Detection of residual stones by peroral direct cholangioscopy in patients with intrahepatic stones after hepaticojejunostomy: A prospective study (with video)
The difficulty of radiographic confirmation of the presence of stones remains a challenge in the treatment of intrahepatic bile duct (IHBD) stones in patients after hepaticojejunostomy (HJ). Peroral direct cholangioscopy (PDCS) enables direct observation of the bile duct and is useful for detecting and removing residual stones; however, its effectiveness is not clearly established in this clinical context. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 15, 2024 Category: Gastroenterology Authors: Kazuyuki Matsumoto, Hironari Kato, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Yuki Fujii, Ryosuke Sato, Nao Hattori, Taisuke Obata, Hiroyuki Terasawa, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Motoyuki Otsuka Source Type: research
Impact of temperature-controlled endobiliary radiofrequency ablation for inoperable hilar cholangiocarcinoma: A propensity score –matched analysis
Conclusions Temperature-controlled endobiliary RFA resulted in favorable stent patency without increasing the rate of AEs but it did not significantly increase OS in patients with inoperable hilar CCA (Clinical trial registration number: KCT0008576). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 15, 2024 Category: Gastroenterology Authors: Shin, Il Sang Moon, Jong Ho Lee, Yun Nah Myeong, Jun Ho Lee, Tae Hoon Yang, Jae Kook Cho, Young Deok Park, Sang-Heum Tags: Original article Source Type: research
Impact of a new dedicated sheath device for tissue sampling of biliary stricture on pathological diagnostic yield: Retrospective study
Conclusions TBFB with the novel sheath device contributed to improved sensitivity for diagnosis of biliary stricture without insertion of forceps outside the bile duct. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 15, 2024 Category: Gastroenterology Authors: Niiya, Fumitaka Ishiwatari, Hirotoshi Sasaki, Keiko Ishikawa, Kazuma Sato, Junya Kishida, Yoshihiro Imai, Kenichiro Hotta, Kinichi Ono, Hiroyuki Tags: Original article Source Type: research
The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
In conclusion, nitazoxanide inhibits liver fibrosis and the underlying mechanisms involve AMPK activation, and STAT3 and Smad2/3 inhibition.PMID:38615918 | DOI:10.1016/j.bcp.2024.116205 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Kai-Xin Liu Zeng-Yang Wang Ya-Ting Ying Rui-Miao Wei De-Li Dong Zhi-Jie Sun Source Type: research
Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone
Bull Environ Contam Toxicol. 2024 Apr 14;112(4):63. doi: 10.1007/s00128-024-03871-4.ABSTRACTResearch on thermal receipts has previously focused on the toxic effects of dermal exposure from the most publicized developers (e.g., bisphenol A (BPA) and bisphenol S (BPS)), while no studies have reported on the other solvent-extractable compounds therein. Diphenyl sulfone (DPS) is a sensitizer added to thermal receipts, but little is known about DPS concentrations in receipts or potential toxicity. Here, we quantified BPA, BPS, and DPS concentrations and tentatively identified the solvent-extractable compounds of thermal receipt...
Source: Bulletin of Environmental Contamination and Toxicology - April 14, 2024 Category: Environmental Health Authors: Tasnia Sharin Lucas J Leinen David Schreiber Vaille A Swenson Sarah A Emsley E Jamie Trammell Patrick Videau Doug Crump Michael O Gaylor Source Type: research
The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
In conclusion, nitazoxanide inhibits liver fibrosis and the underlying mechanisms involve AMPK activation, and STAT3 and Smad2/3 inhibition.PMID:38615918 | DOI:10.1016/j.bcp.2024.116205 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Kai-Xin Liu Zeng-Yang Wang Ya-Ting Ying Rui-Miao Wei De-Li Dong Zhi-Jie Sun Source Type: research
Molecular insights into experimental models and therapeutics for cholestasis
Biomed Pharmacother. 2024 Apr 13;174:116594. doi: 10.1016/j.biopha.2024.116594. Online ahead of print.ABSTRACTCholestatic liver disease (CLD) is a range of conditions caused by the accumulation of bile acids (BAs) or disruptions in bile flow, which can harm the liver and bile ducts. To investigate its pathogenesis and treatment, it is essential to establish and assess experimental models of cholestasis, which have significant clinical value. However, owing to the complex pathogenesis of cholestasis, a single modelling method can merely reflect one or a few pathological mechanisms, and each method has its adaptability and l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wenwen Zhang Hefei Wu Shiman Luo Xiaohua Lu Xiyue Tan Li Wen Xiao Ma Thomas Efferth Source Type: research
Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone
Bull Environ Contam Toxicol. 2024 Apr 14;112(4):63. doi: 10.1007/s00128-024-03871-4.ABSTRACTResearch on thermal receipts has previously focused on the toxic effects of dermal exposure from the most publicized developers (e.g., bisphenol A (BPA) and bisphenol S (BPS)), while no studies have reported on the other solvent-extractable compounds therein. Diphenyl sulfone (DPS) is a sensitizer added to thermal receipts, but little is known about DPS concentrations in receipts or potential toxicity. Here, we quantified BPA, BPS, and DPS concentrations and tentatively identified the solvent-extractable compounds of thermal receipt...
Source: Bulletin of Environmental Contamination and Toxicology - April 14, 2024 Category: Environmental Health Authors: Tasnia Sharin Lucas J Leinen David Schreiber Vaille A Swenson Sarah A Emsley E Jamie Trammell Patrick Videau Doug Crump Michael O Gaylor Source Type: research
Molecular insights into experimental models and therapeutics for cholestasis
Biomed Pharmacother. 2024 Apr 13;174:116594. doi: 10.1016/j.biopha.2024.116594. Online ahead of print.ABSTRACTCholestatic liver disease (CLD) is a range of conditions caused by the accumulation of bile acids (BAs) or disruptions in bile flow, which can harm the liver and bile ducts. To investigate its pathogenesis and treatment, it is essential to establish and assess experimental models of cholestasis, which have significant clinical value. However, owing to the complex pathogenesis of cholestasis, a single modelling method can merely reflect one or a few pathological mechanisms, and each method has its adaptability and l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wenwen Zhang Hefei Wu Shiman Luo Xiaohua Lu Xiyue Tan Li Wen Xiao Ma Thomas Efferth Source Type: research
Sodium/Bile acid co-transporter inhibitors currently in preclinical or early clinical development for the treatment of primary biliary cholangitis
Expert Opin Investig Drugs. 2024 Apr 13. doi: 10.1080/13543784.2024.2343789. Online ahead of print.ABSTRACTINTRODUCTION: Pruritus is common and often undertreated in patients with primary biliary cholangitis (PBC). Existing treatments largely have an aging and low-quality evidence base, and studies included only small numbers of patients. More recent data that has added to our understanding of pruritus treatments has often come from clinical trials where itch was a secondary outcome measure in a trial designed primarily to assess disease modifying agents. This area represents an unmet clinical need in the management of PBC...
Source: Expert Opinion on Investigational Drugs - April 13, 2024 Category: Drugs & Pharmacology Authors: Abhishek Gairola Aaron Wetten Jessica Dyson Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
