FDA Approves Likmez (metronidazole) Oral Suspension for the Treatment of Parasitic and Anaerobic Bacterial Infections
HALIFAX, Nova Scotia--(BUSINESS WIRE) September 25, 2023 -- Appili Therapeutics Inc. (TSX:APLI; OTCQB: APLIF) (the“Company” or“Appili”), a biopharmaceutical company focused on drug development for infectious diseases and... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 25, 2023 Category: Drugs & Pharmacology Source Type: news
Efficacy of adjunctive measures in the non-surgical treatment of peri-implantitis: A systematic review
Conclusions: Different adjunctive measures in the non-surgical treatment of peri-implantitis have different impact in terms of PD and BoP reductions. Improved PD reductions result after the use of systemic antimicrobials, and to a lesser extent, after the use of local antimicrobials. (Source: Dental Technology Blog)
Source: Dental Technology Blog - May 9, 2023 Category: Dentistry Source Type: news
European survey on the current surveillance practices, management guidelines, treatment pathways, and heterogeneity of testing of Clostridioides difficile
Conclusion
Good awareness of guidelines for the management of CDI was observed across the surveyed European hospital sites. However, low compliance with diagnostic testing guidelines, infection control measures for suspected CDI, and insufficient awareness of treatment guidelines were still reported in some countries. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 14, 2022 Category: Consumer Health News Source Type: news
Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an emphasis on rapid restoration of the gut microbiota to minimize the risk of infection relapses. Oral administration of metronidazole results in low concentration in stool, and interaction with fecal microbiota reduces its antimicrobial bioactivity. Reported elevated minimum inhibitory concentrations of metronidazole in epidemic C. difficile ribotypes and the emergence of plasmi...
Source: Current Awareness Service for Health (CASH) - November 15, 2022 Category: Consumer Health News Source Type: news
How can patients with Clostridioides difficile infection on concomitant antibiotic treatment be best managed?
Antibiotics are modifiable risk factors for Clostridioides difficile infection (CDI), driving pathogenesis via gut microbiome disruption. The management of patients with CDI prescribed concomitant non-CDI antibiotics is problematic and influences CDI outcome and recurrence risk. Though an assessment of the ongoing requirement for concomitant antibiotics is essential, discontinuation is often not possible. Antibiotics for other reasons might also need to be commenced during CDI therapy. Attempts to minimise the number and duration of antibiotics with a change to a low-risk class are recommended. Fidaxomicin might be prefera...
Source: Current Awareness Service for Health (CASH) - November 15, 2022 Category: Consumer Health News Source Type: news
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Cochrane Database Syst Rev . 2022 Oct 4;10(10):CD009197. doi: 10.1002/14651858.CD009197.pub5 Abstract Background: There may be an association between periodontitis and cardiovascular disease (CVD); however, the evidence so far has been uncertain about whether periodontal therapy can help prevent CVD in people diagnosed with chronic periodontitis. This is the third update of a review originally published in 2014, and most recently updated in 2019. Although there is a new multidimensional staging and grading system for periodontitis, we have retained the label ' chronic periodontitis ' in this version of the review since ava...
Source: Dental Technology Blog - October 21, 2022 Category: Dentistry Source Type: news
metronidazole antibiotic
Title: metronidazole antibioticCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/23/2022 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 23, 2022 Category: Drugs & Pharmacology Source Type: news
A rare case of metronidazole overdose causing ventricular fibrillation - Elgassim MAM, Saied ASS, Mustafa MA, Abdelrahman A, AlJaufi I, Salem W.
Ventricular fibrillation is not known as a complication of metronidazole poisoning. Although some arrhythmias have been reported as a complication of metronidazole intake while taking antiarrhythmic medications, most such arrhythmias are possibly related t... (Source: SafetyLit)
Source: SafetyLit - June 13, 2022 Category: International Medicine & Public Health Tags: Poisoning Source Type: news
The Mysteries and Underdiagnosis of SIBO
In 2017, shortly after she turned 32, Phoebe Lapine had just spent the previous three years overhauling her health to make up for her ailing thyroid, the result of unchecked Hashimoto’s thyroiditis. She was following a gluten-free diet, drinking kombucha and taking prebiotics, and finally feeling her best when she noticed peculiar gut symptoms starting to rear their head: burping during meals, stomach discomfort, and a bloated belly that simply would not deflate. She turned to a functional doctor who quickly gave her a diagnosis: small intestinal bacterial overgrowth (SIBO), a gut condition not uncommon for hypothyro...
Source: TIME: Health - March 7, 2022 Category: Consumer Health News Authors: Meaghan Beatley Tags: Uncategorized Source Type: news
Nuvessa (Metronidazole Vaginal Gel) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 20, 2021 Category: Drugs & Pharmacology Source Type: news
Management and characteristics of patients suffering from Clostridiodes difficile infection in primary care
Conclusion: GPs provide relevant ambulatory care for mild p rimary episodes of CDI using oral metronidazole. Persistent diarrhoea despite an appropriate anti-Clostridiodes regimen should be interpreted as an early predictor of relapse. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial
Conclusions: The use of systemic metronidazole as an adjunct to non-surgical treatment of peri-implantitis resulted in significant additional improvements in clinical, radiographic, and microbiological parameters after 12 months of follow-up. This study is registered in ClinicalTrials.gov (NCT03564301). (Source: Dental Technology Blog)
Source: Dental Technology Blog - November 30, 2021 Category: Dentistry Source Type: news
Retrospective study of the efficacy and safety of metronidazole and vancomycin for Clostridioides difficile infection
Conclusion: As no significant difference was observed in the response rate of CDI between MNZ and VCM, the Japanese CDI management guidelines, which recommend MNZ as the first choice, were demonstrated to be appropriate. Attention to nausea was also suggested to be necessary when administering MNZ to young females. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile
Conclusions: Our data demonstrate that haem is crucial for medium-dependent metronidazole resistance in C. difficile. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news
How Common are Co-infections with Trichomonas and Bacterial Vaginosis?
Discussion
Vulvovaginitis is a common gynecological complaint for females of all ages. It is specifically the inflammation of the vulva and vagina but is used as a general term often to mean vulvar irritation, itching, and burning that can occur with or without vaginal discharge. In prepubertal females there is lack of estrogenization, and less lactobacillus species which creates a more neutral pH (normal vaginal pH is < 4.5), lack of pubic hair and fat pad which provide trauma protection, location of anus close to the vagina and tendency of poor hygiene in young children. With puberty, estrogen thickens the vaginal tis...
Source: PediatricEducation.org - May 24, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
