Continuous Indirect Calorimetry in Critically Injured Patients Reveals Significant Daily Variability and Delayed, Sustained Hypermetabolism.
CONCLUSION: In critically injured patients, steady-state REE measurements display fluctuations over a 24-hour period and demonstrate a gradual rise over the first few days after injury. Continuous REE, if available, is recommended for more precise matching of energy delivery to metabolic requirements. PMID: 31602681 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - October 10, 2019 Category: Nutrition Authors: Vasileiou G, Mulder MB, Qian S, Iyengar R, Gass LM, Parks J, Lineen E, Byers P, Yeh DD Tags: JPEN J Parenter Enteral Nutr Source Type: research

l-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients.
CONCLUSIONS: We found that perioperative treatment with l-carnitine was significantly better than ordinary treatment in reducing postoperative serum ammonia levels, suggesting that l-carnitine may serve as a pivotal regulator of liver injury and repair and result in shorter postoperative hospitalization (ClinicalTrials.gov trial registration no. NCT03021876). PMID: 31599019 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - October 9, 2019 Category: Nutrition Authors: Okabayashi T, Sui K, Mastumoto T, Iwata J, Morita S, Iiyama T, Shimada Y Tags: JPEN J Parenter Enteral Nutr Source Type: research

Human Milk Retains Important Immunologic Properties After Defatting.
CONCLUSIONS: Unexpectedly, defatted human milk contained significantly less leukocytes than full-fat milk. IgA, IgG, lysozyme, and lactoferrin concentrations were preserved. The ability of defatted milk to inhibit bacterial growth was unaffected, suggesting that the antibacterial benefits of human milk remain after the defatting process. Further investigation regarding the clinical effect of leukocyte loss in defatted milk is warranted. PMID: 31599047 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - October 9, 2019 Category: Nutrition Authors: Jackson BA, Gregg BE, Tutor SD, Bermick JR, Stanley KP Tags: JPEN J Parenter Enteral Nutr Source Type: research

Early Detection of Muscle Weakness and Functional Limitations in the Critically Ill: A Retrospective Evaluation of Bioimpedance Spectroscopy.
CONCLUSION: Site-by-site data suggest that raw impedance variables might be useful for screening weakness and poor function. PMID: 31583738 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - October 3, 2019 Category: Nutrition Authors: Baldwin CE, Fetterplace K, Beach L, Kayambu G, Paratz J, Earthman C, Parry SM Tags: JPEN J Parenter Enteral Nutr Source Type: research

Does Low Body Mass Index Predict Mortality in Asian Hospitalized Patients?
Abstract BACKGROUND: Studies on malnutrition suggest low body mass index (BMI) may be associated with poor clinical outcomes. We investigated published data to identify whether low BMI could predict short-term and long-term clinical outcomes in Asian hospitalized patients. METHODS: A search was conducted in the PubMed database including terms "body mass index" or "BMI" or "malnutrition" or "undernutrition" AND "Asia" or "Asian" AND "outcome" or "complication" or "mortality" or "survival" or "ICU" for ...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 25, 2019 Category: Nutrition Authors: Xue Z, Yu J, Higashikuchi T, Compher C Tags: JPEN J Parenter Enteral Nutr Source Type: research

JPEN Journal Club 49. Pilot Trials.
PMID: 31549417 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 24, 2019 Category: Nutrition Authors: Koretz RL Tags: JPEN J Parenter Enteral Nutr Source Type: research

Comment on "New Prediction Equations to Estimate Appendicular Skeletal Muscle Mass Using Calf Circumference on NHANES Data: Methodological Issues".
Comment on "New Prediction Equations to Estimate Appendicular Skeletal Muscle Mass Using Calf Circumference on NHANES Data: Methodological Issues". JPEN J Parenter Enteral Nutr. 2019 Sep 24;: Authors: Santos LP, Gonzalez MC, Orlandi SP, Bielemann RM, Barbosa-Silva TG, Heymsfield SB, COCONUT Study Group. PMID: 31549418 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 24, 2019 Category: Nutrition Authors: Santos LP, Gonzalez MC, Orlandi SP, Bielemann RM, Barbosa-Silva TG, Heymsfield SB, COCONUT Study Group. Tags: JPEN J Parenter Enteral Nutr Source Type: research

Creation of a Standard Model for Tube Feeding at Neonatal Intensive Care Unit Discharge.
CONCLUSION: Our program is the first of which we know to use a standard care-process model to guide the decision-making and utilization of HEN at NICU discharge. HEFT shows that HEN at NICU discharge can be safe and effective, with high parental satisfaction. PMID: 31549429 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 24, 2019 Category: Nutrition Authors: White BR, Ermarth A, Thomas D, Arguinchona O, Presson AP, Ling CY Tags: JPEN J Parenter Enteral Nutr Source Type: research

Phase 3 Pilot Randomized Controlled Trial Comparing Early Trophic Enteral Nutrition With "No Enteral Nutrition" in Mechanically Ventilated Patients With Septic Shock.
Phase 3 Pilot Randomized Controlled Trial Comparing Early Trophic Enteral Nutrition With "No Enteral Nutrition" in Mechanically Ventilated Patients With Septic Shock. JPEN J Parenter Enteral Nutr. 2019 Sep 19;: Authors: Patel JJ, Kozeniecki M, Peppard WJ, Peppard SR, Zellner-Jones S, Graf J, Szabo A, Heyland DK Abstract BACKGROUND: The optimal dose and timing of enteral nutrition (EN) in septic shock are unclear. METHODS: We conducted a phase 3 single-center randomized controlled pilot trial comparing early trophic EN with "no EN" in mechanically ventilated adults with septic ...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 19, 2019 Category: Nutrition Authors: Patel JJ, Kozeniecki M, Peppard WJ, Peppard SR, Zellner-Jones S, Graf J, Szabo A, Heyland DK Tags: JPEN J Parenter Enteral Nutr Source Type: research

Short-Term Creatine Supplementation May Alleviate the Malnutrition-Inflammation Score and Lean Body Mass Loss in Hemodialysis Patients: A Pilot Randomized Placebo-Controlled Trial.
CONCLUSION: In HD patients, four weeks of creatine supplementation may alleviate the MIS as well as attenuate the LBM loss compared to placebo. PMID: 31531996 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 18, 2019 Category: Nutrition Authors: Marini ACB, Motobu RD, Freitas ATV, Mota JF, Wall BT, Pichard C, Laviano A, Pimentel GD Tags: JPEN J Parenter Enteral Nutr Source Type: research

The Impact of Preoperative Immunonutrition and Standard Polymeric Supplements on Patient Outcomes After Pelvic Exenteration Surgery, Taking Compliance Into Consideration: A Randomized Controlled Trial.
CONCLUSION: Preoperative immunonutrition did not significantly impact length of stay or postoperative complications compared with standard polymeric supplements after pelvic exenteration surgery, despite controlling for protein, energy, and volume. Compliance, protein, and energy may considerably impact the effect of immunonutrition, particularly in malnourished patients. PMID: 31531997 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 18, 2019 Category: Nutrition Authors: Hogan S, Solomon M, Rangan A, Ferrie S, Carey S Tags: JPEN J Parenter Enteral Nutr Source Type: research

Volume-Based Protocol Improves Delivery of Enteral Nutrition in Critically Ill Trauma Patients.
CONCLUSION: Implementation of a VP significantly increased delivery of EN by 8.3% over that given by the CM in critically ill trauma patients with no difference in feeding-related complications. PMID: 31532004 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 18, 2019 Category: Nutrition Authors: Sachdev G, Backes K, Thomas BW, Sing RF, Huynh T Tags: JPEN J Parenter Enteral Nutr Source Type: research

Macronutrient Analysis of Modified-Fat Breast Milk Produced by 3 Methods of Fat Removal.
CONCLUSION: Breast milk fat removal did not significantly alter protein levels. In skimmed breast milk, the overestimation of fat content using creamatocrit method suggests a need for more accurate bedside methods to assess macronutrient content. The similar macronutrient composition of breast milk skimmed by cream separator and centrifuge suggests the potential for cream separator use as a new, portable defatting method for hospitals and families. PMID: 31529507 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 17, 2019 Category: Nutrition Authors: Barbas KH, O'Brien K, Forbes PW, Belfort MB, Connor JA, Thiagarajan RR, Huh SY Tags: JPEN J Parenter Enteral Nutr Source Type: research

A Volume-Based Feeding Protocol Improves Nutrient Delivery and Glycemic Control in a Surgical Trauma Intensive Care Unit.
Abstract BACKGROUND: Inadequate delivery of nutrition in critically ill patients has been shown to have adverse outcomes. A surgical trauma intensive care unit provides unique challenges to enteral feeds. Although volume-based feeding protocols, like Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol (PEP uP), have been successfully used in medical intensive care patients, data are sparse on its safety and efficacy in a surgical intensive care unit population. METHODS: A PEP uP protocol was recently initiated at our American College of Surgeons Level 1 verified trauma center. Medical rec...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 16, 2019 Category: Nutrition Authors: Prest PJ, Justice J, Bell N, McCarroll R, Watson CM Tags: JPEN J Parenter Enteral Nutr Source Type: research

Prevalence of Bloodstream Infections in Children With Short-Bowel Syndrome With a Central Line Presenting to Emergency Department With Fever.
CONCLUSION: Children with fever and SBS are at high risk for BSI with gram-positive and gram-negative organisms as well as fungus. WBC count at presentation is a poor predictor of BSI. Though elevated CRP increased the odds of BSI, its low negative predictive value made it a poor predictor of BSI in these patients. Children with SBS and fever should be treated urgently with broad-spectrum antibiotics. PMID: 31512263 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 11, 2019 Category: Nutrition Authors: Fifi AC, Bayes L, Ehrenpreis ED, Chavez H Tags: JPEN J Parenter Enteral Nutr Source Type: research

Malnutrition Predisposes to Endotoxin-Induced Edema and Impaired Inflammatory Response in Parenterally Fed Piglets.
Abstract BACKGROUND: Poor nutrition status is common among hospitalized children and children in low-income countries and may be associated with increased susceptibility to edema and infections. We hypothesized that poor nutrition status, established with a suboptimal composition of parenteral nutrition (PN), predisposes to endotoxemia-induced edema, oxidative stress, and dysregulated immune responses. METHODS: Using a 2 × 2 factorial design, 3-day-old piglets (n = 40) were given either optimal or suboptimal composition of PN for 7 days and then infused with either saline or lipopolysaccharide (LPS...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 11, 2019 Category: Nutrition Authors: Baek O, Fabiansen C, Friis H, Ritz C, Koch J, Willesen JL, Heegaard PMH, Lykkesfeldt J, Briend A, Golden MH, Sangild PT, Thymann T Tags: JPEN J Parenter Enteral Nutr Source Type: research

The Effect of Glutamine Supplementation on Microbial Invasion in Surgical Infants Requiring Parenteral Nutrition: Results of a Randomized Controlled Trial.
CONCLUSION: More than half of surgical infants requiring PN showed evidence of microbial invasion. Approximately half of this was not detectable by conventional blood cultures. Parenteral plus enteral glutamine supplementation had no effect on incidence of microbial invasion. PMID: 31502272 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 9, 2019 Category: Nutrition Authors: Bishay M, Simchowitz V, Harris K, Macdonald S, De Coppi P, Klein N, Eaton S, Pierro A, MIGS Trial Group Tags: JPEN J Parenter Enteral Nutr Source Type: research

Repeated Metabolic Balance Studies in Patients With Short Bowel Syndrome.
CONCLUSION: We observed no signs of late-phase intestinal adaptation in this selected group of patients with SBS. Future prospective MBSs are needed to understand the time course and magnitude of intestinal adaptation. PMID: 31497880 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 9, 2019 Category: Nutrition Authors: Sun H, Eliasson J, Fuglsang KA, Hvistendahl M, Naimi RM, Jeppesen PB Tags: JPEN J Parenter Enteral Nutr Source Type: research

Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure due to Short Bowel Syndrome: A 24-Week, Phase III Study.
This study evaluated the safety and efficacy of teduglutide in pediatric patients with short bowel syndrome-associated intestinal failure (SBS-IF). METHODS: A 24-week, phase III trial with 2 randomized, double-blind teduglutide dose groups and a nonblinded standard of care (SOC) arm was used; patients received 0.025 mg/kg or 0.05 mg/kg teduglutide once daily. Safety end points included treatment-emergent adverse events (TEAEs) and growth parameters. The primary efficacy/pharmacodynamic end point was the number of patients who achieved a ≥20% reduction in parenteral support (PS) from baseline at week 24. ...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 8, 2019 Category: Nutrition Authors: Kocoshis SA, Merritt RJ, Hill S, Protheroe S, Carter BA, Horslen S, Hu S, Kaufman SS, Mercer DF, Pakarinen MP, Venick RS, Wales PW, Grimm AA Tags: JPEN J Parenter Enteral Nutr Source Type: research

Using Bioelectrical Impedance Analysis for Body Composition Assessment: Sorting Out Some Misunderstandings.
PMID: 31486082 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 4, 2019 Category: Nutrition Authors: Gonzalez MC Tags: JPEN J Parenter Enteral Nutr Source Type: research

Healthcare Professionals' Perceptions of Feeding Tube Practices for Patients With Head and Neck Cancer Across 4 International Radiation Oncology Departments.
CONCLUSION: Although the targeted use of FTs was valued by healthcare professionals, several patient and service-structure factors may influence whether the PGT or reactive NGT approach is perceived to be more efficacious. Further research is needed to explore patient preferences, tube dependence, interdisciplinary collaboration, and department infrastructure to promote consistent evidence-based and patient-centered FT practices. PMID: 31478219 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 2, 2019 Category: Nutrition Authors: Hazzard E, Walton K, McMahon AT, Milosavljevic M, Tapsell L Tags: JPEN J Parenter Enteral Nutr Source Type: research

JPEN Journal Club 48. When Systematic Reviews Differ.
PMID: 31475362 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 2, 2019 Category: Nutrition Authors: Koretz RL Tags: JPEN J Parenter Enteral Nutr Source Type: research

Early Predictors of Enteral Autonomy in Pediatric Intestinal Failure Resulting From Short Bowel Syndrome: Development of a Disease Severity Scoring Tool.
Abstract INTRODUCTION: Patients with short bowel syndrome (SBS) are dependent on parenteral nutrition (PN) while their bowel attempts to compensate. Our objective was to create an SBS disease severity score to predict the probability of achieving enteral autonomy (EA). METHODS: A retrospective cohort study of children with SBS managed by our Intestinal Rehabilitation Program was completed. Data abstracted included demographic, bowel anatomy, and outcome variables including conjugated bilirubin (CB) and enteral nutrition (EN) tolerated 6 months postoperatively. Univariate analysis and Cox proportional hazards ...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 28, 2019 Category: Nutrition Authors: Belza C, Fitzgerald K, de Silva N, Avitzur Y, Wales PW Tags: JPEN J Parenter Enteral Nutr Source Type: research

Ethanol Lock Therapy Markedly Reduces Catheter-Related Blood Stream Infections in Adults Requiring Home Parenteral Nutrition: A Retrospective Study From a Tertiary Medical Center.
Abstract BACKGROUND: The use of central venous catheter (CVC) access for home parenteral nutrition (HPN) is associated with catheter-related bloodstream infections (CRBSIs). There are limited data on the use of ethanol lock therapy (ELT) to prevent CRBSI in adult HPN patients. Our aim was to determine whether the routine institution of ELT decreased the incidence of CRBSI compared with historic controls at Emory University Hospital (EUH) in Atlanta, Georgia, USA. METHODS: EUH medical records of adult HPN patients discharged with a tunneled, silicone CVC on ELT were retrospectively studied during a pre-hoc det...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 27, 2019 Category: Nutrition Authors: Gundogan K, Dave NJ, Griffith DP, Zhao VM, McNally TA, Easley KA, Haack CI, Galloway JR, Ziegler TR Tags: JPEN J Parenter Enteral Nutr Source Type: research

Impact of Postnatal Antibiotics and Parenteral Nutrition on the Gut Microbiota in Preterm Infants During Early Life.
CONCLUSION: The early-life microbial composition and functions were markedly different in preterm infants, being associated with the prolonged use of postnatal antibiotics and parenteral nutrition. PMID: 31452218 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 26, 2019 Category: Nutrition Authors: Jia J, Xun P, Wang X, He K, Tang Q, Zhang T, Wang Y, Tang W, Lu L, Yan W, Wang W, Hu T, Cai W Tags: JPEN J Parenter Enteral Nutr Source Type: research

An Observational Study of Smoflipid vs Intralipid on the Evolution of Intestinal Failure-Associated Liver Disease in Infants With Intestinal Failure.
Abstract BACKGROUND: SMOFlipid has a more diverse lipid profile than traditional Intralipid and has become the standard lipid for patients in our intestinal rehabilitation program. Our objective was to compare outcomes in neonates with intestinal failure (IF) who received SMOFlipid against those receiving Intralipid. METHODS: This was a retrospective cohort study of infants with IF with a minimum follow-up of 12 months in 2008-2016. Patients were stratified into 2 groups: group 1 received SMOFlipid; group 2 was a historical cohort who received Intralipid. The primary outcome was liver function evaluated using...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 25, 2019 Category: Nutrition Authors: Belza C, Wales JC, Courtney-Martin G, de Silva N, Avitzur Y, Wales PW Tags: JPEN J Parenter Enteral Nutr Source Type: research

Skeletal Muscle Mass Index Predicts Postoperative Complications in Intestinal Surgery for Crohn's Disease.
CONCLUSION: We present the largest published cohort investigating SMI with regard to major postoperative morbidity in surgery for CD. In multivariable analysis, SMI was the only significant risk factor for Clavien-Dindo complications grade ≥III. Lumbar SMI was reliably determined by CT and MRI alike. Because preoperative abdominal imaging with either modality is common for patients with CD, SMI could be a reliable and largely available tool to stratify the risk of postoperative complications. PMID: 31444789 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 23, 2019 Category: Nutrition Authors: Galata C, Hodapp J, Weiß C, Karampinis I, Vassilev G, Reißfelder C, Otto M Tags: JPEN J Parenter Enteral Nutr Source Type: research

Early Enteral Administration of a Complex Lipid Emulsion Supplement Prevents Postnatal Deficits in Docosahexaenoic and Arachidonic Acids and Increases Tissue Accretion of Lipophilic Nutrients in Preterm Piglets.
CONCLUSIONS: Enteral administration of CLS1 and CLS2 demonstrated similar increases in DHA levels compared with birth levels. Only CLS2 maintained AA birth levels. Providing a concentrated complex lipid emulsion with an AA:DHA ratio> 1 is important in preventing postnatal AA deficits. PMID: 31441521 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 23, 2019 Category: Nutrition Authors: Akinsulire O, Perides G, Anez-Bustillos L, Cluette-Brown J, Nedder A, Pollack E, Singh P, Liu Y, Sanchez-Fernandez LL, Obregon E, Bicak E, Kiefer S, Yakah W, Gutierrez HV, Dao DT, Vurma M, Ehling S, Gordon D, DeMichele S, Freedman SD, Martin CR Tags: JPEN J Parenter Enteral Nutr Source Type: research

Metabolic and Inflammatory Effects of an ω-3 Fatty Acid-Based Eucaloric Ketogenic Diet in Mice With Endotoxemia.
CONCLUSION: An O3KD leads to reduced inflammation and maintains glucose homeostasis in mice with endotoxemia. PMID: 31435972 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 21, 2019 Category: Nutrition Authors: Anez-Bustillos L, Dao DT, Finkelstein A, Pan A, Cho BS, Mitchell PD, Gura KM, Bistrian BR, Puder M Tags: JPEN J Parenter Enteral Nutr Source Type: research

Prognostic Value of Prolonged Feeding Intolerance in Predicting All-Cause Mortality in Critically Ill Patients: A Multicenter, Prospective, Observational Study.
CONCLUSION: FI was associated with increased mortality and longer duration of mechanical ventilation and vasoactive support. Prolonged or relapsing FI represented an incremental risk of adverse outcomes in critically ill patients. PMID: 31429970 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 20, 2019 Category: Nutrition Authors: Hu B, Sun R, Wu A, Ni Y, Liu J, Guo F, Ying L, Ge G, Ding A, Shi Y, Liu C, Xu L, Jiang R, Lu J, Lin R, Zhu Y, Wu W, Xie B Tags: JPEN J Parenter Enteral Nutr Source Type: research

JPEN Journal Club 47. How Good Should Evidence Be?
PMID: 31423594 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 18, 2019 Category: Nutrition Authors: Koretz RL Tags: JPEN J Parenter Enteral Nutr Source Type: research

Results of Surgical and Medical Rehabilitation for Adult Patients With Type III Intestinal Failure in a Comprehensive Unit Today: Building a New Model to Predict Parenteral Nutrition Independency.
CONCLUSIONS: AGIRS in this group of patients enabled intestinal length increase and also intestinal anatomy conversion into a more favorable type for intestinal rehabilitation. TED treatment was useful to discontinue PN in patients with classical negative anatomical predictors. The novel predicting formula has an ROC area under the curve = 0.82. Further studies are necessary to validate this formula. PMID: 31423603 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 18, 2019 Category: Nutrition Authors: Gondolesi GE, Doeyo M, Echevarria Lic C, Lobos F, Rubio S, Rumbo C, Ramisch D, Crivelli A, Schelotto PB, Solar H Tags: JPEN J Parenter Enteral Nutr Source Type: research

Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials.
CONCLUSION: Although this analysis was limited by low patient numbers, results suggest that SBS-IF characteristics of lower baseline PS volume and non-IBD etiology were associated with PS reduction benefits with teduglutide in terms of days off per week and enteral autonomy. PMID: 31423614 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 18, 2019 Category: Nutrition Authors: Seidner DL, Gabe SM, Lee HM, Olivier C, Jeppesen PB Tags: JPEN J Parenter Enteral Nutr Source Type: research

Parameters of Bioelectrical Impedance Are Good Predictors of Nutrition Risk, Length of Stay, and Mortality in Critically Ill Patients: A Prospective Cohort Study.
Abstract BACKGROUND: Assessment of nutrition risk in the intensive care unit (ICU) is limited by characteristics of critically ill patients, and new methods have been investigated for their applicability and predictive validity. The aim of the present study was to evaluate the validity of bioelectrical impedance analysis (BIA) parameters as predictors of nutrition risk and clinical outcomes in critically ill patients. METHODS: This was a prospective cohort study of patients admitted to an ICU. The modified Nutrition Risk in the Critically Ill score was used for assessment of nutrition risk, and BIA was perfor...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 18, 2019 Category: Nutrition Authors: Razzera EL, Marcadenti A, Rovedder SW, Alves FD, Fink JDS, Silva FM Tags: JPEN J Parenter Enteral Nutr Source Type: research

Relationship Between Dietary Fiber Intake and Short-Chain Fatty Acid-Producing Bacteria During Critical Illness: A Prospective Cohort Study.
This study evaluated the safety and effect of fiber in ICU patients with gut microbiome sampling. METHODS: This was a retrospective study nested within a prospective cohort. Adults were included if newly admitted to the ICU and could receive oral nutrition, enteral feedings, or no nutrition. Rectal swabs were performed at admission and 72 hours later. The primary exposure was fiber intake over 72 hours, classified in tertiles and adjusted for energy intake. The primary outcome was the relative abundance (RA) of SCFA producers via 16S RNA sequencing and the tolerability of fiber. RESULTS: In 129 patients, median f...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - August 6, 2019 Category: Nutrition Authors: Fu Y, Moscoso DI, Porter J, Krishnareddy S, Abrams JA, Seres D, Chong DH, Freedberg DE Tags: JPEN J Parenter Enteral Nutr Source Type: research

Gastrointestinal Dysfunction in Critical Illness: A Review of Scoring Tools.
Abstract Gastrointestinal dysfunction/failure (GDF) is a common feature of critical illness. There is no consensus on the best way to measure severity of GDF. The aim of this systematic review was to evaluate and compare all gastrointestinal dysfunction scoring tools (GDSTs) to determine aspects that might be useful to construct a new gut scoring tool for intensive care patients. A comprehensive database search of MEDLINE and EMBASE on GDSTs in acute, surgical, and critically ill patients was conducted. Extraction of data was conducted for study characteristics, GDST domains, feasibility of the scoring process, cl...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 26, 2019 Category: Nutrition Authors: Asrani VM, Brown A, Huang W, Bissett I, Windsor JA Tags: JPEN J Parenter Enteral Nutr Source Type: research

Indications and Patterns of Use for Parenteral Nutrition in Pediatric Oncology.
CONCLUSION: Inpatient PN use is common in childhood cancer. Indications include mucositis, feed intolerance, and surgical management. Patterns of use are influenced by cancer diagnosis and treatment, with greater use in children with hematological cancer and HSCT. Improved understanding and specific indications may guide appropriate PN prescription and minimize unnecessary risk, cost, and inconsistency in care. PMID: 31332795 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 22, 2019 Category: Nutrition Authors: McGrath KH, Evans V, Yap J Tags: JPEN J Parenter Enteral Nutr Source Type: research

Pediatric Sarcopenia: A Paradigm in the Overall Definition of Malnutrition in Children?
CONCLUSION: Consensus needs to be reached in methodological approaches in sarcopenia diagnosis, body composition measurements, and age-appropriate muscle function tests in pediatrics. Careful considerations on growth, neurocognitive status, and factors influencing development in various clinical populations are warranted. Early identification of sarcopenia is crucial to enable targeted treatment and prevention to be carried out across the pediatric clinical populations. PMID: 31328301 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 22, 2019 Category: Nutrition Authors: Ooi PH, Thompson-Hodgetts S, Pritchard-Wiart L, Gilmour SM, Mager DR Tags: JPEN J Parenter Enteral Nutr Source Type: research

New Prediction Equations to Estimate Appendicular Skeletal Muscle Mass Using Calf Circumference on NHANES Data: Methodological Issues.
PMID: 31317561 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 18, 2019 Category: Nutrition Authors: Naderi M, Sabour S Tags: JPEN J Parenter Enteral Nutr Source Type: research

Inferior Outcomes of Patients With Acute Myocardial Infarction and Comorbid Protein-Energy Malnutrition.
Abstract BACKGROUND: Protein-energy malnutrition (PEM) diminishes amino acid and energy availability, impairing the body's healing capability after injury, such as in myocardial damage following acute myocardial infarction (AMI). AIMS: We sought to investigate the influence of PEM on clinical outcomes of AMI. METHODS: We identified records with a primary discharge diagnosis of AMI from the Nationwide Inpatient Sample (2012-2014), stratified by concomitant PEM. We matched PEM to no-PEM (1:1) using a greedy algorithm-based propensity methodology and estimated the impact of PEM on health outcomes (SAS 9.4)....
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 18, 2019 Category: Nutrition Authors: Adejumo AC, Adejumo KL, Adegbala OM, Enwerem N, Ofosu A, Akanbi O, Fijabi DO, Ogundipe OA, Pani L, Adeboye A Tags: JPEN J Parenter Enteral Nutr Source Type: research

Gastrointestinal Hormone Profiles Associated With Enteral Nutrition Tolerance and Gastric Emptying in Pediatric Critical Illness: A Pilot Study.
CONCLUSION: GI hormone profiles are associated with time to achieve 50% of EN goal and gastric emptying in critically ill children. We have described a feasible model to study the role of GI hormones in this cohort, including the potential clinical applicability of GI hormone measurement in the management of delayed gastric emptying. PMID: 31304610 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 15, 2019 Category: Nutrition Authors: Martinez EE, Panciotti C, Pereira LM, Kellogg MD, Stylopoulos N, Mehta NM Tags: JPEN J Parenter Enteral Nutr Source Type: research

Trends of INR and Fecal Excretion of Vitamin K During Cholestasis Reversal: Implications in the Treatment of Neonates With Intestinal Failure-Associated Liver Disease.
CONCLUSION: Children with IFALD are at risk for vitamin K deficiency during cholestasis reversal. Close monitoring and quantified supplementation of vitamin K may be warranted during this period. However, this should not be guided by INR alone, as it is a poor indicator of vitamin K status. PMID: 31282035 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 7, 2019 Category: Nutrition Authors: Dao DT, Anez-Bustillos L, Finkelstein AM, Mitchell PD, O'Loughlin AA, Fell GL, Baker MA, Potemkin AK, Gura KM, Puder M Tags: JPEN J Parenter Enteral Nutr Source Type: research

An Exploratory Retrospective Study of Factors Affecting Energy Expenditure in Critically Ill Children.
The objective of this study was to determine clinical factors associated with measured energy expenditure (MEE), expressed in kcal/kg/d, in critically ill children. METHODS: This was a retrospective study at 2 Canadian pediatric intensive care units (ICUs). Patients were mechanically ventilated children who had 1 or more MEE using indirect calorimetry. Associations between MEE and 28 clinical factors were evaluated in univariate regression and 16 factors in a multivariate regression model accounting for repeated measurements. RESULTS: Data from 239 patients (279 measurements) were analyzed. Median (Q1, Q3) MEE wa...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 2, 2019 Category: Nutrition Authors: Mtaweh H, Garros C, Ashkin A, Tuira L, Allard JP, Pencharz P, Pullenayegum E, Joffe A, Parshuram CS Tags: JPEN J Parenter Enteral Nutr Source Type: research

Ketogenic Diets in Critical Care?
PMID: 31250460 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 27, 2019 Category: Nutrition Authors: Bistrian BR Tags: JPEN J Parenter Enteral Nutr Source Type: research

ω-3 Fatty-Acid Enriched Parenteral Nutrition in Hospitalized Patients: Systematic Review With Meta-Analysis and Trial Sequential Analysis.
ω-3 Fatty-Acid Enriched Parenteral Nutrition in Hospitalized Patients: Systematic Review With Meta-Analysis and Trial Sequential Analysis. JPEN J Parenter Enteral Nutr. 2019 Jun 27;: Authors: Pradelli L, Mayer K, Klek S, Omar Alsaleh AJ, Clark RAC, Rosenthal MD, Heller AR, Muscaritoli M Abstract This systematic review and meta-analysis investigated ω-3 fatty-acid enriched parenteral nutrition (PN) vs standard (non-ω-3 fatty-acid enriched) PN in adult hospitalized patients (PROSPERO 2018 CRD42018110179). We included 49 randomized controlled trials (RCTs) with intervention and control ...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 27, 2019 Category: Nutrition Authors: Pradelli L, Mayer K, Klek S, Omar Alsaleh AJ, Clark RAC, Rosenthal MD, Heller AR, Muscaritoli M Tags: JPEN J Parenter Enteral Nutr Source Type: research

Long-Term Parenteral Nutrition in a Patient With Cystic Fibrosis During Pregnancy.
PMID: 31240725 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 25, 2019 Category: Nutrition Authors: Mulherin DW, Bensink J, Zuckerwise L, Murphree JN, Tolle J, Seidner DL Tags: JPEN J Parenter Enteral Nutr Source Type: research

Reducing Hospitalizations and Costs: A Home Health Nutrition-Focused Quality Improvement Program.
CONCLUSIONS: Rates of hospitalization and healthcare resources can be significantly reduced through the implementation of a nutrition-focused QIP delivering oral nutritional supplements in home health settings for adults at-risk/malnourished. These results highlight the importance of nutrition as a strategy for HHAs and other post-acute care institutions to improve patients' health outcomes and generate cost savings. PMID: 31231830 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 24, 2019 Category: Nutrition Authors: Riley K, Sulo S, Dabbous F, Partridge J, Kozmic S, Landow W, VanDerBosch G, Falson MK, Sriram K Tags: JPEN J Parenter Enteral Nutr Source Type: research

Plasma Citrulline Concentrations in Neonates With or Without Gastrointestinal Disease During Periods of Parenteral and Enteral Nutrition.
CONCLUSION: Premature neonates with bowel resection had lower plasma citrulline concentrations, confirming its role as gut mass marker, though without differences during transitional feeding. PCA may affect expression of this protein. PMID: 31231843 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 23, 2019 Category: Nutrition Authors: Herrera OR, Talati AJ, Helms RA Tags: JPEN J Parenter Enteral Nutr Source Type: research

American Society for Parenteral and Enteral Nutrition Clinical Guidelines: The Validity of Body Composition Assessment in Clinical Populations.
Abstract On behalf of the American Society for Parenteral and Enteral Nutrition (ASPEN), a systematic review was conducted to evaluate the best available evidence regarding the validity of relevant body composition methods (eg, dual energy X-ray absorptiometry [DXA], ultrasound [US], and bioelectrical impedance analysis [BIA]) in clinical populations. The guidelines targeted adults>18 years of age with a potentially inflammatory condition or pathological end point associated with a specific disease or clinical condition. In total, 7375 studies were retrieved, and 15 DXA, 7 US, and 23 BIA studies provided a...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 19, 2019 Category: Nutrition Authors: Sheean P, Gonzalez MC, Prado CM, McKeever L, Hall AM, Braunschweig CA Tags: JPEN J Parenter Enteral Nutr Source Type: research

A Comparative Analysis of Equations to Estimate Patient Energy Requirements Following Cardiopulmonary Bypass for Correction of Congenital Heart Disease.
CONCLUSION: In a cohort of pediatric patients with congenital heart disease following CPB, no currently utilized clinical estimation equation reliably estimated REE. Allometric scaling proved inferior in estimating REE in children following CPB. Indirect calorimetry remains the ideal method of determining REE after CPB until nonlinear methods can be derived due to overestimation using linear equations. PMID: 31209916 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - June 17, 2019 Category: Nutrition Authors: Roebuck N, Fan CS, Floh A, Harris ZL, Mazwi ML Tags: JPEN J Parenter Enteral Nutr Source Type: research