Warburg Effect Reshapes Tumor Immunogenicity
Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-24-1304. Online ahead of print.ABSTRACTTumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift also modulates the immunogenicity of the tumor cells. Recently, Mahmood and colleagues reported a connection between mitochondrial DNA mutations in cancer cells and their response to immunotherapy in a mouse model of melanoma.PMID:3...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Jose A Enr íquez Mar ía Mittelbrunn Source Type: research
Comprehensive genetic profiling reveals frequent alterations of driver genes on the X chromosome in extranodal NK/T-cell lymphoma
Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-24-0132. Online ahead of print.ABSTRACTExtranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, R...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yuta Ito Amira Marouf Yasunori Kogure Junji Koya Rapha ël Liévin Julie Bruneau Mariko Tabata Yuki Saito Sumito Shingaki Mitsuhiro Yuasa Kentaro Yamaguchi Koichi Murakami Robert Weil Manon Vavasseur Guillaume P Andrieu Mehdi Latiri Layla Veleanu Micha ë Source Type: research
Upregulation of FGF9 and NOVA1 in cancer-associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer
In conclusion, our results indicated the tumor-promoting role of CAFs in TNBC progression. FGF9 and NOVA1 upregulation in CAFs induced cell proliferation, migration and invasion in vitro, and facilitated tumor growth in vivo in TNBC development.PMID:38657094 | DOI:10.1002/ddr.22185 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Bo Zhang Yang Liu Jinsong Yu Xi Lin Source Type: research
Miliutine C methyl ester, a new drimane sesquiterpene and bioactive alkaloids from the stems of < em > Miliusa velutina < /em >
In this study, from the most active ethyl acetate extract of the stems of Miliusa velutina, seven compounds were isolated and determined structures, including a new drimane sesquiterpenoid compound named miliutine C methyl ester (1) and three bioactive alkaloids (5-7). These three alkaloids (5-7) exhibited strong anticancer activities against various cancer cell lines such as MCF-7, HepG2, HeLa, NCI H460 and normal fibroblasts. Especially, on MCF-7 and normal fibroblasts with values of IC50 (μM) in order for compounds 5 (3.38, 31.15), 6 (21.96, 102.00), 7 (7.90, greater than 300), to compare with positive control camptoth...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Thi Thuy Duong Ngo Ngoc Phuc Bui Thi Kieu Loan Vo Thi My Nuong Nguyen Hoang Khang Le Thanh Tung Phan Poul Erik Hansen Quang Ton That Source Type: research
L-Glutamine Substantially Improves 5-Fluorouracil-Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice
CONCLUSIONS: These findings underscore glutamine's potential in preventing 5-FU-induced mucositis by modulating gut microbiota and inflammation pathways.PMID:38656560 | DOI:10.1002/mnfr.202300704 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Ya-Ru Kuo Cheng-Hung Lin Wei-Sheng Lin Min-Hsiung Pan Source Type: research
The involvement of RIPK4 in TNF- α-stimulated IL-6 and IL-8 production by melanoma cells
CONCLUSION: These data reveal a complex role for RIPK4 in regulating the immune signaling network in melanoma cells and suggest that this kinase may represent an alternative target for melanoma-targeted adjuvant therapy.PMID:38656555 | DOI:10.1007/s00432-024-05732-3 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Ewelina Madej Anna Lisek Anna A Bro żyna Agnieszka Cierniak Norbert Wronski Milena Deptula Anna Wardowska Agnieszka Wolnicka-Glubisz Source Type: research
UBE2L3 expression in human gastric cancer and its clinical significance
CONCLUSIONS: The findings of our study demonstrate the significant involvement of UBE2L3 in the pathogenesis and advancement of gastric cancer, suggesting its potential as a therapeutic target.PMID:38656363 | DOI:10.1007/s00432-024-05669-7 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Xiaoxia Zhang Yujie Wei Fanqi Wu Mei Li Cong Han Chengdong Huo Zhi Li Futian Tang Wenting He Yang Zhao Yumin Li Source Type: research
Study on the Role and Mechanism of SLC3A2 in Tumor-Associated Macrophage Polarization and Bladder Cancer Cells Growth
Conclusion: Interference with SLC3A2 inhibited the growth of BLCA cells and the polarization of tumor-associated macrophages by promoting ferroptosis in BLCA cells.PMID:38656249 | DOI:10.1177/15330338241246649 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Peishan Wu Lingna Zhao Guangqi Kong Bo Song Source Type: research
Impact of Anti-angiogenic Drugs on Severity of COVID-19 in Patients with Non-Small Cell Lung Cancer
Conclusion: Our data suggests that the use of anti-angiogenic drugs may not exacerbate COVID-19 severity in NSCLC patients, indicating their potential safe application even during the pandemic period.PMID:38656242 | DOI:10.1177/15330338241248573 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Sujuan Peng Hongxiang Huang Jinhong Chen Xinjing Ding Xie Zhu Yangyang Liu Li Chen Zhihui Lu Source Type: research
Isoglutaminyl Cyclase Overexpression Enhances KYSE30 Cancer Cell Proliferation and Migration via the MAPK Signaling Pathway
J Proteome Res. 2024 Apr 24. doi: 10.1021/acs.jproteome.4c00197. Online ahead of print.ABSTRACTTo understand how upregulated isoglutaminyl cyclase (isoQC) is involved in the initiation of diseases such as cancer, we developed a human KYSE30 carcinoma cell model in which isoQC was stably overexpressed. GO and KEGG analysis of the DEGs (228) and DEPs (254) respectively implicated isoQC on the proliferation invasion and metastasis of cells and suggested that isoQC might participate in the regulation of MAPK, RAS, circadian rhythm, and related pathways. At the functional level, isoQC-overexpressing KYSE30 cells showed enhanced...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Xiaojie Chen Xi Yu Yangqing Cui Lang Du Qingqing Zhou Wei Xiong Chenyang Li Chenshu Xu Haiqiang Wu Source Type: research
Different Modes of Mechanism of Gamma-Mangostin and Alpha-Mangostin to Inhibit Cell Migration of Triple-Negative Breast Cancer Cells Concerning CXCR4 Downregulation and ROS Generation
CONCLUSIONS: These findings suggest that both γ-mangostin and α-mangostin inhibit breast cancer cell migration and induce cellular ROS levels in MDA-MB-231 cells; notably, γ-mangostin suppresses CXCR4 mRNA expression that might correlate to its activity to inhibit MDA-MB-231 cell migration.PMID:38655233 | PMC:PMC11036650 | DOI:10.5812/ijpr-138856 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Sarmoko Sarmoko Dhania Novitasari Manami Toriyama Muhamad Salman Fareza Nur Amalia Choironi Hiroshi Itoh Edy Meiyanto Source Type: research
Patterns in the Reporting of Aggressive Histologic Subtypes in Papillary Thyroid Cancer
CONCLUSIONS: Aggressive subtypes of PTC are associated with worse outcomes. Academic and other facilities in the Middle Atlantic were more likely to report aPTC. This suggests the need for further evaluation of environmental or geographic factors versus a need for increased awareness and more accurate diagnosis of these subtypes.PMID:38657351 | DOI:10.1016/j.jss.2024.03.023 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yeon J Lee Caitlin E Egan Jacques A Greenberg Teagan Marshall Abhinay Tumati Brendan M Finnerty Toni Beninato Rasa Zarnegar Thomas J Fahey Minerva A Romero Arenas Source Type: research
Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery
Angew Chem Int Ed Engl. 2024 Apr 24:e202404703. doi: 10.1002/anie.202404703. Online ahead of print.ABSTRACTSelf-assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting-hydrolysis-transformation (THT) assembly of glycosylated peptides in living cells holistically resembling viral infection for efficient cargo delivery and combined tumor therapy. We design a glycosylated peptide via incorporating a β-galactose-serine residue into bola-amphiphilic sequences. Co-assembling of the gl...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Feng Tian Ruo-Chen Guo Chunxia Wu Xin Liu Zeyu Zhang Yamei Wang Hao Wang Gongyu Li Zhilin Yu Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
