NAFLD and renal function in children: is there a genetic link?
Expert Rev Gastroenterol Hepatol. 2021 Apr 14:1-10. doi: 10.1080/17474124.2021.1906649. Online ahead of print.ABSTRACTIntroduction: Over the past decades, a large amount of both adult and pediatric data has shown relationship between Nonalcoholic Fatty Liver Disease (NAFLD) and chronic kidney disease (CKD), resulting in an overall increased cardiometabolic burden. In view of the remarkable role of the genetic background in the NAFLD pathophysiology, a potential influence of the major NAFLD polymorphisms (e.g. the I148M variant of the Patatin-like phospholipase containing domain 3 (PNPLA3) gene, the E167K allele of the Tran...
Source: Expert Review of Gastroenterology and Hepatology - April 14, 2021 Category: Gastroenterology Authors: Anna Di Sessa Stefano Guarino Antonio Paride Passaro Laura Liguori Giuseppina Rosaria Umano Grazia Cirillo Emanuele Miraglia Del Giudice Pierluigi Marzuillo Source Type: research

Cholangiocarcinoma: is it time for a revolution?
Expert Rev Gastroenterol Hepatol. 2021 Apr 15:1-4. doi: 10.1080/17474124.2021.1915766. Online ahead of print.NO ABSTRACTPMID:33840344 | DOI:10.1080/17474124.2021.1915766 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 12, 2021 Category: Gastroenterology Authors: Takuji Okusaka Source Type: research

Cholangiocarcinoma: is it time for a revolution?
Expert Rev Gastroenterol Hepatol. 2021 Apr 10. doi: 10.1080/17474124.2021.1915766. Online ahead of print.NO ABSTRACTPMID:33840344 | DOI:10.1080/17474124.2021.1915766 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 12, 2021 Category: Gastroenterology Authors: Takuji Okusaka Source Type: research

Ivosidenib for the treatment of isocitrate dehydrogenase-1 mutant cholangiocarcinoma
Expert Rev Gastroenterol Hepatol. 2021 Apr 9. doi: 10.1080/17474124.2021.1915765. Online ahead of print.ABSTRACTIntroduction: Cholangiocarcinomas (CCAs) are associated with poor survival outcomes, with limited treatment options in the unresectable or metastatic setting. A precision medicine approach to cancer treatment has revealed new therapeutic options that provide an alternative to traditional chemotherapeutic strategies. Isocitrate dehydrogenase 1 (IDH1) mutations are identified in approximately 10-15% of CCAs and may be targeted by ivosidenib, an oral selective inhibitor of mutant IDH1.Areas covered: This review will...
Source: Expert Review of Gastroenterology and Hepatology - April 9, 2021 Category: Gastroenterology Authors: Lynda Corrigan Maeve Lowery Source Type: research

Antibiotics for induction and maintenance of remission in ulcerative colitis: Systematic review and meta-analysis
Conclusion: The use of oral antibiotics in the setting of non-severe active UC could have some benefit in clinical response. The use of antibiotics is not of benefit in acute severe colitis, but oral antibiotics need to be evaluated in adult patients.PMID:33827360 | DOI:10.1080/17474124.2021.1914586 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 8, 2021 Category: Gastroenterology Authors: Shubhra Mishra Daya Krishna Jha Anupam Kumar Singh Praveen Kumar-M Amol Patil Vishal Sharma Source Type: research

New pharmacologic treatments for idiopathic chronic constipation: a financial strain for strainers
Expert Rev Gastroenterol Hepatol. 2021 Apr 2. doi: 10.1080/17474124.2021.1913054. Online ahead of print.NO ABSTRACTPMID:33798026 | DOI:10.1080/17474124.2021.1913054 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Gabrio Bassotti Source Type: research

Teduglutide for pediatric short bowel syndrome patients
This article reviews and educates the reader on this novel pharmacologic therapy and its use in pediatrics.Areas covered: This article reviews the pharmacology, safety, efficacy, and tolerability of GLP-2 analogue teduglutide in pediatric patients greater than 1 year of age. We review all current studies and discuss teduglutide's place in pediatric SBS therapy.Expert opinion: Teduglutide marks the first successful pharmacological intervention that augments the natural process of adaptation safely and effectively in SBS pediatric patients. More studies and further development are needed to optimize its potential in other pe...
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Beatrice E Rosete Danielle Wendel Simon P Horslen Source Type: research

New pharmacologic treatments for idiopathic chronic constipation: a financial strain for strainers
Expert Rev Gastroenterol Hepatol. 2021 Apr 2. doi: 10.1080/17474124.2021.1913054. Online ahead of print.NO ABSTRACTPMID:33798026 | DOI:10.1080/17474124.2021.1913054 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Gabrio Bassotti Source Type: research

Teduglutide for pediatric short bowel syndrome patients
This article reviews and educates the reader on this novel pharmacologic therapy and its use in pediatrics.Areas covered: This article reviews the pharmacology, safety, efficacy, and tolerability of GLP-2 analogue teduglutide in pediatric patients greater than 1 year of age. We review all current studies and discuss teduglutide's place in pediatric SBS therapy.Expert opinion: Teduglutide marks the first successful pharmacological intervention that augments the natural process of adaptation safely and effectively in SBS pediatric patients. More studies and further development are needed to optimize its potential in other pe...
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Beatrice E Rosete Danielle Wendel Simon P Horslen Source Type: research

New pharmacologic treatments for idiopathic chronic constipation: a financial strain for strainers
Expert Rev Gastroenterol Hepatol. 2021 Apr 2. doi: 10.1080/17474124.2021.1913054. Online ahead of print.NO ABSTRACTPMID:33798026 | DOI:10.1080/17474124.2021.1913054 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Gabrio Bassotti Source Type: research

Teduglutide for pediatric short bowel syndrome patients
This article reviews and educates the reader on this novel pharmacologic therapy and its use in pediatrics.Areas covered: This article reviews the pharmacology, safety, efficacy, and tolerability of GLP-2 analogue teduglutide in pediatric patients greater than 1 year of age. We review all current studies and discuss teduglutide's place in pediatric SBS therapy.Expert opinion: Teduglutide marks the first successful pharmacological intervention that augments the natural process of adaptation safely and effectively in SBS pediatric patients. More studies and further development are needed to optimize its potential in other pe...
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Beatrice E Rosete Danielle Wendel Simon P Horslen Source Type: research

New pharmacologic treatments for idiopathic chronic constipation: a financial strain for strainers
Expert Rev Gastroenterol Hepatol. 2021 Apr 2. doi: 10.1080/17474124.2021.1913054. Online ahead of print.NO ABSTRACTPMID:33798026 | DOI:10.1080/17474124.2021.1913054 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Gabrio Bassotti Source Type: research

Teduglutide for pediatric short bowel syndrome patients
This article reviews and educates the reader on this novel pharmacologic therapy and its use in pediatrics.Areas covered: This article reviews the pharmacology, safety, efficacy, and tolerability of GLP-2 analogue teduglutide in pediatric patients greater than 1 year of age. We review all current studies and discuss teduglutide's place in pediatric SBS therapy.Expert opinion: Teduglutide marks the first successful pharmacological intervention that augments the natural process of adaptation safely and effectively in SBS pediatric patients. More studies and further development are needed to optimize its potential in other pe...
Source: Expert Review of Gastroenterology and Hepatology - April 2, 2021 Category: Gastroenterology Authors: Beatrice E Rosete Danielle Wendel Simon P Horslen Source Type: research

Role of adjuvant and neoadjuvant therapy for resectable biliary tract cancer
Expert Rev Gastroenterol Hepatol. 2021 Apr 1. doi: 10.1080/17474124.2021.1911645. Online ahead of print.ABSTRACTIntroduction: Although the safety of biliary tract cancer resection has improved over the years, the recurrence rate is still high, and the postoperative prognosis remains low after biliary tract cancer resection. Therefore, the development of effective adjuvant therapy is essential to improve treatment outcomes. Because biliary tract cancer is rare compared with other gastrointestinal cancers, there have been only a small number of clinical trials of adjuvant therapy. However, in recent years, the results of sev...
Source: Expert Review of Gastroenterology and Hepatology - April 1, 2021 Category: Gastroenterology Authors: Satoshi Nara Minoru Esaki Daisuke Ban Takeshi Takamoto Takahiro Mizui Kazuaki Shimada Source Type: research

FGFR Inhibitors in Elderly Patients with Advanced Biliary Tract Cancer: An Unsolved Issue
Expert Rev Gastroenterol Hepatol. 2021 Mar 31. doi: 10.1080/17474124.2021.1911646. Online ahead of print.ABSTRACTBackgroundDespite recent advances in the understanding of the molecular landscape of biliary tract cancer (BTC), advanced disease continues to carry a poor prognosis, and the benefit from systemic treatments remains modest. However, BTCs have emerged as malignancies harboring specific potentially-druggable aberrations, and thus, several molecularly targeted treatments have been recently tested. Among these, fibroblast growth factor receptor (FGFR) inhibitors have shown interesting results in previously treated B...
Source: Expert Review of Gastroenterology and Hepatology - March 31, 2021 Category: Gastroenterology Authors: Alessandro Rizzo Angela Dalia Ricci Giorgio Frega Alessandro Di Federico Giovanni Brandi Source Type: research

T-tube or No T-tube for biliary tract reconstruction in orthotopic liver transplantation: an updated systematic review and meta-analysis
Expert Rev Gastroenterol Hepatol. 2021 Mar 15. doi: 10.1080/17474124.2021.1903874. Online ahead of print.ABSTRACTOBJECTIVES: Biliary tract reconstruction with or without T-tube is commonly used in orthotopic liver transplantation (OLT). However, the efficacy and safety of T-tube usage remain controversial. This meta-analysis was conducted to assess the latest evidence of clinical outcomes.METHODS: Embase, Cochrane Library, PubMed, and Web of Science were systematically searched from inception to January 20, 2021 for eligible studies. The analyses were performed using Review Manager (Version 5.3) and Stata (Version 15.0).RE...
Source: Expert Review of Gastroenterology and Hepatology - March 15, 2021 Category: Gastroenterology Authors: Shaoming Song Tingting Lu Wenwen Yang Shiyi Gong Caining Lei Jia Yang Lufang Feng Hongwei Tian Kehu Yang Tiankang Guo Source Type: research

The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1902803. Online ahead of print.ABSTRACTOBJECTIVES: : Since there is increasingly higher number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis (NASH) fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes using propensity-score matched analysis.METHODS: : 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, ...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Uihwan Lee Gregory Hongyuan Fan David Jeffrey Hastie Elyse Ann Addonizio Vibhav Narayan Prakasam Ryan Richard Ahern Kristen Jin Seog Raffi Karagozian Source Type: research

Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1903318. Online ahead of print.ABSTRACTIntroduction: Telomerase is a basic nuclear protein reverse transcriptase, which plays a key role in maintaining telomere stability, genome integrity, long-term cell activity and potential continued proliferation.Area covered: This narrative review discusses key research advances involving telomerase in the development and progression of non-alcoholic fatty liver disease (NAFLD). The review evaluates: a) whether the assessment of telomerase can be used as a non-invasive diagnostic tool; and b) whether modificati...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: Liang-Jie Tang Rafael S Rios Huai Zhang Christopher D Byrne Giovanni Targher Ming-Hua Zheng Source Type: research

The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1902803. Online ahead of print.ABSTRACTOBJECTIVES: : Since there is increasingly higher number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis (NASH) fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes using propensity-score matched analysis.METHODS: : 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, ...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Uihwan Lee Gregory Hongyuan Fan David Jeffrey Hastie Elyse Ann Addonizio Vibhav Narayan Prakasam Ryan Richard Ahern Kristen Jin Seog Raffi Karagozian Source Type: research

Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1903318. Online ahead of print.ABSTRACTIntroduction: Telomerase is a basic nuclear protein reverse transcriptase, which plays a key role in maintaining telomere stability, genome integrity, long-term cell activity and potential continued proliferation.Area covered: This narrative review discusses key research advances involving telomerase in the development and progression of non-alcoholic fatty liver disease (NAFLD). The review evaluates: a) whether the assessment of telomerase can be used as a non-invasive diagnostic tool; and b) whether modificati...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: Liang-Jie Tang Rafael S Rios Huai Zhang Christopher D Byrne Giovanni Targher Ming-Hua Zheng Source Type: research

The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1902803. Online ahead of print.ABSTRACTOBJECTIVES: : Since there is increasingly higher number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis (NASH) fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes using propensity-score matched analysis.METHODS: : 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, ...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Uihwan Lee Gregory Hongyuan Fan David Jeffrey Hastie Elyse Ann Addonizio Vibhav Narayan Prakasam Ryan Richard Ahern Kristen Jin Seog Raffi Karagozian Source Type: research

Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1903318. Online ahead of print.ABSTRACTIntroduction: Telomerase is a basic nuclear protein reverse transcriptase, which plays a key role in maintaining telomere stability, genome integrity, long-term cell activity and potential continued proliferation.Area covered: This narrative review discusses key research advances involving telomerase in the development and progression of non-alcoholic fatty liver disease (NAFLD). The review evaluates: a) whether the assessment of telomerase can be used as a non-invasive diagnostic tool; and b) whether modificati...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: Liang-Jie Tang Rafael S Rios Huai Zhang Christopher D Byrne Giovanni Targher Ming-Hua Zheng Source Type: research

The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals
Expert Rev Gastroenterol Hepatol. 2021 Mar 12. doi: 10.1080/17474124.2021.1902803. Online ahead of print.ABSTRACTOBJECTIVES: : Since there is increasingly higher number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis (NASH) fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes using propensity-score matched analysis.METHODS: : 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, ...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Uihwan Lee Gregory Hongyuan Fan David Jeffrey Hastie Elyse Ann Addonizio Vibhav Narayan Prakasam Ryan Richard Ahern Kristen Jin Seog Raffi Karagozian Source Type: research

Iron deficiency anemia in IBD: an overlooked comorbidity
Expert Rev Gastroenterol Hepatol. 2021 Mar 11. doi: 10.1080/17474124.2021.1900730. Online ahead of print.ABSTRACTIntroduction: Iron Deficiency Anemia (IDA) is a leading cause of anemia in Inflammatory Bowel disease (IBD). IDA affects quality of life (QoL) and lead to developmental and cognitive abnormalities. Diagnosis of IDA in IBD is complicated as biochemical tests available at present cannot help distinguish between IDA and anemia of chronic disease. Soluble transferrin receptor ferritin index has been gaining popularity as it can diagnose IDA in presence of chronic inflammation. ECCO guidelines recommend a Hb increase...
Source: Expert Review of Gastroenterology and Hepatology - March 11, 2021 Category: Gastroenterology Authors: Yash Shah Dhruvan Patel Nabeel Khan Source Type: research

Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis
CONCLUSION: : The combined assay of AFP and GP73 conferred the best outcome among all panels. The triple combined panel of AFP, AFP-L3, and DCP showed higher diagnostic potential than individual random double combinations of the three biomarkers. Multiple-biomarker combined assays will be clinically important for decision-making processes for HCC.PMID:33691550 | DOI:10.1080/17474124.2021.1900731 (Source: Expert Review of Gastroenterology and Hepatology)
Source: Expert Review of Gastroenterology and Hepatology - March 11, 2021 Category: Gastroenterology Authors: Yong-Sheng Fang Qiang Wu Hong-Chuan Zhao Yuan Zhou Lei Ye Sheng-Sheng Liu Xiao-Xue Li Wei-Dong Du Source Type: research

Diagnostic syndromic multiplex approaches for gastrointestinal infections
Expert Rev Gastroenterol Hepatol. 2021 Mar 8. doi: 10.1080/17474124.2021.1899807. Online ahead of print.ABSTRACTIntroduction: Gastrointestinal diseases due to infectious pathogens currently represent an important global health concern, especially in children and developing countries. Early and accurate detection of gastrointestinal pathogens is important to initiate the appropriate type of therapy. Multiplex molecular gastrointestinal panels rapidly detect several gastrointestinal pathogens at once with high sensitivity.Areas covered: We assess the scope and limitations of several multiplex gastrointestinal panels approved...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: H éctor Jesús Maldonado-Garza Elvira Garza-Gonz ález Paola Bocanegra-Ibarias Samantha Flores-Trevi ño Source Type: research

Primary sclerosing cholangitis-associated cholangiocarcinoma: special considerations and best practices
Expert Rev Gastroenterol Hepatol. 2021 Mar 6. doi: 10.1080/17474124.2021.1900732. Online ahead of print.ABSTRACTIntroduction: Primary sclerosing cholangitis (PSC) is a rare, heterogenous, chronic cholestatic liver disease that causes fibro-inflammatory destruction of the intra- and/or extrahepatic bile ducts. The disease course may be variable, though in many cases it ultimately leads to biliary cirrhosis and its associated complications. PSC is also associated with malignancies, in particular cholangiocarcinoma (CCA), a dreaded neoplasm of the biliary tract with a poor prognosis. Identification of at-risk populations and ...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: Brian M Fung James H Tabibian Source Type: research

Diagnostic syndromic multiplex approaches for gastrointestinal infections
Expert Rev Gastroenterol Hepatol. 2021 Mar 8. doi: 10.1080/17474124.2021.1899807. Online ahead of print.ABSTRACTIntroduction: Gastrointestinal diseases due to infectious pathogens currently represent an important global health concern, especially in children and developing countries. Early and accurate detection of gastrointestinal pathogens is important to initiate the appropriate type of therapy. Multiplex molecular gastrointestinal panels rapidly detect several gastrointestinal pathogens at once with high sensitivity.Areas covered: We assess the scope and limitations of several multiplex gastrointestinal panels approved...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: H éctor Jesús Maldonado-Garza Elvira Garza-Gonz ález Paola Bocanegra-Ibarias Samantha Flores-Trevi ño Source Type: research

Primary sclerosing cholangitis-associated cholangiocarcinoma: special considerations and best practices
Expert Rev Gastroenterol Hepatol. 2021 Mar 6. doi: 10.1080/17474124.2021.1900732. Online ahead of print.ABSTRACTIntroduction: Primary sclerosing cholangitis (PSC) is a rare, heterogenous, chronic cholestatic liver disease that causes fibro-inflammatory destruction of the intra- and/or extrahepatic bile ducts. The disease course may be variable, though in many cases it ultimately leads to biliary cirrhosis and its associated complications. PSC is also associated with malignancies, in particular cholangiocarcinoma (CCA), a dreaded neoplasm of the biliary tract with a poor prognosis. Identification of at-risk populations and ...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: Brian M Fung James H Tabibian Source Type: research

Diagnostic syndromic multiplex approaches for gastrointestinal infections
Expert Rev Gastroenterol Hepatol. 2021 Mar 8. doi: 10.1080/17474124.2021.1899807. Online ahead of print.ABSTRACTIntroduction: Gastrointestinal diseases due to infectious pathogens currently represent an important global health concern, especially in children and developing countries. Early and accurate detection of gastrointestinal pathogens is important to initiate the appropriate type of therapy. Multiplex molecular gastrointestinal panels rapidly detect several gastrointestinal pathogens at once with high sensitivity.Areas covered: We assess the scope and limitations of several multiplex gastrointestinal panels approved...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: H éctor Jesús Maldonado-Garza Elvira Garza-Gonz ález Paola Bocanegra-Ibarias Samantha Flores-Trevi ño Source Type: research

Primary sclerosing cholangitis-associated cholangiocarcinoma: special considerations and best practices
Expert Rev Gastroenterol Hepatol. 2021 Mar 6. doi: 10.1080/17474124.2021.1900732. Online ahead of print.ABSTRACTIntroduction: Primary sclerosing cholangitis (PSC) is a rare, heterogenous, chronic cholestatic liver disease that causes fibro-inflammatory destruction of the intra- and/or extrahepatic bile ducts. The disease course may be variable, though in many cases it ultimately leads to biliary cirrhosis and its associated complications. PSC is also associated with malignancies, in particular cholangiocarcinoma (CCA), a dreaded neoplasm of the biliary tract with a poor prognosis. Identification of at-risk populations and ...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: Brian M Fung James H Tabibian Source Type: research