Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
The purinergic P2X7 receptor (P2X7R) plays an important role in the crosstalk between pancreatic stellate cells (PSCs) and cancer cells, thus promoting progression of pancreatic ductal adenocarcinoma (PDAC). S... (Source: Cancer Cell International)
Source: Cancer Cell International - April 25, 2024 Category: Cancer & Oncology Authors: Lara Magni, Haoran Yu, Nynne M. Christensen, Mette H. Poulsen, Alexander Frueh, Ganga Deshar, Astrid Z. Johansen, Julia S. Johansen, Stephan A. Pless, Niklas R. J ørgensen and Ivana Novak Tags: Research Source Type: research
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
AbstractCopper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in vari...
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Return to work and psychosocial trajectories after breast cancer: a longitudinal and sequential approach
ConclusionsThe results of this study suggest that BCS who return to full-time work (slow and quick RTW patterns) recover better than patients who return to part-time work (partial and part-time RTW patterns). (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
Reply to: “Psychosocial symptoms associated with spiritual well‑being in Latino patients and caregivers coping with advanced cancer”
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
High core 1 β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
ConclusionElevated C1GALT1 expression in LUAD is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial –mesenchymal transition (EMT). (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
An endothelial-related prognostic index for bladder cancer patients
ConclusionWe have effectively discerned pivotal genes from the endothelial cell perspective and constructed an EPI for BC patients, thereby offering promising prospects for precision medicine. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma
ConclusionThis study reports a rare case of TdT positive “double hit” HGBL following the treatment of concurrent FL/DLBCL and highlights the mutation characteristics. Collectively, this study will help enrich the knowledge of TdT positive “double hit” HGBL transformed from FL/DLBCL. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
Pan-cancer analysis implicates novel insights of lactate metabolism into immunotherapy response prediction and survival prognostication
Immunotherapy has emerged as a potent clinical approach for cancer treatment, but only subsets of cancer patients can benefit from it. Targeting lactate metabolism (LM) in tumor cells as a method to potentiate... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 25, 2024 Category: Cancer & Oncology Authors: Dongjie Chen, Pengyi Liu, Xiongxiong Lu, Jingfeng Li, Debin Qi, Longjun Zang, Jiayu Lin, Yihao Liu, Shuyu Zhai, Da Fu, Yuanchi Weng, Hongzhe Li and Baiyong Shen Tags: Research Source Type: research
Cancers, Vol. 16, Pages 1671: Association between Periodontitis and Hematologic Cancer: An NHIRD Cohort Study in Taiwan
Conclusions: This study found that being male and having hypertension were the significant risk factors for hematological malignancies. Moreover, the association between chronic periodontitis and specific subtypes of hematologic cancers was confirmed. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Huang Yu Lin Wang Chang Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1668: Germline Genetic Mutations in Adult Patients with Sarcoma: Insight into the Middle East Genetic Landscape
dah
Abdel-Razeq
Data on germline mutations in soft tissue and bone sarcomas are scarce. We sought to identify the prevalence of germline mutations in adult sarcoma patients treated at a tertiary cancer center. Newly diagnosed patients were offered germline genetic testing via an 84-gene panel. The prevalence of pathogenic germline variants (PGVs) and their association with disease-, and patient- related factors are reported. A total of 87 patients were enrolled, the median age was 48 (19–78) years, and 47 (54%) were females. Gastrointestinal stromal tumors (n = 12, 13.8%), liposarcoma (n = 10, 11.5%), ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Abu-Hijlih Sharaf Salah Bani Hani Alqaisieh Alzibdeh Ababneh Mahafdah Abdel-Razeq Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1670: The Current Achievements of Multi-Gene Panel Tests in Clinical Settings for Patients with Non-Small-Cell Lung Cancer
sui
Taguchi
Hataji
Some multi-gene panel tests have been implemented in clinical settings to guide targeted therapy in non-small-cell lung cancer (NSCLC) in Japan. The current performance of multi-gene panel tests under the condition that the Oncomine Dx Target Test (ODxTT) and Amoy Dx® Pan Lung Cancer PCR panel (AmoyDx-multi) are available remains relatively unknown. We retrospectively reviewed consecutive patients with NSCLC, whose FFPE samples were considered for genetic testing. We assessed the submission rates, the success rates, and the driver oncogene detection rates of multi-gene panel tests. ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Sakaguchi Iketani Esumi Esumi Suzuki Ito Fujiwara Nishii Katsuta Yasui Taguchi Hataji Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1667: Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach
Jean-Francois Peyron
Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) relapses are still associated with a dismal outcome, justifying the search for new therapeutic targets and relapse biomarkers. Using single-cell RNA sequencing (scRNAseq) data from three paired samples of pediatric T-ALL at diagnosis and relapse, we first conducted a high-dimensional weighted gene co-expression network analysis (hdWGCNA). This analysis highlighted several gene co-expression networks (GCNs) and identified relapse-associated hub genes, which are considered potential driver genes. Shared relapse-expressed genes were found to be re...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Anthony Kypraios Juba Bennour V éronique Imbert L éa David Julien Calvo Fran çoise Pflumio Rapha ël Bonnet Marie Couralet Virginie Magnone Kevin Lebrigand Pascal Barbry Pierre S. Rohrlich Jean-Francois Peyron Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1669: Quantitative Optical Redox Imaging of Melanoma Xenografts with Different Metastatic Potentials
Lin Z. Li
To develop imaging biomarkers for tumors aggressiveness, our previous optical redox imaging (ORI) studies of the reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp, containing flavin adenine dinucleotide, i.e., FAD) in tumor xenografts of human melanoma associated the high optical redox ratio (ORR = Fp/(Fp + NADH)) and its heterogeneity to the high invasive/metastatic potential, without having reported quantitative results for NADH and Fp. Here, we implemented a calibration procedure to facilitate imaging the nominal concentrations of tissue NADH and Fp in the mouse xenografts of ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: April Peng He N. Xu Lily Moon Paul Zhang Lin Z. Li Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1666: Hypomethylation of ATP1A1 Is Associated with Poor Prognosis and Cancer Progression in Triple-Negative Breast Cancer
Han
Park
Yoo
Park
: Dysregulated DNA methylation in cancer is critical in the transcription machinery associated with cancer progression. Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, but no treatment targeting TNBC biomarkers has yet been developed. To identify specific DNA methylation patterns in TNBC, methyl-binding domain protein 2 (MBD) sequencing data were compared in TNBC and the three other major breast cancer subtypes. Integrated analysis of DNA methylation and gene expression identified a gene set showing a correlation between DNA methylation and gene expressi...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Kim Ko Kong Lee Chung Lim Son Oh Park Kim Lee Han Park Yoo Park Tags: Article Source Type: research
