Synthesis of C3- < em > epi < /em > -virenose and anomerically activated derivatives
Tetrahedron Lett. 2024 Apr;140:155041. doi: 10.1016/j.tetlet.2024.155041.ABSTRACTA 9-step synthetic route to a protected form of the C3-epimer of virenose from D-fucose is described. C3-epi-virenose is the carbohydrate unit of the bioactive polyketide elsamicin B and part of the carbohydrate unit of elsamicin A. The developed route enabled preparation of anomerically activated forms of this unique C6-deoxy sugar, including derivatives with 1-acetyl, 1-acetylthio, 1-trichloroacetimidate, 1-bromo, and 1-fluoro substituents.PMID:38665383 | PMC:PMC7615872 | DOI:10.1016/j.tetlet.2024.155041 (Source: Tetrahedron Letters)
Source: Tetrahedron Letters - April 26, 2024 Category: Chemistry Authors: Liesa R öder Sofia Torres Venegas Klaus Wurst Thomas Magauer Source Type: research
Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards
This study zeroes in on the particular motifs within the orthosteric sites of post-synaptic nicotinic acetylcholine receptors (nAChR) that confer resistance to α-neurotoxins, often through structural alterations of nAChR. This research examined Australian agamid lizards, a primary prey group for Australian elapid snakes, which are subject to predatory selection pressures. We previously showed that Pogona vitticeps (Central bearded dragon) was resistant to α-neurotoxic snake venoms through a steric hindrance form resistance evolving within the nAChR orthosteric, specifically through the 187-189NVT motif resulting in the p...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 26, 2024 Category: Biochemistry Authors: Uthpala Chandrasekara Marco Mancuso Joanna Sumner Dan Edwards Christina N Zdenek Bryan G Fry Source Type: research
Utilization of some fruit rinds in small ruminant feeding: nutritional characteristics determination
In conclusion, the present rinds differed in chemical-nutritional characteristics. These rinds may feed as a substitute for conventional forages in the diets of small ruminants on a large scale throughout the year; however, these in vitro findings need to be scientifically validated unde r in vivo experiments. (Source: Tropical Animal Health and Production)
Source: Tropical Animal Health and Production - April 26, 2024 Category: Veterinary Research Source Type: research
Association Between Low-Carbohydrate-Diet Score, Glycemia and Cardiovascular Risk Factors in Adults with Type 1 Diabetes
This study aims to evaluate associations between low-carbohydrate intakes using LCD score with glycemia and cardiovascular risk factors (lipid profile) in adults with T1D or LADA in Qu ébec, Canada. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 26, 2024 Category: Nutrition Authors: Élisabeth Nguyen, Kayla Wong, Marie-Laure Lalanne-Mistrih, Rémi Rabasa-Lhoret, Anne-Sophie Brazeau Source Type: research
Methionine inducing carbohydrate esterase secretion of Trichoderma harzianum enhances the accessibility of substrate glycosidic bonds
The conversion of plant biomass into biochemicals is a promising way to alleviate energy shortage, which depends on efficient microbial saccharification and cellular metabolism. Trichoderma spp. have plentiful CA... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 26, 2024 Category: Microbiology Authors: Yang Liu, Tuo Li, Han Zhu, Linhua Cao, Lebin Liang, Dongyang Liu and Qirong Shen Tags: Research Source Type: research
Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Maider Parra-Santamaria, Aran Insausti, Elena R. Alonso, Francisco J. Basterretxea, Emilio J. Cocinero This atomic-resolution study reveals glucose changes due to oxidation, exploring key carbohydrate aspects like hydrogen bonding, ring-puckering, anomeric effect, and tautomeric selection. Results confirm mutarotation suppression in the gas phase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Source Type: research
Morphology and optical properties of Au-Ag hybrid nanoparticles regulation and its ultra-sensitive SERS immunoassay detection in carbohydrate antigen 19-9
Talanta. 2024 Apr 19;275:126131. doi: 10.1016/j.talanta.2024.126131. Online ahead of print.ABSTRACTThe development of an ultra-sensitive detection method for carbohydrate antigen 19-9 (CA19-9) is very important for the early diagnosis of pancreatic cancer. In this work, we developed a new strategy to achieve a variety of Au-Ag hybrid nanoparticles from janus to core-satellite which is controlled by the volume of AgNO3 and the concentration of benzimidazolecarboxylic acid (MBIA). With the volume of AgNO3 increased, Au-Ag hybrid nanoparticles changed from janus to core-satellite and the characteristic absorption peak showed ...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Gao-Feng Wu Jian Zhu Guo-Jun Weng Hao-Yu Cai Jian-Jun Li Jun-Wu Zhao Source Type: research
What are the growth kinetics and biochemical compositions of microalgae isolated from diverse aquatic ecosystems in Morocco, France, and Tunisia?
Environ Sci Pollut Res Int. 2024 Apr 25. doi: 10.1007/s11356-024-33412-9. Online ahead of print.ABSTRACTThirty-six microalgae belonging to five taxonomic groups (Cyanobacteria, Chlorophyceae, Diatomophyceae, Euglenophyceae, and Eustigmatophyceae) were identified from six freshwater ecosystems in Morocco, two treatment stations in Etueffont landfill in France and three hot spring waters in Tunisia. Investigations on species growth kinetics and growth rates showed that the cyanobacterium Leptolyngbya gelatinosa exhibited both the highest biomass and growth rate with 4 g DW L-1 and 0.282 day-1, respectively. A significant pro...
Source: Environmental Science and Pollution Research International - April 25, 2024 Category: Environmental Health Authors: Bouchra Assobhi Yamina Bouchelta Majed Alsubih None LamiaTrabelsi Badr Alaoui-Soss é Pascale Bourgeade Lotfi Aleya Mohammed Alaoui Mhamdi Jamila Bahhou Source Type: research
The antiglycation potential of H1 receptor antagonists - in vitro studies in bovine serum albumin model and in silico molecular docking analyses
Biomed Pharmacother. 2024 Apr 24;175:116632. doi: 10.1016/j.biopha.2024.116632. Online ahead of print.ABSTRACTThe H1 receptor belongs to the family of rhodopsin-like G-protein-coupled receptors activated by the biogenic amine histamine. H1 receptor antagonists are widely used in the treatment of allergies. However, these drugs could have a much broader spectrum of activity, including hypoglycemic effects, which can broaden the spectrum of their use. The aim of the study was to evaluate the antiglycation potential of twelve H1 receptor antagonists (diphenhydramine, antazoline, promethazine, ketotifen, clemastine, pheniramin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Grzegorz Biedrzycki Blanka Wolszczak-Biedrzycka Justyna Dorf Daniel Michalak Ma łgorzata Żendzian-Piotrowska Anna Zalewska Mateusz Maciejczyk Source Type: research
Morphology and optical properties of Au-Ag hybrid nanoparticles regulation and its ultra-sensitive SERS immunoassay detection in carbohydrate antigen 19-9
Talanta. 2024 Apr 19;275:126131. doi: 10.1016/j.talanta.2024.126131. Online ahead of print.ABSTRACTThe development of an ultra-sensitive detection method for carbohydrate antigen 19-9 (CA19-9) is very important for the early diagnosis of pancreatic cancer. In this work, we developed a new strategy to achieve a variety of Au-Ag hybrid nanoparticles from janus to core-satellite which is controlled by the volume of AgNO3 and the concentration of benzimidazolecarboxylic acid (MBIA). With the volume of AgNO3 increased, Au-Ag hybrid nanoparticles changed from janus to core-satellite and the characteristic absorption peak showed ...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Gao-Feng Wu Jian Zhu Guo-Jun Weng Hao-Yu Cai Jian-Jun Li Jun-Wu Zhao Source Type: research
What are the growth kinetics and biochemical compositions of microalgae isolated from diverse aquatic ecosystems in Morocco, France, and Tunisia?
Environ Sci Pollut Res Int. 2024 Apr 25. doi: 10.1007/s11356-024-33412-9. Online ahead of print.ABSTRACTThirty-six microalgae belonging to five taxonomic groups (Cyanobacteria, Chlorophyceae, Diatomophyceae, Euglenophyceae, and Eustigmatophyceae) were identified from six freshwater ecosystems in Morocco, two treatment stations in Etueffont landfill in France and three hot spring waters in Tunisia. Investigations on species growth kinetics and growth rates showed that the cyanobacterium Leptolyngbya gelatinosa exhibited both the highest biomass and growth rate with 4 g DW L-1 and 0.282 day-1, respectively. A significant pro...
Source: Environmental Science and Pollution Research International - April 25, 2024 Category: Environmental Health Authors: Bouchra Assobhi Yamina Bouchelta Majed Alsubih None LamiaTrabelsi Badr Alaoui-Soss é Pascale Bourgeade Lotfi Aleya Mohammed Alaoui Mhamdi Jamila Bahhou Source Type: research
The antiglycation potential of H1 receptor antagonists - in vitro studies in bovine serum albumin model and in silico molecular docking analyses
Biomed Pharmacother. 2024 Apr 24;175:116632. doi: 10.1016/j.biopha.2024.116632. Online ahead of print.ABSTRACTThe H1 receptor belongs to the family of rhodopsin-like G-protein-coupled receptors activated by the biogenic amine histamine. H1 receptor antagonists are widely used in the treatment of allergies. However, these drugs could have a much broader spectrum of activity, including hypoglycemic effects, which can broaden the spectrum of their use. The aim of the study was to evaluate the antiglycation potential of twelve H1 receptor antagonists (diphenhydramine, antazoline, promethazine, ketotifen, clemastine, pheniramin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Grzegorz Biedrzycki Blanka Wolszczak-Biedrzycka Justyna Dorf Daniel Michalak Ma łgorzata Żendzian-Piotrowska Anna Zalewska Mateusz Maciejczyk Source Type: research
Microwave-Assisted Synthesis of Highly Sulfated Mannuronate Glycans as Potential Inhibitors against SARS-CoV-2
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00466C, PaperYirong Zhu, Xiaotong Wang, Siqian Lu, Jibin Zheng, Youling Liang, Liangliang Zhang, Pengfei Fang, Peng Xu, Biao Yu, You Yang Algae-based marine carbohydrate drugs are typically decorated with negative ion groups such as carboxylation and sulfation. However, precise synthesis of highly sulfated alginates is challenging, thus impeding their structure –activity relationship... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 25, 2024 Category: Molecular Biology Authors: Yirong Zhu Source Type: research
Structural and functional insights of starch processing α-amylase from hyperthermophilic archaeon Pyrococcusabyssi
Carbohydr Res. 2024 Apr 22;539:109122. doi: 10.1016/j.carres.2024.109122. Online ahead of print.ABSTRACTThe genomic screening of hyper-thermophilic Pyrococcus abyssi showed uncharacterized novel α-amylase sequences. Homology modelling analysis revealed that the α-amylase from P. abyssi consists of an N-terminal GH57 catalytic domain, α-amylase central, and C-terminal domain. Current studies emphasize in-silico structural and functional analysis, recombinant expression, characterization, structural studies through CD spectroscopy, and ligand binding studies of the novel α-amylase from P. abyssi. The soluble expression o...
Source: Carbohydrate Research - April 24, 2024 Category: Genetics & Stem Cells Authors: Mohsin Shad Hafiz Muzzammel Rehman Muhammad Waheed Akhtar Muhammad Sajjad Source Type: research
Endogenous Antimicrobial-Immunomodulatory Molecules: Networking Biomolecules of Innate Immunity
Chembiochem. 2024 Apr 24:e202400089. doi: 10.1002/cbic.202400089. Online ahead of print.ABSTRACTEndogenous antimicrobial-immunomodulatory molecules (EAIMs) are essential to immune-mediated human health and evolution. Conventionally, antimicrobial peptides (AMPs) have been regarded as the dominant endogenous antimicrobial molecule; however, AMPs are not sufficient to account for the full spectrum of antimicrobial-immunomodulatory duality occurring within the human body. The threat posed by pathogenic microbes is pervasive with the capacity for widespread impact across many organ systems and multiple biochemical pathways; ac...
Source: Chembiochem - April 24, 2024 Category: Biochemistry Authors: Donald F Weaver Source Type: research
