Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients
CONCLUSION: Serum TBA is an independent risk factor for disability and poor functional outcomes after AIS or TIA, and exerts a protective effects on brain.PMID:38650617 | PMC:PMC11033300 | DOI:10.3389/fnins.2024.1388748 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Zhaobin Wang Jing Li Yingxin Xu Ye Liu Zhe Zhang Qin Xu Jinxi Lin Yong Jiang Yongjun Wang Jing Jing Anxin Wang Xia Meng Source Type: research
Comprehensive Analysis of Immune Signatures in Primary Biliary Cholangitis and Autoimmune Hepatitis
In conclusion, our analyses reveal that PBC and AIH share similarities and differences regarding to immune profiles. And γδ T, TIGIT+Vδ2 T, and Tfh1 cell frequencies are potential noninvasive immunological markers that can differentiate PBC from AIH.PMID:38652703 | DOI:10.1093/jleuko/qiae085 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Xiaoxue Yang Jiawei Li Meiling Ren Xuemei Pan Huiling Liu Jie Jiang Man Li Zhe Yang Bingyu Han Lina Ma Jianlei Hao Yuanyuan Duan Zhinan Yin Yan Xu Zheng Xiang Bin Wu Source Type: research
BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Pancreatitis after Percutaneous Transhepatic Biliary Intervention
A 50-year-old man who had undergone distal gastrectomy and adjuvant chemotherapy for gastric adenocarcinoma presented with new hyperbilirubinemia and biliary ductal dilation (Fig 1a, black arrow) secondary to a common bile duct (CBD) mass (Fig 1a, white arrow). Owing to his gastrojejunostomy (Fig 1a, open arrow), he was not a candidate for endoscopic retrograde cholangiopancreatography. A percutaneous transhepatic cholangiogram confirmed abrupt truncation of the CBD (Fig 1b, white arrow), and a brush biopsy (Cellebrity Cytology Brush; Boston Scientific, Marlborough, Massachsetts) was performed (Fig 1b, black arrow) bef...
Source: Journal of Vascular and Interventional Radiology : JVIR - April 23, 2024 Category: Radiology Authors: Jacob DePolo, Alexander Miller, Joseph Buchholz, James Ronald Tags: Lessons in IR: M & Source Type: research
Effects of bile acid metabolism on intestinal health of livestock and poultry
AbstractBile acids are synthesised in the liver and are essential amphiphilic steroids for maintaining the balance of cholesterol and energy metabolism in livestock and poultry. They can be used as novel feed additives to promote fat utilisation in the diet and the absorption of fat-soluble substances in the feed to improve livestock performance and enhance carcass quality. With the development of understanding of intestinal health, the balance of bile acid metabolism is closely related to the composition and growth of livestock intestinal microbiota, inflammatory response, and metabolic diseases. This paper systematically...
Source: Journal of Animal Physiology and Animal Nutrition - April 23, 2024 Category: Zoology Authors: Hongpeng Jia,
Na Dong Tags: REVIEW Source Type: research
Caffeic acid combined with arabinoxylan or β-glucan attenuates diet-induced obesity in mice via modulation of gut microbiota and metabolites
Int J Biol Macromol. 2024 Apr 20:131683. doi: 10.1016/j.ijbiomac.2024.131683. Online ahead of print.ABSTRACTPolyphenols and dietary fibers in whole grains are important bioactive compounds to reduce risks for obesity. However, whether the combination of the two components exhibits a stronger anti-obesity effect remains unclear. Caffeic acid is a major phenolic acid in cereals, and arabinoxylan and β-glucan are biological macromolecules with numerous health benefits. Here, we investigated the effect of caffeic acid combined with arabinoxylan or β-glucan on glucose and lipid metabolism, gut microbiota, and metabolites in m...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Wei Fang Mingyu Jin Wentao Qi Chunli Kong Ge Song Wenting Peng Yong Wang Source Type: research
Who won?
Families, Systems, & Health, Vol 42(1), Mar 2024, 139; doi:10.1037/fsh0000844This poem describes the ugly face of misinformation and lies-spewing bile as COVID shook us and humanity came undone. Vaccines were rejected and lockdowns were broken. We barely withstood. Who won? No one. (PsycInfo Database Record (c) 2024 APA, all rights reserved) (Source: Families, Systems, and Health)
Source: Families, Systems, and Health - April 22, 2024 Category: International Medicine & Public Health Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
Network analysis of microbiome and metabolome to explore the mechanism of raw rhubarb in the protection against ischemic stroke via microbiota-gut-brain axis
In conclusion, our work demonstrated that RR could effectively ameliorate ischemic stroke by modulating the microbiota and metabolic disorders.PMID:38643860 | DOI:10.1016/j.fitote.2024.105969 (Source: Fitoterapia)
Source: Fitoterapia - April 21, 2024 Category: Biochemistry Authors: Minghua Xian Zuqing Ma Sikai Zhan Lin Shen Ting Li Huiting Lin Mingmin Huang Jiale Cai Tao Hu Jiaying Liang Shengwang Liang Shumei Wang Source Type: research
Review: Mechanism of herbivores synergistically metabolizing toxic plants through liver and intestinal microbiota
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 19:109925. doi: 10.1016/j.cbpc.2024.109925. Online ahead of print.ABSTRACTInterspecific interactions are central to ecological research. Plants produce toxic plant secondary metabolites (PSMs) as a defense mechanism against herbivore overgrazing, prompting their gradual adaptation to toxic substances for tolerance or detoxification. P450 enzymes in herbivore livers bind to PSMs, whereas UDP-glucuronosyltransferase and glutathione S-transferase increase the hydrophobicity of the bound PSMs for detoxification. Intestinal microorganisms such as Bacteroidetes metabolize cellul...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 21, 2024 Category: Biochemistry Authors: Yuchen Tan Kang An Junhu Su Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation
ConclusionThis study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 21, 2024 Category: Food Science Authors: Mengcheng Jin,
Tangbin Zou,
Hairong Huang,
Ming Chen,
Haoqi Zou,
Baoyan Chen,
Chengze Lai,
Huawen Li,
Peiwen Zhang Tags: Research Article Source Type: research
New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study
CONCLUSIONS: In human liver regeneration FGF19 upregulation may constitute a protective response from BAs excess during liver regeneration. Our findings suggest the existence of post-translational mechanisms regulating CYP7A1 activity, and therefore BAs synthesis, independent from CYP7A1/Cyp7a1 gene transcription.PMID:38642480 | DOI:10.1016/j.bbadis.2024.167166 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Iker Uriarte Eva Santamaria Amaya L ópez-Pascual Mar ía J Monte Josepmaria Argem í M Ujue Latasa Elena Ad án-Villaescusa Ainara Irigaray Jose M Herranz Mar ía Arechederra Jorge Basualdo Felipe Lucena Fernando J Corrales Fernando Rotellar Fernando Par Source Type: research
Effects of p-coumaric acid on probiotic properties of Lactobacillus acidophilus LA-5 and lacticaseibacillus rhamnosus GG
Arch Microbiol. 2024 Apr 20;206(5):223. doi: 10.1007/s00203-024-03957-x.ABSTRACTProbiotics are defined as "live microorganisms that provide health benefits to the host when administered in adequate amounts." Probiotics have beneficial effects on human health, including antibacterial activity against intestinal pathogens, regulation of blood cholesterol levels, reduction of colitis and inflammation incidence, regulation of the immune system, and prevention of colon cancer. In addition to probiotic bacteria, some phenolic compounds found in foods we consume (both food and beverages) have positive effects on human health. p-c...
Source: Archives of Microbiology - April 20, 2024 Category: Microbiology Authors: Buse Nur Derebasi Sena Davran Bulut Busra Aksoy Erden Nastaran Sadeghian Parham Taslimi Hasan Ufuk Celebioglu Source Type: research
GSE228477 An exosomal circRNA signature in the diagnosis and prognostification of cholangiocarcinoma: circRNA microarray analysis for 10 human bile samples
Contributors : Ningyuan Wen ; Dingzhong Peng ; Jiong Lu ; Bei LiSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensWe have completed the Arraystar Human circRNA Array V2 analysis of 10 bile exosome samples (5 cholangiocarcinoma-induced biliary obstruction vs. 5 benign biliary obstruction). Total RNA from each sample was quantified using the NanoDrop ND-1000. The sample preparation and microarray hybridization were performed based on the Arraystar ’s standard protocols. Briefly, total RNAs were digested with Rnase R (Epicentre, Inc.) to remove linear RNAs and enrich c...
Source: GEO: Gene Expression Omnibus - April 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research
