Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Effects of Prevotella copri on insulin, gut microbiota and bile acids
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 16, 2024 Category: Microbiology Authors: Jiatai GongQianjin ZhangRuizhi HuXizi YangChengkun FangLiping YaoJing LvLong WangMingkun ShiWentao ZhangSiqi MaHongkun XiangHongfu ZhangDe-Xing HouYulong YinJianhua HeLijun PengShusong Wua Hunan Collaborative Innovation Center for Utilization of Botanical Source Type: research
HAIC Combined with lenvatinib plus PD-1 versus lenvatinib Plus PD-1 in patients with high-risk advanced HCC: a real-world study
The treatment of hepatocellular carcinoma (HCC) patients exhibiting high-risk characteristics (Vp4, and/or bile duct invasion, and/or tumor occupancy ≥ 50%) lacks standardized approaches and yields unfavorable... (Source: BMC Cancer)
Source: BMC Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Xu Chang, Xinge Li, Peng Sun, Zhenfeng Li, Pengfei Sun and Shangkun Ning Tags: Research Source Type: research
Subtotal cholecystectomy with omental pedicle plug for the challenging gallbladder: A case report and review of the literature
Key Clinical MessageIf patient anatomy or disease does not allow for a traditional or partial cholecystectomy, an omental pedicle plug may be a viable option to limit the risk of postoperative uncontrolled bile leak from the cystic duct and to control patient symptoms. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 15, 2024 Category: General Medicine Authors: Michael A. Stellon,
Cullen J. Fleming,
John E. Scarborough Tags: CASE REPORT Source Type: research
Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
CONCLUSION: MXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia.PMID:38622728 | DOI:10.1186/s40001-024-01777-9 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Shiying Zhang Bei Li Liuting Zeng Kailin Yang Junyao Jiang Fangguo Lu Ling Li Weiqing Li Source Type: research
Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice
ConclusionsThe dynamics of liver macrophage subsets, and the compositions of the gut microbiota and bile acids at steady state and post-onset of MASH, had major impacts on MASH development. (Source: Inflammation Research)
Source: Inflammation Research - April 15, 2024 Category: Research Source Type: research
Ileum excision partially reverses improvement of glucose metabolism in diabetic rats after biliopancreatic diversion with duodenal switch
Bile acids can stimulate the secretion of glucagon-like peptide-1 (GLP-1) and be mostly reabsorbed in the ileum. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - April 15, 2024 Category: Surgery Authors: Weijie Chen, Jianhao Huang, Jianchun Xiao, Qiang Xu, Wei Liu, Xiaodong He Tags: Original articles Source Type: research
Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
ConclusionMXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research
Detection of residual stones by peroral direct cholangioscopy in patients with intrahepatic stones after hepaticojejunostomy: A prospective study (with video)
The difficulty of radiographic confirmation of the presence of stones remains a challenge in the treatment of intrahepatic bile duct (IHBD) stones in patients after hepaticojejunostomy (HJ). Peroral direct cholangioscopy (PDCS) enables direct observation of the bile duct and is useful for detecting and removing residual stones; however, its effectiveness is not clearly established in this clinical context. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 15, 2024 Category: Gastroenterology Authors: Kazuyuki Matsumoto, Hironari Kato, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Yuki Fujii, Ryosuke Sato, Nao Hattori, Taisuke Obata, Hiroyuki Terasawa, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Motoyuki Otsuka Source Type: research
