Distinct experiences and care needs of advanced cancer patients with good ECOG performance status: a qualitative phenomenological study
Advanced cancer patients with good Eastern Cooperative Oncology Group (ECOG) performance status (score 0 –1) are underrepresented in current qualitative reports compared with their dying counterparts. (Source: BMC Palliative Care)
Source: BMC Palliative Care - April 17, 2024 Category: Palliative Care Authors: Ping Chen, Mingfu Ding, Changlin Li, Yujuan Long, Deng Pan, Li Ma, Taiguo Liu and Cheng Yi Tags: Research Source Type: research
Decoding dynamic miRNA:ceRNA interactions unveils therapeutic insights and targets across predominant cancer landscapes
Competing endogenous RNAs play key roles in cellular molecular mechanisms through cross-talk in post-transcriptional interactions. Studies on ceRNA cross-talk, which is particularly dependent on the abundance ... (Source: BioData Mining)
Source: BioData Mining - April 17, 2024 Category: Bioinformatics Authors: Selcen Ari Yuka and Alper Yilmaz Tags: Research Source Type: research
Effectiveness of standard treatments in non-small-cell lung cancer with METexon14 skipping mutation: a real-world study
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Muhammad Furqan Siddharth Karanth Ravi K Goyal Beilei Cai Julien Rombi Keith L Davis Nydia Caro Teddy Saliba Source Type: research
Phase II trial of niraparib for BRCA-mutated biliary tract, pancreatic and other gastrointestinal cancers: NIR-B
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Yasuyuki Kawamoto Chigusa Morizane Yoshito Komatsu Shunsuke Kondo Makoto Ueno Satoshi Kobayashi Masayuki Furukawa Lingaku Lee Taroh Satoh Daisuke Sakai Masafumi Ikeda Hiroshi Imaoka Arisa Miura Yutaka Hatanaka Isao Yokota Yoshiaki Nakamura Takayuki Yoshin Source Type: research
A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Thyroid ®, Ahead of Print. (Source: Thyroid)
Source: Thyroid - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research
Menopause hormone therapy prescribing in ambulatory care visits among midlife and older U.S. women from 2018 to 2019
Menopause hormone therapy (HT) is indicated for the treatment of vasomotor symptoms of menopause, premature menopause, genitourinary syndrome of menopause, and prevention of osteoporosis [1]. After the 2002 Women's Health Initiative (WHI) study results were published, HT prescribing rates plummeted 66 % amidst fears of cardiovascular disease, venous thromboembolism, and breast cancer [2]. In 2009–2010, the prevalence of HT use was 4.7 %, decreased from 22.4 % in 1999–2000 [3]. Almost no recent studies have reported HT prescribing rates in representative patient samples in the U.S. (Source: Maturitas)
Source: Maturitas - April 17, 2024 Category: Primary Care Authors: Talia H. Sobel, Nadra E. Lisha, Alison J. Huang Tags: Short communication Source Type: research
Ultrasound-based radiomics for early predicting response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review with meta-analysis
ConclusionUS-based radiomics may be a potentially crucial adjuvant method for evaluating the response of breast cancer to NAC. Due to limited data available and low quality of eligible studies, more multicenter prospective studies with rigorous methods are required to confirm our findings. (Source: La Radiologia Medica)
Source: La Radiologia Medica - April 17, 2024 Category: Radiology Source Type: research
Akkermansia muciniphila improves gastric cancer treatment by modulating the immune microenvironment
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - April 17, 2024 Category: Microbiology Authors: Jianming Fang Huizhong Zhang Xiaodong Zhang Xiaolong Lu Junjie Liu Haiyang Li Jianxin Huang Source Type: research
Can predictive factors determine the time to treatment initiation for oral and oropharyngeal cancer? A classification and regression tree analysis
by D ébora Rosana Alves Braga Silva Montagnoli, Vitória Ferreira Leite, Yasmim Silva Godoy, Vitória Marçolla Lafetá, Edmilson Antônio Pereira Junior, Akhilanand Chaurasia, Maria Cássia Ferreira Aguiar, Mauro Henrique Nogueira Guimarães Abreu, Renata Castro Martins
This ecological study aimed to identify the factors with the greatest power to discriminate the proportion of oral and oropharyngeal cancer (OOC) records with time to treatment initiation (TTI) within 30 days of diagnosis in Brazilian municipalities. A descriptive analysis was performed on the var iables grouped into five dimensions related to patient ch...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: D ébora Rosana Alves Braga Silva Montagnoli Source Type: research
Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma
In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, t...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Aki Sasaki Source Type: research
Fragile hands: targeting nonmelanoma skin cancer on older hands using 595 nm pulsed dye laser
ConclusionTwo treatments of PDL for NMSC on the dorsal hands of older patients was well tolerated, had low recurrence, and seemed more effective than one treatment. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - April 17, 2024 Category: Laser Surgery Source Type: research
Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway
ConclusionsWe conclude that autophagy events are more active in HCC tissues compared to the adjacent non-cancer tissues. We also reported the possible role of several miRNAs in regulating autophagy-related genes in the autophagy pathway in HCC. This may contribute to the development of potential therapeutic targets for improving HCC therapy. Future investigations are warranted to validate the target genes reported in this study using a larger sample size and more targeted molecular technique. (Source: Journal of Molecular Histology)
Source: Journal of Molecular Histology - April 17, 2024 Category: Laboratory Medicine Source Type: research
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4. (Source: Immunity)
Source: Immunity - April 17, 2024 Category: Allergy & Immunology Authors: Jay K. Mandula, Rosa A. Sierra-Mondragon, Rachel V. Jimenez, Darwin Chang, Eslam Mohamed, Shiun Chang, Julio A. Vazquez-Martinez, Yu Cao, Carmen M. Anadon, Sae Bom Lee, Satyajit Das, L éo Rocha-Munguba, Vincent M. Pham, Roger Li, Ahmad A. Tarhini, Muhamm Tags: Article Source Type: research
Ambient polycyclic aromatic hydrocarbon exposure and breast cancer risk in a population-based Canadian case –control study
ConclusionThis study provides support for the hypothesis that ambient PAH exposures increase the risk of premenopausal breast cancer. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 17, 2024 Category: Cancer & Oncology Source Type: research
Attitudes of people diagnosed with cancer and cancer care providers towards use of nicotine vaping products in high-income countries: a scoping review
ConclusionFindings show differences in beliefs and attitudes of e-cigarettes between clinicians and people diagnosed with cancer. Additional research into the health impacts of e-cigarettes in people with a current or previous cancer diagnosis will allow for greater congruence between patients and clinicians and assist providers in recommending effective tools for smoking cessation within this population.Implications for Cancer SurvivorsThis study provides an overview of the attitudes, beliefs and perceptions of e-cigarette use among people with a current or previous diagnosis of cancer and health practitioners. Given the ...
Source: Journal of Cancer Survivorship - April 17, 2024 Category: Cancer & Oncology Source Type: research
