Cholangiocarcinoma: new perspectives for new horizons
Expert Rev Gastroenterol Hepatol. 2021 Oct 20. doi: 10.1080/17474124.2021.1991313. Online ahead of print.ABSTRACTINTRODUCTION: : Biliary tract cancer represents a heterogeneous group of malignancies characterized by dismal prognosis and scarce therapeutic options.AREA COVERED: In the last years a growing interest in BTCs pathology has emerged, thus highlighting a significant heterogeneity of the pathways underlying the carcinogenesis process, from both a molecular and genomic point of view. A better understanding of these differences is mandatory in order to deepen the behavior of this complex disease, as well as to identi...
Source: Expert Review of Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Margherita Rimini Marco Puzzoni Federica Pedica Nicola Silvestris Lorenzo Fornaro Giuseppe Aprile Eleonora Loi Oronzo Brunetti Caterina Vivaldi Francesca Simionato Patrizia Zavattari Mario Scartozzi Valentina Burgio Ratti Francesca Luca Aldrighetti Stefan Source Type: research

Cross-Talk between Immune System and Microbiota in COVID-19
Expert Rev Gastroenterol Hepatol. 2021 Oct 15. doi: 10.1080/17474124.2021.1991311. Online ahead of print.ABSTRACTINTRODUCTION: Human gut microbiota plays a crucial role in providing protective responses against pathogens, particularly by regulating immune system homeostasis. There is a reciprocal interaction between the gut and lung microbiota, called the gut-lung axis (GLA). Any alteration in the gut microbiota or their metabolites can cause immune dysregulation, which can impair the antiviral activity of the immune system against respiratory viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SAR...
Source: Expert Review of Gastroenterology and Hepatology - October 16, 2021 Category: Gastroenterology Authors: Shaghayegh Baradaran Ghavami Mahsa Pourhamzeh Maryam Farmani Hediye Keshavarz Shabnam Shahrokh Anastasia Shpichka Hamid Asadzadeh Aghdaei Mojdeh Hakemi-Vala Nikoo Hosein-Khannazer Peter Timashev Massoud Vosough Source Type: research

Investigation of Etiology-Specific Alterations in the Gut Microbiota in Liver Cirrhosis
CONCLUSION: No robust microbial signal was found to differentiate between various underlying etiologies in cirrhotic patients. The data indicate that the geographical origin of cirrhotic patients could affect the composition of the gut microbiome, the effect of which obscure the impact of the etiology of cirrhosis.PMID:34632902 | DOI:10.1080/17474124.2021.1991312 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - October 11, 2021 Category: Gastroenterology Authors: Mohadeseh Naseri Hamidreza Houri Abbas Yadegar Hamid Asadzadeh Aghdaei Javad Zahiri Source Type: research

Current Epidemiology in Hepatocellular Carcinoma
Expert Rev Gastroenterol Hepatol. 2021 Oct 8. doi: 10.1080/17474124.2021.1991792. Online ahead of print.ABSTRACTIntroductionHepatocellular carcinoma (HCC) is the sixth most common cancer and the third-leading cause of cancer-related mortality in the world.Areas coveredThis review will discuss risk factors, demographic differences, global trends, and the economic burden of HCC. Viral hepatitis, particularly hepatitis B virus (HBV) infection, is the most common underlying liver disease leading to HCC in those with cirrhosis. Other important risk factors include alcoholic liver disease, nonalcoholic fatty liver disease, metab...
Source: Expert Review of Gastroenterology and Hepatology - October 8, 2021 Category: Gastroenterology Authors: Peter Konyn Aijaz Ahmed Donghee Kim Source Type: research

Towards personalized therapy for cholangiocarcinoma: new insights and challenges
Expert Rev Gastroenterol Hepatol. 2021 Sep 23. doi: 10.1080/17474124.2021.1984879. Online ahead of print.NO ABSTRACTPMID:34553646 | DOI:10.1080/17474124.2021.1984879 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - September 23, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Angela Dalia Ricci Gennaro Gadaleta-Caldarola Giovanni Brandi Source Type: research

An update of pharmacology, efficacy and safety of vonoprazan in acid-related disorders
Expert Rev Gastroenterol Hepatol. 2021 Sep 22. doi: 10.1080/17474124.2021.1984878. Online ahead of print.ABSTRACTINTRODUCTION: Patients with acid-related disorders (ARDs) of the upper digestive tract remain highly prevalent and need to be continuously investigated to improve their management.AREAS COVERED: This review provides a summary of the most recent advancements in the treatment of ARDs with particular focus on the new drugs available to overcome the unmet needs of traditional therapies.EXPERT OPINION: Proton pump inhibitors remain the best therapy in treating ARDs, but a consistent proportion of these patients conti...
Source: Expert Review of Gastroenterology and Hepatology - September 22, 2021 Category: Gastroenterology Authors: Vincenzo Savarino Luca Antonioli Matteo Fornai Elisa Marabotto Maria Giulia Demarzo Fabiana Zingone Matteo Ghisa Brigida Barberio Patrizia Zentilin Mentore Ribolsi Edoardo Savarino Source Type: research

Virologic response maintenance and hepatocellular carcinoma in chronic hepatitis B patients treated with entecavir
Expert Rev Gastroenterol Hepatol. 2021 Sep 20:1-8. doi: 10.1080/17474124.2021.1980385. Online ahead of print.ABSTRACTINTRODUCTION: The treatment evidence for entecavir-treated chronic hepatitis B (CHB) patients without maintaining of virologic response (MVR, defined as persistent HBV DNA
Source: Expert Review of Gastroenterology and Hepatology - September 13, 2021 Category: Gastroenterology Authors: Xiaomo Wang Yu Chen Manman Xu Kailiang Cheng Xiaoman Duan Wei Liao Yanhong Wang Ying Lu Zhongping Duan Li Wang Source Type: research

Virologic response maintenance and hepatocellular carcinoma in chronic hepatitis B patients treated with entecavir
Expert Rev Gastroenterol Hepatol. 2021 Sep 11. doi: 10.1080/17474124.2021.1980385. Online ahead of print.ABSTRACTINTRODUCTION: The treatment evidence for entecavir-treated chronic hepatitis B (CHB) patients without maintaining of virologic response (MVR, defined as persistent HBV DNA
Source: Expert Review of Gastroenterology and Hepatology - September 13, 2021 Category: Gastroenterology Authors: Xiaomo Wang Yu Chen Manman Xu Kailiang Cheng Xiaoman Duan Wei Liao Yanhong Wang Ying Lu Zhongping Duan Li Wang Source Type: research

Differences between current clinical guidelines for screening, diagnosis and management of non-alcoholic fatty liver disease and real-world practice: a targeted literature review
Expert Rev Gastroenterol Hepatol. 2021 Sep 8. doi: 10.1080/17474124.2021.1974295. Online ahead of print.ABSTRACTINTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and is associated with obesity and metabolic comorbidities. Liver steatosis can progress to non-alcoholic steatohepatitis (NASH) exhibiting a relevant risk of fibrosis and ultimately liver failure. To date, no approved treatment for NASH to reduce its clinical and humanistic burden has been developed.AREAS COVERED: We undertook a literature review to identify English language, national and international clinical guidelines fo...
Source: Expert Review of Gastroenterology and Hepatology - September 8, 2021 Category: Gastroenterology Authors: J ├Ârn M Schattenberg Quentin M Anstee Cyrielle Caussy Elisabetta Bugianesi Branko Popovic Source Type: research

Safety and efficacy of indocyanine green fluorescence imaging-guided radical gastrectomy: a systematic review and meta-analysis
CONCLUSION: ICG fluorescence imaging-guided radical gastrectomy scores over conventional gastrectomy and appears to be a promising approach in patients who require radical gastrectomy. However, further research is warranted to explore the potential long-term survival benefit of ICG fluorescence imaging in patients with gastric cancer.PMID:34488515 | DOI:10.1080/17474124.2021.1970530 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - September 7, 2021 Category: Gastroenterology Authors: Jianqiao Yang Zixiao Wang Kangdi Dong Ronghua Zhang Kun Xiao Liang Shang Leping Li Source Type: research

Role of noninvasive imaging in the evaluation of intrahepatic cholangiocarcinoma: from diagnosis and prognosis to treatment response
Expert Rev Gastroenterol Hepatol. 2021 Sep 1:1-13. doi: 10.1080/17474124.2021.1974294. Online ahead of print.ABSTRACTINTRODUCTION: Intrahepatic cholangiocarcinoma is the second most common liver cancer. Desmoplastic stroma may be revealed as distinctive histopathologic findings favoring intrahepatic cholangiocarcinoma. Meanwhile, a range of imaging manifestations is often accompanied with rich desmoplastic stroma in intrahepatic cholangiocarcinoma, which can indicate large bile duct ICC, and a higher level of cancer-associated fibroblasts with poor prognosis and weak treatment response.AREAS COVERED: We provide a comprehen...
Source: Expert Review of Gastroenterology and Hepatology - August 28, 2021 Category: Gastroenterology Authors: Qian Li Feng Che Yi Wei Han-Yu Jiang Yun Zhang Bin Song Source Type: research

Role of noninvasive imaging in the evaluation of intrahepatic cholangiocarcinoma: from diagnosis and prognosis to treatment response
Expert Rev Gastroenterol Hepatol. 2021 Aug 27. doi: 10.1080/17474124.2021.1974294. Online ahead of print.ABSTRACTINTRODUCTION: Intrahepatic cholangiocarcinoma is the second most common liver cancer. Desmoplastic stroma may be revealed as distinctive histopathologic findings favouring intrahepatic cholangiocarcinoma. Meanwhile, a range of imaging manifestations is often accompanied with rich desmoplastic stroma in intrahepatic cholangiocarcinoma, which can indicate large bile duct ICC, and a higher level of cancer-associated fibroblasts with poor prognosis and weak treatment response.AREAS COVERED: We provide a comprehensiv...
Source: Expert Review of Gastroenterology and Hepatology - August 28, 2021 Category: Gastroenterology Authors: Qian Li Feng Che Yi Wei Han-Yu Jiang Yun Zhang Bin Song Source Type: research

Radiofrequency ablation for intrahepatic cholangiocarcinoma: a tool upon the path of integrative modalities?
Expert Rev Gastroenterol Hepatol. 2021 Aug 27. doi: 10.1080/17474124.2021.1974296. Online ahead of print.NO ABSTRACTPMID:34449276 | DOI:10.1080/17474124.2021.1974296 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - August 27, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Angela Dalia Ricci Gennaro Gadaleta-Caldarola Giovanni Brandi Source Type: research

First-line Immune Checkpoint Inhibitor-Based Combinations in Unresectable Hepatocellular Carcinoma: Current Management and Future Challenges
Expert Rev Gastroenterol Hepatol. 2021 Aug 25. doi: 10.1080/17474124.2021.1973431. Online ahead of print.ABSTRACTINTRODUCTION: Immunotherapy has recently taken on an extremely important role in medical oncology, as first- or later-line treatment in several tumor types, and recent years have seen the emerging of clinical trials assessing immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma (HCC).AREAS COVERED: Herein, we provide an overview of recently published studies exploring the dual immune checkpoint blockade or the combination of ICIs plus biological treatments as first-line treatment in HCC p...
Source: Expert Review of Gastroenterology and Hepatology - August 25, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Angela Dalia Ricci Gennaro Gadaleta-Caldarola Giovanni Brandi Source Type: research

Differentiated/undifferentiated mixed type is a prognostic factor for T2/T3 gastric cancer patients
Expert Rev Gastroenterol Hepatol. 2021 Aug 25. doi: 10.1080/17474124.2021.1973430. Online ahead of print.ABSTRACTBACKGROUND: : Mixed histological type, including differentiated and undifferentiated components, accounts for a large proponent among gastric cancer patients and have been widely studied among early gastric cancer. Gastric cancer patients with mixed type tend to show poorer prognosis than those with pure-type histology. However, the association of mixed-type histology and prognosis of T2/T3 GC patients is still unclear.METHODS: : Eligible T2/T3 gastric cancer patients who underwent surgical treatment between Jan...
Source: Expert Review of Gastroenterology and Hepatology - August 25, 2021 Category: Gastroenterology Authors: Huiwen Lu Yimeng Sun Zirui Zhu Huimian Xu Rui Huang Baojun Huang Source Type: research

First-line Immune Checkpoint Inhibitor-Based Combinations in Unresectable Hepatocellular Carcinoma: Current Management and Future Challenges
Expert Rev Gastroenterol Hepatol. 2021 Aug 25. doi: 10.1080/17474124.2021.1973431. Online ahead of print.ABSTRACTINTRODUCTION: Immunotherapy has recently taken on an extremely important role in medical oncology, as first- or later-line treatment in several tumor types, and recent years have seen the emerging of clinical trials assessing immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma (HCC).AREAS COVERED: Herein, we provide an overview of recently published studies exploring the dual immune checkpoint blockade or the combination of ICIs plus biological treatments as first-line treatment in HCC p...
Source: Expert Review of Gastroenterology and Hepatology - August 25, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Angela Dalia Ricci Gennaro Gadaleta-Caldarola Giovanni Brandi Source Type: research

Differentiated/undifferentiated mixed type is a prognostic factor for T2/T3 gastric cancer patients
Expert Rev Gastroenterol Hepatol. 2021 Aug 25. doi: 10.1080/17474124.2021.1973430. Online ahead of print.ABSTRACTBACKGROUND: : Mixed histological type, including differentiated and undifferentiated components, accounts for a large proponent among gastric cancer patients and have been widely studied among early gastric cancer. Gastric cancer patients with mixed type tend to show poorer prognosis than those with pure-type histology. However, the association of mixed-type histology and prognosis of T2/T3 GC patients is still unclear.METHODS: : Eligible T2/T3 gastric cancer patients who underwent surgical treatment between Jan...
Source: Expert Review of Gastroenterology and Hepatology - August 25, 2021 Category: Gastroenterology Authors: Huiwen Lu Yimeng Sun Zirui Zhu Huimian Xu Rui Huang Baojun Huang Source Type: research

Metabolic disorders and the risk of cholangiocarcinoma
Expert Rev Gastroenterol Hepatol. 2021 Aug 21:1-9. doi: 10.1080/17474124.2021.1946393. Online ahead of print.ABSTRACTIntroduction: Cholangiocarcinoma (CCA) is a malignancy which arises from the biliary epithelium. Carcinogenesis of CCA is mainly linked to aberrant glucose metabolism and creation of an immunosuppressive environment around normal biliary epithelium. The incidence of CCA is higher in the East due to Opisthorchis viverrini, an endemic liver fluke. CCA has also be attributed to genetic, metabolic, and lifestyle risk factors.Areas covered: Differences in epidemiological risk factors are associated with varying p...
Source: Expert Review of Gastroenterology and Hepatology - August 23, 2021 Category: Gastroenterology Authors: Michele Ghidini Daryl Ramai Antonio Facciorusso Jameel Singh Waqqas Tai Erika Rijavec Barbara Galassi Francesco Grossi Alice Indini Source Type: research