Evaluation of Ornidazole Tablets Bioequivalence in Chinese Healthy Participants Under Fasted and Fed Conditions Using Pharmacokinetic Parameters
ConclusionThe bioequivalence and tolerability of ornidazole tablet reference and test formulations were evaluated among healthy Chinese participants under both fasting and fed conditions. The results indicated that both formulations were bioequivalent and generally well tolerated; besides, the interaction between food and drug may affect drug pharmacokinetics.Trial RegistrationCTR20212873, registered on 15 November 2021; ChiCTR2300069098, registered on 7 March 2023. (Source: Drugs in R&D)
Source: Drugs in R&D - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Performing Trichomonas vaginalis culture in research studies in low-resource settings
Trichomonas vaginalis is the most common non-viral sexually transmitted infection (STI) worldwide, with an estimated 156 million new cases per year globally.1 Incidence and prevalence are highest in low-income settings, especially the African region.2 If symptomatic, T. vaginalis causes vaginal discharge and dysuria. Untreated T. vaginalis has been associated with adverse birth outcomes and an increased risk of HIV acquisition and transmission.3 Antimicrobial resistance to 5-nitroimidazole agents such as metronidazole is reported to occur in about 5%–10% of isolates in the USA.4 T. vaginalis can be diagnosed by wet m...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Peters, R. P. H., Mdingi, M. M., Gigi, R. M. S., Lim, L., Medina-Marino, A., Klausner, J. D., Muzny, C. A. Tags: PostScript Source Type: research
Oral Antibiotics vs IV and Oral Antibiotics for Uncomplicated Appendicitis
This secondary analysis of a randomized clinical trial assesses the 3-year clinical outcomes of oral moxifloxacin vs combined intravenous ertapenem plus oral levofloxacin and metronidazole in patients with uncomplicated acute appendicitis. (Source: JAMA Surgery)
Source: JAMA Surgery - April 17, 2024 Category: Sports Medicine Source Type: research
Metronidazole may display anti ‐inflammatory features in periodontitis treatment: A scoping review
ConclusionTaken together, this scoping review supported a potential anti-inflammatory effect of MTZ in periodontitis treatment. We recommend that future clinical studies should be conducted to evaluate specific MTZ anti-inflammatory pathways in the treatment of periodontitis. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - April 13, 2024 Category: Microbiology Authors: Lina J Su árez,
Roger M Arce,
Cristiane Gonçalves,
Camila Pinheiro Furquim,
Nidia Castro Dos Santos,
Belén Retamal‐Valdes,
Magda Feres Tags: REVIEW ARTICLE Source Type: research
Promising effects of 1,8 Cineole to control Giardia lamblia infection: Targeting the inflammation, oxidative stress, and infectivity
In this study, we aimed to investigate the in vitro and in vivo effects of eucalyptol (ECT, 1,8 cineole) alone and in combination with metronidazole (MNZ) on Giardia lamblia. The effects of ECT on cell viability, plasma membrane permeability, and gene expression levels of adenylate cyclase (AK) and extracellular signal kinases 1 and 2 (ERK1 and ERK2) in trophozoites of G. lamblia were assessed. In vivo, the effects of ECT alone and in combination with MNZ were assessed on mice infected with G. lamblia. In addition, the gene expression of inflammatory genes (e.g., TNF-α, IL-1β, and IL-10) and antioxidant genes (catalase (...
Source: Acta Tropica - April 11, 2024 Category: Infectious Diseases Authors: Leila Masoori Amal Khudair Khalaf Fatemeh Ezatkhah Rafael Bala ña-Fouce Hossein Mahmoudvand Source Type: research
Promising effects of 1,8 Cineole to control Giardia lamblia infection: Targeting the inflammation, oxidative stress, and infectivity
In this study, we aimed to investigate the in vitro and in vivo effects of eucalyptol (ECT, 1,8 cineole) alone and in combination with metronidazole (MNZ) on Giardia lamblia. The effects of ECT on cell viability, plasma membrane permeability, and gene expression levels of adenylate cyclase (AK) and extracellular signal kinases 1 and 2 (ERK1 and ERK2) in trophozoites of G. lamblia were assessed. In vivo, the effects of ECT alone and in combination with MNZ were assessed on mice infected with G. lamblia. In addition, the gene expression of inflammatory genes (e.g., TNF-α, IL-1β, and IL-10) and antioxidant genes (catalase (...
Source: Acta Tropica - April 11, 2024 Category: Infectious Diseases Authors: Leila Masoori Amal Khudair Khalaf Fatemeh Ezatkhah Rafael Bala ña-Fouce Hossein Mahmoudvand Source Type: research
Tackling antibiotic contaminations in wastewater with novel Modified-MOF nanostructures: A study of molecular simulations and DFT calculations
In conclusion, our study highlighted the importance of modeling in developing practical solutions for removing antibiotics as PHCs from wastewater. The insights gained from our calculations can facilitate the design of more effective adsorption materials, ultimately leading to a more hygienic and sustainable ecosystem.PMID:38599447 | DOI:10.1016/j.envres.2024.118856 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Iman Salahshoori Majid Namayandeh Jorabchi Afsaneh Mazaheri Seyedeh Masoomeh Sadat Mirnezami Mahdis Afshar Mahdi Golriz Marcos A L Nobre Source Type: research
Tackling antibiotic contaminations in wastewater with novel Modified-MOF nanostructures: A study of molecular simulations and DFT calculations
In conclusion, our study highlighted the importance of modeling in developing practical solutions for removing antibiotics as PHCs from wastewater. The insights gained from our calculations can facilitate the design of more effective adsorption materials, ultimately leading to a more hygienic and sustainable ecosystem.PMID:38599447 | DOI:10.1016/j.envres.2024.118856 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Iman Salahshoori Majid Namayandeh Jorabchi Afsaneh Mazaheri Seyedeh Masoomeh Sadat Mirnezami Mahdis Afshar Mahdi Golriz Marcos A L Nobre Source Type: research
Chemical constituents of the aerial parts of < em > Mitracarpus hirtus < /em > (L.) DC (Rubiaceae)
Nat Prod Res. 2024 Apr 8:1-7. doi: 10.1080/14786419.2024.2337110. Online ahead of print.ABSTRACTA phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2-4), four flavonoids (5-8), three iridoid glycosides (9 - 11) and two coumarins (12 and 13). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2-4 are th...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Xinyi Wei Yingrun Ma Mingming Xu Ding Heng Monday M Onakpa Jin-Ao Duan Chun-Tao Che Hongkai Bi Junfei Zhou Ming Zhao Source Type: research
Chemical constituents of the aerial parts of < em > Mitracarpus hirtus < /em > (L.) DC (Rubiaceae)
Nat Prod Res. 2024 Apr 8:1-7. doi: 10.1080/14786419.2024.2337110. Online ahead of print.ABSTRACTA phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2-4), four flavonoids (5-8), three iridoid glycosides (9 - 11) and two coumarins (12 and 13). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2-4 are th...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Xinyi Wei Yingrun Ma Mingming Xu Ding Heng Monday M Onakpa Jin-Ao Duan Chun-Tao Che Hongkai Bi Junfei Zhou Ming Zhao Source Type: research
Metronidazole and cefazolin versus cefazolin alone for surgical site infection prophylaxis in gynecologic surgery at a comprehensive cancer center
Surgical site infection (SSI) is one of the most common complications of gynecologic cancer surgery. Current guidelines recommend the administration of cefazolin pre-operatively to reduce SSI rates for patients undergoing clean-contaminated surgeries such as hysterectomy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 7, 2024 Category: OBGYN Authors: Anne Knisely, Maria D. Iniesta, Claire A. Marten, Gary Chisholm, Kathleen M. Schmeler, Jolyn S. Taylor Tags: Original Research: Gynecology Source Type: research
Metronidazole and cefazolin vs cefazolin alone for surgical site infection prophylaxis in gynecologic surgery at a comprehensive cancer center
Surgical site infection is one of the most common complications of gynecologic cancer surgery. Current guidelines recommend the administration of cefazolin preoperatively to reduce surgical site infection rates for patients undergoing clean-contaminated surgeries such as hysterectomy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 7, 2024 Category: OBGYN Authors: Anne Knisely, Maria D. Iniesta, Claire A. Marten, Gary Chisholm, Kathleen M. Schmeler, Jolyn S. Taylor Tags: Original Research Source Type: research
Amebic liver abscess: An update
World J Hepatol. 2024 Mar 27;16(3):316-330. doi: 10.4254/wjh.v16.i3.316.ABSTRACTAmebic liver abscess (ALA) is still a common problem in the tropical world, where it affects over three-quarters of patients with liver abscess. It is caused by an anaerobic protozoan Entamoeba hystolytica, which primarily colonises the cecum. It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris. People of the male gender, during their reproductive years, are most prone to ALA, and this appears to be due to a poorly mounted immune response linked to serum testosterone levels. ALA is more co...
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Ramesh Kumar Rishabh Patel Rajeev Nayan Priyadarshi Ruchika Narayan Tanmoy Maji Utpal Anand Jinit R Soni Source Type: research
