Sofosbuvir/velpatasvir for the treatment of Hepatitis C in pediatric patients
Expert Rev Gastroenterol Hepatol. 2021 Aug 2. doi: 10.1080/17474124.2021.1963231. Online ahead of print.ABSTRACTIntroduction: Sofosbuvir/velpatasvir is a combination of direct-acting antivirals with pangenotypic activity for treatment of chronic hepatitis C virus infection. It was approved in 2020 for use in children aged 6-17 years and in June 2021 for the age group 3-5 years.Areas covered: A literature search of PUBMED and EMBASE was conducted on April 30th and updated on June 10th. Other citations were identified in references of available literature and from ClinicalTrials.gov. The aim of the present research was to ou...
Source: Expert Review of Gastroenterology and Hepatology - August 2, 2021 Category: Gastroenterology Authors: Chiara Rubino Sandra Trapani Giuseppe Indolfi Source Type: research

Gut Microbiota: A Target for Intervention in Obesity
We present data on microbiome markers and the future of microbiota therapeutics for obesity.AREAS COVERED: : We summarize the pathogenesis of obesity, relationship between gut microbiota and obesity, use of microbiota-based therapies. Data were gathered by a literature search of articles in PubMed from the date of inception till August 2020. Keywords used were "gut microbiota", "gut microbiome," "microbiota," "microbiome," "obesity," and "obesity and fecal microbiota transplantation" as MeSH terms.EXPERT OPINION: : The direct relationship of gut microbiota in caus...
Source: Expert Review of Gastroenterology and Hepatology - July 30, 2021 Category: Gastroenterology Authors: Kanika Sehgal Sahil Khanna Source Type: research

Metabolic-associated fatty liver disease and autoimmune hepatitis: an overlooked interaction
Expert Rev Gastroenterol Hepatol. 2021 Jul 15:1-9. doi: 10.1080/17474124.2021.1952867. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic-associated fatty liver disease (MAFLD) is the most common liver disease globally, and affects about a quarter of the general population. Autoimmune hepatitis (AIH) is a severe (sometimes fatal) liver disease that affects children and adults, with a rising prevalence. Thus, not surprisingly, both conditions can frequently coexist, with potential synergistic impact on the course of the disease and response to therapy of both entities.AREAS COVERED: In this work, the authors aimed to pro...
Source: Expert Review of Gastroenterology and Hepatology - July 15, 2021 Category: Gastroenterology Authors: Yasmine Gaber Mohamed AbdAllah Asmaa Salama Manar Sayed Shereen Abdel Alem Shaymaa Nafady Source Type: research

Emerging data on nivolumab for esophageal squamous cell carcinoma
Expert Rev Gastroenterol Hepatol. 2021 Jul 12:1-10. doi: 10.1080/17474124.2021.1948836. Online ahead of print.ABSTRACTINTRODUCTION: Esophageal cancer (EC) is the seventh most common malignancy in the world. The standard treatment for advanced EC patients is systemic chemotherapy, but few effective cytotoxic agents are available. Recently, nivolumab, a human monoclonal immunoglobulin G4 antibody that inhibits programmed cell death protein 1, has been tested for the treatment of advanced squamous cell carcinoma (ESCC) patients. The ATTRACTION-1 trial showed a promising efficacy of nivolumab monotherapy for advanced ESCC pati...
Source: Expert Review of Gastroenterology and Hepatology - July 12, 2021 Category: Gastroenterology Authors: Toshiharu Hirose Shun Yamamoto Ken Kato Source Type: research

A consensus integrated care pathway for patients with primary biliary cholangitis: a guideline-based approach to clinical care of patients
This article describes the development by expert consensus of a 'PBC Integrated Patient Care Pathway' to simplify and standardize the management of PBC for clinicians based on current practice.EXPERT OPINION: Guideline adoption is potentially poor in practice since most patients with PBC in the community are seen by general gastroenterologists or hepatologists without a special interest in autoimmune liver disease. The PBC Integrated Patient Care Pathway is a best practice tool for clinicians designed to complement the EASL Clinical Practice Guidelines for the diagnosis and management of PBC patients. It gives clinicians a...
Source: Expert Review of Gastroenterology and Hepatology - July 8, 2021 Category: Gastroenterology Authors: Gideon M Hirschfield Olivier Chazouill ères Helena Cortez-Pinto Guilherme Macedo Victor de L édinghen Femi Adekunle Marco Carbone Source Type: research

Roles of nuclear receptors in hepatic stellate cells
Expert Rev Gastroenterol Hepatol. 2021 Jul 7:1-12. doi: 10.1080/17474124.2021.1949288. Online ahead of print.ABSTRACTIntroduction: Hepatic stellate cells (HSCs) are essential for physiological homeostasis of the liver extracellular matrix (ECM). Excessive transdifferentiation of HSC from a quiescent to an activated phenotype contributes to disrupt this balance and can lead to liver fibrosis. Accumulating evidence has suggested that nuclear receptors (NRs) are involved in the regulation of HSC activation, proliferation, and function. Therefore, these NRs may be therapeutic targets to balance ECM homeostasis and inhibit HSC ...
Source: Expert Review of Gastroenterology and Hepatology - July 6, 2021 Category: Gastroenterology Authors: Shiyun Pu Hongjing Zhou Yan Liu Jiao Liu Yuanxin Guo Houfeng Zhou Source Type: research

Periodontal and dental health in inflammatory bowel diseases: a systematic review
Expert Rev Gastroenterol Hepatol. 2021 Jul 6. doi: 10.1080/17474124.2021.1952866. Online ahead of print.ABSTRACTINTRODUCTION: An increased risk of dental caries and periodontal diseases has been reported for inflammatory bowel disease (IBD) patients and are challenging conditions to manage.AREAS COVERED: The authors searched international databases to find all studies assessing dental/periodontal outcomes in patients with IBD and other immune-mediated inflammatory disease (IMID), as well as the association between IMID medications and dental/periodontal status.EXPERT OPINION: IBD are associated with a higher risk of both p...
Source: Expert Review of Gastroenterology and Hepatology - July 6, 2021 Category: Gastroenterology Authors: Kevimy Agossa Lidia Roman Marjolaine Gosset Clara Yzet Mathurin Fumery Source Type: research

Roles of nuclear receptors in hepatic stellate cells
Expert Rev Gastroenterol Hepatol. 2021 Jul 6. doi: 10.1080/17474124.2021.1949288. Online ahead of print.ABSTRACTINTRODUCTION: Hepatic stellate cells (HSCs) are essential for physiological homeostasis of the liver extracellular matrix (ECM). Excessive transdifferentiating of HSC from a quiescent to an activated phenotype contributes to disrupt this balance and can lead to liver fibrosis. Accumulating evidence has suggested that Nuclear receptors (NRs) are involved in the regulation of HSC activation, proliferation, and function. Therefore, these NRs may be therapeutic targets to balance ECM homeostasis and inhibit HSC activ...
Source: Expert Review of Gastroenterology and Hepatology - July 6, 2021 Category: Gastroenterology Authors: Shiyun Pu Hongjing Zhou Yan Liu Jiao Liu Yuanxin Guo Houfeng Zhou Source Type: research

Periodontal and dental health in inflammatory bowel diseases: a systematic review
Expert Rev Gastroenterol Hepatol. 2021 Jul 6. doi: 10.1080/17474124.2021.1952866. Online ahead of print.ABSTRACTINTRODUCTION: An increased risk of dental caries and periodontal diseases has been reported for inflammatory bowel disease (IBD) patients and are challenging conditions to manage.AREAS COVERED: The authors searched international databases to find all studies assessing dental/periodontal outcomes in patients with IBD and other immune-mediated inflammatory disease (IMID), as well as the association between IMID medications and dental/periodontal status.EXPERT OPINION: IBD are associated with a higher risk of both p...
Source: Expert Review of Gastroenterology and Hepatology - July 6, 2021 Category: Gastroenterology Authors: Kevimy Agossa Lidia Roman Marjolaine Gosset Clara Yzet Mathurin Fumery Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jul 1:1-15. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTIntroduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal, and clinical studies in chronic liver ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jul 1:1-15. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTIntroduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal, and clinical studies in chronic liver ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jul 1:1-15. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTIntroduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal, and clinical studies in chronic liver ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jul 1:1-15. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTIntroduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal, and clinical studies in chronic liver ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jun 26. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTOxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), non-alcoholic steatohepatitis (NASH), hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal and clinical studies in chronic liver disease is also rev...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jun 26. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTOxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), non-alcoholic steatohepatitis (NASH), hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal and clinical studies in chronic liver disease is also rev...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Chronic liver disease and oxidative stress - a narrative review
Expert Rev Gastroenterol Hepatol. 2021 Jun 26. doi: 10.1080/17474124.2021.1949289. Online ahead of print.ABSTRACTOxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), non-alcoholic steatohepatitis (NASH), hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal and clinical studies in chronic liver disease is also rev...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Sophia Seen Source Type: research

Irritable Bowel Syndrome and Migraine: Evidence from Mendelian Randomization Analysis in the UK Biobank
This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.RESULTS: : The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, ...
Source: Expert Review of Gastroenterology and Hepatology - June 28, 2021 Category: Gastroenterology Authors: Jie Chen Xuejie Chen Ying Xie Yuhao Sun Xiaoyan Wang Therese Hesketh Source Type: research

Risk of selected gastrointestinal toxicities in metastatic renal cell carcinoma patients treated with immuno-TKI combinations: a meta-analysis
CONCLUSION: The meta-analysis suggested that immuno-TKI combinations are associated with a higher risk of certain GI toxicities compared with sunitinib. Beyond the efficacy of immuno-TKI combinations in mRCC patients, careful consideration should be given to treatment-related adverse events, including GI toxicities. Early recognition and treatment are critical to maximize recovery.PMID:34167420 | DOI:10.1080/17474124.2021.1948328 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - June 25, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Veronica Mollica Matteo Santoni Francesco Massari Source Type: research

Spleen Angiosarcoma: A World Review
In this study, we aim to provide a comprehensive review of SA.AREAS COVERED: On 27 February 2021, a literature search was done Pubmed and Embase database. The search yielded 122 articles involving 205 patients. The focus was on patient demographics, risk factors, clinical presentations, investigation results, preliminary diagnoses, therapies provided, and patient outcomes. These factors were analyzed to identify possible risk factors, diagnostic modalities, and therapeutic principles that were not mentioned before.EXPERT OPINION: The clinical presentation or investigation results of patients with SA are often non-specific....
Source: Expert Review of Gastroenterology and Hepatology - June 23, 2021 Category: Gastroenterology Authors: Brian Lee Juin Hsien Vishal Girishchandra Shelat Source Type: research

The mechanism of esophagus dysmotility in diabetes and research progress of relating treatments
Expert Rev Gastroenterol Hepatol. 2021 Jun 22. doi: 10.1080/17474124.2021.1945921. Online ahead of print.ABSTRACTINTRODUCTION: Esophagus dysmotility is a crucial risk factor of gastroesophageal reflux disease (GERD), which is one of the most common diseases in digestive medicine globally. This review emphasizes the mechanisms of esophagus dysmotility in diabetes and summarizes more targeted treatments for these patients to avoid the overuse of proton pump inhibitors (PPIs).AREAS COVERED: Diabetes mellitus (DM) is a clear factor that must not be neglected in the development of GERD. Previous studies have preliminarily resea...
Source: Expert Review of Gastroenterology and Hepatology - June 22, 2021 Category: Gastroenterology Authors: Jiarong Lin Gongkai Liu Zhijun Duan Source Type: research

Antibiotics in pediatric Inflammatory Bowel Diseases: a systematic review
This study systematically assessed efficacy and safety of antibiotics in pediatric IBD. CENTRAL, EMBASE (Ovid) and Medline (Pubmed) were searched for Randomized Controlled Trials (RCTs). Quality assessment of included articles was conducted with the Cochrane risk-of-bias tool.EXPERT OPINION: : Two RCT's (n=101, 4.4-18 years, 43% male) were included. Both studies had overall low risk of bias. In mild-to-moderate Crohn's disease, azithromycin+metronidazole (AZ+MET) (n=35) compared to metronidazole (MET) alone (n=38) did not induce a significantly different response (PCDAI drop ≥12.5 points or remission) (p=0.07). For indu...
Source: Expert Review of Gastroenterology and Hepatology - June 21, 2021 Category: Gastroenterology Authors: Charlotte M Verburgt W Pepijn Heutink Lot I M Kuilboer Julie D Dickmann Faridi S van Etten-Jamaludin Marc A Benninga Wouter J de Jonge Johan E Van Limbergen Merit M Tabbers Source Type: research