A Review of Practice-Changing Therapies in Oncology in the Era of Personalized Medicine
Curr Oncol. 2024 Apr 2;31(4):1913-1919. doi: 10.3390/curroncol31040143.ABSTRACTIn the past decade, a lot of insight was gathered into the composition of the host and tumor factors that promote oncogenesis and treatment resistance. This in turn has led to the ingenious design of multiple new classes of drugs, which have now become the new standards of care in cancer therapy. These include novel antibody-drug conjugates, chimeric antigen receptor T cell therapies (CAR-T), and bispecific T cell engagers (BitTE). Certain host factors, such as the microbiome composition, are also emerging not only as biomarkers for the response...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mariana Pilon Capella Khashayar Esfahani Source Type: research
High-Grade Serous Ovarian Cancer during Pregnancy: From Diagnosis to Treatment
CONCLUSIONS: There have not been long-term follow-ups of patients' oncologic and obstetric outcomes. As patients should be comprehensively informed, more detailed case reports or series with longer follow-up periods are needed.PMID:38668047 | DOI:10.3390/curroncol31040144 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Gregor Vivod Sebastjan Merlo Nina Kovacevic Source Type: research
Determining the Need for Metastatic Staging in Patients with Bilateral Breast Cancers
Conclusions: Both the nodal status and a 30 months cut-off time interval between the two cancers can be used to identify patients who will benefit from metastatic staging. This finding requires validation in larger studies.PMID:38668048 | DOI:10.3390/curroncol31040145 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Veronica Siton Alcantara Sut Mo Zachary Chan Fuh Yong Wong John Carson Allen Geok Hoon Lim Source Type: research
Developing innovative strategies of tumor ‑infiltrating lymphocyte therapy for tumor treatment
Oncol Rep. 2024 Jun;51(6):85. doi: 10.3892/or.2024.8744. Epub 2024 Apr 26.ABSTRACTCancer is the main cause of global mortality, and thus far, effective therapeutic strategies for cancer treatment are in high demand. Adoptive transfer of tumor‑infiltrating lymphocytes (TILs) represents a promising avenue in immunotherapy for the management of malignancies. The clinical safety and efficacy of TIL‑based therapy have been established through numerous rigorous clinical trials. However, the efficacy of TIL infusion in inducing an anti‑tumor response is limited to a subset of clinical patients with cancer. Therefore, there ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Zhongjie Yu Jianhua Shi Yuan Fang Yi Zhao Aotian Xu Ning Li Source Type: research
Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research
Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)
Oncol Rep. 2024 Jun;51(6):84. doi: 10.3892/or.2024.8743. Epub 2024 Apr 26.ABSTRACTEven under aerobic conditions, tumor cells can reprogram their metabolism to preferentially metabolize glucose into lactic acid. This abnormal metabolic pattern, known as the 'Warburg' effect or aerobic glycolysis, promotes cancer progression. Long non‑coding RNAs (lncRNAs) are RNAs that are >200 nucleotides in length and do not have protein‑coding capabilities. However, these RNAs play a key role in tumor development. There is increasing evidence to indicate that lncRNAs regulate glucose metabolism in tumor cells by affecting metaboli...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Qiongqing Huang Zhengui Liang Qiqi Huang Xueyu Li Jingjing Xia Lining Huang Lin Bing Huang Chao Ou Source Type: research
[Corrigendum] miR ‑27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker
Oncol Rep. 2024 Jun;51(6):83. doi: 10.3892/or.2024.8742. Epub 2024 Apr 26.ABSTRACTFollowing the publication of this article, an interested reader drew to the authors' attention that the western blots in Fig. 4B on p. 3560 and Fig. 6B on p. 3562 shared remarkably similar data (including both the GAPDH and the FAM172A blots in Fig. 4B), such that these data were likely to have been derived from the same original source. Upon asking the authors to provide an explanation, the authors realized that these errors inadvertently arose during the process of assembling these figures. Due to a mislabelling of the files, representative...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Wenjun Liu Kai Qian Xing Wei Haijun Deng Bei Zhao Qing Chen Jinqian Zhang Hao Liu Source Type: research
Real-World Outcomes of Patients with Advanced Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer in Canada Using Data Extracted by Large Language Model-Based Artificial Intelligence
This study's objective was to use previously validated DARWENTM artificial intelligence (AI) to extract data from electronic heath records of patients with non-squamous NSCLC at University Health Network (UHN) to describe EGFR mutation prevalence, treatment patterns, and outcomes. Of 2154 patients with NSCLC, 613 had advanced disease. Of these, 136 (22%) had common sensitizing EGFR mutations (cEGFRm; ex19del, L858R), 8 (1%) had exon 20 insertions (ex20ins), and 338 (55%) had EGFR wild type. One-year overall survival (OS) (95% CI) for patients with cEGFRm, ex20ins, and EGFR wild type tumours was 88% (83, 94), 100% (100, 100...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Ruth Moulson Jennifer Law Adrian Sacher Geoffrey Liu Frances A Shepherd Penelope Bradbury Lawson Eng Sandra Iczkovitz Erica Abbie Julia Elia-Pacitti Emmanuel M Ewara Viktoriia Mokriak Jessica Weiss Christopher Pettengell Natasha B Leighl Source Type: research
A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature
In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication.PMID:38668050 | DOI:10.3390/curroncol31040147 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Monika P éčová Jakub Benko Martin Jozef P éč Jakub Jurica Simona Horn á Tom áš Bolek Tatiana Hurtov á J án Sýkora Kamil Zele ňák Matej Samo š Juraj Sokol Source Type: research
The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research
Prevalence of high-risk HPV and cervical dysplasia in IUD users and controls: a cross sectional study
CONCLUSIONS: Reported use of levonorgestrel intrauterine system and hormonal contraception, but not use of copper IUD, was associated with a higher prevalence of HPV infections and histological HSIL + compared to no reported use of contraception.PMID:38666336 | DOI:10.1080/13625187.2024.2340521 (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - April 26, 2024 Category: Reproduction Medicine Authors: Lina Jans Jan Brynhildsen Evin Cherif Linnea Tenerz Lovisa Bergengren Source Type: research
Neoadjuvant nivolumab plus chemotherapy followed by resection for superior sulcus tumour with high PD ‐L1 expression: A case report
This report represents a new treatment option for superior sulcus tumours. (Source: Respirology Case Reports)
Source: Respirology Case Reports - April 26, 2024 Category: Respiratory Medicine Authors: Takahito Nakaya,
Yoshimitsu Hirai,
Hiroaki Akamatsu,
Fumiyoshi Kojima,
Hideto Iguchi,
Aya Fusamoto,
Yumi Yata,
Takahiro Nagai,
Daiki Kitahara,
Toshiaki Takakura,
Yoshiharu Nishimura,
Nobuyuki Yamamoto Tags: CASE REPORT Source Type: research
Immunocompromised individuals are at increased risk of COVID ‐19 breakthrough infection, hospitalization, and death in the post‐vaccination era: A systematic review
ConclusionThis demonstrated that vaccination does not offer an adequate level of protection in these groups, necessitating further measures such as Evusheld and further boosters. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 26, 2024 Category: Allergy & Immunology Authors: Jola Bytyci,
Yuxin Ying,
Lennard Y. W. Lee Tags: REVIEW ARTICLE Source Type: research
Historical trends of breast cancer burden attributable to metabolic factors among Chinese women, 1990 –2019: A population‐based epidemiological study
ConclusionsAge was the main reason for the increase of attributable burden, and postmenopausal women were the high-risk groups. Therefore, targeted prevention measures should be developed to improve postmenopausal women's awareness and effectively reduce the prevalence of obesity and diabetes, thereby reducing the breast cancer burden caused by metabolic factors in China. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Liang ‐Zi Zhang,
Qi‐Cheng Sun,
Hang‐Hang Luan,
Qian‐Qian Yuan,
Tong Deng,
Li‐Sha Luo,
Xiao‐Lin Tan Tags: ORIGINAL ARTICLE Source Type: research
GSE264477 Transcriptional effects of co-culture on the spatiotemporal dynamics of T cell motility and cancer-T cell interactions [RNA-seq]
Contributors : Xinyue Li ; Taoli Jin ; Lisha Wang ; Ming Li ; Weijing Han ; Xuefei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInsufficient infiltration of cytotoxic T cells into solid tumors poses a major challenge in cancer immunotherapy, largely due to the intricate tumor microenvironment. To address this, we co-cultured mouse cancer cell lines (B16-WT or B16-OVA) with cancer-specific cytotoxic T cells (activated OT-1) in vitro to uncover the impact of cancer-T cell interactions on T cell motility, pivotal for effective tumor infiltration. To investigate the potential m...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
