Sphingolipids in prostate cancer prognosis: integrating single-cell and bulk sequencing
CONCLUSION: This study contributes to our understanding of the role of sphingolipid metabolism in prostate cancer diagnosis and treatment. The identified prognostic model holds promise for improving risk stratification and patient outcomes in clinical settings.PMID:38713159 | DOI:10.18632/aging.205803 (Source: Aging)
Source: Aging - May 7, 2024 Category: Biomedical Science Authors: Shan Zhou Li Sun Fei Mao Jing Chen Source Type: research
AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression
Aging (Albany NY). 2024 May 6;16. doi: 10.18632/aging.205801. Online ahead of print.ABSTRACTAurora kinase B (AURKB) initiates the phosphorylation of serine 10 on histone H3 (pH3S10), a crucial process for chromosome condensation and cytokinesis in mammalian mitosis. Nonetheless, the precise mechanisms through which AURKB regulates the cell cycle and contributes to tumorigenesis as an oncogenic factor in colorectal cancer (CRC) remain unclear. Here, we report that AURKB was highly expressed and positively correlated with Ki-67 expression in CRC. The abundant expression of AURKB promotes the growth of CRC cells and xenograft...
Source: Aging - May 7, 2024 Category: Biomedical Science Authors: Ling Li Ke Xie Honghu Xie Lei Wang Zhong Li Qicheng Lu Jin Feng Source Type: research
The prognostic value and immunological role of MVP in pan-cancer study
Aging (Albany NY). 2024 May 6;16. doi: 10.18632/aging.205802. Online ahead of print.ABSTRACTMajor Vault Protein (MVP) has emerged as a potential prognostic and immunological biomarker in various cancer types. This pan-cancer study aimed to investigate expression of MVP and its correlation with clinical outcomes and immune infiltration across diverse cancer types. We conducted an analysis of extensive transcriptomic and clinical data from publicly available databases. Our findings unveiled a significant association between MVP expression and cancer progression, with higher expression levels predicting poorer overall surviva...
Source: Aging - May 7, 2024 Category: Biomedical Science Authors: Chunlin Li Min Gao Nashunbayaer Zha Gang Guo Source Type: research
Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model
CONCLUSION: A helpful prediction model was developed and validated to identify ideal candidates who may benefit from primary tumor resection in mPC.PMID:38712480 | DOI:10.1080/07357907.2024.2349585 (Source: Cancer Investigation)
Source: Cancer Investigation - May 7, 2024 Category: Cancer & Oncology Authors: Kaifeng Su Ruifeng Duan Yang Wu Source Type: research
What are the true benefits of robotic pancreaticoduodenectomy for patients with pancreatic cancer?
In conclusion, RPD allows safe implementation of minimally-invasive PD. The current literature shows that RPD is either equivalent, or superior in certain aspects to OPD. Once more centers gain sufficient experience, RPD is likely to demonstrate clear superiority over alternative approaches.PMID:38712525 | DOI:10.1080/17474124.2024.2351398 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - May 7, 2024 Category: Gastroenterology Authors: Francesca Vescio Irena Stefanova Felix Nickel Nabeel Merali Michele Ammendola Rajiv P Lahiri Tim D Pencavel Tim R Worthington Adam E Frampton Source Type: research
Functional roles of microRnas in vasculogenic mimicry and resistance to therapy in human cancers: an update
Expert Rev Clin Immunol. 2024 May 7. doi: 10.1080/1744666X.2024.2352484. Online ahead of print.ABSTRACTINTRODUCTION: Vasculogenic mimicry (VM) alludes to the ability of cancer cells to organize on three-dimensional channels-like structures to obtain nutrients and oxygen. This mechanism confers an aggressive phenotype, metastatic potential, and resistance to chemotherapy resulting in a poor prognosis. Recent studies have been focused on the identification of microRNAs (miRNAs) that regulate the VM representing potential therapeutic targets in cancer.AREAS COVERED: A overview of the roles of miRNAs on VM development, and the...
Source: Expert Review of Clinical Immunology - May 7, 2024 Category: Allergy & Immunology Authors: Alejandra Paola Garc ía-Hernández Gricelda S ánchez-Sánchez Angeles Carlos-Reyes C ésar López-Camarillo Source Type: research
Recent advances in CAR-T cell therapy for acute myeloid leukaemia
J Cell Mol Med. 2024 May;28(9):e18369. doi: 10.1111/jcmm.18369.ABSTRACTAcute myeloid leukaemia (AML) is a fatal and refractory haematologic cancer that primarily affects adults. It interferes with bone marrow cell proliferation. Patients have a 5 years survival rate of less than 30% despite the availability of several treatments, including chemotherapy, allogeneic haematopoietic stem cell transplantation (Allo-HSCT), and receptor antagonist drugs. Allo-HSCT is the mainstay of acute myeloid leukaemia treatment. Although it does work, there are severe side effects, such as graft-versus-host disease (GVHD). In recent years, c...
Source: J Cell Mol Med - May 7, 2024 Category: Molecular Biology Authors: Chi Gao Xin Li Yao Xu Tongcun Zhang Haichuan Zhu Di Yao Source Type: research
Molecule engineering strategy of toll-like receptor 7/8 agonists designed for potentiating immune stimuli activation
Chem Commun (Camb). 2024 May 7. doi: 10.1039/d4cc00792a. Online ahead of print.ABSTRACTToll-like receptor 7/8 (TLR-7/8) agonists serve as a promising class of pattern recognition receptors that effectively evoke the innate immune response, making them promising immunomodulatory agents for tumor immunotherapy. However, the uncontrollable administration of TLR-7/8 agonists frequently leads to the occurrence of severe immune-related adverse events (irAEs). Thus, it is imperative to strategically design tumor-microenvironment-associated biomarkers or exogenous stimuli responsive TLR-7/8 agonists in order to accurately evaluate...
Source: Chemical Communications - May 7, 2024 Category: Chemistry Authors: Liuwei Gu Xiaojie Kong Mengyan Li Rui Chen Ke Xu Guo Li Yulin Qin Li Wu Source Type: research
Comparing the efficacy of combined versus single immune cell adaptive therapy targeting colorectal cancer
CONCLUSION: The results suggested that combined immune cell adaptive therapy could overcome the limited efficacy of cell immunotherapy.PMID:38712438 | DOI:10.3393/ac.2023.00402.0057 (Source: Annals of Coloproctology)
Source: Annals of Coloproctology - May 7, 2024 Category: Gastroenterology Authors: Denis Nchang Che NaHye Lee Hyo-Jung Lee Yea-Won Kim Solongo Battulga Ha Na Lee Won-Kook Ham Hyunah Lee Mi Young Lee Dawoon Kim Haengji Kang Subin Yun Jinju Park Daeyoun David Won Jong Kyun Lee Source Type: research
Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
Ann Coloproctol. 2024 Apr;40(2):89-113. doi: 10.3393/ac.2024.00059.0008. Epub 2024 Apr 30.ABSTRACTColorectal cancer is the third most common cancer in Korea and the third leading cause of death from cancer. Treatment outcomes for colon cancer are steadily improving due to national health screening programs with advances in diagnostic methods, surgical techniques, and therapeutic agents.. The Korea Colon Cancer Multidisciplinary (KCCM) Committee intends to provide professionals who treat colon cancer with the most up-to-date, evidence-based practice guidelines to improve outcomes and help them make decisions that reflect th...
Source: Annals of Coloproctology - May 7, 2024 Category: Gastroenterology Authors: Hyo Seon Ryu Hyun Jung Kim Woong Bae Ji Byung Chang Kim Ji Hun Kim Sung Kyung Moon Sung Il Kang Han Deok Kwak Eun Sun Kim Chang Hyun Kim Tae Hyung Kim Gyoung Tae Noh Byung-Soo Park Hyeung-Min Park Jeong Mo Bae Jung Hoon Bae Ni Eun Seo Chang Hoon Song Mi S Source Type: research
Changes in management of head and neck malignancies during the COVID-19 pandemic
CONCLUSIONS: During the COVID-19 pandemic, significantly fewer patients were under 65 at the time of initial work-up, potentially reflecting the more enhanced disease-related anxiety of the younger population. Future studies are warranted to address this population's specific educational and psychological needs to ensure appropriate cancer care.PMID:38712519 | DOI:10.14639/0392-100X-N2779 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - May 7, 2024 Category: ENT & OMF Authors: Alexander Lein Fuad Brkic David T Liu Markus Haas Almir Salkic Azra Ibrisevic Sabrina Uscuplic Alen Harcinovic Thomas Thurner Faris F Brkic Source Type: research
Outcomes of a universal germline screening program in a community urology practice
In this study, we report outcomes of a universal germline screening program in a community urology practice. Between November 2021 and September 2022, all patients referred for urology clinic visits at Frederick Health (Frederick, MD, USA) were provided an online genetics screening questionnaire prior to the visit. Responses were compared against National Comprehensive Cancer Network (NCCN) criteria for germline testing. Those who met criteria were provided educational materials at the end of the questionnaire, and then counseled by a trained urologic oncologist (HC) in the clinic or referred to a genetic counselor prior t...
Source: Clinical Genetics - May 7, 2024 Category: Genetics & Stem Cells Authors: Neil Mendhiratta Herman Hauver Whitley Hatton Andrew Ostrusky Devika S Sathe Sandeep Gurram Patricia Rice Heather Chalfin Source Type: research
Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin ‐Mediated Cell‐ECM Interactions
The synergistic effects of matrix biophysical properties can not only regulate cell behavior but also orchestrate the intricate equilibrium between these properties and ECM remodeling. AbstractThe biophysical properties of the extracellular matrix (ECM) play a pivotal role in modulating cancer progression via cell-ECM interactions. However, the biophysical properties specific to gastric cancer (GC) remain largely unexplored. Pertinently, GC ECM shows significantly heterogeneous metamorphoses, such as matrix stiffening and intricate restructuring. By combining collagen I and alginate, this study designs an in vitro biomimet...
Source: Small - May 7, 2024 Category: Nanotechnology Authors: Cailan Xiao,
Ning Xie,
Qiuai Shu,
Xiru Liang,
Ziwei Wang,
Jian Wu,
Nianyuan Shi,
Xindi Huang,
Zhong ‐Cao Wei,
Xiaoliang Gao,
Hao Liu,
Kaichun Wu,
Jingyuan Xu,
Jin‐Hai Wang,
Na Liu,
Feng Xu Tags: Research Article Source Type: research
Population pharmacokinetics of adebrelimab – Support of alternative flat dose regimen in extensive‐stage small‐cell lung cancer
AbstractAdebrelimab, a novel anti-PD-L1 antibody, has been approved by the National Medical Products Administration of China as an intravenous infusion for use in combination with carboplatin and etoposide as first-line treatment for extensive-stage small-cell lung cancer in 2023. A two-compartment model with empirical time-varying CL for adebrelimab was established based on data from 263 patients receiving body weight-based doses from two clinical studies. Significant covariate effects of baseline body weight, albumin levels, tumor size, neutrophil counts, and presence of anti-drug antibodies were identified on CL of d...
Source: CPT: Pharmacometrics and Systems Pharmacology - May 7, 2024 Category: Drugs & Pharmacology Authors: Peng Chen,
Yanyan Zhang,
Yike Wang,
Ke Ma,
Wei Shi,
Nassim Djebli,
Kai Shen Tags: ARTICLE Source Type: research
Comparative analysis of genetic testing utilization rates among people with and without disabilities in South Korea from 2016 to 2019, focusing on malignant neoplasms: A national population ‐based study
ConclusionAlthough the cancer-related genetic test uptake rate is higher among people with disabilities than among those without disabilities, it is still possible that information on these tests is not as readily available to people with disabilities. Therefore, it is imperative for the government to actively devise strategies to enhance national cancer screening rates among people with disabilities. (Source: Cancer Medicine)
Source: Cancer Medicine - May 7, 2024 Category: Cancer & Oncology Authors: Gwanwook Bang,
Minji Park,
Jeong ‐yeon Seon,
So‐Youn Park Tags: RESEARCH ARTICLE Source Type: research
