestational diabetes mellitus (GDM) poses a significant global health concern, impacting both maternal and fetal well-being. Early detection and treatment are imperative to mitigate adverse outcomes during pregnancy. This review delves into the pivotal role of insulin function and the influence of genetic variants, including SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK, in GDM development. These genetic variations affect beta-cell function and insulin activity in crucial tissues, such as muscle, disrupting glucose regul...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Gyan Watson Ray Qiaoli Zeng Phidelia Kusi Hengli Zhang Taotao Shao Taili Yang Yue Wei Mianqin Li Xiaoqun Che Runmin Guo Source Type: research
Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases
Front Pharmacol. 2024 Apr 17;15:1398381. doi: 10.3389/fphar.2024.1398381. eCollection 2024.ABSTRACTCardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all global deaths. With an aging population and changing lifestyles, CVDs pose a major threat to human health. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are communication platforms between cellular organelles and regulate cellular physiological functions, including apoptosis, autophagy, and programmed necrosis. Further research has sh...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Yanqiu Ding Nanyang Liu Dawu Zhang Lijun Guo Qinghua Shang Yicheng Liu Gaocan Ren Xiaochang Ma Source Type: research
Needs-based considerations for the role of low-dose aspirin along the CV risk continuum
Am J Prev Cardiol. 2024 Apr 15;18:100675. doi: 10.1016/j.ajpc.2024.100675. eCollection 2024 Jun.ABSTRACTCardiovascular disease (CVD) remains the leading cause of death worldwide. The risk of a cardiovascular (CV) event is not static and increases along a continuum, making identification and management complex. Aspirin has been the cornerstone of antiplatelet therapy in CV risk reduction and remains the only antiplatelet agent with current guideline recommendations throughout the CV risk continuum. In light of recent trials, the role of aspirin in CVD prevention in asymptomatic patients has been downgraded in clinical guide...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Francesca Santilli Gerhard Albrecht Michael Blaha Angel Lanas Li Li Dirk Sibbing Source Type: research
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease
CONCLUSION: The gut microbiota is emerging as a potential therapeutic target for CVD prevention and management. However, current research has limitations, including the need for larger and more diverse studies, the challenges of establishing causality, and concerns regarding the long-term consequences and safety of gut microbiota modulation. Despite these limitations, understanding the gut-heart axis holds promise for the development of personalized therapies and interventions for cardiovascular health. Further research is needed to expand our knowledge and address the ethical and safety issues associated with gut microbio...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Sanobar Shariff Alicia Kwan Su Huey Nishant Parag Soni Amer Yahia Doha Hammoud Abubakar Nazir Olivier Uwishema Magda Wojtara Source Type: research
Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR(-/-) Hamsters
In this study, CHL was induced in low-density lipoprotein receptor-deficient (LDLR-/-) hamsters through an 8-week high-fat and high-cholesterol (HFHC) diet or a 4-month high-cholesterol (HC) diet. Placebo or antibiotics were administered through separate or cohousing approaches. Analysis through 16S rDNA sequencing revealed that intermittent antibiotic treatment and the cohousing approach effectively modulated the gut microbiota community without impacting its overall abundance in LDLR-/- hamsters exhibiting severe CHL. Antibiotic treatment mitigated HFHC diet-induced obesity, hyperglycemia, and hyperlipidemia, enhancing t...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Guolin Miao Jiabao Guo Wenxi Zhang Pingping Lai Yitong Xu Jingxuan Chen Lianxin Zhang Zihao Zhou Yufei Han Gonglie Chen Jinxuan Chen Yijun Tao Lemin Zheng Ling Zhang Wei Huang Yuhui Wang Xunde Xian Source Type: research
Carotid intimamedia thickness in patients with severe hypertriglyceridemia
CONCLUSIONS: Our findings suggest that extreme TG elevations in severe HTG patients are not significantly associated with carotid IMT, in contrast to the increased IMT seen in FH patients. These findings add perspective to the complex relationship between severe HTG and ASCVD risk.PMID:38694144 | PMC:PMC11060956 | DOI:10.1016/j.athplu.2024.04.001 (Source: Atherosclerosis)
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Maud Ahmad Brooke A Kennedy Surim Son Adam D McIntyre Julieta Lazarte Jian Wang Robert A Hegele Source Type: research
Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease
Cardiovasc Res. 2024 May 2:cvae099. doi: 10.1093/cvr/cvae099. Online ahead of print.ABSTRACTDespite the emergence of novel diagnostic, pharmacological, interventional and prevention strategies, atherosclerotic cardiovascular disease remains a significant cause of morbidity and mortality. Nanoparticle-based platforms encompass diverse imaging, delivery and pharmacological properties that provide novel opportunities for refining diagnostic and therapeutic interventions for atherosclerosis at the cellular and molecular level. Macrophages play a critical role in atherosclerosis and therefore represent an important disease-rela...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Victoria Nankivell Achini K Vidanapathirana Ayla Hoogendoorn Joanne T M Tan Johan Verjans Peter J Psaltis Mark R Hutchinson Brant C Gibson Yiqing Lu Eva Goldys Gang Zheng Christina A Bursill Source Type: research
Curcumin Equipped Nanozyme-Like Metal-Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability
Adv Sci (Weinh). 2024 May 2:e2309062. doi: 10.1002/advs.202309062. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis and treatment of atherosclerosis (AS) are crucial for reducing the occurrence of acute cardiovascular events. However, early diagnosis of AS is challenging, and oral anti-AS drugs suffer from limitations like imprecise targeting and low bioavailability. To overcome the aforementioned shortcomings, Cur/MOF@DS is developed, a nanoplatform integrating diagnosis and treatment by loading curcumin (Cur) into metal-organ...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Fanzhen Lv Huaqiang Fang Li Huang Qingqing Wang Shuangyuan Cao Wenpeng Zhao Zhibin Zhou Weimin Zhou Xiaolei Wang Source Type: research
Continuity of care between dyslipidemia patients and multiple providers: A cohort study
CONCLUSIONS: The study shows that patients with high relational care continuity with doctors and pharmacists achieved better clinical results and utilized health care less, resulting in reduced expenses. Further exploration for the group that exhibits an ongoing relationship solely with pharmacists is warranted.PMID:38696494 | DOI:10.1371/journal.pone.0300745 (Source: Atherosclerosis)
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Eunyoung Choi Juhee Lee Eunjung Choo Eun Jin Jang Iyn-Hyang Lee Source Type: research
Role of Early Left Atrial Functional Decline in Predicting Cardiotoxicity in HER2 Positive Breast Cancer Patients Treated With Trastuzumab
Cardiovasc Toxicol. 2024 May 2. doi: 10.1007/s12012-024-09861-6. Online ahead of print.ABSTRACTTrastuzumab is widely used in HER2 breast cancer. However, it may cause left ventricular (LV) dysfunction. A decrease in LV global longitudinal strain (GLS) has been previously demonstrated to be a good predictor of subsequent cancer therapy related dysfunction (CTRCD). Left atrial morphological remodeling during Trastuzumab therapy has also been shown. The aim of this study is exploring the relationship between early changes in left atrial function and the development of Trastuzumab-induced cardiotoxicity. Consecutive patients w...
Source: Cardiovascular Toxicology - May 2, 2024 Category: Cardiology Authors: Corinna Bergamini Lorenzo Niro Paolo Springhetti Luisa Ferri Laura Trento Ilaria Minnucci Caterina Maffeis Elvin Tafciu Andrea Rossi Elena Fiorio Giovanni Benfari Flavio Ribichini Source Type: research
Iron chelators: as therapeutic agents in diseases
Ann Med Surg (Lond). 2024 Mar 19;86(5):2759-2776. doi: 10.1097/MS9.0000000000001717. eCollection 2024 May.ABSTRACTThe concentration of iron is tightly regulated, making it an essential element. Various cellular processes in the body rely on iron, such as oxygen sensing, oxygen transport, electron transfer, and DNA synthesis. Iron excess can be toxic because it participates in redox reactions that catalyze the production of reactive oxygen species and elevate oxidative stress. Iron chelators are chemically diverse; they can coordinate six ligands in an octagonal sequence. Because of the ability of chelators to trap essentia...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Zohreh Salimi Mehdi Afsharinasab Mehdi Rostami Yaser Eshaghi Milasi Seyedeh Fatemeh Mousavi Ezmareh Fariba Sakhaei Maryam Mohammad-Sadeghipour Sayyed Mehdi Rasooli Manesh Zatollah Asemi Source Type: research
Smoking behaviour in post-acute myocardial infarction patients: cross-sectional study
CONCLUSION: Multinomial logistic regression analysis identified current smoking as a significant predictor of intention to quit in the preparation and contemplation stages. Overall, this study underscores the importance of considering smoking behaviour when evaluating the intention to quit smoking post-MI and highlights the need for tailored interventions and support strategies to address smoking cessation in this population. These findings offer valuable insights for the development of effective strategies aimed at reducing persistent smoking following MI and improving patient outcomes.PMID:38694391 | PMC:PMC11060240 | DO...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Waseem Barkhurdar Arif Hussain Muhammad Saqlain Rida Zahra Irshad Hussain Muhammad Saqib Hassan Mumtaz Source Type: research
Efficacy and outcomes of antiplatelet therapy versus oral anticoagulants in patients undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis
CONCLUSIONS: Although the risk of valve thrombosis increased in patients receiving APT, the risk of other endpoints was comparable between the two groups.PMID:38694361 | PMC:PMC11060210 | DOI:10.1097/MS9.0000000000001908 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Aman Goyal Fatima Qayyum Abbasi Muhammad Daoud Tariq Sai Gautham Kanagala Mah I Kan Changez Darsh Safi Jawad Basit Samia Aziz Sulaiman Mohammed Dheyaa Marsool Marsool Mohamed Daoud Amir H Sohail Source Type: research
Should varicocele screening be conducted in men diagnosed with chronic venous insufficiency? A prospective study
CONCLUSIONS: There is a significant association between left GSV diameter and varicocele (p = 0.004). Varicocele screening can be carried out with 71.4% sensitivity in adult male patients with a left GSV diameter of 5.35 cm and above. Both cardiovascular surgeons and radiologists can conduct varicocele screening by measuring pampiniform veins in patients with a left GSV diameter of 5.35 cm and above. This approach has the potential to reduce the incidence of varicocele and associated infertility.PMID:38693978 | PMC:PMC11059024 | DOI:10.5114/kitp.2024.138486 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ferit Çetinkaya Kamil Do ğan Ay şe Taş Source Type: research
