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A spotlight on intestinal permeability and inflammatory bowel diseases
Expert Rev Gastroenterol Hepatol. 2023 Aug 22:1-10. doi: 10.1080/17474124.2023.2242772. Online ahead of print.ABSTRACTINTRODUCTION: The intestinal barrier is a multi-faced structure lining the surface of the intestinal mucosa of the GI tract. To exert its main functions as a physical and immunological defense barrier, several components of the intestinal barrier act in a concerted and cooperative manner.AREAS COVERED: Herein, we first introduce to the basic organization of the intestinal barrier and then summarize different methods to assess barrier function in and ex vivo. Finally, we provide an in-depth overview of the r...
Source: Expert Review of Gastroenterology and Hepatology - August 22, 2023 Category: Gastroenterology Authors: Timo Rath Raja Atreya Markus F Neurath Source Type: research

Therapeutics for < em > Clostridioides difficile < /em > infection: molecules and microbes
Expert Rev Gastroenterol Hepatol. 2023 Aug 25:1-9. doi: 10.1080/17474124.2023.2250716. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is a major healthcare problem in the developed world, and effective management of recurrent infection remains one of the biggest challenges. Several advances have occurred in the management of CDI, and in the last 15 years, multiple new agents have been tested. Since 2011, four new products have been approved by the US FDA for treatment of CDI or prevention of recurrent CDI.AREAS COVERED: This review focuses on therapeutics of CDI and includes sections o...
Source: Expert Review of Gastroenterology and Hepatology - August 22, 2023 Category: Gastroenterology Authors: Sahil Khanna Elida Voth Source Type: research

Therapeutics for < em > Clostridioides difficile < /em > infection: molecules and microbes
Expert Rev Gastroenterol Hepatol. 2023 Aug 22. doi: 10.1080/17474124.2023.2250716. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is a major healthcare problem in the developed world, and effective management of recurrent infection remains one of the biggest challenges. Several advances have occurred in the management of CDI and in the last 15 years, multiple new agents have been tested. Since 2011, four new products have been approved by the United States FDA for treatment of CDI or prevention of recurrent CDI.AREAS COVERED: This review focuses on therapeutics of CDI and includes sect...
Source: Expert Review of Gastroenterology and Hepatology - August 22, 2023 Category: Gastroenterology Authors: Sahil Khanna Elida Voth Source Type: research