Molecules, Vol. 29, Pages 2010: Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
asmané Semde
A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence the immune system’s effectiveness, potentially leading to immune system failure. This review aims to provide an overview of the structure and action of immunomodulators isolated from African medicinal plants. The research was conducted according to PRISMA guidelines. Full-text access research articles published in English up to December 2023, including plant characteristics, isolated phytochemicals, and immuno-modulatory activities, were screened. The chemical structures of the isolated ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wendwaoga Ars ène Nikiema Moussa Ou édraogo Windbedma Prisca Ou édraogo Souleymane Fofana Boris Honor é Amadou Ouédraogo Talwendpanga Edwige Delma Belem Amad é Gambo Moustapha Abdoulaye Aim é Serge Sawadogo Raogo Ou édraogo Rasman é Semde Tags: Systematic Review Source Type: research
Molecules, Vol. 29, Pages 2002: Carbon Quantum Dots: Properties, Preparation, and Applications
This article provides an overview of the properties, preparation methods, raw materials for preparation, and the heteroatom doping of carbon quantum dots, and it summarizes the applications in related fields, such as optoelectronics, bioimaging, drug delivery, cancer therapy, sensors, and environmental remediation. Finally, currently encountered issues of carbon quantum dots are presented. The latest research progress in synthesis and application, as well as the challenges outlined in this review, can help and encourage future research on carbon quantum dots. (Source: Molecules)
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Jichuan Kong Yihui Wei Feng Zhou Liting Shi Shuangjie Zhao Mengyun Wan Xiangfeng Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1993: A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice
ong Huang
Abnormal viscosity is closely related to the occurrence of many diseases, such as cancer. Therefore, real-time detection of changes in viscosity in living cells is of great importance. Fluorescent molecular rotors play a critical role in detecting changes in cellular viscosity. Developing red emission viscosity probes with large Stokes shifts and high sensitivity and specificity remains an urgent and important topic. Herein, a novel viscosity-sensitive fluorescent probe (TCF-VIS1) with a large stokes shift and red emission was prepared based on the 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Beilei Wang Dezhi Yang Xiaohong Zhong Yuhui Liu Yong Huang Tags: Article Source Type: research
CAR T-cell therapy: a potential treatment strategy for pediatric midline gliomas
AbstractPediatric brain tumors are the primary cause of death in children with cancer. Diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG) are frequently unresectable due to their difficult access location, and 5-year survival remains less than 20%. Despite significant advances in tumor biology and genetics, treatment options remain limited and ineffective. Immunotherapy using T cells with a chimeric antigen receptor (CAR) that has been genetically engineered is quickly emerging as a new treatment option for these patients. High levels of expression were detected for both disialoganglioside (GD2) and B...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Rapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL
Blood Cancer Journal, Published online: 26 April 2024; doi:10.1038/s41408-024-01057-zRapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - April 26, 2024 Category: Hematology Authors: Giuseppe Gritti Silvia Ferrari Federico Lussana Anna Maria Barbui Francesco Landi Monica Rondi Alessandro Putelli Francesco Ballardini Giulia Quaresmini Muriel Paganessi Chiara Pavoni Arianna Ghirardi Elisa Gotti Chiara Capelli Jos ée Golay Martino Intro Source Type: research
Response to: The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
We appreciate the interest that emerged from our recent publication [1], ‘Association between public health policies on alcohol and worldwide cancer, liver disease, and cardiovascular disease outcomes’ [2]. In our research, we evidenced a strong relationship between alcohol-related public health policies (PHP) establishment and the decrease of alcohol-related health consequences over time among 169 countries, including liver disease and other significant causes of burden of disease worldwide. These associations were stronger over time, and consistent with the framework SAFER proposed by the World Health Organization (W...
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Luis Antonio D íaz, Eduardo Fuentes-López, Juan Pablo Arab Tags: Letter to the Editor Source Type: research
Preparation, quality control, and absorbed dose estimation of 89Zr-DFO-Cetuximab for imaging of EGFR-expressing tumors
In this study,89Zr-DFO-Cetuximab was prepared under the optimized conditions with a radiochemical purity > 99%, and a specific activity of 185 GBq g−1. Cellular studies on EGFR + SW480 colon cancer and EGFR-CHO cell lines were performed, indicating the remarkable capability of89Zr-DFO-Cetuximab for binding to the low EGFR-expressing cells. High accumulation was observed in tumors of nude mice-bearing SW480 cell lines. Human absorbed dose estimation showed the liver receives the highest absorbed dose (0.94 mGy MBq−1). This radiopharmaceutical is the suitable PET agent for imaging of EGFR-expressing tu...
Source: Journal of Radioanalytical and Nuclear Chemistry - April 26, 2024 Category: Nuclear Medicine Source Type: research
Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis
ConclusionThe most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 26, 2024 Category: Cancer & Oncology Source Type: research
What can hospital emergency admissions prior to cancer diagnosis tell us about socio-economic inequalities in cancer diagnosis? Evidence from population-based data in England
British Journal of Cancer, Published online: 26 April 2024; doi:10.1038/s41416-024-02688-6What can hospital emergency admissions prior to cancer diagnosis tell us about socio-economic inequalities in cancer diagnosis? Evidence from population-based data in England (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Aimilia Exarchakou Bernard Rachet Georgios Lyratzopoulos Camille Maringe Francisco Javier Rubio Source Type: research
The role of social support among caregivers of people with cancer from Chinese and Arabic communities: a qualitative study
ConclusionEmpirical testing of culturally appropriate strategies that improve social support seeking among caregivers from CALD communities is recommended. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 26, 2024 Category: Cancer & Oncology Source Type: research
Clonal expansion of shared T cell receptors reveals the existence of immune commonality among different lesions of synchronous multiple primary lung cancer
In conclusion, this study provided evidences of the distinctive mutational landscape, activation of oncogenic signaling pathways, and TCR repertoire in MPLC as compared with SN. The significant clonal expansion of shared TCR clonotypes demonstrated the existence of immune commonality among different lesions of the same patient and shed new light on the individually tailored precision therapy for MPLC. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 26, 2024 Category: Cancer & Oncology Source Type: research
The prevalence of mild cognitive impairment in breast cancer patients receiving chemotherapy according to the criteria of the National Institute on Aging-Alzheimer ’s Association (NIA-AA)
ConclusionsTwenty percent of breast cancer patients treated with chemotherapy met NIA-AA criteria for MCI, compared with 7.6% of the controls.Implications for Cancer SurvivorsThese criteria, which include formal test performance as well as a person ’s symptoms and functional status, can be useful in clinical practice and scientific research. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 26, 2024 Category: Cancer & Oncology Source Type: research
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
ConclusionOur study proposes Dectin-1 as a potential adjunctive target with ICBs, orchestrating a comprehensive engagement of innate and adaptive immune responses in melanoma. This innovative approach holds promise for overcoming acquired resistance to ICBs in cancer treatment, offering avenues for further exploration and development. (Source: Cellular Oncology)
Source: Cellular Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1689: A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis
mez-Bueno
Pablo Garcia-Pavia
Javier Segovia-Cubero
Laura Rosiñol
Juan-José Lahuerta
Joaquín Martínez-López
Joan Bladé
Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple score to predict mortality based on three frailty-associated variables: age, ECOG performance status (<2 vs. ≥2) and NT-proBNP (<8500 vs. ≥8500 ng/L). Four-hundred and sixteen consecutive newly diagnosed patien...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Rafael R íos-Tamayo Ram ón Lecumberri Mar ía Teresa Cibeira Ver ónica González-Calle Rafael Alonso Amalia Domingo-Gonz ález Elena Landete Cristina Encinas Bel én Iñigo Mar ía-Jesús Blanchard Elena Alejo Isabel Krsnik Manuel G ómez-Bueno Pablo G Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1687: Development of an Artificial-Intelligence-Based Tool for Automated Assessment of Cellularity in Bone Marrow Biopsies in Ph-Negative Myeloproliferative Neoplasms
o
Andrea Ronchi
The cellularity assessment in bone marrow biopsies (BMBs) for the diagnosis of Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) is a key diagnostic feature and is usually performed by the human eyes through an optical microscope with consequent inter-observer and intra-observer variability. Thus, the use of an automated tool may reduce variability, improving the uniformity of the evaluation. The aim of this work is to develop an accurate AI-based tool for the automated quantification of cellularity in BMB histology. A total of 55 BMB histological slides, diagnosed as Ph- MPN b...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Giuseppe D ’Abbronzo Antonio D ’Antonio Annarosaria De Chiara Luigi Panico Lucianna Sparano Anna Diluvio Antonello Sica Gino Svanera Renato Franco Andrea Ronchi Tags: Article Source Type: research
