Role of diet in the risks of esophageal adenocarcinoma and squamous cell carcinoma: an updated umbrella review
ConclusionsThis umbrella review highlighted convincing evidence regarding the associations of areca nut and high alcohol with a higher risk of ESCC. Additionally, an association between vitamin B6 and a decreased risk of EAC was observed. Further research is needed to examine the dietary factors with weak evidence regarding their associations with ESCC and EAC. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 30, 2024 Category: Nutrition Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid
Zool Res. 2024 May 18;45(3):520-534. doi: 10.24272/j.issn.2095-8137.2024.028.ABSTRACTIridovirus poses a substantial threat to global aquaculture due to its high mortality rate; however, the molecular mechanisms underpinning its pathogenesis are not well elucidated. Here, a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus (SGIV), focusing on the roles of key metabolites. Results showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the liver. Furthermore, SGIV significantly reduced the contents of lipid droplets, triglycerides, cholesterol, a...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Lin Liu Ya Zhang Meng-Di Yuan Dong-Miao Xiao Wei-Hua Xu Qi Zheng Qi-Wei Qin You-Hua Huang Xiao-Hong Huang Source Type: research
A novel "microbiota-host interaction model" to study the real-time effects of fermentation of non-digestible carbohydrate (NDCs) on gut barrier function
In this study, an in vitro co-culture model using an electric cell-substrate impedance sensing system (ECIS) for testing the impact of real-time fermentation of non-digestible carbohydrates (NDCs) by the intestinal microbiota on gut barrier function was established. We applied Lactobacillus plantarum WCFS1 as a model intestinal bacterium and alginate-pectin as immobilization polymers as well as a source of NDCs to determine the impact of pectin fermentation on the barrier function of T84 gut epithelial cells. In the first design, L. plantarum WCFS1 was encapsulated in an alginate capsule followed by embedding in an agar la...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Xiaochen Chen Luis Llanos Moreno Xin Tang Naschla Gasaly Henk A Schols Paul de Vos Source Type: research
Influence of blood glucose fluctuations on chemotherapy efficacy and safety in type 2 diabetes mellitus patients complicated with lung carcinoma
CONCLUSION: The greater the BG fluctuation in LC patients after chemotherapy, the more unfavorable the therapeutic effect of chemotherapy; the higher the level of tumor markers and inflammatory cytokines, the more adverse reactions the patient experiences.PMID:38680689 | PMC:PMC11045413 | DOI:10.4239/wjd.v15.i4.645 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Tian-Zheng Fang Xian-Qiao Wu Ting-Qi Zhao Shan-Shan Wang Guo-Mei-Zhi Fu Qing-Long Wu Cheng-Wei Zhou Source Type: research
Telemedicine for Ketogenic Dietary Treatment in Refractory Epilepsy and Inherited Metabolic Disease: State of Play and Future Perspectives
Stud Health Technol Inform. 2024 Apr 26;313:160-166. doi: 10.3233/SHTI240031.ABSTRACTKetogenic dietary therapies (KDT) are diets that induce a metabolic condition comparable to fasting. All types of KDT comprise a reduction in carbohydrates whilst dietary fat is increased up to 90% of daily energy expenditure. The amount of protein is normal or slightly increased. KDT are effective, well studied and established as non-pharmacological treatments for pediatric patients with refractory epilepsy and specific inherited metabolic diseases such as Glucose Transporter Type 1 Deficiency Syndrome. Patients and caregivers have to con...
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Alexander H öller Stefan Welte Anna Katharina Sch önlaub Charlotte Uhlisch Sabine Scholl-B ürgi Anastasia Male-Dressler Bernhard Pfeifer G ünter Schreier Source Type: research
Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Biochem Genet. 2024 Apr 29. doi: 10.1007/s10528-024-10803-8. Online ahead of print.ABSTRACTLiver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes and progression of LIHC and to provided potential prognostic markers and therapy targets for LIHC. Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues. The differential co-expression genes were extracted by Weig...
Source: Biochemical Genetics - April 29, 2024 Category: Genetics & Stem Cells Authors: Jiawei Sun Zizhen Zhang Jiaru Cai Xiaoping Li Xiaoling Xu Source Type: research
HPLC-Based Automated Synthesis and Purification of Carbohydrates
Chemistry. 2024 Apr 29:e202401214. doi: 10.1002/chem.202401214. Online ahead of print.ABSTRACTReported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.PMID:38684455 | DOI:10.1002/chem.202401214 (Source: Chemistry)
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Gustavo Kashiwagi Laura Petrosilli Samira Escopy Luigi Lay Keith Stine Cristina De Meo Alexei V Demchenko Source Type: research
Pioglitazone does not enhance exogenous glucose oxidation or metabolic clearance rate during aerobic exercise in men under acute high altitude exposure
This study investigated the impact of Pioglitazone (PIO) on exogenous glucose oxidation and glucose turnover compared to placebo (PLA) during aerobic exercise at HA. Using a randomized, crossover design, native lowlanders (n=7 males, mean±SD, age: 23±6 yr, body mass: 84±11 kg) consumed 145 g (1.8 g/min) glucose while performing 80-min of steady-state (1.43±0.16 V̇O2 L/min) treadmill exercise at HA (460 mmHg) following short-term (5 days) use of PIO (15 mg oral dose per day) or PLA (microcrystalline cellulose pill). Substrate oxidation and glucose turnover were determined using indirect calorimetry and stable isotopes ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 29, 2024 Category: Physiology Authors: Lee M Margolis Marques Wilson Devin J Drummer Christopher T Carrigan Nancy E Murphy Jillian T Allen M Alan Dawson Christos S Mantzoros Andrew J Young Stefan M Pasiakos Source Type: research
Hsp70 Knockdown in the Brine Shrimp Artemia franciscana: Implication on Reproduction, Immune Response and Embryonic Cuticular Structure
Mar Biotechnol (NY). 2024 Apr 29. doi: 10.1007/s10126-024-10318-8. Online ahead of print.ABSTRACTThe potential functional role(s) of heat shock protein 70 (Hsp70) in the brine shrimp, Artemia franciscana, a crucial crustacean species for aquaculture and stress response studies, was investigated in this study. Though we have previously reported that Hsp70 knockdown may have little or no impact on Artemia development, the gestational survival and number of offspring released by adult females were impaired by obscuring Hsp70 synthesis. Transcriptomic analysis revealed that several cuticle and chitin synthetic genes were downr...
Source: Marine Biotechnology - April 29, 2024 Category: Biotechnology Authors: Irene K R Tiong Cher Chien Lau Patrick Sorgeloos Mimi Iryani Mat Taib Tengku Sifzizul Tengku Muhammad Muhd Danish-Daniel Min Pau Tan Liying Sui Min Wang Yeong Yik Sung Source Type: research
Oestrogens in oral contraception: considerations for tailoring prescription to women's needs
CONCLUSION: Today various COCs contain different oestrogens. Prescribers must be familiar with the different properties of each oestrogen for a tailored contraceptive recommendation, considering their safety and contraceptive efficacy, as well as women's needs and preferences.PMID:38683756 | DOI:10.1080/13625187.2024.2334350 (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - April 29, 2024 Category: Reproduction Medicine Authors: Franca Fruzzetti Tiziana Fidecicchi Marco Gambacciani Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Telemedicine for Ketogenic Dietary Treatment in Refractory Epilepsy and Inherited Metabolic Disease: State of Play and Future Perspectives
Stud Health Technol Inform. 2024 Apr 26;313:160-166. doi: 10.3233/SHTI240031.ABSTRACTKetogenic dietary therapies (KDT) are diets that induce a metabolic condition comparable to fasting. All types of KDT comprise a reduction in carbohydrates whilst dietary fat is increased up to 90% of daily energy expenditure. The amount of protein is normal or slightly increased. KDT are effective, well studied and established as non-pharmacological treatments for pediatric patients with refractory epilepsy and specific inherited metabolic diseases such as Glucose Transporter Type 1 Deficiency Syndrome. Patients and caregivers have to con...
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Alexander H öller Stefan Welte Anna Katharina Sch önlaub Charlotte Uhlisch Sabine Scholl-B ürgi Anastasia Male-Dressler Bernhard Pfeifer G ünter Schreier Source Type: research
Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Biochem Genet. 2024 Apr 29. doi: 10.1007/s10528-024-10803-8. Online ahead of print.ABSTRACTLiver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes and progression of LIHC and to provided potential prognostic markers and therapy targets for LIHC. Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues. The differential co-expression genes were extracted by Weig...
Source: Biochemical Genetics - April 29, 2024 Category: Genetics & Stem Cells Authors: Jiawei Sun Zizhen Zhang Jiaru Cai Xiaoping Li Xiaoling Xu Source Type: research
