The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors
Expert Rev Gastroenterol Hepatol. 2023 Jul 27. doi: 10.1080/17474124.2023.2242261. Online ahead of print.ABSTRACTINTRODUCTION: Well-differentiated gastric, duodenal, and rectal neuroendocrine neoplasms (NETs) are rare diseases usually managed by endoscopic treatment. Although several endoscopic techniques are available, the number of patients with incomplete (R1) resection is significant.AREAS COVERED: This review focuses on the meaning of incomplete R1 findings after endoscopic resection in type I gastric NETs; non-functioning, non-ampullary duodenal NETs; and small rectal NETs. Data were identified by MEDLINE database se...
Source: Expert Review of Gastroenterology and Hepatology - July 27, 2023 Category: Gastroenterology Authors: Gianluca Esposito Elisabetta Dell'unto Irene Ligato Matteo Marasco Francesco Panzuto Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 26:1-6. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is a major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines lists specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics, and ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 26:1-15. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. T...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. The re...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. The re...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how ...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Abrar K Thabit Huda J Aljedaani Rawan H Alghamdi Raghad M Badahdah Manar O Lashkar Abeer Alnajjar Source Type: research

Prioritization in inflammatory bowel disease therapy
Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240699. Online ahead of print.ABSTRACTINTRODUCTION: Most guidelines for IBD still recommend step-by-step therapy with initially classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing certain biological drugs and JAK inhibitors in the complicated course. This review provides an aid to pending therapy decisions.AREAS COVERED: In this review, we analyze the evidence for Crohn's disease as well as ulcerative colitis in order to optimize and 'personalize' the choice of therapy, especially in difficult cases. The re...
Source: Expert Review of Gastroenterology and Hepatology - July 22, 2023 Category: Gastroenterology Authors: Klaus R Herrlinger Eduard F Stange Source Type: research

Histamine-producing bacteria and their role in gastrointestinal disorders
Expert Rev Gastroenterol Hepatol. 2023 Jul-Dec;17(7):709-718. doi: 10.1080/17474124.2023.2230865. Epub 2023 Jul 6.ABSTRACTINTRODUCTION: Gut microbiota produces thousands of metabolites, which have a huge impact on the host health. Specific microbial strains are able to synthesize histamine, a molecule with a crucial role in many physiologic and pathologic mechanisms of the host. This function is mediated by the histidine decarboxylase enzyme (HDC) that converts the amino acid histidine to histamine.AREAS COVERED: This review summarizes the emerging data on histamine production by gut microbiota, and the effect of bacterial...
Source: Expert Review of Gastroenterology and Hepatology - July 3, 2023 Category: Gastroenterology Authors: Marcello Fiorani Livio Enrico Del Vecchio Pasquale Dargenio Francesco Kaitsas Tommaso Rozera Serena Porcari Antonio Gasbarrini Giovanni Cammarota Gianluca Ianiro Source Type: research

Histamine-producing bacteria and their role in gastrointestinal disorders
Expert Rev Gastroenterol Hepatol. 2023 Jul 6:1-10. doi: 10.1080/17474124.2023.2230865. Online ahead of print.ABSTRACTINTRODUCTION: Gut microbiota produces thousands of metabolites, which have a huge impact on the host health. Specific microbial strains are able to synthesize histamine, a molecule with a crucial role in many physiologic and pathologic mechanisms of the host. This function is mediated by the histidine decarboxylase enzyme (HDC) that converts the amino acid histidine to histamine.AREAS COVERED: This review summarizes the emerging data on histamine production by gut microbiota, and the effect of bacterial-deri...
Source: Expert Review of Gastroenterology and Hepatology - July 3, 2023 Category: Gastroenterology Authors: Marcello Fiorani Livio Enrico Del Vecchio Pasquale Dargenio Francesco Kaitsas Tommaso Rozera Serena Porcari Antonio Gasbarrini Giovanni Cammarota Gianluca Ianiro Source Type: research