Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes and participate as inductive organs of systemic and mucosal immunity. ... (Source: Immunity and Aging)
Source: Immunity and Aging - April 12, 2024 Category: Geriatrics Authors: Roc ío Pastor, Juliana Puyssegur, M. Paula de la Guardia, Lindybeth Sarmiento Varón, Gladys Beccaglia, Nicolás Spada, Andrea Paes de Lima, M. Soledad Collado, Andrés Blanco, Isabel Aspe Scetti, M. Elena Arabolaza, Bibiana Paoli, Fernando Chirdo and El Tags: Research Source Type: research
B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is th... (Source: Immunity and Aging)
Source: Immunity and Aging - April 3, 2024 Category: Geriatrics Authors: Kyoko Hayakawa, Yan Zhou and Susan A. Shinton Tags: Research Source Type: research
Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer ’s disease and vascular dementia in a prospective study
It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model. (Source: Immunity and Aging)
Source: Immunity and Aging - April 3, 2024 Category: Geriatrics Authors: Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner and Ben Sch öttker Tags: Research Source Type: research
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has hig... (Source: Immunity and Aging)
Source: Immunity and Aging - March 21, 2024 Category: Geriatrics Authors: Sudhanshu Agrawal, Michelle Thu Tran, Tara Sinta Kartika Jennings, Marlaine Maged Hosny Soliman, Sally Heo, Bobby Sasson, Farah Rahmatpanah and Anshu Agrawal Tags: Research Source Type: research
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune system is thought to fuel frailty, we characterized the immune activation profiles linked t... (Source: Immunity and Aging)
Source: Immunity and Aging - March 13, 2024 Category: Geriatrics Authors: Lucy Kundura, Renaud Cezar, Sandrine Gimenez, Manuela Pastore, Christelle Reynes, Albert Sotto, Jacques Reynes, Clotilde Allavena, Laurence Meyer, Alain Makinson and Pierre Corbeau Tags: Research Source Type: research
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic low-grade inflammation, which contributes to a faster progression of aged-r... (Source: Immunity and Aging)
Source: Immunity and Aging - March 12, 2024 Category: Geriatrics Authors: Monica Cattaneo, Andrea Baragetti, Alberto Malovini, Elena Ciaglia, Valentina Lopardo, Elena Olmastroni, Manuela Casula, Carolina Ciacci, Alberico L. Catapano and Annibale A. Puca Tags: Research Source Type: research
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and par... (Source: Immunity and Aging)
Source: Immunity and Aging - March 8, 2024 Category: Geriatrics Authors: Mailton Prestes Madruga, Lucas Kich Grun, Let ícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro Tags: Research Source Type: research
Immune aging in annual killifish
Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hallmarks that affect multiple organs. These hallmarks include protein aggregation, telomere s... (Source: Immunity and Aging)
Source: Immunity and Aging - March 8, 2024 Category: Geriatrics Authors: Gabriele Morabito, Alina Ryabova and Dario Riccardo Valenzano Tags: Review Source Type: research
Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
(Source: Immunity and Aging)
Source: Immunity and Aging - February 21, 2024 Category: Geriatrics Authors: Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur and Eva L. Feldman Tags: Correction Source Type: research
Ageing on the impact of distribution about preformed anti-HLA and anti-MICA antibody specificities in recipients prior to initial HSCT from East China
With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies coul... (Source: Immunity and Aging)
Source: Immunity and Aging - February 20, 2024 Category: Geriatrics Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou Tags: Research Source Type: research
The interplay between obesity, immunosenescence, and insulin resistance
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has... (Source: Immunity and Aging)
Source: Immunity and Aging - February 5, 2024 Category: Geriatrics Authors: Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery and Hamid Zand Tags: Review Source Type: research
The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of agin... (Source: Immunity and Aging)
Source: Immunity and Aging - February 5, 2024 Category: Geriatrics Authors: Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang and Peng Yu Tags: Review Source Type: research
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological changes that affect the process of bone fracture healing. These changes are accompanie... (Source: Immunity and Aging)
Source: Immunity and Aging - February 3, 2024 Category: Geriatrics Authors: Clement Shema, Yining Lu, Ling Wang and Yingze Zhang Tags: Review Source Type: research
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of agi... (Source: Immunity and Aging)
Source: Immunity and Aging - January 27, 2024 Category: Geriatrics Authors: Hui-Hui Shen, Xin-Yan Zhang, Nan Liu, Yang-Yang Zhang, Hui-Hua Wu, Feng Xie, Wen-Jun Wang and Ming-Qing Li Tags: Research Source Type: research
Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine
In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, w... (Source: Immunity and Aging)
Source: Immunity and Aging - January 27, 2024 Category: Geriatrics Authors: Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan and Xiaolin Jiang Tags: Research Source Type: research
