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Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes
In this study, we examined the survival and viability of both young and senescent astrocytes in culture after adding propofol and ketamine to the media at varying strengths. Oxidative stimulus was applied to commercially available fetal cell lines of human astrocytes in vitro to induce morphological changes in cellular senescence. Our results indicate that propofol reduces the survival of young astrocytes as compared to controls, as well as to ketamine. These effects were seen in comparisons of total cell count and at both high and low dose concentrations. High doses of propofol also significantly reduced cell viability co...
Source: Anesthesiology Research and Practice - April 18, 2024 Category: Anesthesiology Authors: Liang Huang Ferit Tuzer Abigail Murtha Michael Green Claudio Torres Henry Liu Shadi Malaeb Source Type: research