Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling
AbstractThis work shows the utilization of a physiologically based biopharmaceutics model (PBBM) to mechanistically explain the impact of diverse food types on the pharmacokinetics (PK) of isoniazid (INH) and acetyl-isoniazid (Ac-INH). The model was established and validated using published PK profiles for INH along with a combination of measured and predicted values for the physico-chemical and biopharmaceutical propertied of INH and Ac-INH. A dedicated ontogeny model was developed for N-acetyltransferase 2 (NAT2) in human integrating Michaelis Menten parameters for this enzyme in the physiologically based pharmacokinetic...
Source: The AAPS Journal - April 24, 2024 Category: Drugs & Pharmacology Source Type: research
Clinical Utility of the Combined Use of CA19-9 and DUPAN-2 in Pancreatic Adenocarcinoma
CONCLUSIONS: Only patients with normal CA19-9 and DUPNA-2 values should be diagnosed with early-stage PDAC.PMID:38652196 | DOI:10.1245/s10434-024-15221-z (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Tatsuaki Sumiyoshi Kenichiro Uemura Ryuta Shintakuya Kenjiro Okada Kenta Baba Takumi Harada Masahiro Serikawa Yasutaka Ishii Shinya Nakamura Koji Arihiro Yoshiaki Murakami Shinya Takahashi Source Type: research
Photosensitizer-thioglycosides enhance photodynamic therapy by augmenting cellular uptake
Carbohydr Res. 2024 Apr 18;539:109119. doi: 10.1016/j.carres.2024.109119. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) uses photosensitizing agents along with light to ablate tissue, including cancers. Such light-driven localized delivery of free-radical oxygen to kill target tissue depends on photosensitizer cell penetration efficacy. While the attachment of monosaccharides and disaccharides to photosensitizers has been shown to potentially provide improved photosensitizer delivery, the range of glycan entities tested thus far is limited. We sought to expand such knowledge by coupling N-acetylglucosamine (GlcN...
Source: Carbohydrate Research - April 23, 2024 Category: Genetics & Stem Cells Authors: Shuen-Shiuan Wang Shuai Shao Arun Singh Ryoma Hombu Jonathan F Lovell Khushi L Matta Sriram Neelamegham Source Type: research
Low-intensity alternating ventilation achieves effective humification during food waste composting by enhancing the intensity of microbial interaction and carbon metabolism
This study set three experimental groups with varying ventilation intensities based on self-made alternating ventilation composting reactor (AL2: 0.2 L·kg-1 DM·min-1; AL4: 0.4 L·kg-1 DM·min-1; AL6: 0.6 L·kg-1 DM·min-1) to explore the optimal alternating ventilation rate. The results showed that the cumulative ammonia emission of AL2 group reduced by 25.13% and 12.59% compared to the AL4 and AL6 groups. The humification degree of the product was 1.18 times and 1.25 times higher than the other two groups. AL2 increased the relative abundance of the core species Saccharomonospora, thereby strengthening microbial interac...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: Lin Zhu Chunxu Tan Xiaohan Wang Liyuan Liu Chifei Dong Zhenyu Qi Meng Zhang Baolan Hu Source Type: research
Acceptor-Reactivity-Controlled Stereoconvergent Synthesis and Immunological Activity of a Unique Pentasaccharide from the Cell Wall Polysaccharide of Cutibacterium acnes C7
Angew Chem Int Ed Engl. 2024 Apr 23:e202405297. doi: 10.1002/anie.202405297. Online ahead of print.ABSTRACTBacterial cell-surface polysaccharides are involved in various biological processes and have attracted widespread attention as potential targets for developing carbohydrate-based drugs. However, the accessibility of structurally well-defined polysaccharide or related active oligosaccharide domains remains challenging. Herein, we describe an efficiently stereocontrolled approach for the first total synthesis of a unique pentasaccharide repeating unit containing four difficult-to-construct 1,2-cis-glycosidic linkages fr...
Source: Angewandte Chemie - April 23, 2024 Category: Chemistry Authors: Tianhui Hao Ke Feng Hongzhen Jin Jiawei Li Chenkai Zhou Xingbang Liu Wei Zhao Fan Yu Tiehai Li Source Type: research
Low-intensity alternating ventilation achieves effective humification during food waste composting by enhancing the intensity of microbial interaction and carbon metabolism
This study set three experimental groups with varying ventilation intensities based on self-made alternating ventilation composting reactor (AL2: 0.2 L·kg-1 DM·min-1; AL4: 0.4 L·kg-1 DM·min-1; AL6: 0.6 L·kg-1 DM·min-1) to explore the optimal alternating ventilation rate. The results showed that the cumulative ammonia emission of AL2 group reduced by 25.13% and 12.59% compared to the AL4 and AL6 groups. The humification degree of the product was 1.18 times and 1.25 times higher than the other two groups. AL2 increased the relative abundance of the core species Saccharomonospora, thereby strengthening microbial interac...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: Lin Zhu Chunxu Tan Xiaohan Wang Liyuan Liu Chifei Dong Zhenyu Qi Meng Zhang Baolan Hu Source Type: research
Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults
CONCLUSIONS: Impaired metabolic flexibility to fasting, reflected by an inability to transition away from carbohydrate oxidation, is linked with increased energy intake.PMID:38650517 | DOI:10.1002/oby.24011 (Source: Obesity)
Source: Obesity - April 23, 2024 Category: Eating Disorders & Weight Management Authors: Yigit Unlu Paolo Piaggi Emma J Stinson Tom ás Cabeza De Baca Theresa L Rodzevik Mary Walter Jonathan Krakoff Douglas C Chang Source Type: research
Clinical Utility of the Combined Use of CA19-9 and DUPAN-2 in Pancreatic Adenocarcinoma
CONCLUSIONS: Only patients with normal CA19-9 and DUPNA-2 values should be diagnosed with early-stage PDAC.PMID:38652196 | DOI:10.1245/s10434-024-15221-z (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Tatsuaki Sumiyoshi Kenichiro Uemura Ryuta Shintakuya Kenjiro Okada Kenta Baba Takumi Harada Masahiro Serikawa Yasutaka Ishii Shinya Nakamura Koji Arihiro Yoshiaki Murakami Shinya Takahashi Source Type: research
Photosensitizer-thioglycosides enhance photodynamic therapy by augmenting cellular uptake
Carbohydr Res. 2024 Apr 18;539:109119. doi: 10.1016/j.carres.2024.109119. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) uses photosensitizing agents along with light to ablate tissue, including cancers. Such light-driven localized delivery of free-radical oxygen to kill target tissue depends on photosensitizer cell penetration efficacy. While the attachment of monosaccharides and disaccharides to photosensitizers has been shown to potentially provide improved photosensitizer delivery, the range of glycan entities tested thus far is limited. We sought to expand such knowledge by coupling N-acetylglucosamine (GlcN...
Source: Carbohydrate Research - April 23, 2024 Category: Genetics & Stem Cells Authors: Shuen-Shiuan Wang Shuai Shao Arun Singh Ryoma Hombu Jonathan F Lovell Khushi L Matta Sriram Neelamegham Source Type: research
Low-intensity alternating ventilation achieves effective humification during food waste composting by enhancing the intensity of microbial interaction and carbon metabolism
This study set three experimental groups with varying ventilation intensities based on self-made alternating ventilation composting reactor (AL2: 0.2 L·kg-1 DM·min-1; AL4: 0.4 L·kg-1 DM·min-1; AL6: 0.6 L·kg-1 DM·min-1) to explore the optimal alternating ventilation rate. The results showed that the cumulative ammonia emission of AL2 group reduced by 25.13% and 12.59% compared to the AL4 and AL6 groups. The humification degree of the product was 1.18 times and 1.25 times higher than the other two groups. AL2 increased the relative abundance of the core species Saccharomonospora, thereby strengthening microbial interac...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: Lin Zhu Chunxu Tan Xiaohan Wang Liyuan Liu Chifei Dong Zhenyu Qi Meng Zhang Baolan Hu Source Type: research
Low-intensity alternating ventilation achieves effective humification during food waste composting by enhancing the intensity of microbial interaction and carbon metabolism
This study set three experimental groups with varying ventilation intensities based on self-made alternating ventilation composting reactor (AL2: 0.2 L·kg-1 DM·min-1; AL4: 0.4 L·kg-1 DM·min-1; AL6: 0.6 L·kg-1 DM·min-1) to explore the optimal alternating ventilation rate. The results showed that the cumulative ammonia emission of AL2 group reduced by 25.13% and 12.59% compared to the AL4 and AL6 groups. The humification degree of the product was 1.18 times and 1.25 times higher than the other two groups. AL2 increased the relative abundance of the core species Saccharomonospora, thereby strengthening microbial interac...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: Lin Zhu Chunxu Tan Xiaohan Wang Liyuan Liu Chifei Dong Zhenyu Qi Meng Zhang Baolan Hu Source Type: research
Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults
CONCLUSIONS: Impaired metabolic flexibility to fasting, reflected by an inability to transition away from carbohydrate oxidation, is linked with increased energy intake.PMID:38650517 | PMC:PMC11045162 | DOI:10.1002/oby.24011 (Source: Obesity)
Source: Obesity - April 23, 2024 Category: Eating Disorders & Weight Management Authors: Yigit Unlu Paolo Piaggi Emma J Stinson Tom ás Cabeza De Baca Theresa L Rodzevik Mary Walter Jonathan Krakoff Douglas C Chang Source Type: research
Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
Parasitol Res. 2024 Apr 22;123(4):190. doi: 10.1007/s00436-024-08204-2.ABSTRACTThe intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by host intestinal damage. During developmental cycle, E. tenella undergoes versatile transitional stages such as oocyst, sporozoites, merozoites, and gametocytes. These developmental transitions involve changes in cell shape and cell size requiring cytoskeletal remodeling and changes in membrane proteins, which may require transcriptional and translational regulations as well as post-translational modification of proteins. Palmitoylation is a...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Zigang Qu Yuqiong Li Wenhui Li Nianzhang Zhang Joshua Seun Olajide Xiaoyun Mi Baoquan Fu Source Type: research
First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways
In this study conducted in Brazilian patients, an in-depth whole transcriptome analysis was performed on 14 primary hepatoblastomas, compared to control liver tissues. The analysis unveiled 1,492 differentially expressed genes (1,031 upregulated and 461 downregulated), including 920 protein-coding genes (62%). Upregulated biological processes were linked to cell differentiation, signaling, morphogenesis, and development, involving known hepatoblastoma-associated genes (DLK1, MEG3, HDAC2, TET1, HMGA2, DKK1, DKK4), alongside with novel findings (GYNG4, CDH3, and TNFRSF19). Downregulated processes predominantly centered aroun...
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Talita Ferreira Marques Aguiar Maria Prates Rivas Edson Mario de Andrade Silva Sara Ferreira Pires Gustavo Dib Dangoni Taiany Curdulino Macedo Alexandre Defelicibus Bruna Dur ães de Figueiredo Barros Estela Novak Lilian Maria Cristofani Vicente Odone Mon Source Type: research
Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer
Conclusion: More routinely available TME, SIR and tumor markers alone and in combination deliver reliable prognostic data for choosing the patients with higher risk for propagation. CMS4 is linked with high TSR and poor prognosis, but in overall, CMS-classification showed only limited effect on SIR- and tumor-markers.PMID:38645565 | PMC:PMC11026638 | DOI:10.3389/pore.2024.1611574 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 22, 2024 Category: Pathology Authors: Anna Jakab Árpád V Patai M ónika Darvas Karolina Torm ássi-Bély Tam ás Micsik Source Type: research
