COLUMBUS 7-year update: a randomized, open-label, phase III trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF V600E/K-mutant melanoma
We report results from the 7-year analysis of COLUMBUS part 1 (NCT01909453) at 99.7 months (median duration between randomization and data cutoff). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Dirk Schadendorf, Reinhard Dummer, Keith T. Flaherty, Caroline Robert, Ana Arance, Jan Willem B. de Groot, Claus Garbe, Helen J. Gogas, Ralf Gutzmer, Ivana Krajsov á, Gabriella Liszkay, Carmen Loquai, Mario Mandalà, Naoya Yamazaki, Paola Queirolo, Carol Tags: Original Research Source Type: research
Skin cancers are the most frequent cancers in fair-skinned populations, but we can prevent them.
Cancers of the skin are the most commonly occurring cancers in humans. In fair-skinned populations, up to 95% of keratinocyte skin cancers and 70-95% of cutaneous melanomas are caused by ultraviolet radiation and are thus theoretically preventable. Currently, however, there is no comprehensive global advice on practical steps to be taken to reduce the toll of skin cancer. To address this gap, an expert working group comprising clinicians and researchers from Africa, America, Asia, Australia, and Europe, together with learned societies (European Association of Dermato-Oncology, Euromelanoma, Euroskin, European Union of Medi...
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Claus Garbe, Ana-Maria Forsea, Teresa Amaral, Petr Arenberger, Philippe Autier, Marianne Berwick, Brigitta Boonen, Matilda Bylaite, Veronique del Marmol, Brigitte Dreno, Maria Concetta Fargnoli, Alan C. Geller, Adele C. Green, R üdiger Greinert, Axel Hau Tags: Current Perspective Source Type: research
A new vision of the efficacy of both CAR-NK and CAR-T cells in treating cancers and autoimmune diseases
AbstractChimeric Antigen Receptor (CAR) based therapies are becoming increasingly important in treating patients. CAR-T cells have been shown to be highly effective in the treatment of hematological malignancies. However, harmful therapeutic barriers have been identified, such as the potential for graft-versus-host disease (GVHD), neurotoxicity, and cytokine release syndrome (CRS). As a result, CAR NK-cell therapy is expected to be a new therapeutic option. NK cells act as cytotoxic lymphocytes, supporting the innate immune response against autoimmune diseases and cancer cells by precisely detecting and eliminating maligna...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
SMARCA4-Deficient Undifferentiated Esophageal Carcinoma: A Clinical Case Series and Literature Review
ConclusionsResearch in SMARCA-deficient UEC is very limited. It is more common in men, age is variable, and associated with Barret ’s esophagus. Further research is necessary to better understand it and to establish treatment guidelines; however, it is clear that SMARCA4-deficient UEC carries a significantly poor prognosis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 24, 2024 Category: Cancer & Oncology Source Type: research
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
AbstractMyeloid neoplasms are a group of bone marrow diseases distinguished by disruptions in the molecular pathways that regulate the balance between hematopoietic stem cell (HSC) self-renewal and the generation of specialized cells. Cytokines and chemokines, two important components of the inflammatory process, also influence hematological differentiation. In this scenario, immunological dysregulation plays a pivotal role in the pathogenesis of bone marrow neoplasms. The STING pathway recognizes DNA fragments in the cell cytoplasm and triggers an immune response by type I interferons. The role of STING in cancer has not ...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays a key role in the development of ESCC. CircR... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei, Ruihao Liang, Jialu Liang, Nan Lu, Jing Huang, Ke Xu, Binghua Tan, Kexi Wang, Yicheng Liang, Wenjian Wang, Huayue Lin and Minghui Wang Tags: Research Source Type: research
Palliative care integration and end-of-life care intensity for patients with NSCLC
Lung cancer is the leading cause of cancer incidence and mortality worldwide, accounting for about 2 million diagnoses and 1.8 million deaths [1]. After an increase up to the 1990 s, its incidence and mortality are tending to decrease, with 5-year survival estimated around 20 % at all stages [2]. Metastatic non-small cell lung cancer (NSCLC) accounts for 40–55 % of cases where medical management is based on systemic treatment. In a recent meta-analysis, it was found that combining PD-1/PD-L1 inhibitors with conventional chemotherapy can dramatically improve the prognosis of NSCLC patients, clearly enhancing the re...
Source: Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: A. Martin, M. Carton, L. Thery, A. Burnod, C. Daniel, P. Du Rusquec, N. Girard, C. Bouleuc Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1639: LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes
Conclusions: Our results suggest that LINC01021 may restrict the extent and strength of p53-mediated transcriptional changes via context-dependent regulation of the expression and splicing of a subset of p53-regulated genes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Kaller Forn é Imhof Hermeking Tags: Article Source Type: research
Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients
Pleural mesothelioma is a fatal cancer of the pleural cavity, primarily caused by asbestos. Overall survival (OS) after diagnosis is poor and the long latency period of the disease after asbestos exposure is responsible for the still increasing incidence of mesothelioma worldwide [1,2]. Several options are available for the treatment of pleural mesothelioma to improve OS, ranging from multimodal therapy including surgery and chemotherapy to, chemotherapy or immunotherapy [3,4]. Monitoring the disease progression after treatment is essential, but imaging techniques are of limited value in mesothelioma, in contrast to severa...
Source: Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Laura V. Klotz, Swaantje Casjens, Georg Johnen, Dirk Taeger, Alexander Brik, Florian Eichhorn, Laura F örster, Nina Kaiser, Thomas Muley, Christa Stolp, Marc Schneider, Jan Gleichenhagen, Thomas Brüning, Hauke Winter, Martin Eichhorn, Daniel G. Weber Tags: Research Paper Source Type: research
Cancers, Vol. 16, Pages 1640: Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
őző
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possib...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: G ábor Cserni Rita Bori Éva Ambrózay Orsolya Serf őző Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1641: Detection and Real-Time Surgical Assessment of Colorectal Liver Metastases Using Near-Infrared Fluorescence Imaging during Laparoscopic and Robotic-Assisted Resections
Conclusions: ICG fluorescence imaging can be integrated with other conventional intraoperative imaging techniques to optimize intraoperative staging. Rim fluorescence proved to be a valid indicator of the resection margins: by removing the entire fluorescent area, a tumor-negative resection (R0) is achieved. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Piccolo Barabino Ghilardi Masserano Lecchi Piozzi Bianchi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1637: Pentraxin 3: A Main Driver of Inflammation and Immune System Dysfunction in the Tumor Microenvironment of Glioblastoma
Paola Capra
Brain tumors are a heterogeneous group of brain neoplasms that are highly prevalent in individuals of all ages worldwide. Within this pathological framework, the most prevalent and aggressive type of primary brain tumor is glioblastoma (GB), a subtype of glioma that falls within the IV-grade astrocytoma group. The death rate for patients with GB remains high, occurring within a few months after diagnosis, even with the gold-standard therapies now available, such as surgery, radiation, or a pharmaceutical approach with Temozolomide. For this reason, it is crucial to continue looking for cutting-edge therape...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Sarah Adriana Scuderi Alessio Ardizzone Ayomide Eniola Salako Giuseppe Pant ò Fabiola De Luca Emanuela Esposito Anna Paola Capra Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1638: Emotional Distress, Cognitive Complaints, and Care Needs among Advanced Cancer Survivors Treated with Immune Checkpoint Blockade: A Mixed-Method Study
Conclusion: Our results indicate the existence of persistent psychological, physical, and cognitive issues, and support the need for routine screening for FCR. The identified triggers related to severe psychological distress can aid clinicians in timely referring the patient, thereby enhancing survivorship care. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Nathalie Vanlaer Iris Dirven Bart Neyns Anne Rogiers Tags: Article Source Type: research
Patients ’ and dermatologists’ preferences in AI-driven skin cancer diagnostics: prospective multicentric survey study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 24, 2024 Category: Dermatology Authors: Sarah Haggenm üller, Roman C. Maron, Achim Hekler, Eva Krieghoff-Henning, Jochen S. Utikal, Maria Gaiser, Verena Müller, Sascha Fabian, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Michael Weichenthal, Lars E. Source Type: research
