An insight into < em > Clostridioides difficile < /em > -associated diarrhea in Saudi children: diagnosis and treatment

Expert Rev Gastroenterol Hepatol. 2023 Jul 22. doi: 10.1080/17474124.2023.2240704. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile infection (CDI) is the major cause for antibiotic-associated diarrhea. Specific factors put the pediatrics at risk. International guidelines list specific recommendations for the diagnosis and treatment of pediatric CDI. The practice of diagnosing and treating pediatric CDI in Saudi Arabia is slightly different from the recommendations of the guidelines.AREAS COVERED: This review summarizes pediatric CDI in Saudi Arabia in terms of epidemiology, current diagnostics and how the practice compares to recommendations of the guidelines, and available treatment options.EXPERT OPINION: Although pediatric CDI epidemiology in Saudi Arabia doesn't impose a burden on the healthcare system, it should be noted that not all hospitals follow CDI diagnostic recommendations of international guidelines, which may result in cases underreporting. However, due to the presumed low CDI prevalence, the traditional regimen of oral metronidazole for non-severe CDI remains effective, whereas vancomycin is used for severe cases. While fidaxomicin is approved for pediatrics, its high acquisition cost and low CDI rates make it challenging for hospitals to use it. Overall, pediatrics at risk of CDI recurrence should be evaluated, such as reviewing current antibiotics for potential discontinuation. Future studies evaluating the epidemiology and treatment for...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research