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Algorithms for early detection of silent liver fibrosis in the primary care setting - a scoping review
Expert Rev Gastroenterol Hepatol. 2023 Sep 11. doi: 10.1080/17474124.2023.2255522. Online ahead of print.ABSTRACTINTRODUCTION: Fatty liver disease affects almost 30% of the adult population worldwide.Most patients are asymptomatic and there is not a linear relationship between exposure to risk factors and the risk of developing fibrosis. The combination of a very large, asymptomatic risk population where only a few percent will develop life-threatening liver disease, is a growing diagnostic challenge for the health services. Accurate fibrosis assessment in primary care is limited by poor correlation with liver blood tests ...
Source: Expert Review of Gastroenterology and Hepatology - September 11, 2023 Category: Gastroenterology Authors: Line Ravndal Katrine P Lindvig Ellen L Jensen Anita Sunde Damoun Nassehi Maja Thiele Aleksander Krag Svein Kjosavik Source Type: research

Mistakes in managing hepatocellular carcinoma and how to avoid them: a narrative review
Expert Rev Gastroenterol Hepatol. 2023 Sep 7:1-7. doi: 10.1080/17474124.2023.2255515. Online ahead of print.ABSTRACTINTRODUCTION: Hepatocellular carcinoma (HCC) is the most common liver-related cancer and the third leading cause of worldwide cancer-related mortality.AREAS COVERED: There have been many updated guidelines on the management of HCC in the past few years. Given the increasing burden of HCC in clinical practice, knowledge of evidence-based standards of care for these patients is essential for any practitioner managing patients with HCC. Early detection and judicious treatment based on the stage of the HCC can im...
Source: Expert Review of Gastroenterology and Hepatology - September 6, 2023 Category: Gastroenterology Authors: Madunil Anuk Niriella Uditha Dassanayake H Janaka de Silva Source Type: research

Mistakes in managing hepatocellular carcinoma and how to avoid them: a narrative review
Expert Rev Gastroenterol Hepatol. 2023 Sep 6. doi: 10.1080/17474124.2023.2255515. Online ahead of print.ABSTRACTINTRODUCTION: Hepatocellular carcinoma (HCC) is the most common liver-related cancer and the third leading cause of worldwide cancer-related mortality.AREAS COVERED: There have been many updated guidelines on the management of HCC in the past few years. Given the increasing burden of HCC in clinical practice, knowledge of evidence-based standards of care for these patients is essential for any practitioner managing patients with HCC. Early detection and judicious treatment based on the stage of the HCC can improv...
Source: Expert Review of Gastroenterology and Hepatology - September 6, 2023 Category: Gastroenterology Authors: Madunil Anuk Niriella Uditha Dassanayake H Janaka de Silva Source Type: research

Alagille syndrome: understanding the genotype-phenotype relationship and its potential therapeutic impact
Expert Rev Gastroenterol Hepatol. 2023 Sep 5:1-10. doi: 10.1080/17474124.2023.2255518. Online ahead of print.ABSTRACTINTRODUCTION: Alagille syndrome (ALGS) is an autosomal dominant, multisystem genetic disorder with wide phenotypic variability caused by mutations in the Notch signaling pathway, specifically from mutations in either the Jagged1 (JAG1) or NOTCH2 gene. The range of clinical features in ALGS can involve various organ systems including the liver, heart, eyes, skeleton, kidney, and vasculature. Despite the genetic mutations being well-defined, there is variable expressivity and individuals with the same mutation...
Source: Expert Review of Gastroenterology and Hepatology - September 5, 2023 Category: Gastroenterology Authors: Jennifer Halma Henry C Lin Source Type: research

A spotlight on intestinal permeability and inflammatory bowel diseases
Expert Rev Gastroenterol Hepatol. 2023 Aug 22:1-10. doi: 10.1080/17474124.2023.2242772. Online ahead of print.ABSTRACTINTRODUCTION: The intestinal barrier is a multi-faced structure lining the surface of the intestinal mucosa of the GI tract. To exert its main functions as a physical and immunological defense barrier, several components of the intestinal barrier act in a concerted and cooperative manner.AREAS COVERED: Herein, we first introduce to the basic organization of the intestinal barrier and then summarize different methods to assess barrier function in and ex vivo. Finally, we provide an in-depth overview of the r...
Source: Expert Review of Gastroenterology and Hepatology - August 22, 2023 Category: Gastroenterology Authors: Timo Rath Raja Atreya Markus F Neurath Source Type: research

Therapeutics for < em > Clostridioides difficile < /em > infection: molecules and microbes
Expert Rev Gastroenterol Hepatol. 2023 Aug 25:1-9. doi: 10.1080/17474124.2023.2250716. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is a major healthcare problem in the developed world, and effective management of recurrent infection remains one of the biggest challenges. Several advances have occurred in the management of CDI, and in the last 15 years, multiple new agents have been tested. Since 2011, four new products have been approved by the US FDA for treatment of CDI or prevention of recurrent CDI.AREAS COVERED: This review focuses on therapeutics of CDI and includes sections o...
Source: Expert Review of Gastroenterology and Hepatology - August 22, 2023 Category: Gastroenterology Authors: Sahil Khanna Elida Voth Source Type: research