Hsp70 Knockdown in the Brine Shrimp Artemia franciscana: Implication on Reproduction, Immune Response and Embryonic Cuticular Structure
Mar Biotechnol (NY). 2024 Apr 29. doi: 10.1007/s10126-024-10318-8. Online ahead of print.ABSTRACTThe potential functional role(s) of heat shock protein 70 (Hsp70) in the brine shrimp, Artemia franciscana, a crucial crustacean species for aquaculture and stress response studies, was investigated in this study. Though we have previously reported that Hsp70 knockdown may have little or no impact on Artemia development, the gestational survival and number of offspring released by adult females were impaired by obscuring Hsp70 synthesis. Transcriptomic analysis revealed that several cuticle and chitin synthetic genes were downr...
Source: Marine Biotechnology - April 29, 2024 Category: Biotechnology Authors: Irene K R Tiong Cher Chien Lau Patrick Sorgeloos Mimi Iryani Mat Taib Tengku Sifzizul Tengku Muhammad Muhd Danish-Daniel Min Pau Tan Liying Sui Min Wang Yeong Yik Sung Source Type: research
Oestrogens in oral contraception: considerations for tailoring prescription to women's needs
CONCLUSION: Today various COCs contain different oestrogens. Prescribers must be familiar with the different properties of each oestrogen for a tailored contraceptive recommendation, considering their safety and contraceptive efficacy, as well as women's needs and preferences.PMID:38683756 | DOI:10.1080/13625187.2024.2334350 (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - April 29, 2024 Category: Reproduction Medicine Authors: Franca Fruzzetti Tiziana Fidecicchi Marco Gambacciani Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix
AbstractThe ability of most opportunistic bacteria to form biofilms, coupled with antimicrobial resistance, hinder the efforts to control widespread infections, resulting in high risks of negative outcomes and economic costs. Endolysins are promising compounds that efficiently combat bacteria, including multidrug-resistant strains and biofilms, without a low probability of subsequent emergence of stable endolysin-resistant phenotypes. However, the details of antibiofilm effects of these enzymes are poorly understood. To elucidate the interactions of bacteriophage endolysins LysAm24, LysAp22, LysECD7, and LysSi3 with bacter...
Source: World Journal of Microbiology and Biotechnology - April 29, 2024 Category: Microbiology Source Type: research
Anti-Atherosclerotic Properties of < em > Aronia melanocarpa < /em > Extracts Influenced by Their Chemical Composition Associated with the Ripening Stage of the Berries
In this study, the anti-atherosclerotic effect of Aronia extracts was assessed. The impact on the level of adhesion molecules and the inflammatory response of human umbilical vein endothelial cells (HUVECs) was shown in relation to the chemical composition and the stage of ripening of the fruits. Samples were collected between May (green, unripe) and October (red, overripe) on two farms in Poland, which differed in climate. The content of chlorogenic acids, anthocyanins, and carbohydrates in the extracts was determined using HPLC-DAD/RI. The surface expression of ICAM-1 and VCAM-1 in HUVECs was determined by flow cytometry...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Agnieszka Zieli ńska Dorota Bryk Katarzyna Paradowska Pawe ł Siudem Iwona Wawer Ma łgorzata Wrzosek Source Type: research
Diabetic Cardiomyopathy-From Basics through Diagnosis to Treatment
Biomedicines. 2024 Mar 29;12(4):765. doi: 10.3390/biomedicines12040765.ABSTRACTDiabetic cardiomyopathy (DCM) is the development of myocardial dysfunction in patients with diabetes despite the absence of comorbidities such as hypertension, atherosclerosis or valvular defect. The cardiovascular complications of poorly controlled diabetes are very well illustrated by the U.K. Prospective Diabetes Study (UKPDS), which showed a clear association between increasing levels of glycated hemoglobin and the development of heart failure (HF). The incidence of HF in patients with diabetes is projected to increase significantly, which i...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Ewa Radzioch Bart łomiej Dąbek Marta Balcerczyk-Lis Weronika Fr ąk Piotr Fularski Ewelina M łynarska Jacek Rysz Beata Franczyk Source Type: research
Trends in preoperative carbohydrate load practice: A systematic review
CONCLUSION: Variation in PCL practices prevent meaningful data pooling and outcome analysis, highlighting the need for standardized PCL prescription. Efforts dedicated to the establishment of a gold standard PCL prescription are necessary so that studies can be pooled and analyzed with respect to meaningful clinical end points that impact surgical outcomes and patient satisfaction.PMID:38676554 | DOI:10.1002/jpen.2633 (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - April 27, 2024 Category: Nutrition Authors: Robert J Canelli Joseph Louca Rafael M Gonzalez Luis F Rendon Ciana R Hartman Federico Bilotta Source Type: research
An investigation on antimicrobial and anticancer competence of macro red algae under in-vitro condition
Environ Res. 2024 Apr 25:119026. doi: 10.1016/j.envres.2024.119026. Online ahead of print.ABSTRACTThe purpose of this study was to look into the proximate parameters (moisture, ash, total fat, protein, and total carbohydrate) , mineral composition (Fe, Cu, Mg, and Zn ), antimicrobial as well as cytotoxic (anticancer) properties of extracts from the marine red macro algae Gracilaria corticata, Chondrus ocellatus, and Posphyra perforata against a few prevalent microbial pathogens (Salmonella typhi, Streptococcus pneumoniae, Corynebacterium diphtheriae, Clostridium tetani, and Treponema pallidum as well as fungal pathogens su...
Source: Environmental Research - April 27, 2024 Category: Environmental Health Authors: Thi-Van Hoang Saleh Alfarraj Sulaiman Ali Alharbi Source Type: research
Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu < sup > 2+ < /sup > -PPi interaction using bimetallic Au-Ag nanoclusters
Anal Chim Acta. 2024 May 29;1305:342584. doi: 10.1016/j.aca.2024.342584. Epub 2024 Apr 10.ABSTRACTBACKGROUND: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic p...
Source: Analytica Chimica Acta - April 27, 2024 Category: Chemistry Authors: Deepika Sharma Nishima Wangoo Rohit K Sharma Source Type: research
Advanced application of carbohydrate-based micro/nanoparticles for rheumatoid arthritis
Int J Biol Macromol. 2024 Apr 25:131809. doi: 10.1016/j.ijbiomac.2024.131809. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a kind of synovitis and progressive joint destruction disease. Dysregulated immune cell activation, inflammatory cytokine overproduction, and subsequent reactive oxidative species (ROS) production contribute to the RA process. Carbohydrates, including cellulose, chitosan, alginate and dextran, are among the most abundant and important biomolecules in nature and are widely used in biomedicine. Carbohydrate-based micro/nanoparticles(M/NPs) as functional excipients have the ability to improv...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Linxian Cui Jinkui Pi Boquan Qin Ting Cui Zhenfei Liu Lei Lei Shizhou Wu Source Type: research
Photocatalytic degradation of Acid Red 18 by synthesized AgCoFe < sub > 2 < /sub > O < sub > 4 < /sub > @Ch/AC: Recyclable, environmentally friendly, chemically stable, and cost-effective magnetic nano hybrid catalyst
Int J Biol Macromol. 2024 Apr 25:131897. doi: 10.1016/j.ijbiomac.2024.131897. Online ahead of print.ABSTRACTChitosan (Ch) is a linear biodegradable natural carbohydrate polymer and the most appealing biopolymer, such as low-cost biodegradability, biocompatibility, hydrophilicity, and non-toxicity. In this case, Ch was utilized to synthesize AgCoFe2O4@Chitosan (Ch)/Activated Carbon (AC) by the modified microwave-assisted co-precipitation method. The physical and chemical structure of magnetic nanocomposites was analyzed and characterized by Field Emission Scanning Electron Microscope (FESEM), Transmission electron microscop...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Majid Amiri Gharaghani Abbas Dehdarirad Hakimeh Mahdizadeh Hassan Hashemi Alireza Nasiri Mohammad Reza Samaei Amin Mohammadpour Source Type: research
Techno-economic analysis of biomass value-added processing informed by pilot scale de-ashing of paper sludge feedstock
Bioresour Technol. 2024 Apr 25:130744. doi: 10.1016/j.biortech.2024.130744. Online ahead of print.ABSTRACTPaper sludge biomass represents an underutilized feedstock rich in pulped and processed cellulose which is currently a waste stream with significant disposal cost to industry for landfilling services. Effective fractionation of the cellulose from paper sludge presents an opportunity to yield cellulose as feedstock for value-added processes. A novel approach to cellulose fractionation is the sidehill screening system, herein studied at the pilot-plant scale. Composition analysis determined ash removal and carbohydrate r...
Source: Bioresource Technology - April 27, 2024 Category: Biotechnology Authors: Phoenix Tiller Hyeonji Park David Cruz Rios Edgar Carrejo David K Johnson Ashutosh Mittal Richard Venditti Sunkyu Park Source Type: research
Carbohydrate binding modules: Compact yet potent accessories in the specific substrate binding and performance evolution of carbohydrate-active enzymes
Biotechnol Adv. 2024 Apr 25:108365. doi: 10.1016/j.biotechadv.2024.108365. Online ahead of print.ABSTRACTCarbohydrate binding modules (CBMs) are independent non-catalytic domains widely found in carbohydrate-active enzymes (CAZymes), and they play an essential role in the substrate binding process of CAZymes by guiding the appended catalytic modules to the target substrates. Owing to their precise recognition and selective affinity for different substrates, CBMs have received increasing research attention over the past few decades. To date, CBMs from different origins have formed a large number of families that show a vari...
Source: Biotechnology Advances - April 27, 2024 Category: Biotechnology Authors: Yuxian You Haocun Kong Caiming Li Zhengbiao Gu Xiaofeng Ban Zhaofeng Li Source Type: research
Anti-Atherosclerotic Properties of < em > Aronia melanocarpa < /em > Extracts Influenced by Their Chemical Composition Associated with the Ripening Stage of the Berries
In this study, the anti-atherosclerotic effect of Aronia extracts was assessed. The impact on the level of adhesion molecules and the inflammatory response of human umbilical vein endothelial cells (HUVECs) was shown in relation to the chemical composition and the stage of ripening of the fruits. Samples were collected between May (green, unripe) and October (red, overripe) on two farms in Poland, which differed in climate. The content of chlorogenic acids, anthocyanins, and carbohydrates in the extracts was determined using HPLC-DAD/RI. The surface expression of ICAM-1 and VCAM-1 in HUVECs was determined by flow cytometry...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Agnieszka Zieli ńska Dorota Bryk Katarzyna Paradowska Pawe ł Siudem Iwona Wawer Ma łgorzata Wrzosek Source Type: research
Diabetic Cardiomyopathy-From Basics through Diagnosis to Treatment
Biomedicines. 2024 Mar 29;12(4):765. doi: 10.3390/biomedicines12040765.ABSTRACTDiabetic cardiomyopathy (DCM) is the development of myocardial dysfunction in patients with diabetes despite the absence of comorbidities such as hypertension, atherosclerosis or valvular defect. The cardiovascular complications of poorly controlled diabetes are very well illustrated by the U.K. Prospective Diabetes Study (UKPDS), which showed a clear association between increasing levels of glycated hemoglobin and the development of heart failure (HF). The incidence of HF in patients with diabetes is projected to increase significantly, which i...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Ewa Radzioch Bart łomiej Dąbek Marta Balcerczyk-Lis Weronika Fr ąk Piotr Fularski Ewelina M łynarska Jacek Rysz Beata Franczyk Source Type: research
