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Preoperative endoscopic ultrasound-guided biliary drainage for primary drainage in obstructive jaundice
Expert Rev Gastroenterol Hepatol. 2023 Dec 20:1-8. doi: 10.1080/17474124.2023.2293813. Online ahead of print.ABSTRACTINTRODUCTION: Endoscopic transpapillary approach by endoscopic retrograde cholangiopancreatography (ERCP) is the established technique for preoperative biliary drainage (PBD). Recently, endoscopic ultrasound-guided biliary drainage (EUS-BD) has been reported to be a useful alternative technique after ERCP fail. However, the optimal strategy remain controversial.AREA COVERED: This review summarizes the literature on EUS-BD techniques for PBD with a literature search using PubMed, Web of Science, and the Cochr...
Source: Expert Review of Gastroenterology and Hepatology - December 21, 2023 Category: Gastroenterology Authors: Shuntaro Mukai Takao Itoi Source Type: research

Evaluating the molecular and genetic mechanisms underlying gut motility disorders
Expert Rev Gastroenterol Hepatol. 2023 Dec 20. doi: 10.1080/17474124.2023.2296558. Online ahead of print.ABSTRACTINTRODUCTION: Gastrointestinal (GI) motility disorders comprise a wide range of different diseases affecting the structural or functional integrity of the GI neuromusculature. Their clinical presentation and burden of disease depends on the predominant location and extent of gut involvement as well as the component of the gut neuromusculature affected.AREAS COVERED: A comprehensive literature review was conducted using the PubMed and Medline databases to identify articles related to GI motility and functional di...
Source: Expert Review of Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Authors: Atchariya Chanpong Maria M Alves Elena Bonora Roberto De Giorgio Nikhil Thapar Source Type: research

Diagnosis and management of pancreatic insufficiency in patients with gastrectomy due to cancer or gastric ulcers: a virtual roundtable expert discussion
Expert Rev Gastroenterol Hepatol. 2023 Dec 18. doi: 10.1080/17474124.2023.2296762. Online ahead of print.ABSTRACTINTRODUCTION: Pancreatic exocrine insufficiency (PEI) is common after gastric resection for cancer or ulcers but is under-recognized and undertreated. Although pancreatic enzyme replacement therapy (PERT) is the mainstay of PEI management, robust evidence supporting its use after gastric surgery is limited.AREAS COVERED: In the absence of guideline recommendations specific for patients with pancreatic insufficiency after gastrectomy, a panel of experts from different geographical regions convened in a virtual me...
Source: Expert Review of Gastroenterology and Hepatology - December 18, 2023 Category: Gastroenterology Authors: Daniel Croagh Christoph W Michalski Mark I van Berge Henegouwen Sergio Alfieri Source Type: research

Managing complications of chronic pancreatitis: a guide for the gastroenterologist
Expert Rev Gastroenterol Hepatol. 2023 Dec 14. doi: 10.1080/17474124.2023.2295498. Online ahead of print.ABSTRACTINTRODUCTION: Chronic pancreatitis is a heterogeneous and complex syndrome that, in most cases, causes pain as a cardinal symptom and affects both the morphology and function of the pancreas, leading to several serious complications.AREAS COVERED: The present review, based on a non-systematic PubMed search updated to June 2023, aims to present the current available evidence on the role of gastroenterologists in the diagnosis and treatment of both local and systemic complications by either endoscopic or medical t...
Source: Expert Review of Gastroenterology and Hepatology - December 14, 2023 Category: Gastroenterology Authors: Gabriele Capurso Matteo Tacelli Giuseppe Vanella Ruggero Ponz de Leon Pisani Giuseppe Dell'anna Martina Abati Roberto Mele Gaetano Lauri Afrodita Panaitescu Rubino Nunziata Piera Zaccari Livia Archibugi Paolo Giorgio Arcidiacono Source Type: research

Risankizumab to treat moderately to severely active Crohn's disease in adults: an evaluation of trials and data
Expert Rev Gastroenterol Hepatol. 2023 Dec 14. doi: 10.1080/17474124.2023.2295496. Online ahead of print.ABSTRACTINTRODUCTION: Risankizumab is a humanized monoclonal antibody that selectively inhibits interleukin (IL)-23. It is approved for the treatment of moderate-to-severe plaque psoriasis, psoriatic arthritis, and more recently moderate-to-severe Crohn's disease (CD).AREAS COVERED: After examining the current landscape of CD management including therapies which are currently approved and those in late stages of development, we will review the interleukin pathway and discuss the specific mechanism of targeted IL-23 inhi...
Source: Expert Review of Gastroenterology and Hepatology - December 14, 2023 Category: Gastroenterology Authors: Amanda M Johnson Edward V Loftus Source Type: research

Recent advances in the treatment of gastrointestinal motility disorders in children
Expert Rev Gastroenterol Hepatol. 2023 Dec 14. doi: 10.1080/17474124.2023.2295495. Online ahead of print.ABSTRACTINTRODUCTION: Paediatric gastrointestinal motility disorders represent some of the most challenging clinical conditions with largely undefined pathogenetic pathways and therefore limited therapeutic options. Herein, we provide an overview of the recent advances in treatment options for these disorders and their clinical impact.AREAS COVERED: PubMed and Medline databases were searched for relevant articles related to treatment of achalasia, esophageal atresia, gastroparesis, PIPO and constipation published betwee...
Source: Expert Review of Gastroenterology and Hepatology - December 14, 2023 Category: Gastroenterology Authors: Andreia Florina Nita Atchariya Chanpong Kornilia Nikaki Anna Rybak Nikhil Thapar Osvaldo Borrelli Source Type: research