Design and development of novel self-assembled catechol-modified bile acid conjugates as pH-responsive apical sodium-dependent bile acid transporter targeting nanoparticles
This study underscores the therapeutic potential of the newly developed catechol-based, pH-responsive ASBT-inhibiting nanoparticles presenting a promising avenue for advancing therapy.PMID:38552366 | DOI:10.1016/j.biomaterials.2024.122539 (Source: Biomaterials)
Source: Biomaterials - March 29, 2024 Category: Materials Science Authors: Dong-Nyeong Lee Seong-Bin Yang Seho Kweon Jun-Hyuck Lee Kyeong-Ju Lee Yeonsu Ryu Dong Wook Shin Young Jun Kim Yong-Kyu Lee Jooho Park Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
Production and immunological characterization of the novel single-chain variable fragment (scFv) antibodies against the epitopes on Opisthorchis viverrini cathepsin F (OvCatF)
CONCLUSION: Our produced scFv antibodies will be the potential candidates for developing a practical diagnostic procedure for O. viverrini infection in humans in the future.PMID:38552996 | DOI:10.1016/j.actatropica.2024.107199 (Source: Acta Tropica)
Source: Acta Tropica - March 29, 2024 Category: Infectious Diseases Authors: Pongsakorn Martviset Jeeraphong Thanongsaksrikul Amornrat Geadkaew-Krenc Salisa Chaimon Kantaphon Glab-Ampai Wanlapa Chaibangyang Phornphan Sornchuer Potjanee Srimanote Jittiporn Ruangtong Parisa Prathaphan Tonkla Taechadamrongtham Nattaya Torungkitmangmi Source Type: research
The bile-gut axis and metabolic consequences of cholecystectomy
Eur J Endocrinol. 2024 Mar 29:lvae034. doi: 10.1093/ejendo/lvae034. Online ahead of print.ABSTRACTCholelithiasis and cholecystitis affect individuals of all ages and are often treated by surgical removal of the gallbladder (cholecystectomy), which is considered a safe, low-risk procedure. Nevertheless, recent findings show that bile and its regulated storage and excretion may have important metabolic effects and that cholecystectomy is associated with several metabolic diseases postoperatively. Bile acids have long been known as emulsifiers essential to the assimilation of lipids and absorption of lipid-soluble vitamins, b...
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Andreas H Lange Miriam G Pedersen Anne-Marie Ellegaard Henriette H Nerild Andreas Br ønden David P Sonne Filip K Knop Source Type: research
Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling
CONCLUSION: Single-dose colesevelam had no effect on postprandial GLP-1 responses or glucose tolerance but disrupted postprandial gallbladder refilling by increasing CCK secretion and reducing circulating concentrations of FGF19 and bile acids. These findings leave the antidiabetic actions of colesevelam unresolved but provide mechanistic insights into its effect on gallbladder motility.PMID:38551029 | DOI:10.1093/ejendo/lvae033 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ida M Gether Emilie Bahne Henriette H Nerild Jens F Rehfeld Bolette Hartmann Jens J Holst Tina Vilsb øll David P Sonne Filip K Knop Source Type: research
Evaluation of Alternative Treatment Strategies for Bile Acid Malabsorption in Inflammatory Bowel Disease Patients: A Network Meta-Analysis
CONCLUSIONS: Tropifexor has been identified as the most successful medication in mitigating BAM symptoms. To ensure more accurate results, there is a need for randomized controlled clinical trials that involve a larger participant pool.PMID:38550552 | PMC:PMC10970039 | DOI:10.14740/jocmr5007 (Source: Clin Med Res)
Source: Clin Med Res - March 29, 2024 Category: Research Authors: Nooraldin Merza Omar Saab Yusuf Nawras Roua Abdulhussein Ahmed Elmoursi Lena Daddoo Zinah Yaqoob Hiba Al Ani Tamarah Al Hamdany Ahmed Gadelmawla Mohamed Khalil Mona Hassan Abdallah Kobeissy Source Type: research
Safety and efficacy of novel oblique-viewing scope for B2-endoscopic ultrasound-guided hepaticogastrostomy
CONCLUSIONS: B2-EUS-HGS can be performed safely with the novel EG-740UT (Fujifilm) OV-scope without transesophageal puncture and with a high success rate. B2-EUS-HGS using this novel OV scope may be the preferred strategy for EUS-HGS.PMID:38549245 | DOI:10.5946/ce.2023.129 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - March 29, 2024 Category: Gastroenterology Authors: Sho Ishikawa Kazuo Hara Nozomi Okuno Nobumasa Mizuno Shin Haba Takamichi Kuwahara Yasuhiro Kuraishi Takafumi Yanaidani Masanori Yamada Tsukasa Yasuda Toshitaka Fukui Teru Kumagi Yoichi Hiasa Source Type: research
Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
Evaluation of Alternative Treatment Strategies for Bile Acid Malabsorption in Inflammatory Bowel Disease Patients: A Network Meta-Analysis
CONCLUSIONS: Tropifexor has been identified as the most successful medication in mitigating BAM symptoms. To ensure more accurate results, there is a need for randomized controlled clinical trials that involve a larger participant pool.PMID:38550552 | PMC:PMC10970039 | DOI:10.14740/jocmr5007 (Source: Clin Med Res)
Source: Clin Med Res - March 29, 2024 Category: Research Authors: Nooraldin Merza Omar Saab Yusuf Nawras Roua Abdulhussein Ahmed Elmoursi Lena Daddoo Zinah Yaqoob Hiba Al Ani Tamarah Al Hamdany Ahmed Gadelmawla Mohamed Khalil Mona Hassan Abdallah Kobeissy Source Type: research
Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research
