Recent advances in the treatment of gastrointestinal motility disorders in children

Expert Rev Gastroenterol Hepatol. 2023 Dec 14. doi: 10.1080/17474124.2023.2295495. Online ahead of print.ABSTRACTINTRODUCTION: Paediatric gastrointestinal motility disorders represent some of the most challenging clinical conditions with largely undefined pathogenetic pathways and therefore limited therapeutic options. Herein, we provide an overview of the recent advances in treatment options for these disorders and their clinical impact.AREAS COVERED: PubMed and Medline databases were searched for relevant articles related to treatment of achalasia, esophageal atresia, gastroparesis, PIPO and constipation published between 2017-2022. In this article we review and summarize recent advances in management of gastrointestinal motility disorders in children with a particular focus on emerging therapies as well as novel diagnostic modalities that help guide their application or develop new, more targeted treatments.EXPERT OPINION: Gastrointestinal motility disorders represent one of the most challenging conundrums in pediatric age and despite significant advances in investigative tools, the palette of treatment options remain limited. Overall, while pharmacological options have failed to bring a curative solution, recent advances in minimal invasive therapeutic and diagnostic techniques have emerged as potential keys to symptom and quality of life improvement such as - ENDOFLIP, POEM, cine-MRI, fecal microbiota transplantation.PMID:38096022 | DOI:10.1080/17474124.2023.2295495
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research