Current and Potential Applications for Indocyanine Green in Liver Transplantation
Indocyanine green (ICG) is a fluorescent dye taken up and almost exclusively cleared by the liver. Measurement of its clearance and visualization of its fluorescence make it suitable for a number of potential applications in liver transplantation including assessment of liver function and real-time assessment of arterial, venous, and biliary structures. ICG clearance can be used to assess donor graft quality before procurement and graft metabolic function before transplant using normothermic ex vivo machine perfusion. ICG clearance in the post–liver transplantation period is able to predict recipient outcomes with correl...
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research

Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study
CONCLUSIONS: This retrospective study showed positive associations between serum TBA level and GICs risk, and a higher serum TBA level constitutes a risk factor for GICs.PMID:35756666 | PMC:PMC9213662 | DOI:10.3389/fonc.2022.859716 (Source: Cancer Control)
Source: Cancer Control - June 27, 2022 Category: Cancer & Oncology Authors: Songbo Li Xiaodong Qu Luyao Zhang Na Wang Min Chen Xingyu Zhao Jie Wang Huanhuan Lv Ying Qi Lifeng Zhang Junye Liu Yongquan Shi Source Type: research

The T Category of Distal Extrahepatic Bile Duct Carcinoma: A Comparative Analysis With Invasive Tumor Thickness
The T category of distal extrahepatic bile duct carcinoma (DBDC) is based on invasion depth from the basal lamina to the deepest infiltrating tumor cells. Recently, invasive tumor thickness (ITT) was proposed, defined as maximal vertical distance of invasive tumor components regardless of the basal lamina. We compared the predictive value of T category, and ITT grading in 424 surgically resected DBDCs. DBDCs were categorized as 6 Tis (1.4%), 134 T1 (12 mm; 18.9%). With ITT, there were 6 G0 (no invasion; 1.4%), 3 G1 ( (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - June 27, 2022 Category: Pathology Tags: Original Articles Source Type: research

The Role of Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease
This article also reviews several therapeutic approaches for the management and prevention of NAFLD targeting the GM-BAs axis. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 27, 2022 Category: Microbiology Source Type: research

Wuwei Qingzhuo San Ameliorates Hyperlipidemia in Mice Fed With HFD by Regulating Metabolomics and Intestinal Flora Composition
In this study, 16 S rRNA gene sequencing and metabolomics were performed to investigate the action mechanism of WQS on hyperlipidemic mice induced by a high-fat diet (HFD). As a result, metabolic pathway enrichment analysis revealed that the intervention of WQS had obviously modulated the metabolism of α-linolenic acid and linoleic acid and the biosynthesis of bile acids. 16 S rRNA sequencing showed that WQS had altered the composition of the intestinal microbiota in hyperlipidemic mice fed with HFD and, especially, adjusted the relative abundance ratio of Firmicutes/Bacteroides. These findings provide new evidence that...
Source: Frontiers in Pharmacology - June 27, 2022 Category: Drugs & Pharmacology Source Type: research

Theabrownin and Poria cocos Polysaccharide Improve Lipid Metabolism via Modulation of Bile Acid and Fatty Acid Metabolism
This study demonstrated that TB, PCP, especially the combination of TB and PCP could be potential therapeutic formula for NAFLD that promoted lipid utilization and inhibited lipid synthesis and absorption. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 27, 2022 Category: Drugs & Pharmacology Source Type: research

Predictive value of serum bile acids as metabolite biomarkers for liver cirrhosis: a systematic review and meta-analysis
ConclusionAltered serum bile acids profile seems to be associated with cirrhosis. Some specific bile acids (GCA, GCDCA, TCA, and TCDCA) may increase with the development of cirrhosis, which possibly underlay their potential role as predictive biomarkers for cirrhosis. Yet this predictive value still needs further investigation and validation in larger prospective cohort studies. (Source: Metabolomics)
Source: Metabolomics - June 27, 2022 Category: Biology Source Type: research

CO100 Correlations between Patient- and Caregiver-Reported Pruritus from PEDFIC 1: Evaluation of Prucision Data in Patients with Progressive Familial Intrahepatic Cholestasis
10.1016/j.jaip.2022.01.038Pruritus can be a debilitating symptom for patients with progressive familial intrahepatic cholestasis (PFIC), a disease that commonly presents in young children. In the phase 3 PEDFIC 1 study (NCT03566238), odevixibat, an ileal bile acid transporter inhibitor, reduced pruritus compared with placebo based on caregiver report in children with PFIC using the PRUCISION scale. Patient-reported pruritus data were also collected from patients aged ≥8 years. This analysis examines the correlation between patient- and caregiver-reported pruritus scores in PEDFIC 1. (Source: Value in Health)
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: C Clemson, Q Ni, P Horn Source Type: research

Does Intraoperative Frozen Section and Revision of Margins Lead to Improved Survival in Patients Undergoing Resection of Perihilar Cholangiocarcinoma? A Systematic Review and Meta-analysis
CONCLUSIONS: This review supports routine intraoperative biliary margin evaluation during resection of PHC with revision if technically feasible.PMID:35752725 | DOI:10.1245/s10434-022-12041-x (Source: Ann Oncol)
Source: Ann Oncol - June 25, 2022 Category: Cancer & Oncology Authors: Tori Lenet Richard W D Gilbert Rory Smoot Ching-Wei D Tzeng Flavio G Rocha Lavanya Yohanathan Sean P Cleary Guillaume Martel Kimberly A Bertens Source Type: research

Biliary Stricture After Necrotizing Pancreatitis: An Underappreciated Challenge
Objective: Biliary stricture in necrotizing pancreatitis (NP) has not been systematically categorized; therefore, we sought to define the incidence and natural history of biliary stricture caused by NP. Summary of Background Data: Benign biliary stricture occurs secondary to bile duct injury, anastomotic narrowing, or chronic inflammation and fibrosis. The profound locoregional inflammatory response of NP creates challenging biliary strictures. Methods: NP patients treated between 2005 and 2019 were reviewed. Biliary stricture was identified on cholangiography as narrowing of the extrahepatic biliary tree...
Source: Annals of Surgery - June 24, 2022 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis
Objective: To determine the associations of pancreatobiliary maljunction (PBM) in the West. Background: PBM (anomalous union of common bile duct and pancreatic duct) is mostly regarded as an Asian-only disorder, with 200X risk of gallbladder cancer (GBc), attributed to reflux of pancreatic enzymes. Methods: Radiologic images of 840 patients in the US who underwent pancreatobiliary resections were reviewed for PBM and contrasted with 171 GBC cases from Japan. Results: Eight % of the US GBCs (24/300) had PBM (similar to Japan; 15/ 171, 8.8%), in addition to 1/42 bile duct carcinomas and 5/33 choledochal cys...
Source: Annals of Surgery - June 24, 2022 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Primary Biliary Cholangitis with Ankylosing Spondylitis
Korean J Gastroenterol. 2022 Jun 25;79(6):270-273. doi: 10.4166/kjg.2022.048.ABSTRACTPrimary biliary cholangitis is a chronic inflammatory autoimmune liver disease that is characterized by a positive antimitochondrial antibodies test and progressive destruction of the small intrahepatic bile duct. Ankylosing spondylitis is a chronic, systemic, inflammatory disease of the spine and the sacroiliac joints. The association between these two is very low. This paper reports a rare case who had ankylosing spondylitis and developed primary biliary cholangitis.PMID:35746842 | DOI:10.4166/kjg.2022.048 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - June 24, 2022 Category: Gastroenterology Authors: Young Mi Hong Ki Tae Yoon Mong Cho Source Type: research

Association analysis for SNPs of < em > BAAT < /em > and < em > COL1A1 < /em > genes with cashmere production performance and other production traits in Liaoning cashmere goats
This study aimed to investigate the relationship between the polymorphism of bile acid-CoA: amino acid N-acyltransferase (BAAT) and collagen type I alpha 1 chain (COL1A1) genes and the production performance of Liaoning Cashmere goat (LCG). The potential single nucleotide polymorphisms (SNPs) of LCG were detected by sequence comparison of BAAT and COL1A1 genes and PCR-Seq polymorphism, and the effect of SNPs on production performance was analyzed by SPSS software. The results showed that three SNPs loci were detected in BAAT gene: G7900A, T7967C, C7998T, and one SNP locus T6716C was detected in COL1AL gene. At G7900A locus...
Source: Animal Biotechnology - June 24, 2022 Category: Biotechnology Authors: Weidong Cai Yanan Xu Zhixian Bai Guangyu Lin Lingling Wang Xingtang Dou Di Han Zhanhong Wang Jiaming Wang Xinjiang Zhang Yu Zhang Yuting Qin Ming Gu Yinggang Sun Yanzhi Wu Rui Chen Zeying Wang Source Type: research

Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome
In this study, the potential of C8 as an anti-hepatic fibrosis agent was investigated. In human hepatic stellate cell (HSC) line LX-2, C8 suppressed the increased expression of COL1A1 and α-SMA induced by TGFβ1, which indicated that C8 could repress the activation of HSCs. In bile duct ligated rats, C8 administration (100 mg/kg, i.p.) markedly attenuated liver injury, fibrosis, and inflammation, and suppressed the expression of the macrophage surface marker F4/80. In terms of mechanism, C8 treatment blocked the activation of the NLRP3 inflammasome, which was stimulated by LPS and nigericin in bone marrow-derived macropha...
Source: Bioorganic Chemistry - June 24, 2022 Category: Chemistry Authors: Wei-Xiao Niu Yun-Yang Bao Na Zhang Zhen-Ning Lu Mao-Xu Ge Yi-Ming Li Yi Li Ming-Hua Chen Hong-Wei He Source Type: research

Primary Biliary Cholangitis with Ankylosing Spondylitis
Korean J Gastroenterol. 2022 Jun 25;79(6):270-273. doi: 10.4166/kjg.2022.048.ABSTRACTPrimary biliary cholangitis is a chronic inflammatory autoimmune liver disease that is characterized by a positive antimitochondrial antibodies test and progressive destruction of the small intrahepatic bile duct. Ankylosing spondylitis is a chronic, systemic, inflammatory disease of the spine and the sacroiliac joints. The association between these two is very low. This paper reports a rare case who had ankylosing spondylitis and developed primary biliary cholangitis.PMID:35746842 | DOI:10.4166/kjg.2022.048 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - June 24, 2022 Category: Gastroenterology Authors: Young Mi Hong Ki Tae Yoon Mong Cho Source Type: research