A narrative review on the diagnosis and management of constipation in infants
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242255. Online ahead of print.ABSTRACTINTRODUCTION: Functional constipation is one of the common disorders of gut-brain interaction in infancy, and decreases the quality of life of infants and parents.AREAS COVERED: Relevant articles up to November 2022 were reviewed. We searched in PubMed, Google Scholar and MEDLINE for guidelines, position papers, reviews and randomized controlled trials on infant constipation.EXPERT OPINION: Randomized controlled trials in this specific age group are mostly limited to trials with infant formula. The prevalence of...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Laurine Steurbaut Elvira Ingrid Levy Charlotte De Geyter Stefanie Buyse Yvan Vandenplas Source Type: research

Strengths and limitations of risk stratification tools for patients with upper gastrointestinal bleeding: a narrative review
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242252. Online ahead of print.ABSTRACTINTRODUCTION: Despite advances in the management of patients with upper gastrointestinal bleeding (UGIB), associated morbidity and mortality remain significant. Most patients, however, will experience favorable outcomes without a need for hospital-based interventions. Risk assessment scores may assist in such early risk-stratification. These scales may optimize identification of low-risk patients, resulting in better resource utilization, including a reduced need for early endoscopy and fewer hospital admissions...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Ali A Alali Antoine Boustany Myriam Martel Alan N Barkun Source Type: research

The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242261. Online ahead of print.ABSTRACTINTRODUCTION: Well-differentiated gastric, duodenal, and rectal neuroendocrine neoplasms (NETs) are rare diseases usually managed by endoscopic treatment. Although several endoscopic techniques are available, the number of patients with incomplete (R1) resection is significant.AREAS COVERED: This review focuses on the meaning of incomplete R1 findings after endoscopic resection in type I gastric NETs; non-functioning, non-ampullary duodenal NETs; and small rectal NETs. Data were identified by MEDLINE database se...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Gianluca Esposito Elisabetta Dell'unto Irene Ligato Matteo Marasco Francesco Panzuto Source Type: research

Electrosurgical unit in GI endoscopy: The proper settings for practice
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242243. Online ahead of print.ABSTRACTINTRODUCTION: Electrosurgical unit (ESU) is integral to the endoscopy unit. The proper knowledge of the Mode with setting is essential for good therapeutic outcomes and the safety of the patients.AREAS COVERED: ESU generates high-frequency electric current, which could perform cutting and coagulation for various therapeutic interventions. We review the proper settings for common endoscopic interventions like hemostasis, polypectomy, sphincterotomy, and advanced procedures like endoscopic ultrasound-guided cysto-...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Anuraag Jena Shubham Jain Sridhar Sundaram Anupam Kumar Singh Sanjay Chandnani Pravin Rathi Source Type: research

The challenging role of micro-RNAs in non-alcoholic fatty liver disease in children with obesity: is it time for a new era?
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242245. Online ahead of print.ABSTRACTINTRODUCTION: As the pediatric obesity epidemic, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in childhood. Pediatric NAFLD pathophysiology is tangled and still unclear, but insulin resistance (IR), genetics, epigenetics, oxidative stress, and inflammation act as key players. Due to the increased cardiometabolic risk of these patients, several biomarkers have been proposed for early NAFLD identification, but their clinical utility is poor. Recently, hepatic dysregula...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Mario Bartiromo Michele Nardolillo Serena Ferrara Giuseppina Russo Emanuele Miraglia Del Giudice Anna Di Sessa Source Type: research

A narrative review on the diagnosis and management of constipation in infants
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242255. Online ahead of print.ABSTRACTINTRODUCTION: Functional constipation is one of the common disorders of gut-brain interaction in infancy, and decreases the quality of life of infants and parents.AREAS COVERED: Relevant articles up to November 2022 were reviewed. We searched in PubMed, Google Scholar and MEDLINE for guidelines, position papers, reviews and randomized controlled trials on infant constipation.EXPERT OPINION: Randomized controlled trials in this specific age group are mostly limited to trials with infant formula. The prevalence of...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Laurine Steurbaut Elvira Ingrid Levy Charlotte De Geyter Stefanie Buyse Yvan Vandenplas Source Type: research

Strengths and limitations of risk stratification tools for patients with upper gastrointestinal bleeding: a narrative review
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242252. Online ahead of print.ABSTRACTINTRODUCTION: Despite advances in the management of patients with upper gastrointestinal bleeding (UGIB), associated morbidity and mortality remain significant. Most patients, however, will experience favorable outcomes without a need for hospital-based interventions. Risk assessment scores may assist in such early risk-stratification. These scales may optimize identification of low-risk patients, resulting in better resource utilization, including a reduced need for early endoscopy and fewer hospital admissions...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Ali A Alali Antoine Boustany Myriam Martel Alan N Barkun Source Type: research

The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242261. Online ahead of print.ABSTRACTINTRODUCTION: Well-differentiated gastric, duodenal, and rectal neuroendocrine neoplasms (NETs) are rare diseases usually managed by endoscopic treatment. Although several endoscopic techniques are available, the number of patients with incomplete (R1) resection is significant.AREAS COVERED: This review focuses on the meaning of incomplete R1 findings after endoscopic resection in type I gastric NETs; non-functioning, non-ampullary duodenal NETs; and small rectal NETs. Data were identified by MEDLINE database se...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Gianluca Esposito Elisabetta Dell'unto Irene Ligato Matteo Marasco Francesco Panzuto Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 26:1-6. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is a major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines lists specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics, and ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 26:1-15. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. T...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. The re...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. The re...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research