Exploring research progress in studying serum exosomal miRNA-21 as a molecular diagnostic marker for breast cancer
AbstractBreast cancer is one of the most prevalent malignancies affecting women globally and poses a significant public health challenge. Early clinical detection plays a pivotal role in providing optimal treatment opportunities and favorable prognoses, crucial for reducing breast cancer mortality and enhancing patients ’ quality of life. Therefore, the timely identification and diagnosis of breast cancer are imperative. Conventional tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3), serve as reliable methods for actively monitoring disease progression and have become a routine ...
Source: Clinical and Translational Oncology - April 11, 2024 Category: Cancer & Oncology Source Type: research
Simplified integration of optimal self-management behaviors is associated with improved HbA1c in patients with type 1 diabetes
ConclusionsSix optimal self-management behaviors, especially CGM usage, were associated with improved glycemic control, emphasizing the feasibility of implementing a simplified version of DSMES in the routine clinical care.Registration number: ClinicalTrials.gov Identifier: NCT03610984 (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2024 Category: Endocrinology Source Type: research
On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Julia A. Turner, Hendrik Zipse, Mark S. Taylor Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Julia A. Turner Source Type: research
Enhancing Protein Solubility via Glycosylation: From Chemical Synthesis to Machine Learning Predictions
This study aimed to bridge this gap by investigating the solubility of a model glycoprotein molecule, the carbohydrate-binding module (CBM), through a two-stage process. In the first stage, an approach involving chemical synthesis, comparative analysis, and molecular dynamics simulations of a library of glycoforms was employed to elucidate the effect of different glycosylation patterns on solubility and the key factors responsible for the effect. In the second stage, a predictive mathematical formula, innovatively harnessing machine learning algorithms, was derived to relate solubility to the identified key factors and acc...
Source: Biomacromolecules - April 10, 2024 Category: Biochemistry Authors: Bo Ma Hedi Chen Jinyuan Gong Wenqiang Liu Xiuli Wei Yajing Zhang Xin Li Meng Li Yani Wang Shiying Shang Boxue Tian Yaohao Li Ruihan Wang Zhongping Tan Source Type: research
Enhancing Protein Solubility via Glycosylation: From Chemical Synthesis to Machine Learning Predictions
This study aimed to bridge this gap by investigating the solubility of a model glycoprotein molecule, the carbohydrate-binding module (CBM), through a two-stage process. In the first stage, an approach involving chemical synthesis, comparative analysis, and molecular dynamics simulations of a library of glycoforms was employed to elucidate the effect of different glycosylation patterns on solubility and the key factors responsible for the effect. In the second stage, a predictive mathematical formula, innovatively harnessing machine learning algorithms, was derived to relate solubility to the identified key factors and acc...
Source: Biomacromolecules - April 10, 2024 Category: Biochemistry Authors: Bo Ma Hedi Chen Jinyuan Gong Wenqiang Liu Xiuli Wei Yajing Zhang Xin Li Meng Li Yani Wang Shiying Shang Boxue Tian Yaohao Li Ruihan Wang Zhongping Tan Source Type: research
A review on recent taxonomic updates of gut bacteria associated with social bees, with a curated genomic reference database
Social corbiculate bees harbor relatively simple microbial communities at the phylotypes level, however, genetic diversification is prevalent below phylotypes, i.e. at the species or strain level. Additionally, the genetic diversity and gene repertoires of bacterial isolates vary substantial between host species. This diverse gut microbiota exerts multifaceted effects on the host, such as diet digestion, nutrient provision, pathogen resistance, immune modulation, endocrine signaling, among others. In particular, the gut microbiota is primarily responsible for the digestion and fermentation of dietary carbohydrates, includi...
Source: Insect Science - April 10, 2024 Category: Biology Authors: Chengfeng Yang,
Jiawei Hu,
Qinzhi Su,
Zijing Zhang,
Yating Du,
Jieni Wang,
Huihui Sun,
Benfeng Han,
Junbo Tang,
Lizhen Guo,
Hu Li,
Wanzhi Cai,
Hao Zheng,
Xin Zhou,
Xue Zhang Tags: REVIEW Source Type: research
Nutrient quality in dietary therapy for diabetes and diabetic kidney disease
Diet therapy is crucial for treatment of diabetes and its complications, including diabetic kidney disease. Considering the diversification of the pathophysiology and comorbidities of diabetes, it might become crucial in the future to focus on the quality of nutrients in the diet rather than just the quantity. This suggests that individualized dietary therapy could be increasingly important. ABSTRACTDietary therapy is crucial for diabetes care with the aim of preventing the onset and progression of diabetes and its complications. The traditional approach to dietary therapy for diabetes has primarily focused on restricting ...
Source: Journal of Diabetes Investigation - April 9, 2024 Category: Endocrinology Authors: Hiroaki Tsuruta,
Sho Sugahara,
Shinji Kume Tags: REVIEW ARTICLE Source Type: research
Exploring a de novo route to bradyrhizose and its diastereomers: synthesis and isomeric equilibrium of reducing bicyclic carbohydrates
Chemistry. 2024 Apr 8:e202400886. doi: 10.1002/chem.202400886. Online ahead of print.ABSTRACTA de novo asymmetric strategy for the synthesis of d-bradyrhizose diastereomers from an achiral ketoenolester precursor is described. Key transformations used in the stereodivergent approach include two Noyori asymmetric reductions, an Achmatowicz rearrangement, diastereoselective alkene oxidations, and the first example of a palladium(0)-catalyzed glycosylation of a vinylogous pyranone. The isomeric composition of the bicyclic reducing sugars obtained was analyzed and their behaviour was compared to the natural product, revealing ...
Source: Chemistry - April 9, 2024 Category: Chemistry Authors: Vitor L S Cunha George A O'Doherty Todd Lowary Source Type: research
Melanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence
Appl Microbiol Biotechnol. 2024 Apr 9;108(1):291. doi: 10.1007/s00253-024-13107-4.ABSTRACTMelanin is an Aspergillus flavus cell wall component that provides chemical and physical protection to the organism. However, the molecular and biological mechanisms modulating melanin-mediated host-pathogen interaction in A. flavus keratitis are not well understood. This work aimed to compare the morphology, surface proteome profile, and virulence of melanized conidia (MC) and non-melanized conidia (NMC) of A. flavus. Kojic acid treatment inhibited melanin synthesis in A. flavus, and the conidial surface protein profile was significa...
Source: Applied Microbiology and Biotechnology - April 9, 2024 Category: Microbiology Authors: Ondippili Rudhra Hariharan Gnanam Sivaramakrishnan Sivaperumal VenkateshPrajna Namperumalsamy Lalitha Prajna Dharmalingam Kuppamuthu Source Type: research
Melanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence
Appl Microbiol Biotechnol. 2024 Apr 9;108(1):291. doi: 10.1007/s00253-024-13107-4.ABSTRACTMelanin is an Aspergillus flavus cell wall component that provides chemical and physical protection to the organism. However, the molecular and biological mechanisms modulating melanin-mediated host-pathogen interaction in A. flavus keratitis are not well understood. This work aimed to compare the morphology, surface proteome profile, and virulence of melanized conidia (MC) and non-melanized conidia (NMC) of A. flavus. Kojic acid treatment inhibited melanin synthesis in A. flavus, and the conidial surface protein profile was significa...
Source: Applied Microbiology and Biotechnology - April 9, 2024 Category: Microbiology Authors: Ondippili Rudhra Hariharan Gnanam Sivaramakrishnan Sivaperumal VenkateshPrajna Namperumalsamy Lalitha Prajna Dharmalingam Kuppamuthu Source Type: research
Effects of altering diet carbohydrate profile and physical form on zoo ‐housed giraffe Giraffa camelopardalis reticulata
AbstractUnlike wild giraffe that primarily consume low starch browse, the preference of zoo-housed giraffe for consuming supplemental feeds over forage could increase the risk of digestive disorders such as ruminal acidosis. Our objective was to evaluate the effects of modifying a supplemental feed's non-fibre carbohydrate profile and physical form on nutritional, behavioural, and blood measures of giraffe in a zoological setting. Six non-lactating, adult, female reticulated giraffes were used in a two-pen modified reversal study using two dietary treatments in seven 21-day periods with data collected on days 15 –21. Die...
Source: Journal of Animal Physiology and Animal Nutrition - April 9, 2024 Category: Zoology Authors: Celeste C. Kearney,
Ray L. Ball,
Mary Beth Hall Tags: ORIGINAL ARTICLE Source Type: research
A complement C4-derived glycopeptide is a biomarker for PMM2-CDG
CONCLUSIONComplement C4-derived Man5GlcNAc2 glycopeptide could be a biomarker for accurate diagnosis and therapeutic monitoring of patients with PMM2-CDG and other CDGs.FUNDINGU54NS115198 (Frontiers in Congenital Disorders of Glycosylation: NINDS; NCATS; Eunice Kennedy Shriver NICHD; Rare Disorders Consortium Disease Network); K08NS118119 (NINDS); Minnesota Partnership for Biotechnology and Medical Genomics; Rocket Fund; R01DK099551 (NIDDK); Mayo Clinic DERIVE Office; Mayo Clinic Center for Biomedical Discovery; IA/CRC/20/1/600002 (Center for Rare Disease Diagnosis, Research and Training; DBT/Wellcome Trust India Alliance)...
Source: Genomics Proteomics ... - April 8, 2024 Category: Genetics & Stem Cells Authors: Kishore Garapati Rohit Budhraja Mayank Saraswat Jinyong Kim Neha Joshi Gunveen S Sachdeva Anu Jain Anna N Ligezka Silvia Radenkovic Madan Gopal Ramarajan Savita Udainiya Kimiyo Raymond Miao He Christina Lam Austin Larson Andrew C Edmondson Kyriakie Sarafo Source Type: research
Rapid identification and determination of chemical components of huai yam based on UPLC-Q-Exactive-MS and fragmentation patterns
In this study, an efficient method for the classification and rapid identification of yam components was established based on UPLC-Q-Exactive-MS and data post-processing techniques. First, the mass spectrometry information including the characteristic fragmentations (CFs) and neutral losses (NLs) of yam reported in the literature were summarised and a database of compounds was established. Then, the mass spectrometry data detected by the yam sample are compared with those described in database for rapid identification of target compounds. Finally, 60 compounds were identified, including 18 flavones, 2 saponins, 10 amino ac...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Huiru Liu Xia Li Haowei Xu Xiaowen Wang Zhimin Gong Yanyan Xu Lexin Shu Yubo Li Source Type: research
Impact of co-substrate molecular weight on methane production potential, microbial community dynamics, and metabolic pathways in waste activated sludge anaerobic co-digestion
This study firstly revealed the complex interactions between co-substrate molecular weight and microbial communities, and demonstrated the feasibility of adjusting co-substrate molecular weight to improve methane production process.PMID:38588784 | DOI:10.1016/j.biortech.2024.130678 (Source: Bioresource Technology)
Source: Bioresource Technology - April 8, 2024 Category: Biotechnology Authors: Weixin Zhao Xinwei Chen Hao Ma Dan Li Haizhou Yang Tianyi Hu Qingliang Zhao Junqiu Jiang Liangliang Wei Source Type: research
Effects of Preoperative Oral Carbohydrate on Perioperative Maternal Outcomes Undergoing Cesarean Section: A Systematic Review and Meta-Analysis
CONCLUSION: Preoperative oral CHO during cesarean section alleviates thirst and hunger, shortens the time of postoperative flatus, and reduces HOMA-IR. However, the available evidence is insufficient to reach a clear consensus on the benefits or harms of preoperative oral CHO during cesarean section. Therefore, it is premature to make a definitive recommendation for or against its routine use.PMID:38586152 | PMC:PMC10999288 | DOI:10.1155/2024/4660422 (Source: Anesthesiology Research and Practice)
Source: Anesthesiology Research and Practice - April 8, 2024 Category: Anesthesiology Authors: Haibin Shi Caihong Zheng Bin Zhu Source Type: research
