First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways
In this study conducted in Brazilian patients, an in-depth whole transcriptome analysis was performed on 14 primary hepatoblastomas, compared to control liver tissues. The analysis unveiled 1,492 differentially expressed genes (1,031 upregulated and 461 downregulated), including 920 protein-coding genes (62%). Upregulated biological processes were linked to cell differentiation, signaling, morphogenesis, and development, involving known hepatoblastoma-associated genes (DLK1, MEG3, HDAC2, TET1, HMGA2, DKK1, DKK4), alongside with novel findings (GYNG4, CDH3, and TNFRSF19). Downregulated processes predominantly centered aroun...
Source: Biochemical Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Talita Ferreira Marques Aguiar Maria Prates Rivas Edson Mario de Andrade Silva Sara Ferreira Pires Gustavo Dib Dangoni Taiany Curdulino Macedo Alexandre Defelicibus Bruna Dur ães de Figueiredo Barros Estela Novak Lilian Maria Cristofani Vicente Odone Mon Source Type: research
Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer
Conclusion: More routinely available TME, SIR and tumor markers alone and in combination deliver reliable prognostic data for choosing the patients with higher risk for propagation. CMS4 is linked with high TSR and poor prognosis, but in overall, CMS-classification showed only limited effect on SIR- and tumor-markers.PMID:38645565 | PMC:PMC11026638 | DOI:10.3389/pore.2024.1611574 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Anna Jakab Árpád V Patai M ónika Darvas Karolina Torm ássi-Bély Tam ás Micsik Source Type: research
GSE264183 Comparing Gut Microbial Composition and Functional Adaptations between SPF and Non-SPF pigs
This study makes an important contribution to elucidating the impact of environments harboring a variety of microorganisms, including pathogens, on the gut microbiota of miniature pigs. Furthermore, we sought to provide foundational data on the characteristics of the gut microbiota in genetically modified pigs, which serve as source animals for xenotransplantation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa Source Type: research
Tumor-associated carbohydrate antigens of MUC1 - Implication in cancer development
Biomed Pharmacother. 2024 Apr 20;174:116619. doi: 10.1016/j.biopha.2024.116619. Online ahead of print.ABSTRACTGlycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to that which is presented by healthy cells. One of such changes is appearing tumor-associated carbohydrate antigens (TACAs) which are rare in normal tissues and are highly correlated with poor clinical outcomes and cancer progression. This review summarizes and describes the role of Tn, T antigens, their sialylated forms as well as fucosylated Lewis epitopes in different aspects of tumor development, progression, and metastasi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Iwona Radziejewska Source Type: research
Bacterial cellulose nanocrystals obtained through enzymatic and acidic routes: A comparative study of their main properties and in vitro biological responses
Carbohydr Res. 2024 Apr 17;539:109104. doi: 10.1016/j.carres.2024.109104. Online ahead of print.ABSTRACTCellulose nanocrystals (CNCs) are crystalline domains isolated from cellulosic fibers. They have been utilized in a wide range of applications, such as reinforcing fillers, antibacterial agents and manufacturing of biosensors. Whitin this context, the aim of this work was to obtain and analyze CNCs extracted from bacterial nanocellulose (BNC) using two distinct methods combined with milling pre-treatment: an acidic hydrolysis using 64 % sulfuric acid and an enzymatic hydrolysis using a commercial cellulase enzyme mixture...
Source: Carbohydrate Research - April 21, 2024 Category: Genetics & Stem Cells Authors: Amanda Maria Claro Isabella Karoline Ribeiro Dias Marina de Lima Fontes Vit ória Maria Medalha Colturato Lais Roncalho Lima Let ícia Borges Sávio Gabriela Leila Berto Valdeir Arantes Hernane da Silva Barud Source Type: research
Microbial exopolysaccharides: Unveiling the pharmacological aspects for therapeutic advancements
In conclusion, this review illuminates the immense pharmaceutical promise of microbial EPS as versatile bioactive compounds with wide-ranging therapeutic applications. By elucidating their structural features, biological activities, and potential applications, this review aims to catalyze further research and development efforts in leveraging the pharmaceutical potential of microbial EPS for the advancement of human health and well-being, while also contributing to sustainable and environmentally friendly practices in the pharmaceutical industry.PMID:38643705 | DOI:10.1016/j.carres.2024.109118 (Source: Carbohydrate Research)
Source: Carbohydrate Research - April 21, 2024 Category: Genetics & Stem Cells Authors: Nahid Akhtar Atif Khurshid Wani Neeta Raj Sharma Samira Sanami Shaikh Kaleem Moch Machfud Titiek Purbiati Sugiono Sugiono Djumali Djumali Paulina Evy Retnaning Prahardini Rully Dyah Purwati Khojin Supriadi Farida Rahayu Source Type: research
Tumor-associated carbohydrate antigens of MUC1 - Implication in cancer development
Biomed Pharmacother. 2024 Apr 20;174:116619. doi: 10.1016/j.biopha.2024.116619. Online ahead of print.ABSTRACTGlycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to that which is presented by healthy cells. One of such changes is appearing tumor-associated carbohydrate antigens (TACAs) which are rare in normal tissues and are highly correlated with poor clinical outcomes and cancer progression. This review summarizes and describes the role of Tn, T antigens, their sialylated forms as well as fucosylated Lewis epitopes in different aspects of tumor development, progression, and metastasi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Iwona Radziejewska Source Type: research
Letter to the editor: Comment on “The effect of chrono-nutritional manipulation of carbohydrate intake on sleep macrostructure: A randomized controlled trial”
(Source: Clinical Nutrition)
Source: Clinical Nutrition - April 21, 2024 Category: Nutrition Authors: Yuou Ying, Jinhan Chen, Yuan Ji, Mingxian Chen Source Type: research
Youth's energy intake during a laboratory-based loss-of-control eating paradigm: Associations with reported current dieting
Eat Behav. 2024 Apr 16;53:101877. doi: 10.1016/j.eatbeh.2024.101877. Online ahead of print.ABSTRACTDieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense of lack of control while eating). Support for this association has largely relied on retrospective self-report data, which does not always correlate with objectively assessed eating behavior in youth. We hypothesized that during a laboratory-based LOC-eating paradigm, children and adolescents who reported current (at the time of the visit) dieting would consume meals consistent with LOC-eating (greater caloric intake, and intake of c...
Source: Eating Behaviors - April 19, 2024 Category: Eating Disorders & Weight Management Authors: Megan N Parker Nasreen A Moursi Praise E Adekola Bess F Bloomer Jennifer Te-Vazquez Ejike E Nwosu Julia Lazareva Jeremiah L Jones Shanna B Yang Sara A Turner Sheila M Brady Kong Y Chen Marian Tanofsky-Kraff Jack A Yanovski Source Type: research
Activation of glycosyl methylpropiolates by TfOH
Carbohydr Res. 2024 Apr 9;539:109106. doi: 10.1016/j.carres.2024.109106. Online ahead of print.ABSTRACTActivation of glycosyl methylpropiolates by TfOH was investigated. Armed and superarmed glycosyl donors can be activated by use of 0.2 equivalent TfOH whereas 1.0 equivalent of TfOH was required for the activation of the disarmed glycosyl donors. All the glycosidations gave very good yields. The method is suitable for synthesis of glycosides and disaccharides and it may result in the hydrolysis of the interglycosidic bond if the sugar at the non-reducing end is armed or superarmed. These problems are not seen when gold-ca...
Source: Carbohydrate Research - April 19, 2024 Category: Genetics & Stem Cells Authors: Gulab Walke Niteshlal Kasdekar Soumyaranjan Pati Marc Taillefer Florian Jaroschik Srinivas Hotha Source Type: research
Casein hydrolysate in naturally-fermented buckwheat sourdough: Effects on fermented and physicochemical characteristics, texture, and bacterial microbial composition
Int J Food Microbiol. 2024 Apr 15;417:110705. doi: 10.1016/j.ijfoodmicro.2024.110705. Online ahead of print.ABSTRACTThe effect of a casein hydrolysate (CH) on the fermentation and quality of a naturally-fermented buckwheat sourdough (NFBS) were investigated, through assessing the fermentation characteristics, carbohydrate and protein degradation, texture, and bacterial composition of NFBS. According to the assaying data, CH might both increase the amount of lactic acid bacteria by 2.62 % and shorten the fermentation period by at least 3 h, subsequently leading to enhanced degradation of carbohydrate and protein, accompanie...
Source: International Journal of Food Microbiology - April 19, 2024 Category: Food Science Authors: Ling Guo Biqi Liu Chen Liang Wen Sun Yujun Jiang Xueqi Yun Lin Lu Xinhuai Zhao Ning Xu Source Type: research
Youth's energy intake during a laboratory-based loss-of-control eating paradigm: Associations with reported current dieting
Eat Behav. 2024 Apr 16;53:101877. doi: 10.1016/j.eatbeh.2024.101877. Online ahead of print.ABSTRACTDieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense of lack of control while eating). Support for this association has largely relied on retrospective self-report data, which does not always correlate with objectively assessed eating behavior in youth. We hypothesized that during a laboratory-based LOC-eating paradigm, children and adolescents who reported current (at the time of the visit) dieting would consume meals consistent with LOC-eating (greater caloric intake, and intake of c...
Source: Eating Behaviors - April 19, 2024 Category: Eating Disorders & Weight Management Authors: Megan N Parker Nasreen A Moursi Praise E Adekola Bess F Bloomer Jennifer Te-Vazquez Ejike E Nwosu Julia Lazareva Jeremiah L Jones Shanna B Yang Sara A Turner Sheila M Brady Kong Y Chen Marian Tanofsky-Kraff Jack A Yanovski Source Type: research
Youth's energy intake during a laboratory-based loss-of-control eating paradigm: Associations with reported current dieting
Eat Behav. 2024 Apr 16;53:101877. doi: 10.1016/j.eatbeh.2024.101877. Online ahead of print.ABSTRACTDieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense of lack of control while eating). Support for this association has largely relied on retrospective self-report data, which does not always correlate with objectively assessed eating behavior in youth. We hypothesized that during a laboratory-based LOC-eating paradigm, children and adolescents who reported current (at the time of the visit) dieting would consume meals consistent with LOC-eating (greater caloric intake, and intake of c...
Source: Eating Behaviors - April 19, 2024 Category: Eating Disorders & Weight Management Authors: Megan N Parker Nasreen A Moursi Praise E Adekola Bess F Bloomer Jennifer Te-Vazquez Ejike E Nwosu Julia Lazareva Jeremiah L Jones Shanna B Yang Sara A Turner Sheila M Brady Kong Y Chen Marian Tanofsky-Kraff Jack A Yanovski Source Type: research
Continuous selenite biotransformation and biofuel production by marine diatom in the presence of fulvic acid
In this study, the biochemical response of Phaeodactylum tricornutum to varying concentrations of inorganic selenium (Se) was investigated. It was observed that, when combined with fulvic acid, P. tricornutum exhibited enhanced uptake and biotransformation of inorganic Se, as well as increased microalgal lipid biosynthesis. Notably, when subjected to moderate (5 and 10 mg/L) and high (20 and 40 mg/L) concentrations of selenite under fulvic acid treatment, there was a discernible redirection of carbon flux towards lipogenesis and protein biosynthesis from carbohydrates. In addition, the key parameters of microalgae-based bi...
Source: Bioresource Technology - April 18, 2024 Category: Biotechnology Authors: Hui-Ying Xu Ruo-Yu Li Zi-Qiang Yang Jia-Fan Qiu Yu-Bin Su Carol Sze Ki Lin Wei-Dong Yang Hong-Ye Li Jian-Wei Zheng Xiang Wang Source Type: research
Regulation of lactose, glucose and sucrose metabolisms in S. thermophilus
Food Microbiol. 2024 Aug;121:104487. doi: 10.1016/j.fm.2024.104487. Epub 2024 Feb 12.ABSTRACTStreptococcus thermophilus is a bacterium widely used in the production of yogurts and cheeses, where it efficiently ferments lactose, the saccharide naturally present in milk. It is also employed as a starter in dairy- or plant-based fermented foods that contain saccharides other than lactose (e.g., sucrose, glucose). However, little is known about how saccharide use is regulated, in particular when saccharides are mixed. Here, we determine the effect of the 5 sugars that S. thermophilus is able to use, at different concentration ...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: C Gasser J M Faurie F Rul Source Type: research
