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Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms
Expert Rev Gastroenterol Hepatol. 2024 Apr 22. doi: 10.1080/17474124.2024.2342837. Online ahead of print.ABSTRACTINTRODUCTION: Pancreatic Neuroendocrine Neoplasms (PanNENs) are characterized by a highly heterogeneous clinical and biological behavior, making their diagnosis challenging. PanNENs diagnostic work-up mainly relies on biochemical markers, pathological examination, and imaging evaluation. The latter including radiological imaging (i.e. computed tomography [CT] and magnetic resonance imaging [MRI]), functional imaging (i.e. 68Gallium [68 Ga]Ga-DOTA-peptide PET/CT and Fluorine-18 fluorodeoxyglucose [18F]FDG PET/CT)...
Source: Expert Review of Gastroenterology and Hepatology - April 22, 2024 Category: Gastroenterology Authors: Anna Battistella Matteo Tacelli Paola Mapelli Marco Schiavo Lena Valentina Andreasi Luana Genova Francesca Muffatti Francesco De Cobelli Stefano Partelli Massimo Falconi Source Type: research

Germline testing and genetic counseling in biliary tract cancer: an operative proposal to improve the state of art
Expert Rev Gastroenterol Hepatol. 2024 Apr 8:1-6. doi: 10.1080/17474124.2024.2337000. Online ahead of print.ABSTRACTINTRODUCTION: A genetic predisposition seems to be involved in biliary tract cancer, but the prevalence of germline mutations in BTC remains unclear, and the therapeutic role of the germline pathologic variants is still unknown.AREA COVERED: The aim of the present work is to systematically review the data available on the hereditary predisposition of biliary tract cancer by a specific research on PubMed, in order to highlight the most important critical points and to define the current possible role of germin...
Source: Expert Review of Gastroenterology and Hepatology - April 8, 2024 Category: Gastroenterology Authors: Margherita Rimini Silvia Presi Giovanni Battista Pipitone Annalisa Russo Raucci Francesca Ratti Angelo Della Corte Federica Pedica Giuseppe Vanella Giovanni Tonon Valentina Burgio Francesco Vitiello Federico Rossari Elisabeth Amadeo Cangi Maria Giulia Lor Source Type: research

Germline testing and genetic counselling in biliary tract cancer: an operative proposal to improve the state of art
Expert Rev Gastroenterol Hepatol. 2024 Apr 8. doi: 10.1080/17474124.2024.2337000. Online ahead of print.ABSTRACTINTRODUCTION: A genetic predisposition seems to be involved in biliary tract cancer, but the prevalence of germline mutations in BTC remains unclear, and the therapeutic role of the germline pathologic variants is still unknown.AREA COVERED: The aim of the present work is to systematically review the data available on the hereditary predisposition of biliary tract cancer by a specific research on PubMed, in order to highlight the most important critical points and to define the current possible role of germinal t...
Source: Expert Review of Gastroenterology and Hepatology - April 8, 2024 Category: Gastroenterology Authors: Margherita Rimini Silvia Presi Giovanni Battista Pipitone Annalisa Russo Raucci Francesca Ratti Angelo Della Corte Federica Pedica Giuseppe Vanella Giovanni Tonon Valentina Burgio Francesco Vitiello Federico Rossari Elisabeth Amadeo Maria Giulia Cangi Lor Source Type: research

Histologic assessments in ulcerative colitis: the evidence behind a new endpoint in clinical trials
Expert Rev Gastroenterol Hepatol. 2024 Jan-Feb;18(1-3):73-87. doi: 10.1080/17474124.2024.2326838. Epub 2024 Mar 21.ABSTRACTINTRODUCTION: Treatment goals for ulcerative colitis (UC) are evolving from the achievement of clinical remission to more rigorous goals defined by endoscopic and histologic healing. Achievement of deeper remission targets aims to reduce the risk of colectomy, hospitalizations, and colorectal cancer.AREAS COVERED: This review covers histologic assessments, histologic remission as a clinical trial endpoint, and the association between histologic disease activity and clinical outcomes. Future directions ...
Source: Expert Review of Gastroenterology and Hepatology - March 21, 2024 Category: Gastroenterology Authors: Rish K Pai Geert D'Haens Taku Kobayashi Bruce E Sands Simon Travis Vipul Jairath Gert De Hertogh Bomina Park Kim McGinnis Isabel Redondo Nicole G Lipitz Theresa Hunter Gibble Fernando Magro Source Type: research