Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury

In this study we show in vitro and in vivo that Park7 has a crucial role in protection from AKI, and upregulated peroxisome activity. These data in combination with published results of Park7's protective role in cardiovascular damage and chronic kidney disease lead us to hypothesize that succinylation of Park7 may ameliorate oxidative damage resulting from AKI and prevent disease progression. This novel mechanism provides a potential therapeutic mechanism that can be targeted.PMID:38695076 | DOI:10.1152/ajprenal.00062.2024
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Source Type: research