Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Creation and validation of a NOVA scored picture set to evaluate ultra-processed foods
Appetite. 2024 Apr 13:107358. doi: 10.1016/j.appet.2024.107358. Online ahead of print.ABSTRACTThere has been a rapid shift in the modern food environment towards increased processing in foods consumed in the United States (US) and globally. The NOVA system (not an acronym) for classifying food on degree of processing currently has the most empirical support. Consumption of foods in the NOVA 4 category, ultra-processed foods (UPF), is a risk factor for a host of poor health outcomes including heart disease, stroke, and cancer. Despite these poor health outcomes, UPF make up 58% of calories consumed in the US. Methodologies ...
Source: Appetite - April 15, 2024 Category: Nutrition Authors: Zach Hutelin Monica Ahrens Mary Elizabeth Baugh Mary E Oster Alexandra L Hanlon Alexandra G DiFeliceantonio Source Type: research
Niche-specific microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 13:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isolate P...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 14;172:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isola...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Exploring glycans as vital biological macromolecules: A comprehensive review of advancements in biomedical frontiers
Int J Biol Macromol. 2024 Apr 12:131511. doi: 10.1016/j.ijbiomac.2024.131511. Online ahead of print.ABSTRACTThis comprehensive review delves into the intricate landscape of glycans and glycoconjugates, unraveling their multifaceted roles across diverse biological dimensions. From influencing fundamental cellular processes such as signaling, recognition, and adhesion to exerting profound effects at the molecular and genetic levels, these complex carbohydrate structures emerge as linchpins in cellular functions and interactions. The structural diversity of glycoconjugates, which can be specifically classified into glycoprote...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Kanika Arora P M Sherilraj K A Abutwaibe Bharti Dhruw Shyam Lal Mudavath Source Type: research
Galectin-8 inhibition and functions in immune response and tumor biology
Med Res Rev. 2024 Apr 13. doi: 10.1002/med.22041. Online ahead of print.ABSTRACTGalectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the LGALS8 gene. Its role is evident in both T- and B-cell immunity and in the innate immune response, where it acts directly on dendritic cells and induces some pro-inflammatory cytokines. G...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Edvin Puri ć Ulf J Nilsson Marko Anderluh Source Type: research
An emerging role of N-glycosylation in cancer chemoresistance
Carbohydr Res. 2024 Apr 9;539:109107. doi: 10.1016/j.carres.2024.109107. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle in the effective treatment of cancer, limiting the success of chemotherapy regimens. N-glycosylation, the most important post-translational modification (PTM), plays multifaceted roles in the intricate landscape of cancer progression, particularly drug resistance in cancer cells. This review explores the complex relationship between N-glycosylation and chemoresistance in cancer. Altered glycosylation patterns have been proven to impact drug efflux mechanisms in cancer cells, wh...
Source: Carbohydrate Research - April 13, 2024 Category: Genetics & Stem Cells Authors: Yuhan Sun Tiangui Wu Jianguo Gu Source Type: research
An emerging role of N-glycosylation in cancer chemoresistance
Carbohydr Res. 2024 Apr 9;539:109107. doi: 10.1016/j.carres.2024.109107. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle in the effective treatment of cancer, limiting the success of chemotherapy regimens. N-glycosylation, the most important post-translational modification (PTM), plays multifaceted roles in the intricate landscape of cancer progression, particularly drug resistance in cancer cells. This review explores the complex relationship between N-glycosylation and chemoresistance in cancer. Altered glycosylation patterns have been proven to impact drug efflux mechanisms in cancer cells, wh...
Source: Carbohydrate Research - April 13, 2024 Category: Genetics & Stem Cells Authors: Yuhan Sun Tiangui Wu Jianguo Gu Source Type: research
Advances in biotin biosynthesis and biotechnological production in microorganisms
AbstractBiotin, also known as vitamin H or B7, acts as a crucial cofactor in the central metabolism processes of fatty acids, amino acids, and carbohydrates. Biotin has important applications in food additives, biomedicine, and other fields. While the ability to synthesize biotinde novo is confined to microorganisms and plants, humans and animals require substantial daily intake, primarily through dietary sources and intestinal microflora. Currently, chemical synthesis stands as the primary method for commercial biotin production, although microbial biotin production offers an environmentally sustainable alternative with p...
Source: World Journal of Microbiology and Biotechnology - April 13, 2024 Category: Microbiology Source Type: research
Effect of feeding Bengal gram residual forage-based pelleted total mixed ration on growth performance, nutrient availability, carcass traits and composition in finisher Barbari kids
AbstractThe study aimed to assess the impact of feeding Bengal gram residual forage-based pelleted Total Mixed Ration (TMR) with varying concentrate (C) to roughage (R) ratios on feed intake, nutrient utilization, growth, and carcass characteristics in Barbari kids. Sixteen weaned male Barbari kids (av. age, 233 ± 11 days; weight, 13.86 ± 0.76 kg) were divided into two groups (T1 and T2), each receiving different pelleted diets (TMR) with distinct concentrate to roughage ratios (T1 with 60:40; T2 with 40:60). The kids were fed for 133 days, and a digestion trial was conducted at the end of the study. After comp...
Source: Tropical Animal Health and Production - April 13, 2024 Category: Veterinary Research Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
